检索结果-南通市图书馆

Stages of care for patients with chronic hepatitis C at a hospital in southern Brazil

世界肝病学杂志:英文版(电子版) 2023年第8期15卷 973-984页

作者： Manoela Badinelli Vaucher Camila Ubirajara Silva Ivana Rosângela Santos Varella Arthur Yu-Shin Kim Dimas Alexandre Kliemann Department of Hepatology Universidade Federal de Ciências da Saúde de Porto AlegrePorto Alegre 90050-170Rio Grande do SulBrazil Department of Medicine Universidade do Vale do TaquariLajeado 95914-014RSBrazil Department of Application and Monitoring of Injectable Drugs Hospital Sanatório PartenonPorto Alegre 90650-000RSBrazil Department of Epidemiology Hospital Nossa Senhora da ConceiçãoPorto Alegre 91350-200Rio Grande do SulBrazil Department of Infectious Diseases Massachusetts General HospitalBostonMA 02114United States Department of Medicine Harvard Medical SchoolBostonMA 02114United States Departament of Infectious Diseases Hospital Nossa Senhora da ConceiçãoPorto Alegre 91350-200Rio Grande do SulBrazil

BACKGROUND Hepatitis C virus(HCV)is defined as a public health problem by the World Health Organization(WHO)and since then has defined targets through the HCV *** HCV cascade of care highlights the progress towards these goals and essential interventions that need to be delivered along this continuum *** To document the treatment cascade for patients with HCV infection at the Hospital nossa senhora da conceição(HNSC),defining the percentage of antibody-positive patients who collected molecular biology tests(polymerase chain reaction),attended outpatient clinic assistance,underwent treatment,and achieved a virologic cure termed sustained virologic response(SVR).METHODS With the retrospective cohort design,patients diagnosed with HCV infection in the period between January 1,2015 and December 31,2020 were *** from HCV notification forms,electronic medical records,Computerized Laboratory Environment Manager System,and Medicine Administration System(evaluation of special medications)were collected in 2022 and all information up to that period was *** data were analyzed with IBM SPSS version 25,and Poisson regression with robust simple variance was performed for analysis of variables in relation to each step of the *** with Pdates receiving HCV treatment and only 29%achieving SVR,despite the 98%response rate to direct acting antivirals documented by follow-up *** city of origin and the place of follow-up were the variables associated with SVR and all other *** comparing the cascade of patients who remained assisted by the HNSC vs external patients,we observed superior data for HNSC patien

关键词： Cascade of care Elimination Hepatitis C virus Sustained virologic response

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Relationship between phase angle,steatosis,and liver fibrosis in patients coinfected with human immunodeficiency virus/hepatitis C virus

引用

World Journal of Hepatology 2022年第6期14卷 1173-1181页

作者： Sabrina Alves Fernandes Cristiane Valle Tovo AndréLuiz Machado da Silva Letícia Pereira Pinto Randhall B Carteri Angelo A Mattos Postgraduate Program in Hepatology Universidade Federal de Ciências da Saúde de Porto Alegre(UFCSPA)Porto Alegre 90050-170Brazil Department of Infectology Service Hospital Nossa Senhora da ConceiçãoPorto Alegre 91350-200Brazil Department of Nutrition Centro Universitário Metodista-IPAPorto Alegre 90420-060Brazil Department of Nutrition Centro Universitário CESUCACachoeirinha 94935-630Brazil

BACKGROUND Malnutrition,lipodystrophy,and dyslipidemia are prevalent characteristics in patients with human immunodeficiency virus(HIV)infection with or without previous *** a clinical condition can lead to the hypothesis of the presence of hepatic steatosis with possible progression to fibrosis and the risk of hepatocellular ***,a low phase angle(PA),evaluated by bioelectrical impedance analysis(BIA),is an independent prognostic marker of clinical progression and survival in HIV-infected *** To evaluate the relationship between PA and body composition with steatosis and hepatic fibrosis in HIV/hepatitis C virus(HCV)-coinfected *** A retrospective observational study by convenience sampling of coinfected HIV/HCV patients,in which all patients underwent transient elastography(Fibroscan)and BIA ***’s t test was used for group comparisons,and Spearman’s or Pearson’s correlation test was used when *** significance level was set at 5%,and analyses were performed using SPSS version *** Forty-three patients who received antiretroviral therapy met the inclusion criteria,and 23(53.5%)were under treatment with protease inhibitors(PIs).There was no difference in PA between those who used PIs and those who did not(P=0.635).There was no correlation between fibrosis grade and PA(P=0.355)or lean mass(P=0.378).There was a significant inverse correlation between the controlled attenuation parameter(CAP)and lean mass(P=0.378),positive correlation between PA and lean mass(P=0.378),and negative correlation between PA and fatty mass(P=0.378),although the CAP and PA were not *** evaluated by sex,no significant correlations were *** PA determines the muscle function of HIV/HCV-coinfected patients,and the CAP values reinforce the association with lean mass,suggesting that patients require early nutritional interventions.

