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Effects of Lactobacillus paracasei N1115 on gut microbial imbalance and liver function in patients with hepatitis B-related cirrhosis

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World Journal of Gastroenterology 2024年第11期30卷 1556-1571页

作者： Yan-Chao Hu Xiang-Chun Ding hui-Juan Liu Wan-Long Ma Xue-Yan Feng Li-Na Ma Department of Infectious disease General Hospital of Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina Infectious disease Clinical Research center of ningxia Yinchuan 750004Ningxia Hui Autonomous RegionChina

BACKGROUND Hepatitis B cirrhosis(HBC)is a chronic disease characterized by irreversible diffuse liver damage and aggravated by intestinal microbial imbalance and metabolic *** the relationship between certain single probiotics and HBC has been explored,the impact of the complex ready-to-eat Lactobacillus paracasei N1115(LP N1115)supplement on patients with HBC has not been *** To compare the changes in the microbiota,inflammatory factor levels,and liver function before and after probiotic treatment in HBC *** This study included 160 HBC patients diagnosed at the General Hospital of ningxia Medical University between October 2018 and December *** were randomly divided into an intervention group that received LP N1115 supplementation and routine treatment and a control group that received routine treatment *** samples were collected at the onset and conclusion of the 12-wk intervention *** structure of the intestinal microbiota and the levels of serological indicators,such as liver function and inflammatory factors,were *** Following LP N1115 intervention,the intestinal microbial diversity significantly increased in the intervention group(P<0.05),and the structure of the intestinal microbiota was characterized by an increase in the proportions of probiotic microbes and a reduction in harmful ***,the intervention group demonstrated notable improvements in liver function indices and significantly lower levels of inflammatory factors(P<0.05).CONCLUSION LP N1115 is a promising treatment for ameliorating intestinal microbial imbalance in HBC patients by modulating the structure of the intestinal microbiota,improving liver function,and reducing inflammatory factor levels.

关键词： Hepatitis B cirrhosis N1115 ready-to-eat lactobacillus Inflammation Liver function Lachnospiraceae incertae sedis Probiotic

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Analysis of Epidemiological and Issues Encountered in Case Reports on Echinococcosis—China,2022

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China CDC weekly 2024年第6期6卷 100-104页

作者： Yan Kui Shuai Han Xiaojuan Zhang Guangzhong Shi Yale Yu Ruirui Li Peizheng Zhan Hongju Duan Wenbo Luo Benfu Li Shaoqi Ning Yalan Zhang Aiya Zhu Jingbo Xue National Institute of Parasitic diseases Chinese Center for Disease Control and Prevention(Chinese Center for Tropical Diseases Research)National Health Commission Key Laboratory of Parasite and Vector BiologyWorld Health Organization Collaborating Center for Tropical DiseasesNational Center for International Research on Tropical DiseasesShanghaiChina Gansu Provincial center for disease control and prevention Lanzhou CityGansu ProvinceChina The center for disease control and prevention of Xinjiang Uygur autonomous region Urumuqi CityXinjiang Uygur Autonomous RegionChina Xinjiang Production and Construction Corps center for disease control and prevention Urumuqi CityXinjiang Uygur Autonomous RegionChina Sichuan Provincial center for disease control and prevention Chengdu CitySichuan ProvinceChina Qinhai Institute for Endemic disease control and prevention Xining CityQinghai ProvinceChina ningxia center for disease control and prevention Yinchuan CityNingxia Hui Autonomous RegionChina Inner Mongolia autonomous region center for Comprehensive disease control and prevention Hohhot CityInner Mongolia AutonomousChina Yunnan Institute of Parasitic diseases Puer CityYunnan ProvinceChina Shaanxi Provincial center for disease control and prevention Xi'an CityShaanxi ProvinceChina Henan Provincial center for disease control and prevention Zhengzhou CityHenan ProvinceChina Guizhou Provincial center for disease control and prevention Guiyang CityGuizhou ProvinceChina

Summary What is already known about this topic?Echinococcosis is classified as a Class C infectious disease in *** is endemic in 370 counties located in the agricultural and pastoral regions of western *** is added by this report?This report provides a comprehensive overview of the cases of echinococcosis reported in China in *** a thorough evaluation conducted by provincial CDCs.

