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Biphasic Insulin Aspart 30 Therapy in Insulin-Naïve and Insulin-Experienced Patients with Type 2 Diabetes: Results from the Jordanian Subgroup of the A<sub>1</sub>chieve Study

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Journal of Diabetes Mellitus 2014年第4期4卷 379-387页

作者： Jihad Haddad Fares H. Haddad Rashad Nasser Abdel-Ellah Al-Shudifat Firas Abbas Annabi Levent Sandalci Moawia Al-Kilani Prince Hamzah Hospital Amman Jordan King Hussein Medical center Amman Jordan Italian Hospital Amman Jordan Islamic Hospital Amman Jordan novo nordisk Business Area Near East Istanbul Turkey Jabal Al Zayton Hospital Zarqa Jordan

Objective: To analyse the safety and effectiveness of biphasic insulin aspart 30 (BIAsp 30) in a Jordanian subgroup of the 24-week, non-interventional A1chieve study. Methods: A total of 509 Jordanian patients with type 2 diabetes (392 insulin-naive and 117 insulin-experienced) starting BIAsp30, alone or in combination with oral glucose-lowering drugs, were included. Safety and effectiveness outcomes were analysed over 24 weeks. Results: Patients had a mean age of 55.8 years, body mass index of 28.8 kg/m2 and diabetes duration of 9.4 years at baseline. Two serious adverse drug reactions of hypoglycaemia were reported. The proportion of patients who reported major hypoglycaemic events decreased (2.4% at baseline vs. 0.2% at Week 24, p = 0.0039). The proportion of patients reporting overall hypoglycaemia increased marginally (6.3% at baseline vs. 9.9% at Week 24, p = 0.0378), primarily attributed to a rise in minor and nocturnal hypoglycaemia reported in insulin-naive patients. From baseline to Week 24, the mean ± SD glycated haemoglobin A1c level decreased from 9.8% ± 1.4% to 7.4% ± 0.9% (p < 0.001). Significant reductions after 24 weeks were also noted in the mean fasting plasma glucose, postprandial plasma glucose, lipids, systolic blood pressure and quality of life (all p < 0.001), while the mean body weight increased by 1.8 ± 6.5 kg (p < 0.001). Conclusion: Overall, BIAsp 30 therapy was well-tolerated and resulted in improved glycaemic control in this Jordanian subgroup over 24 weeks.

关键词： Biphasic Insulin Aspart 30 Jordan Type 2 Diabetes A1chieve Clinical Practice

Regeneration of the central nervous system-principles from brain regeneration in adult zebrafish

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World Journal of Stem Cells 2020年第1期12卷 8-24页

作者： Alessandro Zambusi Jovica Ninkovic Helmholtz center Munich Biomedical CenterInst Stem Cell ResInstitute of Stem Cell ResearchDepartment of Cell Biology and AnatomyUniversity of Munich

Poor recovery of neuronal functions is one of the most common healthcare challenges for patients with different types of brain injuries and/or neurodegenerative *** interventions face two major challenges:(1)How to generate neurons de novo to replenish the neuronal loss caused by injuries or neurodegeneration(restorative neurogenesis)and(2)How to prevent or limit the secondary tissue damage caused by long-term accumulation of glial cells,including microglia,at injury site(glial scar).In contrast to mammals,zebrafish have extensive regenerative capacity in numerous vital organs,including the brain,thus making them a valuable model to improve the existing therapeutic approaches for human brain *** response to injuries to the central nervous system(CNS),zebrafish have developed specific mechanisms to promote the recovery of the lost tissue architecture and functionality of the damaged *** mechanisms include the activation of a restorative neurogenic program in a specific set of glial cells(ependymoglia)and the resolution of both the glial scar and inflammation,thus enabling proper neuronal specification and *** this review,we discuss the cellular and molecular mechanisms underlying the regenerative ability in the adult zebrafish brain and conclude with the potential applicability of these mechanisms in repair of the mammalian CNS.

关键词： Zebrafish Central nervous system Brain injury Glial scar Regeneration Restorative neurogenesis Neural stem cells Inflammation

Novel de novo TRPV4 mutation identified in a Chinese family with metatropic dysplasia inhibits chondrogenic differentiation

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Genes & Diseases 2024年第3期11卷 83-86页

作者： Ping Wei Weizhe Shi Tianying Nong Caixia Xian Xia Li Zhaohui Li Xin Li Jianping Wu Liyuan Shang Fulong Xu Yibo Xu Hongwen Xu Mingwei Zhu Guangzhou Institute of Pediatrics Guangzhou Women and Children's Medical CenterGuangzhou Medical UniversityGuangdong Provincial Clinical Research Center for Child HealthGuangzhouGuangdong 510623China Department of Pediatric Orthopedics Guangzhou Women and Children's Medical CenterGuangzhou Medical UniversityGuangdong Provincial Clinical Research Center for Child HealthGuangzhouGuangdong 510623China

Metatropicdysplasia(MD,MIM156530)is a rare congenital bone dysplasia primarily characterized by severe platyspondyly with long and wide vertebral bodies and dumbbell deformity of the tubular *** can be caused by heterozygous mutations in the gene encoding transient receptor potential vanilloid family member 4(TRPV4).We identifieda novel de novo mutation,c.2353T>C,in the TRPV4 gene,in a Chinese family with mild MD.