关键词： Phase angle Bioelectrical impedance Coinfection Human immunodeficiency virus Hepatitis C virus Nutrition

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Can rainfall seasonality trigger soil water repellency in a tropical riparian forest?

引用

Journal of Forestry Research 2023年第3期34卷 773-780页

作者： Gleicon Queiroz de Brito Johnny Rodrigues de Melo Murta Sérgio Fernandes Mendonca Filho Luiz Felippe Salemi Núcleo de Estudos e Pesquisas Ambientais e Limnológicas(NEPAL) Faculdade UnB de Planaltina(FUP)Universidade de Brasília(UnB)DFVila Nossa Senhora de FátimaÁrea Universitária 1Planaltina 73345-010Brazil

Though riparian areas generally have a shallow water table and higher soil moisture compared to up slope areas,climatic seasonality may trigger water repellency in tropical riparian forests,which,if persistent,could negatively affect essential ecosystem functions related to water resources protection such as reduced overland-flow,sediment transport,and nutrient *** objective of this study was to answer the following:can tropical riparian forests develop water repellency?If so,does water repellency affect infiltration on a seasonal basis?For this,water repellency and infiltration were measured in a grid of 72points during a dry and a wet month of a tropical riparian forest with a shallow water table in a region with highly marked climatic *** repellency and infiltration were significantly different between the wet and dry *** repellency affected negatively infiltration in the dry month,its effect in the wet month was *** a result,a higher infiltration capacity was observed over the wet *** research has claimed that the development and persistence of repellency in soils could promote other hydrological processes such as overland *** findings shown here demonstrate that such phenomenon does not persist longer than the dry season.

关键词： Hydrophobicity Gallery forest Aquifer recharge Climate change Erosion

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Incidence of hepatocellular carcinoma in patients with chronic liver disease due to hepatitis B or C and coinfected with the human immunodeficiency virus:a retrospective cohort study

引用

World Journal of Gastroenterology 2018年第5期24卷 613-622页

作者： Patrícia dos Santos Marcon Cristiane Valle Tovo Dimas Alexandre Kliemann Patrícia Fisch Angelo Alves de Mattos Hepatology Post-Graduate Program Universidade Federal de Ciências da Saúde de Porto Alegre(UFCSPA)Porto Alegre 90020-090RSBrazil Infectology Department at Hospital nossa senhora da conceicao Porto Alegre 91350-200RSBrazil Epidemiology Department at Hospital nossa senhora da conceicao Porto Alegre 91350-200RSBrazil

AIM To assess the incidence of hepatocellular carcinoma(HCC) in chronic liver disease due to hepatitis B virus(HBV) or hepatitis C virus(HCV) coinfected with human immunodeficiency virus(HIV).METHODS A retrospective cohort study was performed, including patients with chronic liver disease due to HBV or HCV, with and without HIV coinfection. Patients were selected in the largest tertiary public hospital complex in southern Brazil between January 2007 and June 2014. We assessed demographic and clinical data, including lifestyle habits such as illicit drug use or alcohol abuse, in addition to frequency and reasons for hospital admissions via medical records *** Of 804 patients were included(399 with HIV coinfection and 405 monoinfected with HBV or HCV). Coinfected patients were younger(36.7 ± 10 vs 46.3 ± 12.5, P < 0.001). Liver cirrhosis was observed in 31.3% of HIV-negative patients and in 16.5% of coinfected(P < 0.001). HCC was diagnosed in 36 patients(10 HIV coinfected and 26 monoinfected). The incidence density of HCC in coinfected and monoinfected patients was 0.25 and 0.72 cases per 100 patient-years(95%CI: 0.12-0.46 vs 0.47-1.05)(long-rank P = 0.002), respectively. The ratio for the HCC incidence rate was 2.98 for HIV-negative. However, when adjusting for age or when only cirrhotic are analyzed, the absence of HIV lost statistical significance for the development of HCC. CONCLUSION In this study, the presence of HIV coinfection in chronic liver disease due to HBV or HCV showed no relation to the increase of HCC incidence.