关键词： China Ech counties

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Mechanism of pachymic acid in the treatment of gastric cancer based on network pharmacology and experimental verification

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World Journal of Gastrointestinal Oncology 2024年第1期16卷 30-50页

作者： Yu-Hua Du Jian-Jun Zhao Xia Li Shi-Cong Huang Na Ning Guo-Qing Chen Yi Yang Yi Nan Ling Yuan College of Pharmacy Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina ningxia Chinese Medicine Research center Manufacturing LaboratoryYinchuan 750004Ningxia Hui Autonomous RegionChina College of Foundation Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina Key Laboratory of ningxia Minority Medicine Modernization Ministry of Education Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina

BACKGROUND Pachymic acid(PA)is derived from Poria *** has a variety of pharmacological and inhibitory effects on various ***,the mechanism of action of PA in gastric cancer(GC)remains *** To investigate the mechanism of PA in treating GC via the combination of network pharmacology and experimental *** The GeneCards and OMIM databases were used to derive the GC targets,while the Pharm Mapper database provided the PA *** the STRING database,a protein-protein interaction network was constructed and core targets were *** analyses of Gene Ontology,Kyoto Encyclopedia of Genes and Genomes(KEGG),and gene set enrichment analysis were conducted,and molecular docking and clinical correlation analyses were performed on the core ***,the network pharmacology findings were validated through in vitro cell assays,encompassing assessments of cell viability,apoptosis,cell cycle,cloning,and western blot *** According to network pharmacology analysis,the core targets were screened,and the PI3K/AKT signaling pathway is likely to be the mechanism by which PA effectively treats GC,according to KEGG enrichment *** experimental findings showed that PA could control PI3K/AKT signaling to prevent GC cell proliferation,induce apoptosis,and pause the cell *** Network pharmacology demonstrated that PA could treat GC by controlling a variety of signaling pathways and acting on a variety of *** has also been supported by in vitro cell studies,which serve as benchmarks for further research.

关键词： Pachymic acid Gastric cancer Network pharmacology Enrichment analysis Cell proliferation

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A Case of Brucellosis Concomitant with Severe Fever with Thrombocytopenia Syndrome—Weifang City,Shandong Province,China,2023

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China CDC weekly 2024年第27期6卷 677-680页

作者： Qingqing Xu Cuiping Wu hui Liu Chao Geng Jinhui Zhang Dongri Piao Hongyan Zhao Yu Fan Guozhong Tian Hai Jiang National Key Laboratory of Intelligent Tracing and Forecasting for Infectious diseases National Institute for Communicable Disease Control and PreventionChinese Center for Disease Control and PreventionBeijingChina Department of Infectious diseases Yidu Central Hospital of WeifangWeifang CityShandong ProvinceChina Institute of Bacterial disease Jinan Center for Disease Control and PreventionJinan CityShandong ProvinceChina Tongliao center for disease control and prevention Tongliao CityInner Mongolia Autonomous RegionChina

Summary What is already known about this topic?Brucellosis and severe fever with thrombocytopenia syndrome(SFTS)are neglected zoonoses,attributable respectively to Brucella and the SFTS virus(SFTSV).While the incidence of these diseases has been rising,instances of co-infection remain *** is added by this report?This represents the first documented case of a rare coinfection involving Brucella and SFTSV.

关键词： neglected instance Shandong

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Neglected Time Intervals Before “1-3-7” Approach About Imported Malaria Cases-China, 2014–2021

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China CDC weekly 2024年第17期6卷 363-367页

作者： Zhiquan He Yuanjing Kou Dan Wang Ying Liu Xiaofeng Lyu hui Yan Wen Lin Xuan Zhang Duoquan Wang Shizhu Li Hongwei Zhang Henan Provincial center for disease control and prevention Zhengzhou CityHenan ProvinceChina Anhui Provincial center for disease control and prevention Hefei CityAnhui ProvinceChina Guangxi Zhuang autonomous region center for disease control and prevention Nanning CityGuangxi Zhuang Autonomous RegionChina Hubei Provincial center for disease control and prevention Wuhan CityHubei ProvinceChina Zhejiang Provincial center for disease control and prevention Hangzhou CityZhejiang ProvinceChina National Institute of Parasitic diseases Chinese Center for Disease Control and Prevention(Chinese Center for Tropical Diseases Research)National Health Commission Key Laboratory of Parasite and Vector BiologyShanghaiChina School of Global Health Chinese Center for Tropical Diseases ResearchShanghai Jiao Tong University School of MedicineShanghaiChina

What is already known about this topic?China’s“1-3-7”approach outlines specific targets to guide and monitor the processes of case reporting,investigation,and ***,few studies have examined the time intervals preceding the initial step,and the timeline from the arrival of imported malaria cases in China to their diagnosis has been largely *** is added by this report?The study demonstrated that the median duration from arrival in China to the onset of symptoms for *** was 78 days,with 71.59%of imported cases manifesting symptoms after more than one *** ***,the median interval was 42 days,with 55.91%exceeding one ***,the median time from symptom onset to malaria treatment in China between 2014 and 2021 was 2 days,with an interquartile range(IQR)of 1-4 *** are the implications for public health practice?This study represents the initial effort to delineate the chronology of imported malaria cases,from their arrival in China to their subsequent *** results underscore the importance of providing malaria health education to populations arriving from ***,enhancing physician training is crucial for improving the diagnosis of malaria.

