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nutritional Quality of Biscuit Supplemented with Wheat Bran and Date Palm Fruits (<i>Phoenix dactylifera</i>L.)

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Food and nutrition Sciences 2012年第3期3卷 322-328页

作者： Gamal A. El-Sharnouby Salah M. Aleid Mutlaq M. Al-Otaibi Date Palm Research Centre of Excellence King Faisal University Al-Ahsa Saudi Arabia. Department of Food and nutrition Sciences College of Agricultural and Food Sciences King Faisal University Al-Ahsa Saudi Arabia

Fruits of date palm (Phoenix dactylifera L.) are consumed throughout the world and are a vital component of the diet in most Arabian countries. The effect of partial replacement of wheat flour with a 1:1 mixture of wheat bran and date palm fruit powder on rheological properties of the biscuit dough was studied. Levels of mixture used were 10%, 20%, 30% and 40%. Dough rheology (farinograph, extensograph properties) and biscuit quality (physical properties, colour, sensory evaluation) were assessed. Results obtained indicated that water absorption gradually increased by increasing the levels of wheat bran: palm date powder, meanwhile mixing tolerance index decreased. Dough stability, which indicates the dough strength, also found to decrease by increasing mixture of wheat bran and date powder (1:1). Furthermore, dough development time gradually increased by increasing the mixture at all levels. It was 6.04 min at level of 40% compared to the control (2.5 min). Extensograph results showed that dough energy and dough resistance to extension and proportional number also increased compared with control sample. The proportional number (R/E) ratios increased largely from 3.20 to 5.27 at the level of 40.0%. Ash and fibre contents gradually increased as the mixture levels increased. However, mineral content progressively increased by increasing the level of date powder in the mixture. Incorporation of wheat bran and date powder mixture decreased the spread of the biscuits from 55.66 to 52.82 mm without change in the thickness of the biscuits. Organoleptic properties revealed that quality of biscuits was acceptable at mixture level of 30%.

关键词： Wheat Flour Wheat Bran Palm Date Fruit Biscuit Dough Rheological Properties nutritional Quality

Lactoferrin improves hepatic pyroptosis in mice after irradiation

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Radiation Medicine and Protection 2022年第1期3卷 16-21页

作者： Ru Zhang Jia Gu Yulu Wei Yaxing Guo Liqiang Qin Jiaying Xu Department of nutrition and Food Hygiene School of Public HealthSoochow UniversitySuzhou 215123China Suzhou National High-tech District Center for Disease Prevention and Control Suzhou 215011China State Key Laboratory of Radiation Medicine and Protection Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education InstitutionsSchool of Radiation Medicine and ProtectionSoochow UniversitySuzhou 215123China

Objective:To investigate the effects of lactoferrin(Lf)on hepatic pyroptosis(an inflammatory form of programmed cell death)in mice exposed to ***:A total of thirty-six BALB/c male mice were randomly divided into four groups,namely the control group,5 Gy group,5 Gyþ2 mg Lf group,and 5 Gyþ4 mg Lf *** mice were administered whole-body ionizing radiation using a PRIMUS accelerator,with a single dose of 5 Gy and an absorbed dose rate of 2.0 Gy/min at a source-skin distance of 100 *** solution was intraperitoneally injected into the mice 2 h before and per day after *** mice were sacrificed 1,3,and 9 d after radiation,and their livers were used for histopathologic examination,immunohistochemistry analysis,and Western blot analysis for absent in melanoma 2(AIM2)inflammasome ***:Histopathologic examination showed the disorder of the hepatocellular structure and the accumulation of inflammatory cells after *** intervention inhibited hepatocellular proliferation and decreased the infiltration of inflammatory *** analysis indicated that AIM2 overexpression was significantly attenuated by 4 mg of Lf(t=3.065,P<0.05)3 d after radiation and by 2 mg and 4 mg of Lf(t=4.032,t=2.786,P<0.05)9 d after *** blot analysis showed that Lf downregulated the hepatic overexpression of AIM2,apoptosis-associated speck-like protein containing a caspase activation and recruitment domain(ASC),IL-1β,and IL-18.2 mg of Lf significantly downregulated the abovementioned protein expression 3 d(t=7.934,4.092,5.193,2.916,P<0.05)and 9 d after radiation(t=5.016,3.882,9.528,P<0.05 for AIM2,ASC,IL-1β).Conclusions:Lf intervention suppressed the hepatic pyroptosis in mice exposed to ionizing radiation by downregulating the protein expression of AIM2 inflammasome.

