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Differential Impact of Fertility on Health-Adjusted Life Expectancy of Older Adults Across Countries of Various Levels of Socio-Demographic Index—Worldwide,1995-2019

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China CDC weekly 2024年第39期6卷 991-995页

作者： Shuai Guo Chen Chen Yunhe Wang Yi Cao Zhiwei Leng Xiaoying Zheng Department of Population Health and Aging Science School of Population Medicine and Public HealthChinese Academy of Medical Sciences/Peking Union Medical CollegeBeijingChina School of Population Medicine and Public Health Chinese Academy of Medical Sciences/Peking Union Medical CollegeBeijingChina nuffield Department of Population Health University of OxfordOxfordUK Center for Health Policy and Health Economics National Infrastructures for Translational MedicineInstitute of Clinical MedicinePeking Union Medical College HospitalChinese Academy of Medical Sciences/Peking Union Medical CollegeBeijingChina Institute for Global Health and Development Peking UniversityBeijingChina

What is already known about this topic?Health-adjusted life expectancy(HALE)is a crucial indicator of global health,which is strongly correlated with the socio-demographic index(SDI)and population *** is added by this report?This study revealed that the correlation between total fertility rate(TFR)and HALE of older adults varies across countries with different SDI levels,offering valuable insights for the development of more targeted health promotion programs and *** are the implications for public health practice?Different health interventions should be tailored to countries with different levels of *** countries with both low fertility rates and low SDI,advanced measures are needed to address the challenge of an aging population that may live longer but face poorer health in the future.

关键词： demographic fertility offering

Genetic diversity of RNA viruses infecting invertebrate pests of rice

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Science China(Life Sciences) 2024年第1期67卷 175-187页

作者： Haoran Wang Shufen Chao Qing Yan Shu Zhang Guoqing Chen Chonghui Mao Yang Hu Fengquan Yu Shuo Wang Liang Lv Baojun Yang Jiachun He Songbai Zhang Liangsheng Zhang Peter Simmonds Guozhong Feng State Key Laboratory of Rice Biology and Breeding China National Rice Research InstituteChinese Academy of Agricultural SciencesHangzhou 311400China State Key Laboratory of Agricultural Microbiology College of Life Science and TechnologyHuazhong Agricultural UniversityWuhan 430070China Institute of Plant Protection&Soil Fertilizer Hubei Academy of Agricultural SciencesWuhan 430064China Institute of Plant Protection Guizhou Academy of Agricultural SciencesGuiyang 550000China Institute of Plant Protection Liaoning Academy of Agricultural SciencesShenyang 110161China Sanya Agricultural Technology Extension and Service Centre Sanya 572000China college of Agriculture Yangtze UniversityJingzhou 434000China Fujian Provincial Key Laboratory of Haixia Applied Plant Systems Biology Fujian Agriculture and Forestry UniversityFuzhou 350002China Genomics and Genetic Engineering Laboratory of Ornamental Plants College of Agriculture and BiotechnologyZhejiang UniversityHangzhou 310012China nuffield Department of Medicine Peter Medawar Building for Pathogen ResearchUniversity of OxfordOxford OX13SYUnited Kingdom

Invertebrate species are a natural reservoir of viral genetic diversity,and invertebrate pests are widely distributed in crop ***,information on viruses infecting invertebrate pests of crops is *** this report,we describe the deep metatranscriptomic sequencing of 88 invertebrate samples covering all major invertebrate pests in rice *** identified 296 new RNA viruses and 13 known RNA *** viruses clustered within 31 families,with many highly divergent viruses constituting potentially new families and *** the identified viruses,13 RNA viruses clustered within the Fiersviridae family of bacteriophages,and 48 RNA viruses clustered within families and genera of *** detected known rice viruses in novel invertebrate hosts at high ***,some novel RNA viruses have genome structures closely matching to known plant viruses and clustered within genera of several plant virus *** potential insect pathogenic RNA viruses were detected in invertebrate *** analysis revealed that host taxonomy plays a major role and geographical location plays an important role in structuring viral ***-species transmission of RNA viruses was detected between invertebrate *** identified viral genomes showed extensive variation for invertebrate viral families or ***,the large-scale metatranscriptomic analysis greatly expands our understanding of RNA viruses in rice invertebrate species,the results provide valuable information for developing efficient strategies to manage insect pests and virus-mediated crop diseases.