关键词： diagnosis Malaria exceeding

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Epidemiological Characteristics of Human Parainfluenza Viruses Infections-China,2019-2023

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China CDC weekly 2024年第12期6卷 235-241,I0003,I0004页

作者： Yixuan Gao Yingwei Ma Daxing Feng Feng Zhang Biao Wang Xiaoqing Liu Bing Zhu hui Xie Linqing Zhao Xiaoru Long Ying Chen Bing Wang Jie Jiang Zhen Zhu Yan Zhang Aili Cui Baicheng Xia Naiying Mao National Key Laboratory of Intelligent Tracking and Forecasting for Infectious diseases National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijingChina Precision Medicine Research center Children’s Hospital of ChangchunChangchun CityJilin ProvinceChina Henan Provincial center for disease control and prevention Zhengzhou CityHenan ProvinceChina Laboratory of Viral diseases Qingdao Municipal Centre for Disease Control and PreventionQingdao CityShandong ProvinceChina Virus Laboratory Gansu Provincial Center for Disease Control and PreventionLanzhou CityGansu ProvinceChina Jiangxi Provincial center for disease control and prevention Nanchang CityGansu ProvinceChina Virus Laboratory Guangzhou Women and Children’s Medical CenterGuangzhou Medical UniversityGuangzhou CityGuangdong ProvinceChina Institute for Immunization and prevention Beijing Center for Disease Prevention and ControlAcademy for Preventive MedicineInstitute of Tuberculosis Control Research and PreventionBeijingChina Laboratory of Virology Beijing Key Laboratory of Etiology of Viral Diseases in ChildrenCapital Institute of PediatricsBeijingChina Department of Infection Children’s Hospital of Chongqing Medical UniversityChongqingChina Inner Mongolia autonomous region Comprehensive center for disease control and prevention Hohhot CityInner Mongolia Autonomous RegionChina Shenyang Prefecture center for disease control and prevention Shenyang CityLiaoning ProvinceChina

Introduction:A retrospective study based on sentinel surveillance was conducted in 10 provinciallevel administrative divisions(PLADs)in China to enhance the understanding of the epidemiological characteristics of human parainfluenza viruses(HPIVs).Methods:From January 2019 to June 2023,respiratory specimens were collected from individuals with acute respiratory infections(ARIs)and screened for four HPIVs serotypes and other common respiratory viruses using multiplex real-time polymerase chain reaction(PCR).This study analyzed the association of HPIVs infections with seasonal patterns,geographical distribution,demographic profiles,clinical features,and co-infection ***:During the study period,a total of 12,866 ARIs were *** overall detection rate of HPIVs was 6.15%,varying from 5.04%in 2022 to 9.70%in *** median age of HPIVs-infected patients was 3 ***2 was more prevalent among individuals aged 5–17 years(42.57%),while HPIV4 was more common in those over 65 years(12.24%).HPIV3(54.16%)and HPIV1(27.18%)were the predominant serotypes,and their prevalence exhibited significant seasonal fluctuations postcoronavirus disease 2019(COVID-19)*** peak of HPIV3 shifted three months later in 2020 compared to 2019 and returned to a summer peak *** peaks of HPIV1 were observed in 2021 following the peak of ***,coinfections were frequent in HPIVs cases(overall rate:22.12%),with human rhinovirus being the most common co-infecting ***:The prevalence of HPIVs in China was predominantly due to HPIV3 and HPIV1,and their seasonal patterns were altered by pandemic ***,continuous surveillance of HPIVs is essential.