关键词： Hepatocellular carcinoma Chronic hepatitis human immunodeficiency virus Coinfection Cirrhosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chronic liver failure-consortium acute-on-chronic liver failure and acute decompensation scores predict mortality in Brazilian cirrhotic patients

引用

World Journal of Gastroenterology 2017年第28期23卷 5237-5245页

作者： Rafael Veiga Picon Franciele Sabadin Bertol Cristiane Valle Tovo Angelo Zambam de Mattos Gastroenterology and Hepatology Unit Nossa Senhora da Conceicao Hospital Gastro-enterology and Hepatology Unit Federal University of Health Sciences of Porto Alegre Gastroenterology and Hepatology Unit Pontifical Catholic University of Rio Grande do Sul

AIM To validate prognostic scores for acute decompensation of cirrhosis and acute-on-chronic liver failure in Brazilian *** This is a prospective cohort study designed to assess the prognostic performance of the chronic liver failure-consortium(CLIF-C) acute decompensation score(CLIF-C AD) and CLIF-C acute-on-chronic liver failure score(CLIF-C ACLF),regarding 28-d and 90-d mortality,as well as to compare them to other prognostic models,such as Model for End-Stage Liver Disease(MELD),MELD Sodium(MELD-Na),ChildPugh(CP) score,and the CLIF-C Organ Failure score(CLIF-C OF). All participants were adults with acute decompensation of cirrhosis admitted to the Emergency Department of a tertiary hospital in southern Brazil. Prognostic performances were evaluated by means of the receiver operating characteristic(ROC) curves,area under the curves(AUC) and 95%*** One hundred and thirteen cirrhotic patients were included. At admission,18 patients had acute-onchronic liver failure(ACLF) and 95 individuals had acute decompensation(AD) without ACLF,of which 24 eventually developed ACLF during the course of hospitalization(AD evolving to ACLF group). The AD group had significantly lower 28-d(9.0%) and 90-d(18.3%) mortality as compared to the AD evolving to ACLF group and to the ACLF group(both P < 0.001). On the other hand,28-d and 90-d mortalities were not significantly different between AD evolving to ACLF group and ACLF group(P = 0.542 and P = 0.708,respectively). Among patients with ACLF,at 28 d from the diagnosis,CLIF-C ACLF was the only score able to predict mortality significantly better than the reference line,with an AUC(95%CI) of 0.71(95%CI: 0.54-0.88,P = 0.021). Among patients with AD,all prognostic scores performed significantly better than the reference line regarding 28-d mortality,presenting with similar AUCs: CLIF-C AD score 0.75(95%CI: 0.63-0.88),CP score 0.72(95%CI: 0.59-0.85),MELD score 0.75(95%CI: 0.61-0.90),MELD-Na score 0.76(95%CI: 0.61-0.90)

关键词： Cirrhosis Acute-on-chronic liver failure Mortality Prediction Prognosis Acute decompensation of cirrhosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hepatitis E:A Literature Review

引用

Journal of Clinical and Translational Hepatology 2017年第4期5卷 376-383页

作者： Juliana Ayres de Alencar Arrais Guerra Katia Cristina Kampa daphne Gon(c)alves Benatti Morsoletto Alcindo Pissaia Junior Cláudia Alexandra Pontes Ivantes nossa senhora das Gracas Hospital Alcides Munhoz Street433-MercêsCuritiba-PRBrazil

Hepatitis E is the fifth known form of human viral *** not very common in our clinical practice,the incidence in Western countries is *** with the hepatitis E virus(HEV)may be related to acute illness,liver failure,chronic hepatitis and *** itself is an RNA virus,with eight described genotypes(HEV 1-8),four of which more commonly affect humans and have,thus,been better *** liver manifestations,genotype 3 is also related to extra-hepatic manifestations,such as neurological,renal and *** to chronic disease occurs especially in patients who underwent transplantation,have hematological malignancies requiring chemotherapy,or have infection with the human immunodeficiency *** diagnosis may be difficult because of the low availability of tests and due to low sensibility and *** acute form of illness does not have to be treated,but the chronic one *** present here a literature review of hepatitis E and the relation between chronic hepatitis E and transplantation.

