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Plasmonic Gold Chip for Multiplexed Detection of Ovarian Cancer Biomarker in Urine

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Chemical Research in Chinese Universities 2022年第4期38卷 935-940页

作者： CHEN Minwen LIAO Tao ZENG Linsheng ZENG Zhongyi YANG Qinglai WANG Guoxin WWHS Biotech.inc. Shenzhen518000P.R.China Center for Molecular Imaging probe Hunan Province Key Laboratory of Tumor Cellular and Molecular PathologyCancer Research InstituteSchool of Preclinical MedicineHengyang Medical SchoolUniversity of South ChinaHengyang421001P.R.China Shenzhen Traditional Chinese Medicine Hospital Shenzhen518033P.R.China

Human epididymal protein 4(HE4),carbohydrate antigen 125(CA125)and osteopontin(OPN)are three key biomarkers in detecting ovarian *** explore the diagnosis value of combined detection of these three biomarkers for ovarian cancer,we developed a multiplexed assay on a plasmonic gold(pGOLD)platform for measuring HE4,CA125 and OPN in *** receiver operator characteristic(ROC)curve was drawn,and the diagnosis values of each biomarker alone or in combination for ovarian cancer were *** the analysis to distinguish ovarian cancer from other gynecological cancers,ovarian cysts and healthy people,the sensitivities of HE4,CA125 and OPN were 72.55%,52.82%and 68.63%,the specificity values were 95.06%,87.65%and 90.12%,while the areas under the curve(AUC)were 0.85,0.75 and 0.77,*** sensitivity and specificity for combination detection of the three markers were 90.20%and 80.25%.The detection methods of HE4,CA125 and OPN based on plasma fluorescence enhanced chip showed good analytic and diagnostic performance,and provided a non-invasive method for the diagnosis of ovarian cancer.

关键词： Plasmonic gold chip Urine Ovarian cancer Multiplexed detection

The onset of surface-enhanced Raman scattering for single-particle detection of submicroplastics

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Journal of Environmental Sciences 2022年第11期34卷 58-64页

作者： Cheng-Hao Lee James Kar-Hei Fang Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic UniversityKowloonHong Kong SARChina Institute of Textiles and Clothing The Hong Kong Polytechnic UniversityKowloonHong Kong SARChina Research Institute for Future Food The Hong Kong Polytechnic UniversityKowloonHong Kong SARChina State Key Laboratory of Marine Pollution City University of Hong KongKowloonHong Kong SARChina

Microplastics represent an emerging environmental problem worldwide, raising ecological and food safety concerns. Compared to microplastics, there is growing evidence of an even higher abundance of submicro-and nanoplastics in the environment, but a reliable monitoring method for detecting these smaller-sized plastics is lacking. Herein we presented the application of surface-enhanced Raman scattering(SERS) for this purpose. Particles of polystyrene(PS;600 nm) were used as the probe analyte. Gold nanourchins(Au nu;50 nm),i.e. urchin-shaped nanoparticles with irregular spikes around the core, were used as the SERS-active substrate. The effectiveness of SERS on PS was evaluated at a single-particle level with different numbers of Au nu in order to determine the minimum conditions required for the onset of the SERS effect. Our findings suggest that SERS of a single particle of PS can be induced by as few as 1–5 particles of Au nu, and that the use of excitation wavelength at 785 nm is appropriate to meet the red-shifted surface plasmon resonance of Au nu upon aggregation. These specifications provide additional information for the development of SERS-based tools for detecting plastic particles < 1 μm in food and environmental samples.

关键词： Microplastics Nanoplastics Gold nanourchins SERS Food contamination

High-repetition-rate(kHz) targets and optics from liquid microjets for high-intensity laser–plasma interactions

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High Power Laser Science and Engineering 2019年第3期7卷 121-141页

作者： K.M.George J.T.Morrison S.Feister G.K.Ngirmang J.R.Smith A.J.Klim J.Snyder D.Austin W.Erbsen K.D.Frische J.Nees C.Orban E.A.Chowdhury W.M.Roquemore Innovative Scientific Solutions Inc.DaytonOhio 45459USA Department of Physics and Astronomy University of CaliforniaLos AngelesCalifornia 90095USA Computer Science Program and Applied Physics Program California State University Channel IslandsCamarilloCalifornia 93012USA National Academies of Science Engineeringand MedicineWashingtonDC 20001USA Air Force Research Laboratory WPAFBOhio 45433USA Department of Physics Ohio State UniversityColumbusOhio 43210USA Department of Mathematical and Physical Sciences Miami UniversityHamiltonOhio 45011USA Center for Ultrafast Optical Sciences University of MichiganAnn ArborMichigan 48109USA Intense Energy Solutions LLC.Plain CityOhio 43064USA

