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Journal of Forestry Research 2012年第2期23卷 323-332页

作者： K. K. Islam Marjanke Hoogstra M.O. Ullah Noriko Sato Forest Policy laboratory Graduate School of Bioresource and Bioenvironmental Sciences Kyushu University Japan Forest and Nature Conservation Policy Group Wageningen University the Netherlands nutrition Metabolism and Genomics Group Wageningen University the Netherlands

In the Forest Department of Bangladesh, a Participatory Agroforestry Program （PAP） was initiated at a denuded Sal forests area to protect the forest resources and to alleviate poverty amongst the local poor population. We explored whether the PAP reduced poverty and what factors might be responsible for poverty alleviation. We used three poverty measurement methods： the Head Count Index, the Poverty Gap Index and the Foster-Greer-Thorbecke index to determine the extent poverty reduction. We used a linear regression model to determine the possible differences among factors in poverty reduction. Data were collected through semi structured questionnaires and face to face interviews within the study area. PAP proved effective at poverty alleviation, considerably improving the local situation. The linear regression model showed that PAP output explained the income differences in poverty reduction. Participants identified bureaucracy and illegal money demands by forest department officials, an uncontrolled market system, and underdeveloped road infrastructure as the main obstacles to reduction of poverty. Overall, PAP is quite successful in alleviating poverty. So this program might be of interest at other degraded forest areas as a tool to alleviate poverty.

关键词： Poverty agroforestry model Sal forests linear regression constraints

Serotonin enrichment of rice endosperm by metabolic engineering

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The Crop Journal 2023年第6期11卷 1943-1948页

作者： Qingqing Yang Yan Tan Ying Ye Dongsheng Zhao Qiaoquan Liu Key laboratory of Crop genomics and Molecular Breeding of Jiangsu Province/Zhongshan Biological Breeding laboratory/Key laboratory of Plant Functional genomics of the Ministry of Education College of AgricultureYangzhou UniversityYangzhou 225009JiangsuChina Jiangsu Co-Innovation Center for Modern Production Technology of Grain Crops/Jiangsu Key laboratory of Crop Genetics and Physiology Yangzhou UniversityYangzhou 225009JiangsuChina

In animals,serotonin is a neurotransmitter and mood *** plants,serotonin functions in energy acquisition,tissue maintenance,delay of senescence,and response to biotic and abiotic *** this study,we examined the effect of serotonin enrichment of rice endosperm on plant growth,endosperm development,and grain *** do so,TDCs and T5H were selected as targets for serotonin *** of TDC1 or TDC3 increased serotonin accumulation relative to overexpression of T5H in rice *** lines of target genes driven by the Gt1 promoter showed better field performance than those driven by the Ubi *** of T5H showed little effect on plant growth or grain physicochemical *** neuronal cell culture assays,serotonin induced neuroprotective action against *** of rice cultivars with high serotonin content may be beneficial for health and nutrition.

关键词： Rice endosperm Serotonin Metabolic engineering TDCs T5H

The untold story between enhancers and skeletal muscle development

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Journal of Integrative Agriculture 2020年第9期19卷 2137-2149页

作者： ZHANG Yong-sheng LU Dan LIU Yu-wen YI Guo-qiang TANG Zhong-lin Shenzhen Branch Guangdong laboratory for Lingnan Modern Agriculture Agricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518124P.R.China Genome Analysis laboratory of the Ministry of Agriculture Agricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518124P.R.China College of Animal Science and Technology Yunnan Agricultural UniversityKunming 650201P.R.China State Key laboratory of Animal nutrition Institute of Animal ScienceChinese Academy of Agricultural SciencesBeijing 100193P.R.China

Currently,enhancers have key transcriptional regulatory roles in muscle *** muscle formation involves various molecules,and in animals,enhancers are one of the main types of transcriptional regulatory regions that are of great importance to regulate myogenic gene *** muscle development,enhancers can generate enhancer RNAs(eRNAs)that are involved in the regulation of gene *** regulation of gene expression by eRNAs offers great potential in improving animal production *** we comprehensively review the roles of enhancers in muscle formation and its potential function in skeletal muscle *** review will describe the future application of enhancers in skeletal muscle development and discuss the prospects that enhancer studies offer for agriculture,biotechnology,and animal breeding.

