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Tumor microenvironment-activatable neuropeptide-drug conjugates enhanced tumor penetration and inhibition via multiple delivery pathways and calcium deposition

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Chinese Chemical Letters 2024年第4期35卷 292-297页

作者： Yi Cao Xiaojiao Ge Yuanyuan Wei Lulu He Aiguo Wu Juan Li ningbo Key Laboratory of Biomedical Imaging Probe materials and Technology Zhejiang International Cooperation Base of Biomedical Materials Technology and ApplicationChinese Academy of Sciences(CAS)Key Laboratory of Magnetic Materials and DevicesNingbo Cixi Institute of Biomedical EngineeringZhejiang Engineering Research Center for Biomedical MaterialsNingbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo 315201China University of Chinese Academy of Sciences Beijing 100049China Advanced Energy Science and Technology Guangdong Laboratory Huizhou 516000China

Peptide-drug conjugates have achieved considerable development and application as a novel strategy for targeted delivery of anticancer drugs. Bioactive peptides induced calcium deposition can irreversibly assist inhibition of tumors. However, active regulation of calcium level through signal transduction of bioactive substances has not been reported yet. In this study, novel neuropeptide-doxorubicin conjugates(NP-DOX) with lysosome-specific acid response were described for neuropeptide Y_1 receptor(Y_1R)-overexpressed triple-negative breast cancer. The delivery mechanism of NP-DOX was clarified that diverse pathways were involved, including intracellular and intercellular transport. Importantly, up-regulation of Y_1 R-mediated intracellular calcium level via second messenger inositol triphosphate was presented in NP-DOX treated MDA-MB-231 cells. In vivo antitumor efficacy demonstrated that NP-DOX showed less organ toxicity and enhanced tumor inhibition benefited from its controlled release and Y_1R-mediated calcium deposition, compared with free DOX. This bioconjugate is a proof-of-concept confirming that neuropeptide-mediated control of signaling responses in neuropeptide-drug conjugates enables great potential for further applications in tumor chemotherapy.

关键词： Neuropeptide-drug conjugate Tumor penetration Calcium deposition Tumor inhibition Triple-negative breast cancer

Insights on advanced substrates for controllable fabrication of photoanodes toward efficient and stable photoelectrochemical water splitting

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Carbon Energy 2024年第4期6卷 164-221页

作者： Huilin Hou Gang Shao Yang Wang Wai‐Yeung Wong Weiyou Yang institute of Micro/Nano materials and Devices Ningbo University of TechnologyNingboChina School of materials Science and Engineering Zhengzhou UniversityZhengzhouChina Department of Applied Biology and Chemical Technology and Research institute for Smart Energy The Hong Kong Polytechnic UniversityHong KongChina

Conversion of solar energy into H_(2) by photoelectrochemical(PEC)water splitting is recognized as an ideal way to address the growing energy crisis and environmental *** a typical PEC cell,the construction of photoanodes is crucial to guarantee the high efficiency and stability of PEC reactions,which fundamentally rely on rationally designed semiconductors(as the active materials)and substrates(as the current collectors).In this review work,we start with a brief introduction of the roles of substrates in the PEC ***,we provide a systematic overview of representative strategies for the controlled fabrication of photoanodes on rationally designed substrates,including conductive glass,metal,sapphire,silicon,silicon carbide,and flexible ***,some prospects concerning the challenges and research directions in this area are proposed.

关键词： hydrogen photoanode photoelectrochemical substrates water splitting

Experimental demonstration of a flexible-grid 1×(2×3)mode-and wavelength-selective switch using silicon microring resonators and counter-tapered couplers

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Chinese Optics Letters 2024年第1期22卷 52-58页

作者：孔德军鲁昊汪鹏君符强戴世勋陈伟伟王栎沣张波豪马凌霄李军戴庭舸杨建义 Faculty of Electrical Engineering and Computer Science Ningbo UniversityNingbo 315211China College of Electrical and Electronic Engineering Wenzhou UniversityWenzhou 325035China College of Science and Technology Ningbo UniversityNingbo 315300China Laboratory of Infrared materials and Devices The Research Institute of Advanced TechnologiesNingbo UniversityNingbo 315211China Department of Information Science and Electronics Engineering and Cyrus Tang Center for Sensor materials and Applications Zhejiang UniversityHangzhou 310027China

A flexible-grid 1×(2×3)mode-and wavelength-selective switch which comprises counter-tapered couplers and silicon microring resonators has been proposed,optimized,and demonstrated experimentally in this *** carefully thermally tuning phase shifters and silicon microring resonators,mode and wavelength signals can be independently and flexibly conveyed to any one of the output ports,and different bandwidths can be generated as *** particle swarm optimization algorithm and finite difference time-domain method are employed to optimize structural parameters of the twomode(de)multiplexer and crossing *** bandwidth-tunable wavelength-selective optical router composed of12 microring resonators is studied by taking advantage of the transfer matrix *** results show that,for the fabricated module,cross talk less than-10.18 dB,an extinction ratio larger than 17.41 d B,an in-band ripple lower than0.79 dB,and a 3-dB bandwidth changing from 0.38 to 1.05 nm are obtained,as the wavelength-channel spacing is 0.40 *** corresponding response time is measured to be 13.64μs.

