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Numerical Analyses of Idealized Total Cavopulmonary Connection Physiologies with Single and Bilateral Superior Vena Cava Assisted by an Axial Blood Pump

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Computer Modeling in Engineering & Sciences 2018年第8期116卷 215-228页

作者： Xudong Liu Yunhan Cai Bing Jia Shengzhang Wang Guanghong Ding institute of biomechanics Department of Aeronautics and AstronauticsFudan UniversityShanghai200433China. Cardiovascular Center Children’s HospitalFudan UniversityShanghai201102China.

Our study evaluated the hemodynamic performance of an axial flow blood pump surgically implanted in idealized total cavopulmonary connection(TCPC)*** blood pump was designed to augment pressure from the inferior vena cava(IVC)to the pulmonary *** Fontan procedures with single and bilateral superior vena cava(SVC)were compared to fit the mechanical supported TCPC *** fluid dynamics(CFD)analyses of two Pump-TCPC models were performed in the ***-flow characteristics,energy efficiency,fluid streamlines,hemolysis and thrombosis analyses were *** simulations indicate that the pump produces pressure generations of 1 mm to 24 mm Hg for rotational speeds ranging from 2000 RPM to 5000 RPM and flow rates of 2 LPM to 4 *** surgical models incorporated with the pump were found to be insignificant in pressure augmentation and energy *** risk assessment of blood trauma and thrombosis generation was evaluated representatively through blood damage index(BDI),particle resident time(PRT)and relative resistant time(RRT).The hemolysis and thrombosis analyses declare the advantage of the pump supported bilateral SVC surgical scheme in balancing flow distribution and reducing the risk of endothelial cell destruction and trauma generation.

关键词： Computational fluid dynamics total cavopulmonary connection bilateral superior vena cava axial flow blood pump blood trauma thrombosis probability

EXPERIMENTAL STUDY OF THE MORPHOLOGY OF CEREBRAL BRIDGING VEIN

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Chinese Medical Sciences Journal 2001年第1期16卷 19-22页

作者：庞琦王成伟胡永生徐广明张珑郝晓光张庆林 Hans Gregersen Department of Neurosurgery the Second Affiliated Hospital of Shandong Medical University Jinan 250033 biomechanics Lab Institute of Experimental Clinical Research Arhus University Hospital Denmark

To investigate the morphological properties of pig cerebral bridging vein. Methods. The morphology and fibre arrangement of 15 cerebral bridging veins obtained from 7 Danish Yorkshire landrace pigs were observed. Results. There was a narrow region at the junction of the cerebral bridging veins and superior sagittal sinus termed“ outflow cuff segment". The diameter and length of outflow cuff segment were much smaller and the thickness was higher than those of the cerebral bridging veins (P0.05). Conclusions. There were differences in fibre arrangement and morphological properties between the outflow cuff segment and the cerebral bridging vein, just like a resistance valve, the outflow cuff segment may play an important role in stabilizing cerebral venous outflow and regulating intracranial pressure.

关键词： cerebral bridging vein morphology venous outflow

Effect of the Wall Thickness of the Vessel on FFRCT of Carotid Artery Stenosis

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Computer Modeling in Engineering & Sciences 2019年第12期121卷 835-844页

作者： Long Yu Kesong Xu Jun Wan Haiyan Lu Shengzhang Wang institute of biomechanics Department of Aeronautics and AstronauticsFudan UniversityShanghaiChina Interventional Department Shanghai Jing’an District Central HospitalShanghaiChina Interventional Ultrasound Division of VIP Clinic Department Dongfang Hospital Affiliated to Tongji UniversityShanghaiChina