关键词： TRPV4 dysplasia congenital

在26周治疗期内任意时间点,接受利拉鲁肽治疗的患者HbA1c达标的可能均高于西格列汀和艾塞那肽治疗者

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在26周治疗期内任意时间点,接受利拉鲁肽治疗的患者HbA1c达标的可...

Emerging roles of the intestine in control of cholesterol metabolism

中华医学会糖尿病学分会第十六次全国学术会议

作者：罗小夫 Eduard Montanya Claus Bo Svendsen Monet Sifford-Wilson Robert Ratner IDIBELL-Hospital Universitari Bellvitge BarcelonaSpain novo nordisk A/S SФborgDenmark novo nordisk Inc PrincetonNJUSA MedStar research Institute HyattsvilleMDUSA

目的在2型糖尿病(T2DM)强化治疗中,较早达到目标HbA1c水平可提高患者对治疗的依从性。方法在一项事后分析中,我们评估了在两项3b期试验中第12、20和26周时达到HbA1c<7.0%的患者比例,这两项试验分别是将利拉鲁肽(n=233)与艾塞那肽BID(n=2...

目的在2型糖尿病(T2DM)强化治疗中,较早达到目标HbA1c水平可提高患者对治疗的依从性。方法在一项事后分析中,我们评估了在两项3b期试验中第12、20和26周时达到HbA1c<7.0%的患者比例,这两项试验分别是将利拉鲁肽(n=233)与艾塞那肽BID(n=23 1)进行比较(LEAD-6)以及将利拉鲁肽OD(1.2 mg:n=221和1.8 mg:n=218)与西格列汀OD(n=219)进行比较(LIRA-DPP-4)。使用

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World Journal of Gastroenterology 2006年第40期12卷 6429-6439页

作者： Janine K Kruit Albert K Groen Theo J van Berkel Folkert Kuipers Department of Pediatrics Center for Liver Digestive and Metabolic Diseases University Medical Center Groningen Groningen The Netherlands Department of Experimental Hepatology Academic Medical Center Amsterdam The Netherlands Division of Biopharmaceutics Leiden/Amsterdam Center for Drug Research Leiden University Leiden The Netherlands

The liver is considered the major “control center” for maintenance of whole body cholesterol homeostasis. This organ is the main site for de novo cholesterol synthesis, clears cholesterol-containing chylomicron remnants and low density lipoprotein particles from plasma and is the major contributor to high density lipoprotein (HDL; good cholesterol) formation. The liver has a central position in the classical definition of the reverse cholesterol transport pathway by taking up periphery-derived cholesterol from lipoprotein particles followed by conversion into bile acids or its direct secretion into bile for eventual removal via the feces. During the past couple of years, however, an additional important role of the intestine in maintenance of cholesterol homeostasis and regulation of plasma cholesterol levels has become apparent. Firstly, molecular mechanisms of cholesterol absorption have been elucidated and novel pharmacological compounds have been identified that interfere with the process and positively impact plasma cholesterol levels. Secondly, it is now evident that the intestine itself contributes to fecal neutral sterol loss as a cholesterol-secreting organ. Finally, very recent work has unequivocally demonstrated that the intestine contributes significantly to plasma HDL cholesterol levels. Thus, the intestine is a potential target for novel anti-atherosclerotic treatment strategies that, in addition to interference with cholesterol absorption, modulate direct cholesterol excretion and plasma HDL cholesterol levels.

关键词： Cholesterol metabolism Intestine High density lipoprotein Cholesterol absorption Reverse cholesterol transport

Adventitious Root Regeneration:Molecular Basis and Influencing Factors

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Phyton-International Journal of Experimental Botany 2023年第10期92卷 2825-2840页

作者： Lulu Zhi Xiangyang Hu Shanghai Key Laboratory of Bio-Energy Crops Research Center for Natural ProductsPlant Science CenterSchool of Life SciencesShanghai UniversityShanghai200444China

Plant regeneration is a self-repair of the plant body in response to adverse conditions or damaged structures,and root regeneration allows the plant body to better adapt to its environment by supplementing the roots’*** research has shown that adventitious roots can be made to occur from scratch in two *** that simulate adventitious root regeneration through natural conditions allow the regeneration process to be broadly divided into three stages:the perception of early signals,the massive accumulation of auxin,and the transformation of cell *** strength of regeneration,in turn,is influenced by wounding,stress,hormones,*** study mainly reviews the molecular mechanisms of de novo adventitious roots and discusses how the environment,hormones,and its own development in Arabidopsis thaliana.

