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Superstable homogeneous lipiodol-ICG formulation:initial feasibility and first-in-human clinical application for ruptured hepatocellular carcinoma

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Regenerative Biomaterials 2023年第1期10卷 326-332页

作者： Yongfu Xiong Pan He Yang Zhang Hu Chen Yisheng Peng Peng He Jie Tian Hongwei Cheng Gang Liu Jingdong Li Department of Hepatobiliary Surgery Academician(Expert)WorkstationAffiliated Hospital of North Sichuan Medical CollegeNanchong 637600China State Key Laboratory of molecular Vaccinology and molecular Diagnostics Center for Molecular Imaging and Translational MedicineSchool of Public HealthXiamen UniversityXiamen 361102China nuclear medicine and molecular imaging Key Laboratory of Sichuan Province Luzhou 646000China Key Laboratory of molecular imaging Institute of AutomationChinese Academy of SciencesBeijing 100190China

The most common treatment of spontaneous tumor rupture hemorrhage(STRH)is transcatheter arterial embolization(TAE)followed by liver resection,and surgical navigation using near-infrared fluorescence is effective method for detecting hidden lesions and ill-defined tumor ***,due to the blockage of the tumor-supplying artery after effective TAE treatment,it is difficult to deliver sufficient fluorescent probes to the tumor *** this study,we report on the successful application of superstable homogeneous intermixed formulation technology(SHIFT)in precise conversion hepatectomy for ruptured hepatocellular carcinoma(HCC).A homogeneous lipiodol-ICG formulation obtained by SHIFT(SHIFT-ICG)was developed for clinical practice for STRH.A ruptured HCC patient received the combined protocol for embolization and fluorescence surgical navigation and exhibited excellent hemostatic *** and ICG were both effectively deposited in the primary lesion,including a small metastatic *** follow-up laparoscopic hepatectomy,SHIFT-ICG could clearly and precisely image the full tumor regions and boundaries in real time,and even indistinguishable satellite lesions still expressed a remarkable fluorescence *** conclusion,the simple and green SHIFT-ICG formulation can be effectively used in emergency embolization hemostasis and later precise fluorescence navigation hepatectomy in patients with ruptured HCC bleeding and has high clinical application value.

关键词： conversion therapy fluorescent navigation hepatectomy spontaneous tumor rupture

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Same day yttrium-90 radioembolization with single photon emission computed tomography/computed tomography: An opportunity to improve care during the COVID-19 pandemic and beyond

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World Journal of Gastrointestinal Oncology 2021年第5期13卷 440-452页

作者： Mohammad Elsayed Mohammad Loya James Galt David M Schuster Zachary L Bercu Janice Newsome David Brandon Sonia Benenati Keywan Behbahani Richard Duszak Ila Sethi Nima Kokabi Division of Interventional Radiology and Image-Guided medicine Department of Radiology and Imaging SciencesEmory University School of MedicineAtlantaGA 30322United States Division of nuclear medicine and molecular imaging Department of Radiology and Imaging SciencesEmory University School of MedicineAtlantaGA 30322United States

BACKGROUND The coronavirus disease 2019(COVID-19)pandemic has made it more challenging for patients to undergo yttrium-90(Y-90)radioembolization(RE).Same day Y-90 RE provides an opportunity to minimize logistical challenges and infection risk associated with COVID-19,thus improving patient *** To describe the use of same day Y-90 RE with routine single photon emission computed tomography/computed tomography(SPECT/CT)in order to optimize *** All patients were selected for Y-90 RE through a multidisciplinary tumor board,and were screened and tested for COVID-19 infection per institutional protocol.A same day procedure was developed,consisting of angiography,imaging,and Y-90 resin particle *** SPECT/CT after technetium-99m macroaggregated albumin(Tc-99m MAA)administration was performed for assessment of arterial supply,personalized dosimetry,and extrahepatic ***-treatment Y-90 bremsstrahlung SPECT/CT was performed for confirmation of particle delivery,by utilization of energy windowing to limit signal from previously administered Tc-99m MAA *** A total of 14 patients underwent same day Y-90 RE between March and June *** lung shunt fraction was 6.13%(range 3.5%-13.1%).Y-90 RE was performed for a single lesion in 7 patients,while the remaining 7 patients had treatment of multifocal *** largest lesion measured 8.3 *** patients tolerated the procedure well and were discharged the same *** Same day Y-90 RE with resin-based microspheres is feasible,and provides an opportunity to mitigate infection risk and logistical challenges associated with the COVID-19 pandemic and *** recommend consideration of SPECT/CT,especially among patients with complex malignancies,for the potential to improve outcomes and eligibility of patients to undergo same day Y-90 RE.

