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Application of ultrasonography-elastography score to suspect porto-sinusoidal vascular disease in patients with portal vein thrombosis

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Hepatobiliary & Pancreatic Diseases International 2024年第1期23卷 20-24页

作者： Stefania Gioia Adriano De Santis Giulia d’Amati Silvia Nardelli Alessandra Spagnoli Arianna Di Rocco Lorenzo Ridola Oliviero Riggio Department of Translational and Precision Medicine Sapienza University of RomeRomeItaly Department of Radiological Oncologicaland Pathological SciencesSapienza University of RomeRomeItaly Department of Public Health and Infectious Diseases Sapienza University of RomeRomeItaly

Background:Porto-sinusoidal vascular disease(PSVD)and portal vein thrombosis(PVT)are causes of portal hypertension characterized respectively by an intrahepatic and a pre-hepatic obstacle to the flow in the portal *** PVT may be a consequence of PSVD,in PVT patients at presentation,a pre-existing PSVD should be *** these patients the identification of an underlying PSVD would have relevant implication regarding follow-up and therapeutic management,but it could be *** this setting ultrasonography may be valuable in differential *** aim of the study was to use ultrasonography to identify parameters to discriminate between PSVD and“pure”PVT and then to suspect PVT secondary to a pre-existing ***:Fifty-three patients with histologically proven PSVD and forty-eight patients affected by chronic PVT were enrolled and submitted to abdominal ultrasonography with elastography by acoustic radiation force impulse(ARFI).Results:ARFI was higher and superior mesenteric vein(SMV)diameter was wider in PSVD patients than in PVT ***,a prognostic score was obtained as linear combinations of the two parameters with a good discrimination capacity between PSVD and PVT(the area under the curve=0.780;95%confidence interval:0.690-0.869).Conclusions:A score based on ARFI and SMV diameter may be useful to suspect an underlying PSVD in patients with PVT and to identify a subgroup of patients to be submitted to liver biopsy.

关键词： Non-cirrhotic portal hypertension Porto-sinusoidal vascular disease Chronic portal vein thrombosis Liver stiffness Portal hypertension Acoustic radiation force impulse

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Methane cracking in molten tin for hydrogen and carbon production—a comparison with homogeneous gas phase process

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Frontiers of Chemical Science and Engineering 2024年第7期18卷 155-166页

作者： Emmanuel Busillo Benedetta de Caprariis Maria Paola Bracciale Vittoria Cosentino Martina Damizia Gaetano Iaquaniello Emma Palo Paolo De Filippis Chemical Engineering Department Sapienza University of RomeRome 00184Italy NextChem S.p.A. Rome 00156Italy

Methane cracking is considered a bridge technology between gray and green hydrogen production *** this work an experimental study of methane cracking in molten tin is *** tests were conducted in a quartz reactor(i.d.=1.5 cm,L=20 cm)with capillary injection,varying temperature(950–1070℃),inlet methane flow rate(30–60 mL·min^(-1))and tin height(0–20 cm).The influence of the residence time in the tin and in the headspace on methane conversion and on carbon morphology was *** conversions obtained in tin and in the empty reactor were measured and compared with results of detailed kinetic simulations(CRECK).Furthermore,an expression of a global kinetic constant for methane conversion in tin was also *** highest conversion(65%at Q_(0)=30 mL·min^(-1) and t=1070℃)is obtained for homogeneous gas phase reaction due to the long residence time(70 s),the presence of tin leads to a sharp decrease of residence time(1 s),obtaining a conversion of 35%at 1070℃,thus meaning that tin owns a role in the *** characterization(scanning electron microscopy,Raman)reported a change in carbon toward sheet-like structures and an increase of the carbon structural order in the presence of molten tin media.