关键词： Arabidopsis thaliana de novo adventitious root regeneration phytohormone regeneration molecular mechanism

Down-staging depth score to predict outcomes in locally advanced rectal cancer achieving ypl stage after neoadjuvant chemo-radiotherapy versus de novo stage pl cohort:A propensity score-matched analysis

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Chinese Journal of Cancer research 2018年第3期30卷 373-381页

作者： Ning Li Jing Jin Jing Yu Shuai Li Yuan Tang Hua Ren Wenyang Liu Shulian Wang Yueping Liu Yongwen Song Hui Fang Zihao Yu Yexiong Li Department of Radiation Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical SciencesPeking Union Medical College

Objective：Prognosis of patients with locally advanced rectal cancer（LARC）but achieving yp T1–2N0 stage after neoadjuvant concurrent chemo-radiotherapy（CRT）has been shown to be *** study aims to determine whether the long-term outcome of yp T1–2N0 cases can be comparable to that of p T1–2N0 cohort that received definitive surgery for early ***：From January 2008 to December 2013,449 consecutive patients with rectal cancer were treated and their outcome maintained in a *** with LARC underwent total mesorectal excision（TME）surgery at4–8 weeks after completion of CRT,and those achieving stage yp I were identified as a *** a comparison,stage p I group pertains to patients whose initially limited disease was not upstaged after TME surgery *** propensity score matching（PSM）,comparisons of local regional control（LC）,distant metastasis-free survival（DMFS）,disease-free survival（DFS）and overall survival（OS）were performed using Kaplan-Meier analysis and log-rank test between yp I and p I ***-staging depth score（DDS）,a novel method of evaluating CRT response,was used for subset ***：Of the 449 patients,168 matched cases were generated for ***-year LC,DMFS,DFS and OS for stage p I *** I groups were 96.7%vs.96.4%（P=0.796）,92.7%vs.73.6%（P=0.025）,91.2%vs.73.6%（P=0.080）and 93.1%vs.72.3%（P=0.040）,*** the DDS-favorable subset of the yp I group,LC,DMFS,DFS and OS resulted in no significant differences in comparison with the p I group（P=0.384,0.368,0.277 and0.458,respectively）.Conclusions：LC was comparable in both groups;however,distant metastasis developed more frequently in down-staged LARC than de novo early stage cases,reflecting the need to improve the efficacy of systemic treatment despite excellent pathologic *** can be an indicator to identify a subset of the yp I group whose longterm oncologic outcomes are as good as those of stage p I cohort.

关键词： Rectal neoplasms neoadjuvant chemo-radiotherapy down-staging propensity score-matched analysis

Quantitative detection of single amino acid polymorphisms by targeted proteomics

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Journal of Molecular Cell Biology 2011年第5期3卷 309-315页

作者： Zhi-Duan Su Liang Sun Dan-Xia Yu Rong-Xia Li Huai-Xing Li Zhi-Jie Yu Quan-Hu Sheng Xu Lin Rong Zeng Jia-Rui Wu Key Laboratory of Systems Biology Institute of Biochemistry and Cell BiologyShanghai Institutes for Biological SciencesChinese Academy of SciencesShanghai 200031China State Key Laboratory of Molecular Biology Institute of Biochemistry and Cell BiologyShanghai Institutes for Biological SciencesChinese Academy of SciencesShanghai 200031China Key Laboratory of Nutrition and Metabolism Institute of Nutritional SciencesShanghai Institutes for Biological SciencesChinese Academy of SciencesShanghai 200031China SIBS-novo nordisk Translational research Centre for PreDiabetes Shanghai Institutes for Biological SciencesChinese Academy of SciencesShanghai 200031China Hefei National Laboratory for Physical Sciences at Microscale and School of Life Science University of Science and Technology of ChinaHefei 230026China

Single-nucleotide polymorphisms(SNPs)are recognized as one kind of major genetic variants in population ***,polymorphisms at the proteome level in population scale remain *** the present study,we named amino acid variances derived from SNPs within coding regions as single amino acid polymorphisms(SAPs)at the proteome level,and developed a pipeline of nontargeted and targeted proteomics to identify and quantify SAP peptides in human *** absolute concentrations of three selected SAP-peptide pairs among 290 Asian individuals were measured by selected reaction monitoring(SRM)approach,and their associations with both obesity and diabetes were further *** work revealed that heterozygotes and homozygotes with various SAPs in a population could have different associations with particular *** addition,the SRM approach allows us for the first time to separately measure the absolute concentration of each SAP peptide in the heterozygotes,which also shows different associations with particular traits.

关键词： single amino acid polymorphism(SAP) proteomics selected reaction monitoring(SRM) diabetes obesity

运用递归分割分析确定利拉鲁肽治疗2型糖尿病的疗效预测指标

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运用递归分割分析确定利拉鲁肽治疗2型糖尿病的疗效预测指标