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Targeting Epac2 and GluA3-containing AMPARs:a novel therapeutic strategy for Alzheimer's disease

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Neural Regeneration Research 2025年第11期20卷 3223-3224页

作者： Tong Zhang Martina Schmidt Department of Molecular Pharmacology Groningen Research Institute of PharmacyUniversity of GroningenGroningenThe Netherlands School of pharmacy Tianjin Medical UniversityTianjinChina

Alzheimer's disease(AD)is a neurodegenerative disease that manifests progressive decline in memory and *** the early stage of AD,memory retrieval is impaired preceding memory acquisition and consolidation(Roy et al.,2016).Prior to the onset of symptoms,pathological amyloid-β(Aβ)plagues and tau protein tangles accumulate in extracellular and intracellular spaces,respectively,leading to *** these hallmark pathologies,Aβ is proposed to be the primary etiology by triggering a cascade of pathogenic events,including neuroinflammation,oxidative stress,tau hyperphosphorylation,synaptic/neuronal dysfunction,and neuronal death(Zhang et al.,2023b).

关键词： Alzheimer impaired Aβ

Advances in phytochemistry, ananlysis methods and pharmacology of Eleutherococcus trifoliatus:A promising medicinal and edible resource with development value

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Chinese Herbal Medicines 2025年第1期17卷 19-30页

作者： Maofang Lu Bin Wang Ling Dai Jian Wu Jiao Luo Changsoo Yook Xiangqian Liu School of pharmacy Hunan University of Chinese Medicine School of pharmacy Hunan Vocational College of Science and Technology Instrumental Analysis Center Shanghai Institute of Organic Chemistry Chinese Academy of Sciences School of pharmacy Kyung Hee University

Eleutherococcus trifoliatus(Araliaceae) is called Baile or Lecai in *** is a medicinal and edible plant widely used in folk *** a TCM,the dried herb of this species can remove damp heat and detoxicity,cure rheumatism,remove blood stasis,relieve pain,and alleviate cough and asthma *** chemical compounds have been reported including diterpenoids,triterpenoids,phenylpropanoids,flavonoids,lignans,caffeoyl quinic acids,steroids,essential oils,etc.,in which flavonoids,saponins,and caffeoyl quinic acids are the most bioactive *** vitro and in vivo pharmacological experiments demonstrated that *** has anti-inflammatory,hypoglycemic,anticancer,antioxidant,antibacterial,anti-hyperalgesic,anti-fatigue,analgesic,and hemostatic *** we reviewed *** in phytochemistry,analysis methods,and pharmacology.

关键词： Acanthopanax Miq. analysis methods anti-inflammatory Eleutherococcus trifoliatus (L.) S. Y. Hu pharmacology phytochemistry toxicity

General synthesis of a dual-atomic-site catalyst library

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Science China Materials 2025年第2期68卷 679-680页

作者： Jingfang Zhang Yi Huang School of Chemical Engineering&pharmacy Wuhan Institute of TechnologyWuhan 430205China College of Chemistry Central China Normal UniversityWuhan 430079China

Single-atom catalysts(SACs),as a bridge between homogeneous and heterogeneous catalysts,have attracted tremendous attention over the past *** atomically dispersed metal active sites,SACs possess maximum atom utilization efficiency and exceptionally high activity towards various catalytic reactions[1].Compared with their nanoparticle counterparts,the unique but uniform configurations of the catalytic sites endow SACs with great potential for mechanism investigation at the atomic level[2,3].Despite of these advantages,SACs are facing the problem of linear scaling relations between intermediates in terms of complicated reactions involving co-adsorption of *** is difficult for a single-atom site to participate in all catalytic steps with high efficiencies,especially for some reactions that need adjacent active sites[4].In this regard,dualatomic-site catalysts(DACs)are emerging as a fascinating frontier in heterogeneous catalysis[5].It has been verified that the synergistic effect of the adjacent atomic pairs in DACs can break the linear scaling relations and optimize the adsorption energy of different intermediates,thus improving the intrinsic catalytic ***,it is of great significance to develop a general synthetic strategy for DACs.