关键词： methane cracking molten media H2 production carbon morphology

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A systematic review of salivary biomarkers in Parkinson's disease

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Neural Regeneration Research 2024年第12期19卷 2613-2625页

作者： Maria Ilenia De Bartolo Daniele Belvisi Romina Mancinelli Matteo Costanzo Claudia Caturano Giorgio Leodori Alfredo Berardelli Giovanni Fabbrini Giorgio Vivacqua IRCCS Neuromed PozzilliItaly Department of Human Neurosciences Sapienza University of RomeRomeItaly Department of Anatomical HistologicalForensic Medicine and Orthopedics SciencesSapienza University of RomeRomeItaly Department of Experimental Morphology and Microscopy-Integrated Research Center(PRAAB)-Campus Biomedico university of rome RomeItaly

The search fo r reliable and easily accessible biomarkers in Parkinson's disease is receiving a growing emphasis,to detect neurodegeneration from the prodromal phase and to enforce disease-modifying *** the need for non-invasively accessible biomarke rs,the majo rity of the studies have pointed to cerebrospinal fluid or peripheral biopsies biomarkers,which require invasive collection *** represents an easily accessible biofluid and an incredibly wide source of molecular *** the present study,after presenting the morphological and biological bases for looking at saliva in the search of biomarkers for Parkinson's disease,we systematically reviewed the results achieved so far in the saliva of different cohorts of Parkinson's disease patients.A comprehensive literature search on PubMed and SCOPUS led to the discovery of *** screening and exclusion,34 relevant articles were derived fo r systematic ***-synuclein,the histopathological hallmark of Parkinson's disease,has been the most investigated Parkinson's disease biomarker in saliva,with oligomeric alphasynuclein consistently found increased in Parkinson's disease patients in comparison to healthy controls,while conflicting results have been reported regarding the levels of total alpha-synuclein and phosphorylated alpha-synuclein,and few studies described an increased oligomeric alpha-synuclein/total alpha-synuclein ratio in Parkinson's *** alpha-synuclein,other biomarkers to rgeting diffe rent molecular pathways have been explored in the saliva of Parkinson's disease patients:total tau,phosphorylated tau,amyloid-β1-42(pathological protein aggregation biomarkers);DJ-1,heme-oxygenase-l,metabolites(alte red energy homeostasis biomarkers);MAPLC-3beta(aberrant proteostasis biomarker);cortisol,tumor necrosis factor-alpha(inflammation biomarkers);DNA methylation,miRNA(DNA/RNA defects biomarkers);acetylcholinesterase activity(synaptic and neuronal network

关键词： alpha-synuclein amyloid-beta autophagy DJ-1 neurodegeneration neuroinflammation Parkinson's disease salivary biomarkers tau

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Pull the fuzes:Processing protein precursors to generate apoplastic danger signals for triggering plant immunity

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Plant Communications 2024年第8期5卷 113-136页

作者： Daniele Del Corpo Daniele Coculo Marco Greco Giulia De Lorenzo Vincenzo Lionetti Department of Biology and Biotechnology“Charles Darwin ”Sapienza University of RomeRomeItaly

The apoplast is one of the first cellular compartments outside the plasma membrane encountered by phytopathogenic microbes in the early stages of plant tissue *** have developed sophisticated surveillance mechanisms to sense danger events at the cell surface and promptly activate ***,a fine tuning of the activation of immune pathways is necessary to mount a robust and effective defense *** endogenous proteins and enzymes are synthesized as inactive precursors,and their post-translational processing has emerged as a critical mechanism for triggering alarms in the *** this review,we focus on the precursors of phytocytokines,cell wall remodeling enzymes,and *** physiological events that convert inactive precursors into immunomodulatory active peptides or enzymes are *** review also explores the functional synergies among phytocytokines,cell wall damage-associated molecular patterns,and remodeling,highlighting their roles in boosting extracellular immunity and reinforcing defenses against pests.