关键词： invertebrate species metatranscriptome viral diversity viral transmission viral genomes

Hepatolithiasis:Epidemiology,presentation,classification and management of a complex disease

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World Journal of Gastroenterology 2024年第13期30卷 1836-1850页

作者： Rodrigo V.Motta Francesca Saffioti Vasileios K Mavroeidis Translational Gastroenterology and Liver Unit Nuffield Department of MedicineUniversity of OxfordOxford OX39DUUnited Kingdom Department of Gastroenterology and Hepatology Oxford University Hospitals NHS Foundation TrustJohn Radcliffe HospitalOxford OX39DUUnited Kingdom UCL Institute for Liver and Digestive Health and Sheila Sherlock Liver Unit Royal Free Hospital and University College LondonLondon NW32QGUnited Kingdom Department of HPB Surgery Bristol Royal InfirmaryUniversity Hospitals Bristol and Weston NHS Foundation TrustBristol BS28HWUnited Kingdom Department of Transplant Surgery North Bristol NHS TrustSouthmead HospitalBristol BS105NBUnited Kingdom Department of Gastrointestinal Surgery North Bristol NHS TrustSouthmead HospitalBristol BS105NBUnited Kingdom

The term hepatolithiasis describes the presence of biliary stones within the intrahepatic bile ducts,above the hilar confluence of the hepatic *** disease is more prevalent in Asia,mainly owing to socioeconomic and dietary factors,as well as the prevalence of biliary *** the last century,owing to migration,its global incidence has *** main pathophysiological mechanisms involve cholangitis,bile infection and biliary strictures,creating a self-sustaining cycle that perpetuates the disease,frequently characterised by recurrent episodes of bacterial infection referred to as syndrome of“recurrent pyogenic cholangitis”.Furthermore,long-standing hepatolithiasis is a known risk factor for development of intrahepatic *** classifications have aimed at providing useful insight of clinically relevant aspects and guidance for *** management of symptomatic patients and those with complications can be complex,and relies upon a multidisciplinary team of hepatologists,endoscopists,interventional radiologists and hepatobiliary surgeons,with the main goal being to offer relief from the clinical presentations and prevent the development of more serious *** comprehensive review provides insight on various aspects of hepatolithiasis,with a focus on epidemiology,new evidence on pathophysiology,most important clinical aspects,different classification systems and contemporary management.

关键词： Cholelithiasis Intrahepatic stones Cholangiocarcinoma Biliary parasites Recurrent pyogenic cholangitis Oriental cholangiohepatitis Hepatectomy Cholangioscopy Liver transplant Paediatric

Future sea level rise along the coast of China and adjacent region under 1.5℃ and 2.0℃ global warming

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Advances in Climate Change Research 2020年第3期11卷 227-238页

作者： QU Ying LIU Yonggang Svetlana JEVREJEVA Luke P.JACKSON Department of Atmospheric and Oceanic Sciences School of PhysicsPeking UniversityBeijing100871China National Oceanography Center LiverpoolL35DAUK Programme for Economic Modelling Nuffield CollegeOxford UniversityOX1 INFUK

Although future sea level rise along the China coast has been projected by various studies for different representative concentration pathways(RCPs),the projections for different warming thresholds,e.g.1.5℃ and 2.0℃,have not been done specifically for this region,to the best of our *** provide such a projection here based on the climate projections of Coupled Model Intercomparison Project Phase 5(CMIP5).The projections are given for 20 tide-gauge stations along the coast of China,Korea,Japan,and *** land motion(VLM)is also estimated for stations that have tide gauge records and satellite altimetry both covering the period of *** land motion(LLM)is then estimated by subtracting the land motion due to glacial isostatic adjustment(GIA)from *** considering LLM,sea level rise by 2100 at median probability is projected to be 38-49 cm relative to the average sea level over 1986-2005 under warming of 1.5℃,and increase to 46-57 cm when the warming threshold is increased to 2.0℃.The steric component is the main contributor to this increase in sea *** of LLM will not affect the sea level increase between the two warming thresholds,but it will make the local sea level rise by 2100 at certain locations substantially higher(up to 36 cm)or lower(up to 13 cm).