关键词： Yttrium-90 radioembolization Same day Selective internal radiotherapy Transarterial radioembolization Single photon emission computed tomography/computed tomography Dosimetry COVID-19

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PET imaging on neurofunctional changes after optogenetic stimulation in a rat model of panic disorder

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Frontiers of medicine 2019年第5期13卷 602-609页

作者： Xiao He Chentao Jin Mindi Ma Rui Zhou Shuang Wu Haoying Huang Yuting Li Qiaozhen Chen Mingrong Zhang Hong Zhang Mei Tian Department of nuclear medicine and Medical PET Center The Second Hospital of Zhejiang University School of MedicineHangzhou 310009China Key Laboratory of Medical molecular imaging of Zhejiang Province Hangzhou 310009China Institute of nuclear medicine and molecular imaging Zhejiang UniversityHangzhou 310009China Department of Psychiatry The Second Hospital of Zhejiang University School of MedicineHangzhou 310009China Department of Advanced nuclear medicine sciences National Institute of Radiological SciencesNational Institutes for Quantum and Radiological Science and TechnologyAnagawa 4-9-1Inage-kuChiba263- 8555Japan

Panic disorder (PD) is an acute paroxysmal anxiety disorder with poorly understood pathophysiology. The dorsal periaqueductal gray (dPAG) is involved in the genesis of PD. However, the downstream neurofunctional changes of the dPAG during panic attacks have yet to be evaluated in vivo. In this study, optogenetic stimulation to the dPAG was performed to induce panic-like behaviors, and in vivo positron emission tomography (PET) imaging with ,8F-flurodeoxyglucose (18F-FDG) was conducted to evaluate neurofunctional changes before and after the optogenetic stimulation. Compared with the baseline, post-optogenetic stimulation PET imaging demonstrated that the glucose metabolism significantly increased (P imaging can successfully detect downstream neurofunctional changes involved in the panic attacks after optogenetic stimulation to the dPAG.

关键词： panic disorder (PD) positron emission tomography (PET) optogenetics dorsal periaqueductal gray (dPAG)

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A Mouse Model of Alzheimer's Disease with Transplanted Stem-Cell-Derived Human Neurons

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Neuroscience Bulletin 2017年第6期33卷 766-768页

作者： Yuankai Zhu Hong Zhang Department of nuclear medicine The Second Hospital of Zhejiang University School of MedicineHangzhou 310009China Zhejiang University Medical PET Center Hangzhou 310009China Institute of nuclear medicine and molecular imaging of Zhejiang University Hangzhou 310009China Key Laboratory of Medical molecular imaging of Zhejiang Province Hangzhou 310009China

Alzheimer’s disease（AD）,the main cause of dementia,is defined by the combined presence of amyloid-b（Ab）deposition and abnormal tau aggregation[1].Experimental models are critical to obtain a better understanding ... 详细信息

关键词： AD A Mouse Model of Alzheimer's Disease with Transplanted Stem-Cell-Derived Human Neurons

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Application of machine learning method in optical molecular imaging: a review

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Science China(Information sciences) 2020年第1期63卷 5-20页

作者： Yu AN Hui MENG Yuan GAO Tong TONG Chong ZHANG Kun WANG Jie TIAN CAS Key Laboratory of molecular imaging Beijing Key Laboratory of Molecular ImagingThe State Key Laboratory of Management and Control for Complex SystemsInstitute of Automation Chinese Academy of Sciences Beijing Advanced Innovation Center for Big Data-Based Precision medicine School of MedicineBeihang University University of Chinese Academy of sciences

Optical molecular imaging(OMI) is an imaging technology that uses an optical signal, such as near-infrared light, to detect biological tissue in organisms. Because of its specific and sensitive imaging performance, it is applied in both preclinical research and clinical surgery. However, it requires heavy data analysis and a complex mathematical model of tomographic imaging. In recent years, machine learning(ML)-based artificial intelligence has been used in different fields because of its ability to perform powerful data processing. Its analytical capability for processing complex and large data provides a feasible scheme for the requirement of OMI. In this paper, we review ML-based methods applied in different OMI modalities.