Fractional flow reserve(FFR)computed from computed tomography angiography(CTA),i.e.,FFRCT has been used in the clinic as a noninvasive parameter for functional assessment of coronary artery *** has also been suggested to be used in the assessment of carotid artery *** wall thickness of the vessel is an important parameter when establishing a fluid-structure coupling model of carotid *** work studies the effect of the vessel wall thickness on hemodynamic parameters such as FFRCT in carotid *** of carotid stenosis are established based on CTA image data using computer-aided design *** is assumed that the vessel wall is a linear elastic and isotropic material,and the blood an incompressible Newtonian *** the pulsating flow condition,ANSYS Transient Structural and CFX are used to simulate the blood flow of fluid-structure coupling in the carotid stenosis model in order to obtain hemodynamic parameters and the corresponding *** results show that when the elastic modulus of the vessel wall is fixed,FFRCT will decrease with the increase of the wall ***,FFRCT will decrease with the increase of the elastic modulus when the wall thickness is *** difference in hemodynamic parameters such as FFRCT,however,is relatively small if the stiffness of the two models are *** results demonstrate that the effect of the vessel wall thickness,especially for a model with small elastic modulus,should be taken into account in using FFRCT for functional assessment of carotid ***,under the linear elasticity and isotropic material assumptions,the stiffness coefficient may replace the elastic modulus and wall thickness as a parameter reflecting material property of the vessel wall in the carotid stenosis model.

关键词： Carotid artery stenosis fractional flow reserve fluid-structure coupling numerical simulation stiffness coefficient

New perspectives of studying gastrointestinal muscle function

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World Journal of Gastroenterology 2006年第18期12卷 2864-2869页

作者： Hans Gregersen Donghua Liao Center for Visceral biomechanics & Pain Aalborg Hospital and the Institute of Health Technology Aalborg University Denmark and Haukeland University Hospital Bergen Norway Center for Visceral biomechanics & Pain Aalborg Hospital Aalborg Denmark

The motor function of the gastrointestinal tract has primarily been studied using manometry and radiography, though more indirect tests have also been applied. Manometry and radiography do not provide detailed information about the muscle properties as can be assessed from studies of muscle properties in muscle strips in vitro. In recent years a technique based on impedance planimetric measurement of pressure-cross-sectional area relations in a distending bag has proven to provide more detailed information about the muscle function in vivo. This review shows examples of new muscle function analysis such as length-tension diagrams, forcevelocity curves and preload-afterload diagrams.

关键词： Muscle analysis Length-tension Force Velocity

Mesenchymal stem cells and collagen patches for anterior cruciate ligament repair

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World Journal of Stem Cells 2015年第2期7卷 521-534页

作者： Benjamin Gantenbein Neha Gadhari Samantha CW Chan Sandro Kohl Sufian S Ahmad Tissue and Organ Mechanobiology Institute for Surgical Technology and BiomechanicsUniversity of Bern EMPA Swiss Federal Laboratories for Materials Science and Technology Orthopedic Department Insel University Hospital

AIM: To investigate collagen patches seeded with mesenchymal stem cells(MSCs) and/or tenocytes(TCs) with regards to their suitability for anterior cruciate ligament(ACL) repair. METHODS: Dynamic intraligamentary stabilization utilizes a dynamic screw system to keep ACL remnants in place and promote biological healing, supplemented by collagen patches. How these scaffolds interact with cells and what type of benefit they provide has not yet been investigated in detail. Primary ACL-derived TCs and human bone marrow derived MSCs were seeded onto two different types of 3D collagen scaffolds, Chondro-Gide?(CG) and Novocart?(NC). Cells were seeded onto the scaffolds and cultured for 7 d either as a pure populations or as "premix" containing a 1:1 ratio of TCs to MSCs. Additionally, as controls, cells were seeded in monolayers and in co-cultures on both sides of porous high-density membrane inserts(0.4 μm). We analyzed the patches by real time polymerase chain reaction, glycosaminoglycan(GAG), DNA and hydroxyproline(HYP) content. To determine cell spreading and adherence in the scaffolds microscopic imaging techniques, i.e., confocal laser scanning microscopy(c LSM) and scanning electron microscopy(SEM), were ***: CLSM and SEM imaging analysis confirmed cell adherence onto scaffolds. The metabolic cell activity revealed that patches promote adherence and proliferation of cells. The most dramatic increase in absolute metabolic cell activity was measured for CG samples seeded with tenocytes or a 1:1 cell premix. Analysis of DNA content and c LSM imaging also indicated MSCs were not proliferating as nicely as tenocytes on CG. The HYP to GAG ratio significantly changed for the premix group, resulting from a slightly lower GAG content, demonstrating that the cells are modifying the underlying matrix. Real-time quantitativepolymerase chain reaction data indicated that MSCs showed a trend of differentiation towards a more tenogenic-like phenotype after 7 ***:

关键词： Anterior cruciate ligament rupture Anteriorcruciate ligament tenocyte Dynamic intraligamentarystabilization system Resazurin red assay Mesenchymalstem cells Real-time polymerase chain reaction Histology Scanning electron microscopy microscopy Scanning electron microscopy

Decellularized extracellular matrix particle-based biomaterials for cartilage repair applications

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Journal of Materials Science & Technology 2023年第29期160卷 194-203页

作者： Peng Guo Nan Jiang Carina Mini Gregor Miklosic Songsong Zhu Andrea J.Vernengo Matteo D’Este Sibylle Grad Mauro Alini Zhen Li AO Research institute Davos Davos 7270Switzerland Department of Spine Surgery The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhou 510655China State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Disease and West China hospital of Stomatology Sichuan UniversityChengdu 610041China institute for biomechanics ETH ZürichZürich 8093Switzerland

Cartilage Decellularized ExtraCellular Matrix(dECM)materials have shown promising cartilage regenera-tion capacity due to their chondrogenic ***,the limited retention of ECM components and the reduced integrity of functional ECM molecules during traditional decellularization processes im-pair the biomimicry of these *** current study aims to fabricate biomimetic materials con-taining decellularized cartilage particles that have an intact molecular structure and native composition as biomaterial inks and hydrogels for cartilage *** this,we established a novel two-fraction de-cellularization strategy for the preparation of reconstituted dECM(rdECM)particles by mixing the two-fraction components,as well as a one-fraction decellularization strategy for the preparation of biomimetic dECM(bdECM)*** acid-tyramine(THA)hydrogels containing rdECM or bdECM particles were produced and characterized via rheological test,swelling and stability evaluation,and compression *** results showed that our novel decellularization strategies preserved intact proteoglycans and collagen at a higher retention rate with adequate DNA removal compared to traditional methods of *** addition of rdECM or bdECM particles significantly increased the shear moduli of the THA bioinks while preserving their shear-thinning *** particle-embedded THA hydrogels also achieved long-term stability with a swelling ratio of 70%and high retention of glycosaminoglycans and collagen after long-term incubation,while rdECM particle-embedded THA hydrogels showed unsat-isfactory stability as self-standing *** to pure THA hydrogels,the addition of bdECM particles significantly enhanced the compression *** summary,our decellularization methods are successful in the retention of functional and intact cartilage components with high *** rdECM and bdECM particles can be supplemented in THA bioinks for biomimet

关键词： Cartilage tissue engineering Decellularized extracellular matrix Proteoglycan integrity Biomimetic hydrogels Biomaterial Bioink

Effect of long-term cyclic compression loading on the structural evolution of trabecular bone

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Medicine in Novel Technology and Devices 2021年第4期12卷 69-76页

作者： Yan Gao Feixiang Lu Shouhui Wang Lianwen Sun Huijie Leng Bo Huo biomechanics Lab Department of MechanicsSchool of Aerospace EngineeringBeijing Institute of TechnologyChina Key Laboratory for biomechanics and Mechanobiology of Ministry of Education School of Biological Science and Medical EngineeringBeihang UniversityChina Department of Orthopaedics Peking University Third HospitalChina