关键词： Lactoferrin Irradiation Liver Pyroptosis Absent in melanoma 2(AIM2)

Dietary L-arginine supplementation enhances the immune status of early-weaned piglets

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Dietary L-arginine supplementation enhances the immune statu...

The Determination of Neutral Detergent Digestibility of Sheep Forage Using Rumen Inoculum in vitro Technique

2007年动物营养、保健与饲料添加剂国际学术研讨会

作者： S.W.Kim I.Shinzato Department of Animal Science Texas A&M UniversityCollege Station Department of Animal and Food Sciences Texas Tech University Department of Animal nutrition Ajinomoto Inc.

The study was conducted to evaluate the effect of dietary arginine supplementation on the immune status of early-weaned piglets.A total of 70 piglets weaned at 7 days of age were assigned randomly to 5 treatment groups(14 pigs/group),representing diets supplemented with 0, 0.2,0.4,0.6 and 0.8%L-arginine,*** Days 7 and 14 after initiation of the supplementation,the weights of immune organs,counts of leucocytes,serum concentrations of immunoglobulins and cytokines,as well as splenic expression of genes for cytokines were *** results showed that the relative weight of spleen in piglets supplemented with 0.2 and 0.8%arginine,as well as that of thymus in piglets supplemented with 0.6%arginine,increased, compared with the control group on Day *** supplementation with 0.8%arginine increased the numbers of white blood cells and granulocytes on Day 7 in comparison with other *** Day 14,the numbers of granulocytes and the granulocyte:leucocyte ratio were greater,while the numbers of lymphocytes and the lymphocyte:leucocyte ratio were lower in piglets supplemented with 0.2 and 0.4%arginine than in the control *** arginine supplementation for the first 7 days resulted in lower concentrations of serum IL-8 and IL-2,but higher concentrations of serum IgM and higher levels of splenic IL-8 gene *** Day 14,concentrations of serum IL-8 and IL-2 were lower,while concentrations of serum IgG,TNF and IL-6 as well as gene expression levels of splenic IL-8 and TNF were higher,in piglets treated with arginine than the control ***,these findings indicate that arginine supplementation may be beneficial for enhancing the immune status in early-weaned piglets.

关键词： Arginine Early-weaned piglet Inhance Immune status

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Feed & Livestock 2009年第1期2卷 27-30页

作者： Zhang Jikun Lu Dexun Key Laboratory of Animal Genetic Characteristics Innovation ＆ nutrition Manipulation Jiangxi Academy of Agricultural Science Nanchang 330200 PR china Inner Mongolian Animal ＆ Agricultural Science Academy Hohhot 010030 PR china

The study of rumen microflora on in vitro NDF digestibility （NDFD） of various sheep forages was conducted. Selected NDF substrates were made from 9 forages （meadow grass hay （MGH）, erect milkvetch hay （EMH）, alfalfa hay （AH）, chinese wildrye hay （CWH）, dahuria wildryegrass hay （DWH）, corn stalk （CS）, sudan grass hay （SGH）, millet straw （MS） and corn stover silage（CSS）. All these substrates were incubated for 24 h with rumen inoculum. NDFD ranked from greatest to least in the following order： DWH （30.19）〉 CWH （25.99）〉 MGH （25.80）〉MS （22.79）〉 CSS （19.75）〉AH （19.68）〉 CS （18.23）〉 EMH （14.73）〉 SGH （8.75）, the figures in parentheses were NDFD, %NDF.