关键词： animal enhancer eRNA skeletal muscle growth and development

A transgene-free method for rapid and efficient generation of precisely edited pigs without monoclonal selection

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Science China(Life Sciences) 2022年第8期65卷 1535-1546页

作者： Kui Xu Xiuling Zhang Zhiguo Liu Jinxue Ruan Changjiang Xu Jingjing Che Ziyao Fan Yulian Mu Kui Li State Key laboratory of Animal nutrition and Key laboratory of Animal Genetics Breeding and Reproduction of Ministry of Agriculture and Rural Affairs of ChinaInstitute of Animal SciencesChinese Academy of Agricultural SciencesBeijing 100193China Genome Analysis laboratory of the Ministry of Agriculture and Rural Affairs Agricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518120China Key laboratory of Agricultural Animal Genetics Breeding and Reproduction(Huazhong Agricultural University)Ministry of EducationWuhan 430070China

Gene-edited pigs for agricultural and biomedical applications are typically generated using somatic cell nuclear transfer(SCNT).However, SCNT requires the use of monoclonal cells as donors, and the time-consuming and laborious monoclonal selection process limits the production of large populations of gene-edited animals. Here, we developed a rapid and efficient method named RE-DSRNP(reporter RNA enriched dual-sg RNA/CRISPR-Cas9 ribonucleoproteins) for generating gene-edited donor cells. RE-DSRNP takes advantage of the precise and efficient editing features of dual-sg RNA and the high editing efficiency, low off-target effects, transgene-free nature, and low cytotoxic characteristics of reporter RNA enriched RNPs(CRISPR-Cas9ribonucleoproteins), thus eliminating the need for the selection of monoclonal cells and thereby greatly reducing the generation time of donor cells from 3–4 weeks to 1 week, while also reducing the extent of apoptosis and chromosomal aneuploidy of donor cells. We applied RE-DSRNP to produce cloned pigs bearing a deletion edit of the wild-type p53-induced phosphatase 1(WIP1)gene: among 32 weaned cloned pigs, 31(97%) carried WIP1 edits, and 15(47%) were homozygous for the designed fragment deletion, and no off-target event was detected. The WIP1 knockout(KO) pigs exhibited male reproductive disorders, illustrating the utility of RE-DSRNP for rapidly generating precisely edited animals for functional genomics and disease research. REDSRNP's strong editing performance in a large animal and its marked reduction in the required time for producing SCNT donor cells support its application prospects for rapidly generating populations of transgene-free cloned animals.

关键词： dual-sg RNA CRISPR-Cas9 ribonucleoproteins transgene-free without monoclonal selection cloned pig

Effects of stocking density on growth performance, blood parameters and immunity of growing pigs

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Animal nutrition 2020年第4期6卷 529-534页

作者： Xue Li Xia Xiong Xin Wu Gang Liu Kai Zhou Yulong Yin Scientific Observing and Experimental Station of Animal nutrition and Feed Science in South-Central Ministry of AgricultureHunan Provincial Engineering Research Center of Healthy LivestockKey Laboratory of Agro-ecological Processes in Subtropical RegionInstitute of Subtropical AgricultureChinese Academy of SciencesChangshaHunan410125China University of Chinese Academy of Science Beijing100049China Key laboratory of Adaptation and Evolution of Plateau Biota Qinghai Key Laboratory of Animal Ecological GenomicsLaboratory of Plateau Fish Evolutionary and Functional GenomicsNorthwest Institute of Plateau BiologyChinese Academy of SciencesXining810001China

This study was conducted to evaluate the effects of different stocking densities on growth performance,blood parameters,intestinal morphology and intestinal immunity of growing pigs.A total of288 male pigs(44.35±0.50 kg)were randomly assigned to groups with stocking densities of 2.46,1.23 and 0.82 m2/pig for a *** results showed that there was no significant difference on growth performance among *** in the stocking density of 0.82 m2/pig had the lowest backfat thickness and spleen weight index among groups(P<0.05).With increasing stocking density,the serum concentrations of blood urea nitrogen(BUN),transglutaminase(TGG),alkaline phosphatase(AKP)and immunoglobulin A(Ig A)were increased,and albumin(ALB),albumin-to-globulin ratio(ALB:GLO),insulin-like growth factor-1(IGF-1)and immunoglobulin(Ig M)were decreased(P<0.05),and cortisol tended to increase and glucose tended to decrease(0.05

