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Evaluation of Malnutrition in Infants Aged 0 - 59 Months in the Suburbs of Dakar

Health 2023年第4期15卷 349-366页

作者： Issa Jessika Fatimata Mbaye Abdallah Diallo Fatou Ly Pape Mbacké Sembène genomics laboratory Department of Animal Biology Faculty of Science and Technology Cheikh Anta Diop University of Dakar Dakar Senegal Pediatric Social Institute of Pikine (IPS) Dakar Senegal National Hospital Center of Pikine (CHN-Pikine) Dakar Senegal

Introduction: Child malnutrition is a major public health concern worldwide, particularly in low- and middle-income countries. The latest report from Senegal’s Continuous Demographic and Health Survey revealed that 18% of children in Senegal were stunted (chronic malnutrition), 8% were wasted (acute malnutrition) and 14% were underweight. Thus, this study aimed to assess the characteristics associated with malnutrition in children according to their nutritional status. Methods: This descriptive transverse study was conducted at the Pediatric Social Institute of Pikine/Guediawaye and the National Hospital Center of Pikine, in Senegal between October and December 2019. A total of 94 children were recruited, with the consent of their legal tutors. Descriptive and multivariate analyses of the factors associated with malnutrition were performed. The z-scores for the indices of nutrition were determined with WHO Anthro® software version 3.2.2. All the data analyses were performed using R software version 4.2.2. Result: From the 94 children recruited, 51.06% were female, with a sex ratio (male/female) of 0.96. Acute malnutrition was recorded in 62.77% of cases, chronic malnutrition in41.49%, and underweight in 71.27%. Linear regression analysis showed that many factors, such as the female gender [OR = 1.82 CI (1.02 - 3.3), P-value = 0.04], consanguinity [OR = 2.84 CI (1.14 - 7.65), P-value = 0.03], low birth weight [OR = 4.83 CI (2.15 - 12.89), P-value = 0.0004], were associated with acute malnutrition. Low birth weight (nutrition ar

关键词： Malnutrition Child Anthropometry Anemia nutritional Status

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Investigating cooked rice textural properties by instrumental measurements

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Food Science and Human Wellness 2020年第2期9卷 130-135页

作者： Keyu Tao Wenwen Yu Sangeeta Prakash Robert G.Gilbert Joint International Research laboratory of Agriculture and Agri-Product Safety College of AgricultureYangzhou UniversityYangzhouJiangsu225009PR China The University of Queensland Centre for Nutrition and Food SciencesQueensland Alliance for Agriculture and Food InnovationBrisbaneQLD4072Australia Department of Food Science&Engineering Jinan UniversityHuangpu West Avenue 601Guangzhou CityGuangdong Province510632PR China The University of Queensland School of Agriculture and Food ScienceQLD4072Australia Jiangsu Key laboratory of Crop Genetics and Physiology Key Laboratory of Plant Functional Genomics of the Ministry of EducationJiangsu Key Laboratory of Crop Genetics and PhysiologyCollege of AgricultureYangzhou UniversityYangzhou225009PR China

Foods wherein the starch is slowly digested contribute to good health by reducing the tendency to,and for the maintenance of,diabetes,obesity and colo-rectal *** foods with high amylose content have this desirable property,they usually do not have high sensory appeal and consumers are reluctant to eat *** sensory evaluation by trained human panelists is the best way to obtain consumer preferences,these tests are expensive,time-consuming and require considerable effort and *** measurements are easier,cheaper and invaluable for screening,but only useful if they correlate with human data for the type of food being ***,we test this using cooked rice with a wide range of amylose *** properties were correlated against quantitative descriptive panelist *** power and breakdown viscosity correlated with all panelist sensory attributes,but no other correlations with gelatinization properties were *** was a strong correlation between hardness and stickiness measured by texture profile analysis(TPA)and by panelists,suggesting that TPA can be used to measure hardness and stickiness of cooked *** also showed that breakdown viscosity is a reliable instrumental means to provide indicative measurements of hardness and rice preference,and swelling power is a predictor of rice stickiness.