关键词： prevalence seasonal Human

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Incidence and warning signs for complications of human brucellosis: a multi-center observational study from China

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Infectious diseases of Poverty 2024年第1期13卷 53-62页

作者： Qing-Nan Shi hui-Jie Qin Qiao-Shan Lu hu Li Zhong-Fa Tao Meng-Guang Fan Mu-Heta Aishan Zeng-Qiang Kou Qiu-Lan Chen Wen-Wu Yin Yan-Ping Zhang National Key Laboratory of Intelligent Tracking and Forecasting for Infectious diseases Chinese Center for Disease Control and PreventionChangbai RoadChangping DistrictBejing 102206China School of Public Health Guangxi Medical UniversityNanningChina Nanning center for disease control and prevention NanningChina Guizhou center for disease control and prevention GuiyangChina Inner Mongolia center for disease control and prevention HohhotChina Xinjiang Uighur autonomous region center for disease control and prevention UrumqiChina Shandong center for disease control and prevention JinanChina

Background Brucellosis is a severe zoonotic disease that is often overlooked, particularly in impoverished countries. Timely identification of focal complications in brucellosis is crucial for improving treatment outcomes. However, there is currently a lack of established indicators or biomarkers for diagnosing these complications. Therefore, this study aimed to investigate potential warning signs of focal complications in human brucellosis, with the goal of providing practical parameters for clinicians to aid in the diagnosis and management of *** A multi-center cross-sectional study was conducted in China from December 2019 to August 2021. The study aimed to investigate the clinical characteristics and complications of patients with brucellosis using a questionnaire survey and medical record system. The presence of warning signs for complications was assessed using univariate and multivariate logistic regression models. Receiver operating characteristic (ROC) curves and the area under the curve (AUC) were used for variable screening and model *** A total of 880 participants diagnosed with human brucellosis were enrolled. The median age of the patients was 50 years [interquartile range (IQR): 41.5-58.0], and 54.8% had complications. The most common organ system affected by complications was the osteoarticular system (43.1%), with peripheral arthritis (30.0%), spondylitis (16.6%), paravertebral abscess (5.0%), and sacroiliitis (2.7%) being the most prevalent. Complications in other organ systems included the genitourinary system (4.7%), respiratory system (4.7%), and hematologic system (4.6%). Several factors were found to be associated with focal brucellosis. These factors included a long delay in diagnosis [odds ratio (OR) = 3.963, 95% confidence interval(CI): 1.906-8.238 for > 90 days], the presence of underlying disease (OR = 1.675, 95%CI: 1.176-2.384), arthralgia (OR = 3.197, 95%CI: 1.986-5.148), eye bulging pain (OR = 3.482, 95%CI:

关键词： Brucellosis Complications Clinical spectrum Warning signs

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Programmable double-unlock nanocomplex self-supplies phenylalanine ammonia-lyase for precise phenylalanine deprivation of tumors

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Chinese Chemical Letters 2024年第8期35卷 455-459页

作者： Chunqing Ou Meijia Xiao Xinyue Zheng Xianzhou Huang Suleixin Yang Yingying Leng Xiaowei Liu Xiuqi Liang Linjiang Song Yanjie You Shaohua Yao Changyang Gong Department of Biotherapy Cancer Center and State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610041China State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoAvenida da UniversidadeTaipaMacao 999087China School of Medical and Life Sciences Chengdu University of Traditional Chinese MedicineChengdu 611137China Department of Gastroenterology People’s Hospital of Ningxia Hui Autonomous RegionYinchuan 750002China

Essential amino acids(EAAs)deprivation is a potential antitumor approach because EAAs are critical for tumor *** efficiently inhibit tumor growth,continuous deprivation of EAAs is required,how-ever,continuous deprivation without precise control will introduce toxicity to normal ***,a programmable double-unlock nanocomplex(ROCK)was prepared,which could self-supply phenylalanine ammonia-lyase(PAL)to tumor cells for phenylalanine(Phe)*** was double-locked in physiological conditions when administered *** ROCK actively targeted to tumor cells by integrinαvβ3/5 and CD44,ROCK was firstly unlocked by cleavage of protease on tumor cell membrane,exposing CendR and R8 to enhance ***,hyaluronic acid was digested by hyaluronidase overexpressed in endo/lysosome of tumor cells,in which ROCK was secondly unlocked,resulting in pro-moting endo/lysosome escape and PAL plasmid(pPAL)*** pPAL could sustainably express PAL in host tumor cells until the self-supplied PAL precisely and successfully deprived Phe,thereby block-ing the protein synthesis and killing tumor cells ***,our precise Phe deprivation strategy effectively inhibited tumor growth with no observable toxicity to normal cells,providing new insights to efficiently remove intratumoral nutrition for cancer therapy.

