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Novel miRNA, miR-sc14, promotes Schwann cell proliferation and migration

Neural Regeneration Research 2019年第9期14卷 1651-1656页

作者： Xi-Meng Ji Shan-Shan Wang Xiao-Dong Cai Xing-Hui Wang Qian-Yan Liu Pan Wang Zhang-Chun Cheng Tian-Mei Qian Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education Co-innovation Center of NeuroregenerationNantong UniversityNantongJiangsu ProvinceChina nonnasality clinical medicine Nanjing Medical UniversityNanjingJiangsu ProvinceChina Affiliated Hospital of Nantong University NantongJiangsu ProvinceChina

MicroRNAs refer to a class of endogenous,short non-coding RNAs that mediate numerous biological *** regulate various physiological and pathological activities of peripheral nerves,including peripheral nerve repair and ***,using a rat sciatic nerve injury model,we identified many functionally annotated novel microRNAs,including ***,we used real-time reverse transcription-polymerase chain reaction to examine miR-sc14 expression in rat sciatic nerve *** results show that miRsc14 is noticeably altered following sciatic nerve injury,being up-regulated at 1 day and diminished at 7 *** and transwell chamber assay results showed that miR-sc14 mimic promoted proliferation and migration of Schwann cells,while miR-sc14 inhiThe study was approved by the Jiangsu Provincial Laboratory Animal Management Committee,China on March 4,2015(approval No.20150304-004).bitor suppressed their proliferation and ***,bioinformatic analysis examined potential target genes of miR-sc14,and found that fibroblast growth factor receptor 2 might be a potential target ***,our results show changes of miR-sc14 expression in the sciatic nerve of rats at different time points after nerve ***,up-regulation of miR-sc14 promoted proliferation and migration of Schwann ***,miR-sc14 may be an intervention target to promote repair of peripheral nerve *** study was approved by the Jiangsu Provincial Laboratory Animal Management Committee,China on March 4,2015(approval No.20150304-004).

关键词： nerve regeneration novel microRNAs miR-sc14 peripheral nerve injury cell proliferation cell migration Schwann cells fibroblast growth factor receptor 2 biological functions peripheral nerve regeneration regulatory mechanisms neural regeneration

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