关键词： Rice Texture Instrumental Viscosity Swellingpower

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Toxicological advances of traditional medicine in 2020

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Traditional Medicine Research 2021年第3期6卷 78-85页

作者： Ya-Ru Li Shu-Li Man Long Ma Wen-Yuan Gao State Key laboratory of Food nutrition and Safety Key Laboratory of Industrial MicrobiologyMinistry of EducationTianjin Key Laboratory of Industry MicrobiologyChina International Science and Technology Cooperation Base of Food Nutrition/Safety and Medicinal ChemistryCollege of BiotechnologyTianjin University of Science&TechnologyTianjin 300457China Tianjin Key laboratory for Modern Drug Delivery and High Efficiency School of Pharmaceutical Science and TechnologyTianjin UniversityTianjin 300072China

There were many researches concerning toxicology of traditional medicine and active natural products during the past 12 *** annual toxicology review summarized different toxic analysis methods of traditional medicine,evaluated models,toxic target organs,toxic mechanisms,popular research issues and herbs in *** elegans came to use for the assessment of *** technology such as genomics,transcriptome,metabolomics and proteomics were applied extensively.2020 toxicology research demonstrated that liver,kidney and heart were the mainly toxic target organs of traditional *** toxic mechanisms included cell apoptosis,metabolic disorder,oxidative stress,inflammatory damage,liver and renal fibrosis and even inducing *** addition,the safety assessment of Aconitum carmichaeli Debx.,Tripterygium wilfordii *** Polygonum multiflorum *** well as their detoxification methods were still hot ***,study on the toxicity mechanism of target organs,processing and extract methods,quality control and dose control,new models and methods should be used in the prevention of traditional medicine toxicology in the future.

关键词： Traditional medicine Natural product Herb Toxic target organs Safety evaluation

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Understandings and future challenges in soybean functional genomics and molecular breeding

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Journal of Integrative Plant Biology 2023年第2期65卷 468-495页

作者： Haiping Du Chao Fang Yaru Li Fanjiang Kong Baohui Liu Guangdong Key laboratory of Plant Adaptation and Molecular Design Guangzhou Key Laboratory of Crop Gene EditingInnovative Center of Molecular Genetics and EvolutionSchool of Life SciencesGuangzhou UniversityGuangzhou 510006China

Soybean(Glycine max)is a major source of plant protein and *** breeding has benefited from advances in functional *** particular,the release of soybean reference genomes has advanced our understanding of soybean adaptation to soil nutrient deficiencies,the molecular mechanism of symbiotic nitrogen(N)fixation,biotic and abiotic stress tolerance,and the roles of flowering time in regional adaptation,plant architecture,and seed yield and ***,many challenges remain for soybean functional genomics and molecular breeding,mainly related to improving grain yield through high-density planting,maize-soybean intercropping,taking advantage of wild resources,utilization of heterosis,genomic prediction and selection breeding,and precise breeding through genome *** review summarizes the current progress in soybean functional genomics and directs future challenges for molecular breeding of soybean.

关键词： flowering time functional genomics grain yield nodulation plant architecture response to nutrition deficiency seed quality soybean stress resistance

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Identification of novel molecular markers of mastitis caused by Staphylococcus aureus using gene expression profiling in two consecutive generations of Chinese Holstein dairy cattle

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Journal of Animal Science and Biotechnology 2021年第1期12卷 155-171页

作者： Di Wang Lei Liu Serafino M.A.Augustino Tao Duan Thomas J.Hall David E.MacHugh Jinhuan Dou Yi Zhang Yachun Wang Ying Yu Key laboratory of Animal Genetics Breeding and ReproductionMinistry of Agriculture&National Engineering Laboratory for Animal BreedingCollege of Animal Science and TechnologyChina Agricultural UniversityBeijing 100193China UCD School of Agriculture and Food Science University College DublinDublin D04 V1W8Ireland Shenzhen Branch Guangdong Laboratory for Lingnan Modern AgricultureGenome Analysis Laboratory of the Ministry of AgricultureAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518120China Department of Animal nutrition and Feed Science College of Animal Science and TechnologyChina Agricultural UniversityBeijing 100193China UCD Conway Institute of Biomolecular and Biomedical Research University College DublinDublin D04 V1W8Ireland