关键词： integrated optics optical waveguide mode-and wavelength-selective switch

Multi-scale modeling for prediction of mechanical performance in brazed GH99 thin-walled structure

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Chinese Journal of Aeronautics 2024年第7期37卷 550-563页

作者： Yazhou LIU Shengpeng HU Yanyu SONG Wei FU Xiaoguo SONG Ning GUO Weimin LONG State Key Laboratory of Advanced Welding and Joining Harbin Institute of TechnologyHarbin 150001China Shandong institute of Shipbuilding Technology Weihai 264209China China Machinery Intelligent Equipment innovation Research institute(ningbo)Co. Ltd.Ningbo 315700China

Superalloy thin-walled structures are achieved mainly by brazing,but the deformation process of brazed joints is non-uniform,making it a challenging research *** paper records a thorough investigation of the effect of brazing parameters on the microstructure of joints and its mechanical properties,which mainly inquires into the deformation and fracture mechanisms in the shearing process of GH99/BNi-5a/GH99 *** macroscopic-microscopic deformation mechanism of the brazing interface during shearing was studied by Crystal Plasticity(CP)and Molecular Dynamics(MD)on the basis of the optimal brazing *** experimental results show that the brazing interface is mainly formed by(Ni,Cr,Co)(s,s)and possesses a shear strength of approximately 546 *** shearing fracture of the brazed joint occurs along the brazing seam,displaying the characteristics of intergranular *** simulations show that dislocations disassociate and transform into fine twinning with increased *** simulated the shear deformation process of the brazed *** multiscale simulation results are consistent with the experimental *** mechanical properties of thin-walled materials for brazing are predicted using MD and CP methods.

关键词： Multi-scale modeling Brazing Shear mechanisms Crystal plasticity GH99 superalloy

Influences of divalent ion substitution on the magnetic and dielectric properties of W-type barium ferrite

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Chinese Physics B 2024年第6期33卷 480-486页

作者：何诗悦刘若水刘煦婕叶先平王利晨沈保根 School of Rare Earths University of Science and Technology of ChinaHefei 230026China Ganjiang innovation Academy Chinese Academy of SciencesGanzhou 341119China ningbo institute of materials Technology&Engineering Chinese Academy of SciencesNingbo 315201China Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China

Saturation magnetization,magneto-crystalline anisotropy field,and dielectric properties are closely related to microwave devices applied at different *** regulating the magnetic and dielectric properties of W-type barium ferrites,single-phase BaMe_(2)Fe_(16)O_(27)(Me=Fe,Mn,Zn,Ni,Co) with different Me ions were synthesized by the high-temperature solid-state *** saturation magnetization(Ms) range from 47.77 emu/g to 95.34 emu/g and the magnetic anisotropy field(H_a) range from 10700.60 Oe(1 Oe=79.5775 A·m^(-1)) to 13739.57 Oe,depending on the type of cation substitution in the hexagonal *** dielectric permittivity and dielectric loss decrease with increasing frequency of the AC electric field in the low-frequency region,while they almost remain constant in the high-frequency *** charac teristics of easy regulation and preparation make it a potential candidate for use in microwave device applications.

关键词： W-type hexaferrite Raman spectra magnetic properties dielectric properties

Dual-symmetry-perturbed all-dielectric resonant metasurfaces for high-Q perfect light absorption

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Chinese Optics Letters 2024年第2期22卷 200-206页

作者：葛俊洋高一骁徐雷周宁沈祥 Laboratory of Infrared materials and Devices Research Institute of Advanced TechnologiesNingbo UniversityNingbo 315211China Key Laboratory of Photoelectric Detection materials and Devices of Zhejiang Province Ningbo 315211China Advanced Optics&Photonics Laboratory Department of EngineeringSchool of Science and TechnologyNottingham Trent UniversityNottingham NG118NSUK School of Physics and Optoelectronic Engineering Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China ningbo institute of Oceanography Ningbo 315832China

We demonstrate a high-Q perfect light absorber based on all-dielectric doubly-resonant *** bound states in the continuum(BICs)protected by different symmetries,we manage to independently manipulate the Q factors of the two degenerate quasi-BICs through dual-symmetry perturbations,achieving precise matching of the radiative and nonradiative Q factors for degenerate critical *** achieve a narrowband light absorption with a>600 Q factor and a>99%absorptance atλ_(0)=1550 nm on an asymmetric germanium metasurface with a 0.2λ_(0)*** work provides a new strategy for engineering multiresonant metasurfaces for narrowband light absorption and nonlinear applications.