关键词： atomic adsorption synthesis

Context-dependent role of sirtuin 2 in inflammation

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Neural Regeneration Research 2025年第3期20卷 682-694页

作者： NoemíSola-Sevilla Maider Garmendia-Berges MCarmen Mera-Delgado Elena Puerta Department of Pharmaceutical Sciences Division of PharmacologySchool of Pharmacy and NutritionUniversity of NavarraPamplonaSpain Navarra institute for Health Research(IdiSNA) PamplonaSpain

Sirtuin 2 is a member of the sirtuin family nicotinamide adenine dinucleotide(NAD~+)-dependent deacetylases, known for its regulatory role in different processes, including inflammation. In this context, sirtuin 2 has been involved in the modulation of key inflammatory signaling pathways and transcription factors by deacetylating specific targets, such as nuclear factor κB and nucleotide-binding oligomerization domain-leucine-rich-repeat and pyrin domain-containing protein 3(NLRP3). However, whether sirtuin 2-mediated pathways induce a pro-or an anti-inflammatory response remains controversial. Sirtuin 2 has been implicated in promoting inflammation in conditions such as asthma and neurodegenerative diseases, suggesting that its inhibition in these conditions could be a potential therapeutic strategy. Conversely, arthritis and type 2 diabetes mellitus studies suggest that sirtuin 2 is essential at the peripheral level and, thus, its inhibition in these pathologies would not be recommended. Overall, the precise role of sirtuin 2 in inflammation appears to be context-dependent, and further investigation is needed to determine the specific molecular mechanisms and downstream targets through which sirtuin 2 influences inflammatory processes in various tissues and pathological conditions. The present review explores the involvement of sirtuin 2 in the inflammation associated with different pathologies to elucidate whether its pharmacological modulation could serve as an effective strategy for treating this prevalent symptom across various diseases.

关键词： interferon inflammation lipopolysaccharide neuroinflammation NLRP3 nuclear factorκB sirtuin 2

A new green approach to synthesizing MIP-202@porous silica microspheres for positional isomer/enantiomer/hydrophilic separation

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Chinese Chemical Letters 2025年第1期36卷 501-505页

作者： Zhefei Hu Jingwen Liao Jiawen Zhou Lulu Zhao Yanjuan Liu Yuefei Zhang Wei Chen Sheng Tang School of Chemistry and Environmental Engineering Hubei Key Laboratory of Novel Reactor and Green Chemical TechnologyWuhan Institute of TechnologyWuhan 430205China School of pharmacy Linyi UniversityLinyi 276000China

Metal-organic frameworks(MOFs)with superior physicochemical properties have great potential for applications in chromatographic ***,currently popular methods for the synthesis of MOFbased silica composite materials usually require the use of harmful organic solvents and long-term hightemperature sealing *** order to respond to the needs of green chromatography,it is urgent to develop a new green organic-solvent-free strategy for the synthesis of MOF@SiO_(2)***-202 is a zirconium-MOF constructed from zirconium ion and l-aspartic acid,which features green synthesis as well as good hydrolytic stability and chemical *** this paper,SiO_(2)-NH_(2) was first prepared in a hydrophilic deep eutectic solvent,and then an amino acid-based MOF material(MIP-202)was modified on the surface of the SiO_(2)-NH_(2) in an aqueous solution to obtain a MIP-202@SiO_(2) composite *** multi-mode separation performance of MIP-202@SiO_(2) as a promising liquid chromatographic stationary phase was particularly evaluated and the separation mechanisms were *** MIP-202@SiO_(2) column exhibited excellent separation ability for aromatic positional *** addition,chiral enantiomers and hydrophilic analytes were also satisfactorily detected and *** work provides a new approach for the facile synthesis of MOF-based liquid chromatographic separation material by using green deep eutectic solvent and water as the reaction media.