关键词：畜牧业饲料消化率微生物

Targeted genotyping for the prediction of celiac disease autoimmunity development in patients with type 1 diabetes and their family members

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World Journal of Diabetes 2019年第3期10卷 189-199页

作者： Maureen M Leonard Stephanie Camhi Victoria Kenyon Rebecca A Betensky Craig Sturgeon Shu Yan Alessio Fasano Mucosal Immunology and Biology Research Center Mass General Hospital for Children Boston MA 02115 United States Center for Celiac Research and Treatment Mass General Hospital for Children Boston MA 02115 United States Department of Pediatric Gastroenterology and nutrition Mass General Hospital for Children Boston MA 02114 United States Department of Biostatistics Harvard T.H. Chan School of Public Health Boston MA 02115 United States

BACKGROUND Patients with type 1 diabetes (T1D) and their first-degree relatives (FDRs) have an increased risk of developing celiac disease (CD) compared to the general population. This is largely explained by the shared association with major histocompatibility class II human leukocyte antigen (HLA) DQ2 and/or DQ8 between the two disease states. AIM To describe the frequency of CD autoimmunity (CDA) and the distribution of HLA and haptoglobin genotypes in patients with T1D and their FDRs. Additionally, we aimed at identifying predictors associated with an increased risk of developing CDA in patients with T1D and their family members. METHODS We obtained clinical information and blood samples from 1027 participants (302 with T1D and 725 FDRs) over a five-year period. Samples were tested for autoantibodies associated with CD, HLA-DQ alleles, and haptoglobin *** fit univariate and multiple logistic regression models for CDA separately for subjects with T1D and for FDRs of subjects with T1D. RESULTS Implementation of a screening program increased the frequency of CDA by 2- fold in participants with T1D and 2.8-fold in their FDRs. Multivariate analysis found that, in participants with T1D, having both DR7-DQ2 and DR4-DQ8 was associated with an increased frequency of CDA. In FDRs of T1D patients, reported CD in the family was associated with an increased frequency of CDA during screening. Haptoglobin 2 genotype was not associated with developing CDA in the multivariate analysis. CONCLUSION Patients with T1D and their FDRs have a high frequency of CDA. Carrying both DR7-DQ2 and DR4-DQ8 was associated with development of CDA in patients with T1D.

关键词： Screening Gluten Diabetic Coeliac Haptoglobin Human leukocyte antigen

Environmental and Genetic Factors of Childhood Obesity in Taiwan

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Environmental and Genetic Factors of Childhood Obesity in Ta...

Favorable prognostic role of IL-26 in HCC patients associated with JAK-STAT3-dependent autophagy

第二届两岸四地营养改善学术会议

作者： Wen-Harn Pan Institute of Biomedical Sciences Academia Sinica nutrition Program Institute of Population ScienceNational Health Research Institutes Department of Biochemistry and technology and Institute of Epidemiology"National Taiwan University"

Prevalence of childhood obesity increased rapidly in Taiwan as well as elsewhere in the world Changing environment is apparent,including increasing prevalence of sedentary lifestyle and eating-out life-style.

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Genes & Diseases 2022年第1期9卷 9-11页

作者： Qihong Zhao Chen Wang Kexin Wang Yue He Anla Hu Min Tang Wanshui Yang Jiyu Cao Dexiang Xu Hua Wang Department of nutrition and Food Hygiene School of Public HealthAnhui Medical UniversityHefeiAnhui 230032PR China Department of Gastroenterology and Hepatology The Fourth Affiliated Hospital of Anhui Medical UniversityHefeiAnhui 230002PR China Department of Oncology The First Affiliated Hospital of Anhui Medical UniversityHefeiAnhui 230022PR China Inflammation and Immune Mediated Diseases Laboratory of Anhui Province Anhui Medical UniversityHefeiAnhui 230032PR China

Interleukin-26(IL-26),originally called AK155,is one of the cytokines of the IL-10 cytokine family,and its gene is located in human chromosome region ***-26 signals through the receptors IL-20R1 and IL-10R2,which form a heterodimer,targets specific cells and induces activation of the JAK-STAT pathway,allowing the rapid phosphorylation of STAT1 and STAT3 and the initiation of their effects.1 This signaling plays an important role in the regulation of host defense and inflammatory ***,whether the role of IL-26 in the progression of hepatocellular carcinoma(HCC)occurs via autophagy remains ***,we analyzed the association between IL-26 levels and the clinicopathological characteristics of 115 patients with HCC and found that IL-26 levels were particularly associated with tumor stage and *** found that IL-26 levels were associated with the prognosis of HCC ***,we found that increased autophagy by IL-26 was dependent on the JAK-STAT3 signaling pathway,which could result in the inhibition of the migration and invasion abilities of these HCC *** findings suggest that the levels of IL-26 may be a useful prognostic marker for HCC patients and may offer insights into the clinical application of IL-26 in the future.

