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Differences in TGFβ signaling in quiescent and activated hepatic stellate cells

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肝脏 2002年第S1期7卷 79-页

作者： Marianna D A Gaca VincentFVellucci MichaelReiss RebeccaGWells InternalMedicineandPathology YaleUniversitySchoolofMedicineNewHavenCTInternalMedicineandPathologyYaleUniversitySchoolofMedicineNewHavenCTInternalMedicineandPathologyYaleUniversitySchoolofMedicineNewHavenCTInstituteofLiverDiseaseShanghaiUnivers

New Astrophysical Reaction Rates for ^18F（P,α）^15O and ^18F（P,γ）^19Ne

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Chinese Physics Letters 2003年第9期20卷 1470-1473页

作者：舒能川 D.W.Bardayan J.C.Blackmon 陈永寿 R.L.Kozub P.D.Parker M.S.Smith ChinaInstituteofAtomicEnergy Beijing102413 PhysicsDivision OakRidgeNationalLaboratoryOakRidgeTennessee37831USA PhysicsDepartment TennesseeTechnologicalUniversityCookevilleTennessee38505USA A.W.WrightNuclearStructureLaboratory YaleUniversityNewHavenConnecticut06520USA

The rates of the thermonuclear 18F(p, α)15O and 18F(p,γ)19Ne reactions in hot astrophysical environments are needed to understand gamma-ray emission from nova explosions. The rates for these reactions have been uncertain due to discrepancies in recent measurements, as well as to a lack of a comprehensive examination of the available structure information in the compound nucleus 19Ne. We have examined the latest experimental measurements with radioactive and stable beams, and made estimates of the unmeasured 19Ne nuclear level parameters, to generate new rates with uncertainties for these reactions. The rates are expressed as numerical values over the temperature range relevant for stellar explosions, as well as analytical expressions as functions of temperature in a format suitable for use in astrophysical simulations. Comparisons with the previous rate calculations are carried out, and the astrophysical implications are briefly discussed.

关键词： Gamma rays

Virtual hairy brush for digital painting and calligraphy

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Science in China(Series F) 2005年第3期48卷 285-303页

作者： XUSonghua LauFrancisC.M XUCongfu PANYunhe StateKeyLabofCAD&CG ZhejiangUniversityHangzhou310027China StateKeyLabofCAD&CG ZhejiangUniversityHangzhou310027China//ComputerScienceDepartmentYaleUniversityNewHavenCT06511USA DepartmentofComputerScience TheUniversityofHongKongPokfulamRoadHongKongChina

The design of user friendly and expressive virtual brush systems for interactive digital painting and calligraphy has attracted a lot of attention and effort in both computer graphics and human-computer interaction circles for a long time. Providing a digital environment for paper-less artwork creation is not only challenging in terms of algorithmic design, but also promising for its potential market values. This paper proposes a novel algorithmic framework for interactive digital painting and calligraphy based a novel virtual hairy brush model. The algorithms in the kernel of our simulation framework are built upon solid modeling techniques. Implementing the algorithms, we have developed a virtual hairy brush prototype system with which end users can interactively produce high-quality digital paintings and calligraphic artwork. (The latest progress of our virtual brush project is reported at the website “http://***/~songhua/e-brush/”.)

关键词： virtual hairy brush digital painting and calligraphy simulation algorithm solid modeling non- photorealistic rendering.

The role of Toll-like receptors in non-infectious lung injury

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Cell Research 2006年第8期16卷 693-701页

作者： Dianhua Jiang~1 Jiurong Liang~1 Yuhang Li~2 Paul W Noble~1 ~1Department of Medicine,Section of Pulmonary and Critical Care Medicine,Yale UniversiO,School of Medicine,333 Cedar Street,New Haven,CT 06520,USA ~2Beijing University of Chinese Medicine,Beijing 100029,China DepartmentofMedicine SectionofPulmonaryandCriticalCareMedicineYaleUniversitySchoolofMedicine333CedarStreetNewHavenCT06520USA BeijingUniversityofChineseMedicine Beijing100029China