关键词： Stocking density Growth performance Blood parameter Intestinal morphology Growing pig

Altered metabolic state impedes limb regeneration in salamanders

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Zoological Research 2021年第6期42卷 772-782页

作者： Zhe-Lun Peng Bin-Xu Yin Rui-Min Ren Yin-Long Liao Hao Cai Heng Wang College of Animal Sciences and Technology Huazhong Agricultural UniversityWuhanHubei 430070China Shenzhen Institute of nutrition and Health Huazhong Agricultural UniversityShenzhenGuangdong 518120China Shenzhen Branch Guangdong Laboratory for Lingnan Modern AgricultureGenome Analysis Laboratory of the Ministry of AgricultureAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhenGuangdong 518120China

Salamanders are unique among tetrapods in their ability to regenerate the limbs throughout *** other poikilothermic amphibians,salamanders also show a remarkable capacity to survive long periods of *** the physiological reserves necessary for tissue regeneration are preserved or sacrificed in starved salamanders is *** the current study,we maintained Iberian ribbed newts(Pleurodeles waltl)under extreme physiological stress to assess the extent of regeneration and identify the molecular and cellular changes that may occur under such *** 19 months of complete food deprivation,the animals exhibited extensive morphological and physiological adaptations but remained behaviorally active and *** was elevated in different tissues and the transformed gut microbiota indicated remodeling of the intestinal tract related to *** limb amputation in animals starved for 21 months,regeneration proceeded with progenitor cell proliferation and migration,leading to limb blastema ***,limb outgrowth and patterning were substantially *** of autophagy inhibited cell proliferation and blastema formation in starved animals,but not in fed ***,tissue autophagy and the regenerative response were tightly coupled only when animals were under *** results demonstrate that under adverse conditions,salamanders can exploit alternative strategies to secure blastema formation for limb regeneration.

关键词： Starvation Stress Autophagy Regeneration Salamander

Improved Eating and Cooking Quality of indica Rice Cultivar YK17 via Adenine Base Editing of Wx^(a)Allele of Granule-Bound Starch Synthase I(GBSS I)

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Rice science 2021年第5期28卷 427-430,I0010-I0017页

作者： Mahmuda Binte Monsur Cao Ni Wei Xiangjin Xie Lihong Jiao Guiai TAng Shaoqing Nese Sreeniwsulu Shao Gaoneng Hu Peisong State Key laboratory of Rice Biology China National Rice Research InstituteHangzhou 310006China Applied Functional genomics Cluster Grain Quality and Nutrition CentreStrategic innovation PlatformInternational Rice Research InstituteLos Banos 4030the Philippines

Amylose content(AC)is the key determinant of eating and cooking quality(ECQ)of *** major Wxa allele of granule-bound starch synthase I(GBSS I)in indica rice produces higher AC,making rice hard and dry after *** work has improved ECQ of japonica rice via clustered regularly interspaced short palindromic repeats/CRISPR-associated protein 9(CRISPR/Cas9)or cytosine base editing(CBE)techniques.

关键词： CRISPR/Cas9 cooking Starch

Salicylic acid inhibits gibberellin signaling through receptor interactions

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Molecular Plant 2022年第11期15卷 1759-1771页

作者： Xiaodong Yu Xiaoyu Cui Chong Wu Shixi Shi Shunping Yan Hubei Hongshan laboratory Wuhan 430070China College of Life Science and Technology Huazhong Agricultural UniversityWuhan 430070China Shenzhen Institute of nutrition and Health Huazhong Agricultural UniversityShenzhen 518000China Shenzhen Branch Guangdong Laboratory for Lingnan Modern AgricultureShenzhen 518000China Agricultural genomics Institute at Shenzhen Chinese Academy of Agricultural SciencesShenzhen 518000China

It is well known that plants activate defense responses at the cost of ***,the underlying molecular mechanisms are not well *** phytohormones salicylic acid(SA)and gibberellin(GA)promote defense response and growth,*** we show that SA inhibits GA signaling to repress plant *** found that the SA receptor NPR1 interacts with the GA receptor *** biochemical studies revealed that NPR1 functions as an adaptor of ubiquitin E3 ligase to promote the polyubiquitination and degradation of GID1,which enhances the stability of DELLA proteins,the negative regulators of GA *** analysis suggested that NPR1,GID1,and DELLA proteins are all required for the SA-mediated growth ***,our study not only uncovers a novel regulatory mechanism of growth-defense trade-off but also reveals the interaction of hormone receptors as a new mode of hormonal crosstalk.