关键词： Sea level rise Coast of China Tide gauge records Vertical land motion Warming of 1.5℃ Warming of 2.0℃

Greenness and Asthma in the Middle-Aged and Elderly Population in a Prospective Cohort Study—China,2011–2018

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China CDC weekly 2022年第42期4卷 931-935,I0002页

作者： Jiawei Wang Teng Yang Zhihu Xu Jianbo Jin Yuxin Wang Guoxing Li Jing Huang Department of Occupational and Environmental Health Sciences Peking University School of Public HealthBeijingChina Environmental Research Group MRC Centre for Environment and HealthImperial College LondonLondonUK Deep Medicine Nuffield Department of Women’s and Reproductive HealthUniversity of OxfordOxfordUK

Summary What is already known about this topic?Greenness,which refers to the density of vegetated land,has been identified as an essential component of a healthy built environment for human *** environment plays a critical role in the progression of early-onset or late-onset *** is added by this report?Based on the China Health and Retirement Longitudinal Study from 2011 to 2018,this study indicates a negative association between greenness and asthma in the middle-aged and elderly population.

关键词： asthma Middle Population

Advancing male age differentially alters levels and localization patterns of PLCzeta in sperm and testes from different mouse strains

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Asian Journal of Andrology 2021年第2期23卷 178-187页

作者： Junaid Kashir Bhavesh V Mistry Maha Adel Gumssani Muhammad Rajab Reema Abu-Dawas Falah AlMohanna Michail Nomikos Celine Jones Raed Abu-Dawud Nadya Al-Yacoub Kevin Coward F Anthony Lai Abdullah M Assiri college of Medicine Alfaisal UniversityRiyadh 11533Saudi Arabia Department of Comparative Medicine King Faisal Specialist Hospital and Research CentreRiyadh 11211Saudi Arabia college of Medicine QU HealthQatar UniversityDoha PO Box 2713Qatar nuffield Department of Women’s and Reproductive Health University of OxfordLevel 3Women’s CentreJohn Radcliffe HospitalOxford OX39DUUnited Kingdom Biomedical Research Centre Qatar UniversityDoha PO Box 2713Qatar

Sperm-specific phospholipase C zeta(PLCζ)initiates intracellular calcium(Ca2+)transients which drive a series of concurrent events collectively termed oocyte *** investigations have linked abrogation and absence/reduction of PLCζwith forms of male infertility in humans where oocyte activation ***,very few studies have examined potential relationships between PLCζand advancing male age,both of which are increasingly considered to be major effectors of male *** efforts in humans may be hindered by inherent PLCζvariability within the human population,alongside a lack of sufficient controllable ***,utilizing immunoblotting,immunofluorescence,and quantitative reverse transcription PCR(qRT-PCR)we examined for the first time PLCζprotein levels and localization patterns in sperm,and PLCζmRNA levels within testes,from mice at 8 weeks,12 weeks,24 weeks,and 36 weeks of age,from two separate strains of mice,C57BL/6(B6;inbred)and CD1(outbred).Collectively,advancing male age generally diminished levels and variability of PLCζprotein and mRNA in sperm and testes,respectively,when both strains were ***,advancing male age altered the predominant pattern of PLCζlocalization in mouse sperm,with younger mice exhibiting predominantly post-acrosomal,and older mice exhibiting both post-acrosomal and acrosomal populations of PLCζ.However,the specific pattern of such decline in levels of protein and mRNA was ***,our results demonstrate a negative relationship between advancing male age and PLCζlevels and localization patterns,indicating that aging male mice from different strains may serve as useful models to investigate PLCζin cases of male infertility and subfertility in humans.