关键词： optical molecular imaging machine learning artificial intelligence

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In vivo radiometric analysis of glucose uptake and distribution in mouse bone

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Bone Research 2016年第1期4卷 31-38页

作者： Meredith L Zoch Diane S Abou Thomas L Clemens Daniel LJ Thorek Ryan C Riddle Department of Orthopaedic Surgery Johns Hopkins University School of Medicine Baltimore USA Division of nuclear medicine an molecular imaging Department of Radiology and Radiological Science Johns Hopkins University School of Medicine Baltimore USA Baltimore Veterans Administration Medical Center Baltimore USA Department of Oncology Cancer Molecular and Functional Imaging Program Sidney Kimmel Comprehensive Cancer Center Johns Hopkins University School of Medicine Baltimore USA

Bone formation and remodeling occurs throughout life and requires the sustained activity of osteoblasts and osteoclasts, particularly during periods of rapid bone growth. Despite increasing evidence linking bone cell activity to global energy homeostasis, little is known about the relative energy requirements or substrate utilization of bone cells. In these studies, we measured the uptake and distribution of glucose in the skeleton in vivo using positron-emitting 18F-fluorodeoxyglucose （[lSF]-FDG） and non-invasive, high-resolution positron emission tomography/computed tomography （PE~/CT） imaging and ex vivo autoradiography. Assessment of [~SF]-FDG uptake demonstrated that relative to other tissues bone accumulated a significant fraction of the total dose of the glucose analog..Skeletal accumulation was greatest in young mice undergoing the rapid bone formation that characterizes early development. PET/CT imaging revealed that [lSF]-FDG uptake was greatest in the epiphyseal and metaphyseal regions of long bones, which accords with the increased osteoblast numbers and activity at this skeletal site. Insulin administration significantly increased skeletal accumulation of [lSF]-FDG, while uptake was reduced in mice lacking the insulin receptor specifically in osteoblasts or fed a high-fat diet. Our results indicated that the skeleton is a site of significant glucose uptake and that its consumption by bone cells is subject to regulation by insulin and disturbances in whole-body metabolism.

关键词： bone FDG

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Differential diagnosis of gallstones by using hypericin as a fluorescent optical imaging agent

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World Journal of Gastroenterology 2016年第29期22卷 6690-6705页

作者： Marlein Miranda Cona Ye-Wei Liu Antoine Hubert Ting Yin Yuan-Bo Feng Peter de Witte Etienne Waelkens Yan-Sheng Jiang Jian Zhang Stefaan Mulier Qian Xia Gang Huang Raymond Oyen Yi-Cheng Ni Department of imaging and Pathology Faculty of Medicine Biomedical Sciences Group University HospitalsKU Leuven Department of Cellular and molecular medicine Biomedical Sciences GroupKU Leuven molecular Biodiscovery Laboratory Faculty of Pharmaceutical Sciences Biomedical Sciences GroupKU Leuven Laboratory of Translational medicine Jiangsu Province Academy of Traditional Chinese Medicine Department of nuclear medicine Ren Ji Hospital School of Medicine Shanghai Jiao Tong University

AIM: To explore the feasibility of using hypericin as an optical imaging probe with affinity for cholesterol for differential fluorescent detection of human ***: Cholesterol, mixed and pigment stones from cholecystectomy patients were incubated with hypericin or solvent. After 72 h, the stones were analysed for fluorescence(365 nm) and treated with 2-propanol/dimethyl sulfoxide for high performance liquid chromatography(HPLC) analysis. Rats with virtual gallbladder containing human cholesterol, mixed or pigment gallstones(VGHG) received 5 mg/kg hypericin or solvent and VGHG rats with cholesterol stones were given different hypericin doses(5-15 mg/kg). Twelve hours later, the stones were analysed at 365 nm. Biliary excretion and metabolites of hypericin were assessed in common bile duct(CBD) cannulated rats for 9 h using fluorospectrometry, HPLC and matrixassisted laser desorption/ionization-time-of-flight mass spectrometry(MALDI-TOF MS).RESULTS: Homogeneous high fluorescence was seen on cholesterol stones either pre-incubated with hypericin or extracted from VGHG rats receiving hypericin. Mixed stones showed a dotted fluorescent pattern, whereas pigment and solvent-treated ones lacked fluorescence. HPLC showed 7.68, 6.65 and 0.08 × 10^(-3) M of cholesterol in extracts from cholesterol, mixed, and pigment gallstones, respectively. Hypericin accounted for 2.0, 0.5 and 0.2 × 10-6 M in that order. On cholesterol stones from VGHG rats receiving different hypericin doses, a positive correlation was observed between dose and fluorescence. In the bile from CBD-cannulated rats, fluorescence represented 20% of the injected dose with two peaks in 9 h. HPLC analysis revealed that hypericin conjugates reached 60% of the peak area. By MALDI-TOF MS, hypericinglucuronide was detected. CONCLUSION: This study proves the potential use of hypericin for differential fluorescent detection of human gallstones regarding their chemical composition.