Background: Mastitis in dairy cows caused by Staphylococcus aureus is a major problem hindering economic growth in dairy farms worldwide. It is difficult to prevent or eliminate due to its asymptomatic nature and long persistence of infection. Although transcriptomic responses of bovine mammary gland cells to pathogens that cause mastitis have been studied, the common responses of peripheral blood leukocytes to S. aureus infection across two consecutive generations of dairy cattle have not been ***: In the current study, RNA-Seq was used to profile the transcriptomes of peripheral blood leukocytes sampled from S. aureus-infected mothers and their S. aureus-infected daughters, and also healthy non-infected mothers and their healthy daughters. Differential gene expression was evaluated as follows: 1) S. aureus-infected cows versus healthy non-infected cows(S vs. H, which include all the mothers and daughters), 2) S. aureus-infected mothers versus healthy non-infected mothers(SM vs. HM), and 3) S. aureus-infected daughters versus healthy noninfected daughters(SMD vs. HMD).Results: Analysis of all identified expressed genes in the four groups(SM, SMD, HM, and HMD) showed that EPOR,IL9, IFNL3, CCL26, IL26 were exclusively expressed in both the HM and HMD groups, and that they were significantly(P 1.2) were detected in the three comparisons, respectively. DEGs with P 2 were used for functional enrichment analyses. For the S vs. H comparison, DEGs detected included CCL20, IL13 and MMP3, which are associated with the IL-17 signaling pathway. In the SM vs. HM and SMD vs. HMD comparisons, five(BLA-DQB, C1 R, C2, FCGR1 A, and KRT10) and six(BLA-DQB, C3 AR1, CFI, FCAR, FCGR3 A, and LOC10498484) genes, respectively, were involved in the S. aureus infection ***: Our stud

关键词： Dairy cow Disease resistance Mastitis Peripheral blood leukocyte Staphylococcus aureus Transcriptome Two generations

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SeqCor:correct the effect of guide RNA sequences in clustered regularly interspaced short palindromic repeats/Cas9 screening by machine learning algorithm

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Journal of Genetics and genomics 2020年第11期47卷 672-680页

作者： Xiaojian Liu Yuanyuan Yang Yan Qiu Md Reyad-ul-ferdous Qiurong Ding Yi Wang CAS Key laboratory of nutrition Metabolism and Food SafetyShanghai Institute of Nutrition and HealthShanghai Institutes for Biological SciencesUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200031China Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijing 100101China Ministry of Education Key laboratory of Contemporary Anthropology Department of Anthropology and Human GeneticsSchool of Life SciencesFudan UniversityShanghai 200438China Human Phenome Institute Fudan UniversityShanghai 200438China

Clustered regularly interspaced short palindromic repeats(CRISPR)/Cas9-based screening using various guide RNA(g RNA)libraries has been executed to identify functional components for a wide range of phenotypes with regard to numerous cell types and *** data from public CRISPR/Cas9-based screening experiments,we found that the sequences of g RNAs in the library influence CRISPR/Cas9-based *** building a standard strategy for correcting results of all g RNA libraries is impractical,we developed Seq Cor,an open-source programming bundle that enables researchers to address the result bias potentially triggered by the composition of g RNA sequences via the organization of g RNA in the library used in CRISPR/Cas9-based ***,Seq Cor completely computerizes the extraction of sequence features that may influence single-guide RNA knockout efficiency using a machine learning *** together,we have developed a software program bundle that ought to be beneficial to the CRISPR/Cas9-based screening platform.