关键词： apoplast immunity activation post-translational processing cell wall proteases pro-peptides proenzymes phytocytokines cell-wall remodeling enzymes phytopathogenic microbes plant immunity

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Aqueous electrochemical delithiation of cathode materials as a strategy to selectively recover lithium from waste lithium-ion batteries

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Journal of Energy Chemistry 2024年第1期88卷 144-153,I0004页

作者： Pier Giorgio Schiavi Andrea Giacomo Marrani Olga Russina Ludovica D’Annibale Francesco Amato Francesca Pagnanelli Pietro Altimari Department of Chemistry Sapienza University of RomePiazzale Aldo Moro n.500185 RomeItaly

Lithium recovery from end-of-life Li-ion batteries(LIBs)through pyro-and hydrometallurgical recycling processes involves several refining stages,with high consumption of reagents and energy.A competitive technological alternative is the electrochemical oxidation of the cathode materials,whereby lithium can be deintercalated and transferred to an electrolyte solution without the aid of chemical extracting *** article investigates the potential to selectively recover Li from LIB cathode materials by direct electrochemical extraction in aqueous *** process allowed to recovering up to 98%of Li from high-purity commercial cathode materials(LiMn_(2)O_(4),LiCoO_(2),and Li Ni_(1/3)Mn_(1/3)Co_(1/3)O_(2))with a faradaic efficiency of 98%and negligible co-extraction of Co,Ni,and *** process was then applied to recover Li from the real waste LIBs black mass obtained by the physical treatment of electric vehicle battery *** black mass contained graphite,conductive carbon,and metal impurities from current collectors and steel cases,which significantly influenced the evolution and performances of Li electrochemical ***,due to concomitant oxidation of impurities,lithium extraction yields and faradaic efficiencies were lower than those obtained with high-purity cathode *** oxidation was found to occur within the voltage range investigated,but it could not quantitatively explain the reduced Li extraction *** fact,a detailed investigation revealed that above 1.3 V ***/Ag Cl,conductive carbon can be oxidized,contributing to the decreased Li *** on the reported experimental results,guidelines were provided that quantitatively enable the extraction of Li from the black mass,while preventing the simultaneous oxidation of impurities and,consequently,reducing the energy consumption of the proposed Li recovery method.

关键词： Lithium recovery Lithium-ion batteries recycling Electrochemical lithium extraction Lithium selective Extraction

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Metal-Halide Perovskite Submicrometer-Thick Films for Ultra-Stable Self-Powered Direct X-Ray Detectors

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Nano-Micro Letters 2024年第9期16卷 410-431页

作者： Marco Girolami Fabio Matteocci Sara Pettinato Valerio Serpente Eleonora Bolli Barbara Paci Amanda Generosi Stefano Salvatori Aldo Di Carlo Daniele M.Trucchi CNR‑ISM Consiglio Nazionale delle RicercheIstituto di Struttura della MateriaSede Secondaria di MontelibrettiDiaTHEMA LabStrada Provinciale 35D900010 MontelibrettiRomeItaly CHOSE–Centre for Hybrid and Organic Solar Energy Department of Electronic EngineeringUniversity of Rome“Tor Vergata”Via del Politecnico 100133 RomeItaly Faculty of Engineering Universita degli Studi Niccolo CusanoVia don Carlo Gnocchi 300166 RomeItaly SpecXLab CNR‑ISMConsiglio Nazionale Delle RicercheIstituto di Struttura Della MateriaArea della Ricerca di Tor VergataVia del Fosso del Cavaliere 10000133 RomeItaly

Metal-halide perovskites are revolutionizing the world of X-ray detectors,due to the development of sensitive,fast,and cost-effective ***-powered operation,ensuring portability and low power consumption,has also been recently demonstrated in both bulk materials and thin ***,the signal stability and repeatability under continuous X-ray exposure has only been tested up to a few hours,often reporting degradation of the detection *** it is shown that self-powered direct X-ray detectors,fabricated starting from a FAPbBr_(3)submicrometer-thick film deposition onto a mesoporous TiO_(2)scaffold,can withstand a 26-day uninterrupted X-ray exposure with negligible signal loss,demonstrating ultra-high operational stability and excellent *** structural modification is observed after irradiation with a total ionizing dose of almost 200 Gy,revealing an unexpectedly high radiation hardness for a metal-halide perovskite thin *** addition,trap-assisted photoconductive gain enabled the device to achieve a record bulk sensitivity of 7.28 C Gy^(−1)cm^(−3)at 0 V,an unprecedented value in the field of thin-film-based photoconductors and photodiodes for“hard”***,prototypal validation under the X-ray beam produced by a medical linear accelerator for cancer treatment is also introduced.