Dynamic remodeling of bone tissue is mediated by the synergistic effects of osteoblast-driven bone formation and Osteoclast-dominated bone ***,how bone cells perceive the mechanical stimuli and regulate bone remodeling have not been fully *** study aims to evaluate the effect of cyclic compression loading on trabecular microstructure for 42 days and identify the relationship between the evolution of trabecular microstructure and cell *** eighth caudal vertebrae of rats were subjected to long-term cyclic compression loading with different *** compression displacement is 1 *** vivo micro-computed tomography was performed at 0,14,28 and 42 days to determine the structural *** bone volume fraction(BV/TV)in the 1 Hz cyclic compression loading group was significantly higher than that in the control and 10 Hz groups,whereas the trabecular separation(***)was significantly *** 10 Hz cyclic compression group had the lowest BV/TV and highest *** 14 days of loading,the BV/TV values of 1 Hz group were 29.62%and 41.6%higher than those of the control and 10 Hz groups,***,the *** of 1 Hz group was approximately 12.33%and 16.52%lower than that of the control and 10 Hz group,*** bone formation and less bone resorption were observed in the 1 Hz group than the control *** addition,more osteoblasts were attached to the area of bone formation,while more osteoclasts were located in the area of bone *** findings may provide a basis for further understanding mechanical stimulation-regulated bone remodeling.

关键词： Bone remodeling Osteoclast Osteoblast Cyclic compression loading Micro-computed tomography

Anti-cancer Effect of 20(S)-Ginsenoside-Rh2 on Oral Squamous Cell Carcinoma Cells via the Decrease in ROS and Downregulation of MMP-2 and VEGF

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Biomedical and Environmental Sciences 2020年第9期33卷 713-717页

作者： ZHANG Bao Ping LI Bo CHENG Jing Yang CAO Rui GAO Shu Ting HUANG Chun Juan LI Rui Ping NING Jing LIU Bin LI Zhi Ge School of Stomatology Lanzhou UniversityLanzhou 730000GansuChina institute of biomechanics and Medical Engineering Lanzhou UniversityLanzhou 730000GansuChina Department of Stomatology Gansu Provincial HospitalLanzhou 730000GansuChina

Squamous cell carcinoma(SCC) is the most common in oral and maxillofacial regions and occupy more than 90% of the malignant lesions in the oral cavity[1]. The complex anatomy of the head and neck region gives rise to ... 详细信息

关键词： Carcinoma anatomy invasion

Three-dimensional surface model analysis in the gastrointestinal tract

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World Journal of Gastroenterology 2006年第18期12卷 2870-2875页

作者： Donghua Liao Jens B Frφk r Jian Yang Jingbo Zhao Asbjφrn M Drewes Odd H Gilja Hans Gregersen Center of Excellence in Visceral biomechanics and Pain Aalborg Hospital and Institute of Health Technology Aalborg University Denmark National Center of Ultrasound in Gastroenterology Bergen University and Haukeland Hospital Bergen Norway

The biomechanical changes during functional loading and unloading of the human gastrointestinal （GI） tract are not fully understood. GI function is usually studled by introducing probes in the GI lumen. Computer modeling offers a promising alternative approach in this regard, with the additional ability to predict regional stresses and strains in inaccessible locations. The tension and stress distributions in the GI tract are related to distensibility （tension-strain relationship） and smooth muscle tone. lore knowledge on the tension and stress on the GI tract are needed to improve diagnosis of patients with gastrointestinal disorders. A modeling framework that can be used to integrate the physiological, anatomical and medical knowledge of the GI system has recently been developed. The 3-D anatomical model was constructed from digital images using ultrasonography, computer tomography （CT） or magnetic resonance imaging （IRI）. Different mathematical algorithms were developed for surface analysis based on thin-walled structure and the finite element method was applied for the mucosa-folded three layered esophageal model analysis. The tools may be useful for studying the geometry and biomechanical properties of these organs in health and disease. These studies will serve to test the structurefunction hypothesis of geometrically complex organs.

关键词： GI tract Surface Tension Stress Three-dimensional