关键词： Programmable double-unlock Essential amino acids deprivation Phenylalanine ammonia-lyase Self-supply Gene therapy

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Systemic inflammatory response index is a predictor of prognosis in gastric cancer patients: Retrospective cohort and meta-analysis

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World Journal of Gastrointestinal Surgery 2024年第2期16卷 382-395页

作者： Jing-Yao Ren Meng Xu Xiang-Dong Niu Shi-Xun Ma Ya-Jun Jiao Da Wang Miao Yu hui Cai School of Clinical Medicine Ningxia Medical UniversityYinchuan 750000Ningxia Hui autonomous regionChina Gansu Provincial Hospital Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina General Surgery Clinical Medical center Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina Medical College of Jiangsu University Jiangsu UniversityZhenjiang 212013Jiangsu ProvinceChina Key Laboratory of Molecular Diagnostics and Precision Medicine for Surgical Oncology in Gansu Province Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina

BACKGROUND The systemic inflammatory response index(SIRI)has been demonstrated to make a significant difference in assessing the prognosis of patients with different solid ***,research is needed to ascertain the accuracy and reliability of applying the SIRI to patients who undergo robotic radical gastric cancer *** To validate the applicability of the SIRI in assessing the survival of gastric cancer patients and evaluate the clinical contribution of preoperative SIRI levels to predicting long-term tumor outcomes in patients,who received robotic radical gastric cancer *** Initially,an exhaustive retrieval was performed in the PubMed,the Cochrane Library,EMBASE,Web of Science,and Scopus databases to identify relevant ***,a meta-analysis was executed on 6 cohort studies iden-tifying the value of the SIRI in assessing the survival of gastric cancer ***,the clinical data of 161 patients undergoing robotic radical gastric cancer surgery were retrospectively analyzed to evaluate their clinicopathological characteristics and relevant laboratory *** association between preoperative SIRI levels and 5-year overall survival(OS)and disease-free survival(DFS)was *** The findings demonstrated an extensive connection between SIRI values and the outcome of patients with gastric *** SIRI levels were identified as an independent hazard feature for both OS and DFS among those who received robotic surgery for gastric *** levels in gastric cancer patients were observed to be associated with the presence of comorbidities,T-stage,carcinoembryonic antigen levels,the development of early serious postoperative complications,and the rate of lymph node *** SIRI values are correlated with adverse in the gastric cancer population and have the potential to be utilized in predicting long-term oncological survival in patients who undergo robotic radical gastric canc

关键词： Systemic inflammatory response index Prognosis Gastric cancer Complications Meta-analysis

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Chlorine-Substituent Regulation in Dopant-Free Small-Molecule Hole-Transport Materials Improves the Effi ciency and Stability of Inverted Perovskite Solar Cells

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Transactions of Tianjin University 2024年第4期30卷 314-323页

作者： Xinyi Liu Xiaoye Zhang Zhanfeng Li Jinbo Chen Yanting Tian Baoyou Liu Changfeng Si Gang Yue Hua Dong Zhaoxin Wu Key Laboratory of Advanced Transducers and Intelligent control System Ministry of Education and Shanxi ProvinceTaiyuan University of TechnologyTaiyuan 030024China School of Electrical Engineering University of South ChinaHengyang 421001China College of Physics and Optoelectronics Taiyuan University of TechnologyTaiyuan 030024China ningxia hui autonomous region Screen Display Organic Materials Engineering Technology Research center Ningxia Sinostar Display Material Co.Ltd.Yinchuan 750003China Organic Semiconductor Centre EaStCHEM School of ChemistryUniversity of St AndrewsFife KY169STUK Key Laboratory of Photonics Technology for Information School of Electronic and Information Engineering Xi’an Jiaotong UniversityXi’an 710049China

Although doped hole-transport materials(HTMs)off er an effi ciency benefi t for perovskite solar cells(PSCs),they inevi-tably diminish the ***,we describe the use of various chlorinated small molecules,specifi cally fl uorenone-triphenylamine(FO-TPA)-x-Cl[x=para,meta,and ortho(p,m,and o)],with diff erent chlorine-substituent positions,as dopant-free HTMs for *** chlorinated molecules feature a symmetrical donor-acceptor-donor structure and ideal intramolecular charge transfer properties,allowing for self-doping and the establishment of built-in potentials for improving charge *** effi cient hole-transfer interfaces are constructed between perovskites and these HTMs by strategi-cally modifying the chlorine ***,the chlorinated HTM-derived inverted PSCs exhibited superior effi ciencies and air ***,the dopant-free HTM FO-TPA-o-Cl not only attains a power conversion effi ciency of 20.82% but also demonstrates exceptional stability,retaining 93.8%of its initial effi ciency even after a 30-day aging test conducted under ambient air conditions in PSCs without *** fi ndings underscore the critical role of chlorine-substituent regulation in HTMs in ensuring the formation and maintenance of effi cient and stable PSCs.

关键词： Hole-transport materials Inverted perovskite solar cells Chlorinated small molecules Donor–acceptor–donor structure

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