关键词： Metal-halide perovskite thin films Direct X-ray detectors Self-powered devices Operational stability Medical linear accelerator

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Solid pseudopapillary tumor of the pancreas:A systematic review of clinical,surgical and oncological characteristics of 1384 patients underwent pancreatic surgery

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Hepatobiliary & Pancreatic Diseases International 2024年第4期23卷 331-338页

作者： Gennaro Mazzarella Edoardo Maria Muttillo Diego Coletta Biagio Picardi Stefano Rossi Simone Rossi Del Monte Vito Gomes Irnerio Angelo Muttillo Division of General and Emergency Surgery San Filippo Neri Hospital00136 RomeItaly Department of Surgery“Pietro Valdoni” Sapienza University of RomeViale del Policlinico 15500161 RomeItaly Surgical and Medical Department of Translational Medicine Sant’Andrea HospitalSapienza University of Rome00185 RomeItaly Department of Surgical Sciences Umberto I University HospitalSapienza University of Rome00136 RomeItaly Department of General Surgery Ospedali Riuniti Marche Nord61121 PesaroItaly Department of Pathology San Filippo Neri Hospital00136 RomeItaly

Background:Pancreatic solid pseudopapillary tumors(SPTs)are rare clinical entity,with low malignancy and still unclear *** account for less than 2%of exocrine pancreatic *** study aimed to perform a systematic review of the main clinical,surgical and oncological characteristics of pancreatic *** sources:MEDLINE/PubMed,Web of Science and Scopus databases were systematically searched for the main clinical,surgical and oncological characteristics of pancreatic SPTs up to April 2021,in accordance with the preferred reporting items for systematic reviews and meta-analyses(PRISMA)*** endpoints were to analyze treatments and oncological ***:A total of 823 studies were recorded,86 studies underwent full-text reviews and 28 met inclusion ***,1384 patients underwent pancreatic *** age was 30 years and 1181 patients(85.3%)were *** most common clinical presentation was non-specific abdominal pain(52.6%of cases).Mean overall survival was 98.1%.Mean recurrence rate was 2.8%.Mean follow-up was 4.2 ***:Pancreatic SPTs are rare,and predominantly affect young women with unclear *** resection is the gold standard of treatment achieving good oncological impact and a favorable prognosis in a yearly life-long follow-up.

关键词： Frantz’s tumor Pancreas Pancreatic neoplasms Pancreatic surgery Solid pseudopapillary tumor

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Validity of self-reported male sexual function scales in a young Chinese population:a comparative study with clinician-assisted evaluation

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Asian Journal of Andrology 2024年第3期26卷 321-327页

作者： Hui Zhang Elena Colonnello Erika Limoncin Tommaso B Jannini Xu-Chong Tu Andrea Sansone Emmanuele A Jannini Yan Zhang Department of Infertility and Sexual Medicine Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510000China Chair of Endocrinology and MedicalSexology(ENDOSEX) Department of Experimental MedicineUniversity of Rome Tor VergataRome 00133Italy Department of Urology First Affiliated Hospital ofGuangzhou University of Chinese MedicineGuangzhou 510000China Section of Medical Pathophysiology Food Science and EndocrinologySapienza University of RomeRome 00133Italy School of Psychiatry Department of Systems MedicineUniversity of Rome Tor VergataRome 00133Italy