The role of Toll-like receptors(TLRs)in pathogen recognition has been expeditiously advanced in recent ***,investigations into the function of TLRs in non-infectious tissue injury have just ***,we andothers have demonstrated that fragmented hyaluronan(HA)accumulates during tissue ***44 is required to clearHA during tissue injury,and impaired clearance of HA results in unremitting ***,fragmentedHA stimulates the expression of inflammatory genes by inflammatory cells at the injury ***,we identified thatHA fragments require both TLR2 and TLR4 to stimulate mouse macrophages to produce inflammatory chemokines *** a non-infectious lung injury model,mice deficient in both TLR2 and TLR4 show an impaired transepithelialmigration of inflammatory cells,increased tissue injury,elevated lung epithelial cell apoptosis,and decreased *** epithelial cell overexpression of high molecular mass HA protected mice against acute lung injury and apoptosis,in part through TLR-dependent basal activation of NF-κ*** exaggerated injury in TLR2 and TLR4 deficient miceappears to be due to impaired HA-TLR interactions on epithelial *** studies identify that host matrix componentHA and TLR interactions provide signals that initiate inflammatory responses,maintain epithelial cell integrity,andpromote recovery from acute lung injury.

关键词： Toll-like receptors hyaluronan lung injury inflammation apoptosis

Personalized medicine:a new horizon for medical therapy

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Precision Clinical Medicine 2018年第1期1卷 1-2页

作者： Sherman MortonWeissman Yale School of Medicine DepartmentofGeneticsPO Box 208005333CedarStreetNewHavenCT06520-8005USA

The development of low-cost high-throughput nucleic acid sequencing has had transformative effects on mul-tiple aspects of biological science and ***-ent among these is an enormous impact on human *** are close to a time when the birthright of each individual,at least in more prosperous countries,will be a complete knowledge of their genomic DNA *** patient with a diagnosed malignancy may well have a genomic sequence of cells from their neoplasm.A challenge for modern medicine is to convert this information into guides to predict the incidence and consequences of disease with more individual precision than previously possible,and to use these data to design optimal approaches for therapy of disorders including cancer and autoimmune diseases.

关键词： horizon consequences convert

Synthesis Reasoning and Its Application in Chinese Calligraphy Generation

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自动化学报 2005年第4期31卷 495-509页

作者： XUSong-Hua PANYun-He ZHUANGYue-Ting FRANCISC.M.Lau CAD＆CGStateKeyLaboratoryofChina ZhejiangUniversityHangzhou310027China／／ComputerScienceDepartmentYaleUniversityNewHavenConnecticut06500USA CAD＆CGStateKeyLaboratoryofChina ZhejiangUniversityHangzhou310027China DepartmentofComputerScience TheUniversityofHongKongHongKongChina

In this paper, we address the demanding task of developing intelligent systems equippedwith machine creativity that can perform design tasks automatically. The main challenge is howto model human beings creativity mathematically and mimic such creativity computationally. Wepropose a “synthesis reasoning model” as the underlying mechanism to simulate human beingscreative thinking when they are handling design tasks. We present the theory of the synthesisreasoning model, and the detailed procedure of designing an intelligent system based on the *** o?er a case study of an intelligent Chinese calligraphy generation system which we have *** on implementation experiences of the calligraphy generation system as well as a few othersystems for solving real-world problems, we suggest a generic methodology for constructing intelligentsystems using the synthesis reasoning model.

关键词：综合推理模型智能系统设计智能书法方法论

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视网膜变性疾病的动物模型和治疗研究进展

中华眼底病杂志 2000年第2期16卷 130-132页

作者：费一坚 Dept.Ophthalmology&VisualScience SchoolofMedicineYaleUniversityBML412330CedarSt.NewHavenCT06520

1 视网膜变性疾病的动物模型1.1 自发视网膜变性动物模型视网膜细胞的分化和发育的基本机制及视觉传导的光电转化反应从无脊椎动物到脊椎动物都很相似,所涉及的基因和蛋白在不同种类的动物,低到果蝇高到人类,大多高度保守.