关键词： Hepatitis E Chronic hepatitis E Immunosuppression Transplantation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Is Pulmonary Auscultation Alone Sufficient for Clinical Practice?

引用

Open Journal of Respiratory Diseases 2020年第3期10卷 49-58页

作者： Waldo Luis Leite Dias de Mattos João Vitor Pinotti dallasen Ana Gabriela Goularte Juchem Douglas da Silva Pinos3, Fabiana Jaeger Federal University of Health Sciences of Porto Alegre (UFCSPA) Porto Alegre Brazil Santa Casa de Misericórdia Hospital Porto Alegre Brazil nossa senhora da conceiç ã o Hospital Porto Alegre Brazil

Objective: The clinical examination is the basis for the diagnosis and rational choice of complementary tests. The aim of the study was to evaluate the performance of auscultation of the chest for screening of disease and for predicting the presence of abnormalities in the other domains of the chest examination. Methods: Patients with COPD, atelectasis, pleural effusion, pneumonia and controls were evaluated by two examiners in the absence of any clinical information, initially only with pulmonary auscultation, and then in the other domains of chest examination. Results: 192 physical examinations were performed in 104 patients. An abnormal pulmonary auscultation had a sensitivity of 85.2%, positive predictive value (PPV) of 84.1%, positive likelihood reason (LR) of 1.53 (95% CI;1.16 to 2.01) and negative LR of 0.33 (95% CI;0.2 to 0.56) to identify the presence of any disease, and also a positive LR of 2.23 (95% CI;1.02 to 4.9) and a negative LR of 0.3 (95% CI;0.17 to 0.51) to predict additional abnormalities. A normal auscultation showed low accuracy to identify healthy individuals, with sensitivity, specificity, NPV and PPV, respectively, of 44%, 43%, 41% and 46%. The agreement between the examiners considering normal versus abnormal findings showed kappa = 0.76 for any changes in the physical examination present (p Conclusions: Auscultation of the chest alone, may not be a sufficient strategy to track diseases or establish whether continuity of the examination is necessary or not.

关键词： Physical Examination Pulmonary Auscultation Clinical Diagnosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chronic hepatitis C genotype 1 virus:Who should wait for treatment?

引用

World Journal of Gastroenterology 2014年第11期20卷 2867-2875页

作者： Cristiane Valle Tovo Angelo Alves de Mattos Paulo Roberto Lerias de Almeida Department of Gastroenterology Universidade Federal de Ciências da Saúde de Porto AlegrePorto Alegre 90430-080Brasil Department of Gastroenterology Hospital Nossa Senhora da Concei??oPorto Alegre 91350-200Brasil

Elucidation of the natural history of chronic hepatitis C(CHC)and the identification of risk factors for its progression to advanced liver disease have allowed many physicians to recommend deferral treatment(triple therapy)in favour of waiting for new drug availability for patients who are at low risk of progression to significant liver *** generation drugs are currently under development,and are expected to feature improved efficacy and safety profiles,as well as less complex and shorter duration delivery regimens,compared to the current standards of *** addition,patients with cirrhosis and prior null responders have a low rate(around 15%)of achieving sustained virological response(SVR)with triple therapy,and physicians must also consider the decision to wait for new treatments in the future for these patients as *** patients are the most likely to achieve a close to 100%SVR rate;therefore,it may be advisable to recommend that patients with mild to moderate CHC should wait for the newer therapy *** contrast,patients with advanced fibrosis and cirrhosis will be those with the greatest need for expedited therapeutic *** remains a need,however,for establishing definitive clinical management guidelines to maximize the benefit of waiting for new drugs and minimize risk of side effects and non-response to the current triple therapy.

关键词： Hepatitis C virus Chronic hepatitis C Treatment of

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Is there a role for liver transplantation in the treatment of hepatocellular carcinoma in non-cirrhotic liver?