Psychometric scales,commonly used to gauge sexual function,can sometimes be influenced by response *** our researchfrom June 2020 to April 2021,we examined the accuracy of self-reported sexual function *** invited patients from theDepartment of Infertility and Sexual Medicine at the Third Affiliated Hospital of Sun Yat-sen university(Guangzhou,China),whohave male sexual dysfunction,to participate by filling out a self-reported version of a specific *** addition,they wentthrough a clinician-assisted version of this questionnaire,encompassing tools such as the Premature Ejaculation Diagnostic Tool(PEDT),the 6-item International Index of Erectile Function(IIEF-6),the Erection Hardness Scale(EHS),and the MasturbationErection Index(MEI).Using the clinician-assisted version as a reference,we categorized patients and applied various statisticalmethods,such as the Chi-square test,intraclass correlation coefficient(ICC),logistic regression,and the Bland–Altman plot,to gauge *** our study with 322 participants,we found that while there were no notable discrepancies in error ratesbased on our categorization,certain scales showed significant differences in terms of overestimation and underestimation,withthe exception of the *** positive diagnosis rate consistency between the self-reported and clinician-assisted versions *** ICC values between the two versions across the scales were indicative of remarkable *** findings showthat the self-reported versions of tools such as EHS,IIEF-6,MEI,and PEDT are credible and hold clinical ***,employing a dual-diagnosis approach might be more prudent to circumvent potential misdiagnoses.

关键词： psychometry scale sexual function sexual health

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Nonlinear response of a multidirectional negative-stiffness isolation system via semirecursive multibody dynamic approach

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International Journal of Mechanical System Dynamics 2024年第3期4卷 258-277页

作者： Wei Dai Biagio Carboni Giuseppe Quaranta Yongjun Pan Walter Lacarbonara College of Mechanical and Vehicle Engineering Chongqing UniversityChongqingChina Department of Structural and Geotechnical Engineering Sapienza University of RomeRomeItaly

This paper investigates an innovative negative-stiffness device(NSD)that modifies the apparent stiffness of the supported structure for seismic *** NSD comprises a lower base on the bottom and a cap on the top,together with a connecting rod,vertical movable wall,and compressed elastic spring,as well as circumferentially arranged,pretensioned external ropes,and inclined shape memory *** configuration can deliver negative stiffness and energy dissipation in any direction within the horizontal plane.A numerical model of the device is developed through a two-step semirecursive method to obtain the force–displacement characteristic *** a model is first validated through comparison with the results obtained via the commercial software ***,a large parametric study is performed to assess the role and the influence of each design variable on the overall response of the proposed *** guidelines are drawn from this analysis to guide the system design and optimization.

关键词： multibody system negative stiffness semirecursive approach seismic protection vibration isolation

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Advancing hepatic recompensation:Baveno VII criteria and therapeutic innovations in liver cirrhosis management

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World Journal of Gastroenterology 2024年第23期30卷 2954-2958页

作者： Lorenzo Ridola Sara Del Cioppo Department of Medical and Surgical Sciences and Biotechnologies Sapienza University of RomePolo PontinoRome 00185Italy

The Baveno VII criteria redefine the management of decompensated liver cirrhosis,introducing the concept of hepatic recompensation marking a significant departure from the conventional view of irreversible *** to this concept is addressing the underlying cause of cirrhosis through tailored therapies,including antivirals and lifestyle *** on alcohol,hepatitis C virus,and hepatitis B virus-related cirrhosis demonstrate the efficacy of these interventions in improving liver function and patient *** intrahepatic portosystemic shunt(TIPS)emerges as a promising intervention,effectively resolving complications of portal hypertension and facilitating ***,optimal timing and patient selection for TIPS remain *** challenges,TIPS offers renewed hope for hepatic recompensation,marking a significant advancement in cirrhosis *** research is needed to refine its implementation and maximize its *** conclusion,TIPS stands as a promising avenue for improving hepatic function and patient outcomes in decompensated liver cirrhosis within the framework of the Baveno VII criteria.

关键词： Hepatic recompensation Baveno VII Transjugular intrahepatic portosystemic shunt Portal hypertension Cirrhosis Decompensation

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