关键词： salicylic acid gibberellin trade-off receptor growth inhibition

Sake or supper? Breeding rice for culinary excellence and optimal brewing

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Molecular Plant 2023年第12期16卷 1879-1881页

作者： Changquan Zhang Qing Liu Qiaoquan Liu Jiangsu Key laboratory of Crop genomics and Molecular Breeding Zhongshan Biological Breeding LaboratoryCollege of AgricultureYangzhou UniversityYangzhou225009China

Improving grain quality is a paramount objective within modern rice breeding *** concept of rice grain quality is intricate,comprising aspects related to milling,appearance,cooking,nutrition,and hygiene(Custodio et al.,2019).It is well established that the quality of rice grain is a sophisticated quantitative trait governed by multiple genes(Ren et al.,2023).Over the past decade,tremendous efforts have been made to breed elite rice varieties with desired grain quality *** instance,the culinary quality of contemporary indica rice has undergone significant enhancements through the substitution of the Wxb allele in place of the Wxa allele,a pivotal domestication-related gene controlling rice grain amylose content,affecting both its cooking and consumption qualities(Zhang et al.,2019;Gu et al.,2023).Recent genomic studies on various modern cultivars and landraces have pinpointed multiple domesticated genes,as well as specific genomic regions,that contribute to distinct agronomic traits and environmental adaptations(Liu et al.,2023).Nevertheless,the identification of genes related to grain quality that have been selected through breeding in modern cultivars continues to be constrained because of the complex regulatory networks implicated.

关键词： breeding cultivar elite

Fetal and neonatal programming of postnatal growth and feed efficiency in swine

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Journal of Animal Science and Biotechnology 2017年第4期8卷 764-778页

作者： Yun Ji Zhenlong Wu Zhaolai Dai Xiaolong Wang Ju Li Binggen Wang Guoyao Wu State Key laboratory of Animal nutrition China Agricultural UniversityBeijing 100193 China Henan Yinfa Animal Husbandry Co. Ltd. XinzhengHenan 451100 China Department of Animal Science and Center for Animal genomics Texas A&M University Room 212 College Station TX 77843 USA.

Maternal undernutrition or overnutrition during pregnancy alters organ structure, impairs prenatal and neonatal growth and development, and reduces feed efficiency for lean tissue gains in pigs. These adverse effects may be carried over to the next generation or beyond. This phenomenon of the transgenerational impacts is known as fetal programming, which is mediated by stable and heritable alterations of gene expression through covalent modifications of DNA and histones without changes in DNA sequences(namely, epigenetics). The mechanisms responsible for the epigenetic regulation of protein expression and functions include chromatin remodeling; DNA methylation(occurring at the 5′-position of cytosine residues within CpG dinucleotides); and histone modifications(acetylation, methylation, phosphorylation, and ubiquitination). Like maternal malnutrition, undernutrition during the neonatal period also reduces growth performance and feed efficiency(weight gain:feed intake; also known as weightgain efficiency) in postweaning pigs by 5–10%, thereby increasing the days necessary to reach the market bodyweight. Supplementing functional amino acids(e.g., arginine and glutamine) and vitamins(e.g., folate) play a key role in activating the mammalian target of rapamycin signaling and regulating the provision of methyl donors for DNA and protein methylation. Therefore, these nutrients are beneficial for the dietary treatment of metabolic disorders in offspring with intrauterine growth restriction or neonatal malnutrition. The mechanism-based strategies hold great promise for the improvement of the efficiency of pork production and the sustainability of the global swine industry.

关键词： Epigenetics Fetal programming Gene expression Neonatal programming nutrition