引用

World Journal of Meta-Analysis 2022年第2期10卷 46-51页

作者： Luis Cesar Bredt Ingryd Betina Garcia Felisberto Doroty Eva Garcia Felisberto Surgical Oncology and Hepatobiliary Surgery Unioeste UniversityCascavel 85819-110ParanáBrazil Internal Medicine Univates UniversityLajeado 95914-014Rio Grande do SulBrazil Department of Surgery Nossa Senhora das Graças HospitalCuritiba 80810-040ParanáBrazil

Whether liver transplantation(LT)plays a role in the treatment of patients with hepatocellular carcinoma(HCC)in non-cirrhotic liver(NCL)is a matter of *** recommendations for LT in this setting are extremely fragile and less welldefined than for cirrhosis-associated *** reports of LT for NCL-HCC revealed that long-term outcomes of these patients are poor,and these dismal figures are justified by the advanced tumor stage at the time of LT,suggesting the presence of systemic micrometastatic *** decision-making regarding LT for NCL-HCC is difficult,since specific selection criteria are scarce,and basically the potential candidates are those with unresectable only-liver tumor at admission,or unresectable intrahepatic recurrence *** the surgical aspects regarding the tumor resectability,other phenotypic and genetic characteristics of the tumor should be considered for the indication of LT in this *** present minireview aims to discuss and analyze the last series of LT for NCL-HCC,in order to help clinicians in the decision-making process regarding the role of LT in NCL-HCC treatment.

关键词： Liver transplantation Non-cirrhotic liver Liver Cancer Hepatocellular carcinoma Treatment

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Polymorphisms and resistance mutations of hepatitis C virus on sequences in the European hepatitis C virus database

引用

World Journal of Gastroenterology 2016年第40期22卷 8910-8917页

作者： Dimas Alexandre Kliemann Cristiane Valle Tovo Ana Beatriz Gorini da Veiga Angelo Alves de Mattos Charles Wood Graduate Program in Medicine: Hepatology-Universidade Federal de Ciências da Saúde de Porto Alegre Porto Alegre RS 90050-170 Brazil Hospital nossa senhora da conceicāo Portto Alegre RS 90050-170 Brazil Department of Basic Health Sciences Laboratory of Molecular Biology Graduate Program in Pathology-Universidade Federal de Ciências da Saúde de Porto Alegre RS 90050-170 Brazil School of Biological Sciences Nebraska Center for Virology University of Nebraska Lincoln NE 68511 United States

AIM To evaluate the occurrence of resistant mutations in treatment-na?ve hepatitis C virus(HCV) sequences deposited in the European hepatitis C virus database(euH CVdb). METHODS The sequences were downloaded from the eu HCVdb(https://***/eu HCVdb/). The search was performed for full-length NS3 protease, NS5 A and NS5 B polymerase sequences of HCV, separated by genotypes 1a, 1b, 2a, 2b and 3a, and resulted in 798 NS3, 708 NS5 A and 535 NS5 B sequences from HCV genotypes1a, 1b, 2a, 2b and 3a, after the exclusion of sequences containing errors and/or gaps or incomplete sequences, and sequences from patients previously treated with direct antiviral agents(daA). The sequence alignment was performed with MEGA 6.06 MAC and the resulting protein sequences were then analyzed using the BioE dit 7.2.5. for mutations associated with resistance. Only positions that have been described as being associated with failure in treatment in in vivo studies, and/or as conferring a more than 2-fold change in replication in comparison to the wildtype reference strain in in vitro phenotypic assays were included in the *** The Q80 K variant in the NS3 gene was the most prevalent mutation, being found in 44.66% of subtype 1a and 0.25% of subtype 1b. Other frequent mutations observed in more than 2% of the NS3 sequences were: I170V(3.21%) in genotype 1a, and Y56F(15.93%), V132I(23.28%) and I170V(65.20%) in genotype 1b. For the NS5 A, 2.21% of the genotype 1a sequences have the P58 S mutation, 5.95% of genotype 1b sequences have the R30 Q mutation, 15.79% of subtypes 2a sequences have the Q30 R mutation, 23.08% of subtype 2b sequences have a L31 M mutation, and in subtype 3a sequences, 23.08% have the M31 L resistant variants. For the NS5 B, the V321 L RAV was identified in 0.60% of genotype 1a and in 0.32% of genotype 1b sequences, and the N142 T variant was observed in 0.32% of subtype 1b sequences. The C316 Y, S556 G, D559 N RAV were identified in 0.33%, 7.82% and 0.

关键词：丙肝病毒抵抗 Quasispecies 指导抗病毒的代理人多型性药抵抗

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：