关键词： SeqCor CRISPR/Cas9-based screening Machine learning

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Recoloring tomato fruit by CRISPR/Cas9-mediated multiplex gene editing

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Horticulture Research 2023年第1期10卷 1-9页

作者： Tianxia Yang Muhammad Ali Lihao Lin Ping Li Hongju He Qiang Zhu Chuanlong Sun Ning Wu Xiaofei Zhang Tingting Huang Chang-Bao Li Chuanyou Li Lei Deng State Key laboratory of Plant genomics National Center for Plant Gene Research(Beijing)Institute of Genetics and Developmental BiologyInnovation Academy for Seed DesignChinese Academy of SciencesBeijing 100101China CAS Center for Excellence in Biotic Interactions University of Chinese Academy of SciencesBeijing 100049China Institute of Vegetable Qingdao Academy of Agricultural SciencesQingdaoShandong 266100China Institute of Agri-food Processing and nutrition Beijing Academy of Agriculture and Forestry SciencesBeijing 100097China Key laboratory of Biology and Genetic Improvement of Horticultural Crops(North China) Ministry of AgricultureBeijing Vegetable Research CenterBeijing Academy of Agriculture and Forestry SciencesBeijing 100097China

Fruit color is an important horticultural trait,which greatly affects consumer *** tomato,fruit color is determined by the accumulation of different pigments,such as carotenoids in the pericarp and f lavonoids in the peel,along with the degradation of chlorophyll during fruit *** fruit color is a multigenic trait,it takes years to introgress all color-related genes in a single genetic background via traditional crossbreeding,and the avoidance of linkage drag during this process is ***,we proposed a rapid breeding strategy to generate tomato lines with different colored fruits from red-fruited materials by CRISPR/Cas9-mediated multiplex gene editing of three fruit color-related genes(PSY1,MYB12,and SGR1).Using this strategy,the red-fruited cultivar‘Ailsa Craig’has been engineered to a series of tomato genotypes with different fruit colors,including yellow,brown,pink,light-yellow,pink-brown,yellow-green,and light *** with traditional crossbreeding,this strategy requires less time and can obtain transgene-free plants with different colored fruits in less than 1 *** importantly,it does not alter other important agronomic traits,like yield and fruit *** strategy has great practical potential for tomato breeding and serves as a reference for improving multigene-controlled traits of horticultural crops.

关键词： breeding cultivar yellow

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Large-scale pharmacogenomic studies and drug response prediction for personalized cancer medicine

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Journal of Genetics and genomics 2021年第7期48卷 540-551页

作者： Fangyoumin Feng Bihan Shen Xiaoqin Mou Yixue Lia Hong Li CAS Key laboratory of Computational Biology Shanghai Institute of Nutrition and HealthUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200031China Hangzhou Institute for Advanced Study University of Chinese Academy of SciencesHangzhou 330106China

The response rate of most anti-cancer drugs is limited because of the high heterogeneity of cancer and the complex mechanism of drug *** treatment that stratifies patients into subgroups using molecular biomarkers is promising to improve clinical *** the accumulation of preclinical models and advances in computational approaches of drug response prediction,pharmacogenomics has made great success over the last 20 years and is increasingly used in the clinical practice of personalized cancer *** this article,we first summarize FDA-approved pharmacogenomic biomarkers and large-scale pharmacogenomic studies of preclinical cancer models such as patient-derived cell lines,organoids,and ***,we comprehensively review the recent developments of computational methods in drug response prediction,covering network,machine learning,and deep learning technologies and strategies to evaluate immunotherapy *** the end,we discuss challenges and propose possible solutions for further improvement.