关键词： Metal-organic framework Stationary phase Deep eutectic solvent Green chromatography High-performance liquid chromatography

A dual-protease-triggered chemiluminescent probe for precise tumor imaging

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Chinese Chemical Letters 2025年第2期36卷 302-306页

作者： Zhihui Zhang Ru Sun Chong Bian Hongbo Wang Zhen Zhao Panpan Lv Jianzhong Lu Haixin Zhang Hulie Zeng Yuanyuan Chen Zhijuan Cao Department of Pharmaceutical Analysis School of PharmacyFudan University Minhang Branch Zhongshan HospitalFudan University China State institute of Pharmaceutical Industry Shanghai Jahwa United Co. Ltd.

Imaging detection of interlinked dual proteases is imperative for precise tumor imaging, which remains challenging due to limited modification position of specific substrate and possible steric ***, we have developed a unimolecular chemiluminescent probe(LGP-CL) tandemly activated by two proteases interlinked with liver cancer to achieve precise tumor imaging. Probe LGP-CL consists of a phenoxy-dioxetane scaffold caged by a tripeptide substrate(LGP, leucine-glycine-proline) as the sensing layer, which can be cleaved sequentially by aminopeptidase N(APN) and dipeptidyl peptidase IV(DPPIV)to turn on a strong chemiluminescent signal, and silenced by specific inhibitor of each enzyme, which accounts for an integrated logic gate(AND, OR and INHIBIT). The successful cleavage of dual proteases on the metabolic site depends on the proper structure of the tripeptide substrate, as confirmed by two probes design. Probe LGP-CL(LGP as the substrate) enables the excellent “dual-lock-dual-key” fit with a382-fold enhancement of chemiluminescent emission while no obvious signal is observed by using GPLCL(GPL as the substrate). By virtue of its rapid response(several minutes), high sensitivity and good cell viability, probe LGP-CL has been utilized to evaluate upregulated levels of proteases in vitro and in living systems, especially to distinguish liver tumor cells(Hep G2) from others(LO2, MCF-7, MCF-10a and RAW264.7). Overall, the newly developed CL probe may facilitate rapid investigation into the role played by proteases in liver diseases, enabling timely selection appropriate treatment. Therefore, our work not only sheds light on the rational design of optical probes for dual protease imaging, but provides a promising tool for clinical diagnosis and even drug discovery.

关键词： Chemiluminescent Dual-protease imaging Logic gates Phenoxy-dioxetane scaffold Tripeptide substrate

Patient and physician factors contributing to delays in inflammatory bowel diseases:Enhancing timely diagnosis

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World Journal of Gastroenterology 2025年第6期31卷 115-120页

作者： Horia Minea Ana-Maria Singeap Laura Huiban Cristina Maria Muzica Carol Stanciu Anca Trifan Department of Gastroenterology Faculty of Medicine“Grigore T.Popa”University of Medicine and PharmacyIasi 700115Romania institute of Gastroenterology and Hepatology “St.Spiridon”University HospitalIasi 700111Romania

In this article,we comment on the article by Blüthner et *** article provides a comprehensive analysis of the factors contributing to the late detection of Crohn’s disease and ulcerative colitis within a German *** highlights the conse-quences on patient outcomes,particularly disease progression and the increased risk of developing *** study identifies specific predictors asso-ciated with both patient-related and physician-related delays,offering a detailed exploration of the initial ***,the article delves into the distinct patterns observed in the German population,stressing the unique aspects of diagnostic delays that may differ from those reported in other *** detailed examination offers valuable insights into the specific challenges faced within the German healthcare system and underscores the necessity of targeted interventions to facilitate early *** importance of improved screening tools,patient education,and better healthcare infrastructure is emphasized as crucial steps toward improving patient care in inflammatory bowel disease.