High-intensity laser–plasma interactions produce a wide array of energetic particles and beams with promising ***,the high repetition rate and high average power requirements for many applications are not satisfied by the lasers,optics,targets,and diagnostics currently ***,we aim to address the need for high-repetition-rate targets and optics through the use of liquids.A novel nozzle assembly is used to generate highvelocity,laminar-flowing liquid microjets which are compatible with a low-vacuum environment,generate little to no debris,and exhibit precise positional and dimensional ***,droplets,submicron-thick sheets,and other exotic configurations are characterized with pump–probe shadowgraphy to evaluate their use as *** demonstrate a highrepetition-rate,consumable,liquid optical element,we present a plasma mirror created by a submicron-thick liquid *** plasma mirror provides etalon-like anti-reflection properties in the low field of 0.1%and high reflectivity as a plasma,69%,at a repetition rate of 1 k *** considerations of fluid compatibility,in-vacuum operation,and estimates of maximum repetition rate are *** targets and optics presented here demonstrate a potential technique for enabling the operation of laser–plasma interactions at high repetition rates.

关键词： high intensity high repetition rate laser-plasma interaction liquid droplet liquid microjet liquid sheet plasma mirror target

“指尖”冷冻治疗探头:治疗鳞状及黑素细胞性结膜肿瘤

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世界核心医学期刊文摘（眼科学分册） 2005年第11期1卷 21-22页

作者： Finger P.T. 桑延智 New York Eye Cancer Center 115 East 61st Street New York City NY United StatesDr.

Aim: To describe the use of a new speculated cryoprobe in treatment of conjunc tival neoplasia. Methods: A new cryoprobe design was submitted to Mira, inc resu lting in new hand held probes capable of producing homogeneous freezing over lar ge surface areas. The active surface of the small, medium, and large spatulated probes are 8.5 mm2, 25.2 mm2, and 70 mm2. End freezing reduces the possibility o f inadvertent freezing of adjacent tissues (outside the targeted zone). In this series, the probes were employed to treat patients with squamous and melanocytic conjunctival neoplasia. Results: 12 consecutive patients with malignant conjunc tival neoplasia were treated with these new cryotherapy probes. Techniques of pr obe construction and clinical use are described. Cryoburns of the cornea, sclera , and conjunctiva were formed and recorded by digital photography. Ophthalmic ex aminations before and after surgery demonstrated that no acute intraocular or ad nexal complications occurred. No loss of visual acuity could be attributed to th is use of the cryoprobes. Conclusion: “Finger-tip”cryoprobes were used to tre at malignant conjunctival neoplasia (squamous and melanocytic). probe design all owed for uniform freezing over large surface areas. This cryoprobe design appear s to be ideal for treatment of conjunctival tumours.

关键词：黑素冷冻治疗细胞性附属器内眼眼科检查靶区数码照相冷冻效果竹片

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“指尖状”冷冻探头辅助的眼球摘除术

世界核心医学期刊文摘（眼科学分册） 2005年第8期1卷 33-33页

作者： Finger P.T. 韩静 New York Eye Cancer Center 115 East 61st Street New York City NY 10021 United States Dr.

] PURPOSE: To report the use of a new cryotherapy probe to induce proptosis duri ng enucleation surgery. DESIGN: Interventional case report. METHODS: Two patient s with uveal melanoma and secondary glaucoma were treated by enucleation. A larg e surface area (70 mm2), spatulated, end-freezing cryotherapy probe (“Finger- tip”probes, MIRA, inc.) was used to induce proptosis during optic nerve transse ction. RESULTS: This new probe offers homogeneous freezing over a relatively lar ge surface area. This new cryoprobe was used to create a large cryo-adhesion on the cornea, for an excellent purchase of the eye during enucleation surgery. Us ing this adhesion, the eye was lifted, enabling transsection of the optic nerve. CONCLUSIONS: This report includes photographs of the cryoprobe, the corneal cry o-adhesion, and describes its use for traction during enucleation surgery.

关键词：眼球摘除术冷冻探头眼球前突继发青光眼葡萄膜牵引作用黑色素瘤冷冻治疗