关键词： Pharmacogenomics Personalized medicine Drug response Biomarkers Deep learning

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Breeding Major Cereal Grains through the Lens o~ ~iutrition Sensitivity

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Molecular Plant 2018年第1期11卷 23-30页

作者： Shu Yu Li Tian Department of Plant Sciences University of California Davis Davis CA 95616 USA Shanghai Chenshan Plant Science Research Center Chinese Academy of Sciences Shanghai 201602 China Shanghai Key laboratory of Plant Functional genomics and Resources Shanghai Chenshan Botanical Garden Shanghai 201602 China

Cereal grains are the common food staples that collectively provide over 50% of dietary calories and proteins for the world＇s population. Although the Green Revolution has greatly increased the yield of commercial cereal crops, they often lack nutrients essential for human health in the edible tissues. In developing nutrition-sensitive agriculture, the nutritional quality of cereal grains has been a major target for improvement using breeding and biotechnology approaches. This review examines recent progress on biofortification of micronutrients （provitamin A and folates） and an essential amino acid （lysine） in three major cereal grains, wheat, rice, and maize, through plant breeding. In addition, how natural variations, induced mutations, and the advanced genome-editing technologies can be applied to improving the nutrient content and stability in these cereal grains are discussed. High-yield cereal crops pyramided with improved （micro）nutrient contents hold great promise to meet the increasing demand of nutritionally limited popula- tions and to contribute to achieving sustainable nutrition security.

关键词： cereal grains nutrition sensitive plant breeding provitamin A lysine folates

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Human apo-SRP72 and SRP68/72 complex structures reveal the molecular basis of protein translocation

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Journal of Molecular Cell Biology 2017年第3期9卷 220-230页

作者： Yina Gao Qi Zhang Yue Lang Yang Liu Xiaofei Dong Zhenhang Chen Wenli Tian Jun Tang Wei Wu Yufeng Tong Zhongzhou Chen Beijing Advanced Innovation Center for Food nutrition and Human Health State Key Laboratory of Agrobiotechno[ogy China Agricultural University Beijing 3.00193 China Structural genomics Consortium Toronto Ontario M5G 1L7 Canada College of Veterinary Medicine China Agricultural University Beijing 100193 China Institute of Apicultural Research Chinese Academy of Agricultural Sciences Beijing 100093 China Department of Pharmacotogy and Toxicology Universityof Toronto Toronto Ontario M5G 1L7 Canada

co 翻译的指向或插入能分泌并且膜蛋白质进 endoplasmic 蜂窝胃(嗯) 一个关键生物过程被信号识别粒子(SRP ) 调停。在优核质， SRP68-SRP72 (SRP68/72 ) heterodimer 在蛋白质 translocation 起一个必要作用。然而，二最大的 SRP 蛋白质... 详细信息

co 翻译的指向或插入能分泌并且膜蛋白质进 endoplasmic 蜂窝胃(嗯) 一个关键生物过程被信号识别粒子(SRP ) 调停。在优核质， SRP68-SRP72 (SRP68/72 ) heterodimer 在蛋白质 translocation 起一个必要作用。然而，二最大的 SRP 蛋白质， SRP68 和 SRP72 的结构的信息，被限制，特别关于他们的相互作用。此处，我们在 2.91 点报导人的 apo-SRP72 和 SRP68/72 建筑群的第一水晶结构吗？并且 1.7？分辨率分别地。SRP72 的 SRP68 有约束力的领域包含四次不正常的 tetratricopeptide 重复(TPR ) 和一顶灵活 C 终端帽子。Apo-SRP72 在答案主要作为 dimers 存在。为了绑在 SRP68， SRP72 homodimer disassociates，和不可缺少的 C 终端帽子，经历一个显著 conformational 变化帮助 SRP68/72 heterodimer 的形成。SRP68 的 A 23 残余多肽为到通过它的不平常地恐水病、扩大的表面的 SRP72 的紧密的绑定是足够的。结构，生物物理，并且 mutagenesis 分析表明联系癌症的变化破坏 SRP68-SRP72 相互作用和他们的合作本地化与嗯在哺乳动物的房间。结果在调停 SRP 的蛋白质 translocation 加亮 SRP68-SRP72 相互作用的必要角色并且为疾病诊断， pathophysiology，和药设计提供一个结构的基础。

关键词：蛋白质转运结构信息分子基础 TiAl基合金异源二聚体人类信号识别颗粒哺乳动物细胞

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