关键词： Inflammatory bowel disease Diagnostic delay Disease awareness Healthcare system Screening tools

A supramolecular nanoprodrug for prevention of gallstone formation

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Chinese Chemical Letters 2025年第2期36卷 354-359页

作者： Xiangjun Zhang Xiaodi Yang Yan Wang Zhongping Xu Sisi Yi Tao Guo Yue Liao Xiyu Tang Jianxiang Zhang Ruibing Wang College of pharmacy Chongqing Medical University Chongqing University Fuling Hospital Department of Pharmaceutics College of PharmacyThird Military Medical University (Army Medical University) Yu-Yue Pathology Scientific Research Center State Key Laboratory of Trauma and Chemical Poisoning Third Military Medical University (Army Medical University) State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of Macau

Cholelithiasis affects approximately 10%-20% of the adult population globally. And cholesterol accumulation and nucleation of cholesterol crystals are commonly recognized as the primary process in the initiation and progression of gallstones. Hydroxypropyl-β-cyclodextrin(HPCD) is a supramolecular host compound that can solubilize cholesterol, potentially serving as a preventative or therapeutic agent for cholelithiasis. However, we found that the administration of HPCD treatment did not impede the formation of gallstones in mice, mainly attributed to the pre-complexation of its cavity during the transition process. Here we synthesized a prodrug of HPCD and prepared a HPCD nanoparticle(HPCD-NP), which can be transported efficiently to the gallbladder through the hepatobiliary system following an intravenous injection. In the bile, the HPCD-NP degraded into free HPCD, bound to cholesterol crystals and gallstones within the gallbladder and effectively increased cholesterol solubilization, leading to gallstones regression. Given the established safety of both HPCD and cyclodextrin-based nanoparticles in numerous animal and human studies, HPCD-NP shows considerable promise for the prevention and treatment of human cholelithiasis.

关键词： Gallstone Hepatobiliary transport Host-guest interaction Hydroxypropyl-β-cyclodextrin Solubilization

Development of a net ozone production rate detection system based on dual-channel cavity ring-down spectroscopy

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Journal of Environmental Sciences 2025年第3期149卷 419-430页

作者： Jinzhao Tong Renzhi Hu Changjin Hu Xiaoyan Liu Haotian Cai Chuan Lin Liujun Zhong JiaweiWang Pinhua Xie School of Environmental Science and Optoelectronic Technology University of Science and Technology of ChinaHefei 230026China Anhui institute of Optics and Fine Mechanics Hefei Institutes of Physical ScienceChinese Academy of SciencesHefei 230031China School of pharmacy Anhui Medical UniversityHefei 230032China

A novel system for measuring net photochemical ozone production rates in the atmosphere based on cavity ring-down spectroscopy(OPR-CRDS)was *** system consists of two chambers(a reaction chamber and a reference chamber)and a dual-channel O_(x)-CRDS *** minimize the wall loss of O_(x)in the chambers,the inner surfaces of both chambers are coated with Teflon *** performance of the OPR-CRDS system was *** was found that even though the photolysis frequency(J value)decreased by 10%,the decrease in the P(O_(3))caused by the ultraviolet-blocking film coating was less than 3%.The two chambers had a good consistency in the mean residence time and the measurement of NO_(2)and O_(x)under the condition of no *** detection limit of the OPR-CRDS was determined to be 0.20 ppbv/*** further verify the accuracy of the system,the direct measurement values of the OPR-CRDS systemwere comparedwith the calculation results based on radical(OH,HO_(2),and RO_(2))reactions,and a good correlation was obtained between the measured and calculated ***,the developed instrument was applied to obtain the comprehensive field observations at an urban site in the Yangtze River Delta(China)for 40 days,the time series and change characteristics of the P(O_(3))were obtained directly,and the good environmental adaptability and stability of the OPR-CRDS system were *** is expected that the new instrument will be beneficial to investigations of the relationship between P(O_(3))and its precursors.

关键词： Ozone Net photochemical production rate CRDS Atmospheric chemistry