关键词： Differential detection Fluorescence Human gallstones Hypericin Rat model of cholelithiasis

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High mobility group box 1 in the central nervous system:regeneration hidden beneath inflammation

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Neural Regeneration Research 2025年第1期20卷 107-115页

作者： Hanki Kim Bum Jun Kim Seungyon Koh Hyo Jin Cho Xuelian Jin Byung Gon Kim Jun Young Choi Department of Brain Science Ajou University School of MedicineSuwonSouth Korea Department of Biomedical sciences Ajou University Graduate School of MedicineSuwonSouth Korea Department of Neurology Ajou University School of MedicineSuwonSouth Korea Department of Geriatrics The Affiliated Suqian First People’s Hospital of Nanjing Medical UniversitySuqianJiangsu ProvinceChina

High-mobility group box 1 was first discovered in the calf thymus as a DNA-binding nuclear protein and has been widely studied in diverse fields,including neurology and ***-mobility group box 1 in the extracellular space functions as a pro-inflammatory damage-associated molecular pattern,which has been proven to play an important role in a wide variety of central nervous system disorders such as ischemic stroke,Alzheimer’s disease,frontotemporal dementia,Parkinson’s disease,multiple sclerosis,epilepsy,and traumatic brain *** drugs that inhibit high-mobility group box 1 as a damage-associated molecular pattern,such as glycyrrhizin,ethyl pyruvate,and neutralizing anti-high-mobility group box 1 antibodies,are commonly used to target high-mobility group box 1 activity in central nervous system *** it is commonly known for its detrimental inflammatory effect,high-mobility group box 1 has also been shown to have beneficial pro-regenerative roles in central nervous system *** this narrative review,we provide a brief summary of the history of high-mobility group box 1 research and its characterization as a damage-associated molecular pattern,its downstream receptors,and intracellular signaling pathways,how high-mobility group box 1 exerts the repair-favoring roles in general and in the central nervous system,and clues on how to differentiate the pro-regenerative from the pro-inflammatory *** targeting high-mobility group box 1 in the central nervous system may benefit from differentiating between the two functions rather than overall suppression of high-mobility group box 1.

关键词： central nervous system damage-associated molecular pattern ethyl pyruvate glycyrhizzin high mobility group box 1 inflammation neural stem cells neurodevelopment oligodendrocyte progenitor cells redox status regeneration

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nuclear medicine imaging in osteonecrosis of hip:Old and current concepts

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World Journal of Orthopedics 2017年第10期8卷 747-753页

作者： Kanhaiyalal Agrawal Sujit Kumar Tripathy Ramesh Kumar Sen S Santhosh Anish Bhattacharya Department of nuclear medicine All India Institute of Medical Sciences Department of Orthopedics All India Institute of Medical Sciences Department of Orthopedics Fortis Hospital Institute of nuclear imaging and molecular medicine Tamilnadu Government Multi Super Specialty Hospital Department of nuclear medicine PGI-MER

Osteonecrosis(ON) is caused by inadequate blood supply leading to bone death, which results in the collapse of the architectural bony structure. Femoral head is the most common site involved in ON. Magnetic resonance imaging(MRI) is a commonly used imaging modality to detect early ON. When MRI is inconclusive, bone scan is helpful in detecting ON during early phase of the disease. As newer nuclear medicine equipment, like single photon emission computed tomography/computed tomography(CT) and positron emission tomography/CT, are emerging in medical science, we review the role of these imaging modalities in ON of femoral head.

关键词： Osteonecrosis Avascular necrosis Bone scan Magnetic resonance imaging Photon emission computed tomography scan Single photon emission computed tomography/computed tomography

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NK cell-based tumor immunotherapy

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Bioactive Materials 2024年第1期31卷 63-86页

作者： Hao Zhang Li Yang Tingting Wang Zhen Li Center for molecular imaging and nuclear medicine State Key Laboratory of Radiation Medicine and ProtectionSchool for Radiological and Interdisciplinary Sciences(RAD-X)Suzhou Medical College of Soochow UniversityCollaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education InstitutionsSuzhou215123China

Natural killer(NK)cells display a unique inherent ability to identify and eliminate virus-infected cells and tumor *** are particularly powerful for elimination of hematological cancers,and have attracted considerable interests for therapy of solid ***,the treatment of solid tumors with NK cells are less effective,which can be attributed to the very complicated immunosuppressive microenvironment that may lead to the inactivation,insufficient expansion,short life,and the poor tumor infiltration of NK ***,the development of advanced nanotechnology has provided potential solutions to these issues,and could improve the immunotherapy efficacy of NK *** this review,we summarize the activation and inhibition mechanisms of NK cells in solid tumors,and the recent advances in NK cell-based tumor immunotherapy boosted by diverse *** also propose the challenges and opportunities for the clinical application of NK cell-based tumor immunotherapy.

关键词： NK cells Nanomaterials Immunotherapy Exogenous NK cells Endogenous NK cells

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