关键词： resonant metasurface perfect light absorption bound states in the continuum

Improving Fatigue Properties of 316L Stainless Steel Welded Joints by Surface Spinning Strengthening

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Acta Metallurgica Sinica(English Letters) 2024年第5期37卷 840-854页

作者： Dongqiqiong Wang Qiang Wang Xiaowu Li Zhefeng Zhang Department of materials Physics and Chemistry School of Materials Science and Engineeringand Key Laboratory for Anisotropy and Texture of Materials(Ministry of Education)Northeastern UniversityShenyang 110819China Shi-Changxu innovation Center for Advanced materials Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China College of Light industry Liaoning UniversityShenyang 110036China

The surface spinning strengthening(3S)mechanism and fatigue life extension mechanism of 316L stainless steel welded joint were systematically elucidated by microstructural analyses and mechanical *** indicate that surface gradient hardening layer of approximately 1 mm is formed in the base material through grain fragmentation and deformation twin strengthening,as well as in the welding zone composed of deformedδ-phases and *** fatigue strength of welded joint after 3S significantly rises by 32%(from 190 to 250 MPa),which is attributed to the effective elimination of surface geometric defects,discrete refinement ofδ-Fe phases and the appropriate improvement in the surface strength,collectively mitigating strain localization and surface fatigue damage within the gradient strengthening *** redistributed fineδ-Fe phases benefited by strong stress transfer of 3S reduce the risk of surface weak phase cracking,causing the fatigue fracture to transition from microstructure defects to crystal defects dominated by slip,further suppressing the initiation and early propagation of fatigue cracks.

关键词： 316L stainless steel Welded joint Surface spinning strengthening Nanotwin Fatigue life

机械驱动生成自支撑的流苏状镍钴磷酸盐电极及其在超级电容器中的应用

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Science China materials 2024年第8期67卷 2671-2682页

作者：冯含芳徐进王乐辰曹晋玮李华阳朱光 3D Manufacturing innovation Center Yongjiang LaboratoryNingbo 315202China New materials institute Department of MechanicalMaterials and Manufacturing EngineeringUniversity of Nottingham Ningbo ChinaNingbo 315100China

过渡金属磷酸盐(TMPs)虽然具有优异的理论比容量和良好的晶体结构,但由于层间结构严重堆积导致的低比电容和倍率性能阻碍了其实际应用.本文首次采用水热搅拌法制备了由超薄纳米片组成的流苏状镍钴磷酸盐(NCP)电极.超薄纳米片可以同时提... 详细信息

过渡金属磷酸盐(TMPs)虽然具有优异的理论比容量和良好的晶体结构,但由于层间结构严重堆积导致的低比电容和倍率性能阻碍了其实际应用.本文首次采用水热搅拌法制备了由超薄纳米片组成的流苏状镍钴磷酸盐(NCP)电极.超薄纳米片可以同时提供大的比表面积、超多的活性位点和畅通的离子传输路径.制备的Ni_(2)C(PO_(4))_(2)(NCP-2)电极在2mA cm^(−2)下的比电容为2518mC cm^(−2)(1007Cg-1),在50mAcm^(−2)时的电容保持率为76.7%,优于先前报道的其他TMPs电极.根据密度泛函理论(DFT)计算结果,NCP-2电极表现出更高的电导率和更强的OH-吸附能.此外,以NCP-2和石墨烯水凝胶分别作为正负极组装成的混合超级电容器(HSC)具有高能量密度和高功率密度.充满电后,HSC可以点亮发光二极管(LED)灯5分钟以上.此外,该电极可与鞋垫形摩擦纳米发电机结合,以收集和储存人类行走时的机械能.此外,还可将其用作柔性压阻传感器的电源.本水热搅拌法可以扩展到其他电活性材料的制备.

关键词：混合超级电容器比电容压阻传感器机械驱动摩擦纳米发电机层间结构搅拌法正负极

Uncovering the electrooxidation behavior of 5-hydroxymethylfurfural on Ni/Co electrodes

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Journal of Energy Chemistry 2024年第5期92卷 1-7页

作者： Shilin Fan Bin Zhu Xiao Yu Yang Gao Weiping Xie Yong Yang Jian Zhang Chunlin Chen ningbo institute of materials Technology&Engineering Chinese Academy of SciencesNingbo 315201ZhejiangChina University of Chinese Academy of Sciences Beijing 100049China

Biomass,derived from plant photosynthesis that captures carbon dioxide to form carbohydrates,offers vast renewable *** electrooxidation of biomass,coupled with the hydrogen evolution reaction,enables the simultaneous production of biomass-based plastic monomers and green hydrogen,attracting significant scholarly ***,ambiguity remains regarding the adsorption mechanism at the catalyst surface(Langmuir-Hinshelwood or Eley-Rideal)and the adsorbed substrate *** address this,we prepared a Ni/Co electrode for the electrooxidation of 5-hydroxymethylfurfural(HMF)into 2,5-furandicarboxylic acid(FDCA)through a corrosion reaction and electro-reduction *** conversion reached 100.00%,FDCA yield reached 96.82%,and Faradic efficiency(FE)reached 92.14%.Meaningfully,utilizing in-situ spectroscopy and electrochemical methods,this work provided valuable insights into active sites and catalyst surface adsorption.

关键词： Electrocatalysis Electrochemistry 2,5-Furandicarboxylicacid 5-Hydroxymethylfurfural Biomass