关键词： ageing fertilization male infertility oocyte activation phospholipase C zeta sperm

From herbal small RNAs to one medicine

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Science China(Life Sciences) 2019年第3期62卷 285-287页

作者： Chao Ji Skirmantas Kriaucionis Benedikt M.Kessler Chengyu Jiang Institute of Basic Medical Sciences Chinese Academy of Medical SciencesDepartment of PharmacologyPeking Union Medical College Ludwig Institute for Cancer Research University of Oxford Target Discovery Institute Nuffield Department of MedicineCAMS-Oxford InstituteUniversity of Oxford State Key Laboratory of Medical Molecular Biology Institute of Basic Medical SciencesCAMS-Oxford InstituteChinese Academy of Medical SciencesDepartment of BiochemistryPeking Union Medical College

In this special topic "Herbal small RNAs, novel precision medicine from Mother Nature", we present four original articles that study the entry of small RNAs derived from herbs used in traditional Chinese medicine into mammalian cells and their function within human and mouse cells, and one review paper focusing on current trends in herb genomics (Du et al., 2017;Huang et al., 2018;Zhang et al., 2018;Li et al., 2019;Xin et al., 2018).

关键词： From herbal small RNAs one medicine

Mapping the epigenetic modifications of DNA and RNA

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Protein & Cell 2020年第11期11卷 792-808页

作者： Lin-Yong Zhao Jinghui Song Yibin Liu Chun-Xiao Song Chengqi Yi Department of Gastrointestinal Surgery and Laboratory of Gastric Cancer State Key Laboratory of BiotherapyWest China HospitalSichuan Universityand Collaborative Innovation Center for BiotherapyChengdu 610041China Ludwig Institute for Cancer Research Nuffield Department of MedicineUniversity of OxfordOxford OX37FZUK Target Discovery Institute Nuffield Department of MedicineUniversity of OxfordOxford OX37FZUK State Key Laboratory of Protein and Plant Gene Research School of Life SciencesPeking UniversityBeijing 100871China Peking-Tsinghua Center for Life Sciences Peking UniversityBeijing 100871China Department of Chemical Biology and Synthetic and Functional Biomolecules Center College of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China

Over 17 and 160 types of chemical modifications have been identified in DNA and RNA,*** interest in understanding the various biological functions of DNA and RNA modifications has lead to the cutting-edged fields of epigenomics and *** chemical and biological tools to detect specific modifications in the genome or transcriptome has greatly facilitated their ***,we review the recent technological advances in this rapidly evolving *** focus on high-throughput detection methods and biological findings for these modifications,and discuss questions to be addressed as *** also summarize third-generation sequencing methods,which enable long-read and single-molecule sequencing of DNA and RNA modification.

关键词： DNA modification DNA methylation RNA modification epitranscriptomics epigenetics long read sequencing

Long-Term Temperature Variability and Risk of Dyslipidemia Among Middle-Aged and Elderly Adults:A Prospective Cohort Study-China,2011-2018

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China CDC weekly 2022年第26期4卷 561-564,I0002,I0003页

作者： Jianbo Jin Yuxin Wang Zhihu Xu Ru Cao Hanbin Zhang Qiang Zeng Xiaochuan Pan Jing Huang Guoxing Li Department of Occupational and Environmental Health Sciences Peking University School of Public HealthBeijingChina Department of Occupational Disease Control and Prevention Tianjin Centers for Disease Control and PreventionTianjinChina Environmental Research Group MRC Centre for Environment and HealthImperial College LondonLondonthe United Kingdom Deep Medicine Nuffield Department of Women’s and Reproductive HealthUniversity of OxfordOxford OX12BQthe United Kingdom

Summary What is already known about this topic?Long-term temperature variability(TV)has been examined to be associated with cardiovascular disease(CVD).TV-related dyslipidemia helps us understand the mechanism of how climate change affects *** is added by this report?Based on the China Health and Retirement Longitudinal Study(CHARLS)from 2011 to 2018,this study estimated the long-term effect of TV on dyslipidemia in middle-aged and elderly adults.

关键词： cardiovascular Middle elderly