关键词： patients invasion STAT3

Functioning Gonadotroph Adenoma with Secondary Hypersecretion of Testosterone

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Open Journal of Endocrine and Metabolic Diseases 2020年第2期10卷 24-28页

作者： Annelie Kérékou Hodé Hubert Dédjan Luphin Hodé Martial Agbokpanzo Service d’Endocrinologie de Métabolisme et de Nutrition CNHU-HKM Cotonou Bénin Service de Traumatologie et d’Orthopédie CNHU-HKM Cotonou Bénin

Introduction: Gonadotroph adenomas are generally nonfunctioning. Hypersecretion of gonadotropins by gonadotroph adenomas rarely induced hypersecretion of testosterone. We report a case of functioning gonadotroph adenoma with secondary hypersecretion of testosterone. Medical Observation: A 25-year-old patient who having had a progressive and bilateral loss of visual acuity for two years. The ophtalmologist’s examination concluded to bitemporal hemianopia. He had no other clinical manifestations of hyper or hypo hormonal secretion. The brain scan has revealed an intrasellar mass with suprasellar development that represses the optic chiasma and the carotids. The assessment carried out revealed an increase in FSH, LH and testosterone. The diagnosis of a functioning gonadotroph macroadenoma with secondary hypersecretion of testosterone was retained. Surgical excision of the adenoma was performed. Anatomo-pathological examination concluded to a pituitary adenoma. The patient showed an improvement in the right visual acuity and developed an adrenal corticotropic insufficiency substituted by hydrocortisone 20 mg per day. The postoperative hormonal profile revealed a normalization of FSH and testosterone. Conclusion: Functioning gonadotroph adenoma with secondary hypersecretion of testosterone is rare. The first-line treatment is surgical and allows an improvement of the cerebral tumor syndrome and the restoration of the gonadotropic function.

关键词： Macroadenoma Pituitary Gonadotroph Testosterone

In vitro neuroprotective potentials of aqueous and methanol extracts from Heinsia crinita leaves

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Food Science and Human Wellness 2016年第2期5卷 95-102页

作者： Ganiyu Oboh Esther E.Nwanna Sunday I.Oyeleye Tosin A.Olasehinde Opeyemi B.Ogunsuyi Aline A.Boligon Functional Foods and Nutraceuticals Unit Department of BiochemistryFederal University of TechnologyAkureNigeria nutrition and Toxicology Division Food Technology DepartmentFederal Institute of Industrial Research OshodiP.M.B.21023 LagosNigeria Phytochemical Research Laboratory Department of Industrial PharmacyFederal University of Santa MariaBuild 26Room 1115Santa Maria CEP 97105-900Brazil

This study was designed to determine the neuroprotective potentials of aqueous and methanol extracts from Heinsia crinita leaves in *** total phenol and flavonoid contents of the extracts were determined using colorimetric method while phenolic characterization of the leaf was analyzed via high performance liquid chromatography-diode array detector(HPLC-DAD).The effects of the extracts on Fe^2+-induced lipid peroxidation in rats’brain homogenate,monoamine oxidase(MAO),Na^+/K^+-ATPase,acetylcholinesterase(AChE)and butyrylcholinesterase(BChE)activities were also *** aqueous extract had higher total phenol and flavonoid contents than the methanol ***-DAD revealed that quercetin ellagic,chlorogenic and caffeic acids were the most abundant phenolic compounds in the *** aqueous extract had higher inhibitory effects on MAO,AChE and BChE activities while there was no significant difference between their Fe^2+-induced lipid peroxidation inhibitory ***,both extracts stimulated Na^+/K^+-ATPase activity;however,methanol extract had higher stimulatory *** neuroprotective properties of *** leaves could be associated with its inhibitory effects on Fe2+-induced lipid peroxidation and modulation of MAO,Na^+/K^+-ATPase,AChE,and BChE ***,*** leaves could be used as a functional food and dietary intervention for the management of some neurodegenerative ***,the aqueous extracts exhibited better neuroprotective properties.

关键词： Heinsia crinita Neurodegeneration Oxidative stress Malondialdehyde Polyphenols