关键词：视网膜变性动物模型治疗

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结膜瓣的显微手术进路

美国医学会眼科杂志（中文版） 2004年第2期16卷 96-99,107页

作者： A1iKhodadoust AniaPorazinskiQuinter 冯云李子良 theConnecticutEyecareCenter，newhaven．DrsKhodadoust Quinterhavenorelevantfinancialinterestinthisarticle 不详不详

目的：描述一种选择性带蒂结膜瓣治疗有或无合并角膜穿孔的慢性角膜溃疡的显微手术进路，并报告了50例连续病例的结果。方法：回顾性的，无对照组的病例报告。患者：选择1982-1996年间于New Haven Connecticut Eyecsre Center所有接受... 详细信息

目的：描述一种选择性带蒂结膜瓣治疗有或无合并角膜穿孔的慢性角膜溃疡的显微手术进路，并报告了50例连续病例的结果。方法：回顾性的，无对照组的病例报告。患者：选择1982-1996年间于New Haven Connecticut Eyecsre Center所有接受显微结膜瓣手术治疗慢性角膜溃疡的病例。介入术式：部分带蒂结膜瓣手术。方法：回顾眼部初始诊断和病情特点，并回顾术后情况。主要结果测定：角膜溃疡的转归和结膜瓣的术后稳定性。结果：经治疗62％的角膜溃疡未出现穿孔，38％出现穿孔。诊断包括单纯疱疹病毒感染(14例)，细菌性溃疡(11例)，风湿性关节炎(8例)，无晶体性大泡性角膜病变(6例)，移植排斥(4例)，带状疱疹病毒感染(5例)和其他(2例)。术后，94％的结膜瓣稳定，3％失败。手术对于64％的患者来说是永久性的，36％是暂时的；其中61％的患者在术后6-24个月接受角膜移植，38％于术后6-12个月因原来病灶完全愈合而去除结膜瓣。结论：选择性的带蒂结膜瓣是一种治疗其他药物无效的穿孔性或非穿孔性角膜溃疡的有效且可行的手术方法。

关键词：显微外科手术进路选择性带蒂结膜瓣角膜穿孔慢性角膜溃疡

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葡萄胎的遗传学基础

中华病理学杂志 2012年第11期41卷 721-724页

作者：惠培刘岩 DepartmentofPathology YaleUniversitySchoolofMedicineNewHavenCT06520—8023USA 北京大学医学部病理学系

妊娠滋养叶细胞疾病（gestational trophoblastic disease，GTD）是一组源自胎盘各种滋养叶细胞的增生性疾病，具有独特的流行病学特征、临床表现、遗传学构成和多样性的生物学行为[1]。该类疾病主要发生在亚洲，特别是东南亚的一些发... 详细信息

妊娠滋养叶细胞疾病（gestational trophoblastic disease，GTD）是一组源自胎盘各种滋养叶细胞的增生性疾病，具有独特的流行病学特征、临床表现、遗传学构成和多样性的生物学行为[1]。该类疾病主要发生在亚洲，特别是东南亚的一些发展中国家。根据世界卫生组织（WHO）肿瘤病理学和遗传学分类标准[2]，GTD包括非肿瘤性葡萄胎（完全性葡萄胎、部分性葡萄胎和侵袭性葡萄胎）和肿瘤性滋养叶细胞增生（妊娠性绒毛膜癌、胎盘部位滋养叶细胞肿瘤和上皮样滋养叶细胞肿瘤[2]。最常见的葡萄胎是以绒毛滋养叶细胞成分为主的增生性病变，而恶性度极高的绒毛膜癌则是以胎盘发育过程中的绒毛前滋养层细胞增生为主的恶性肿瘤。胎盘部位滋养叶细胞肿瘤及胎盘部位过度性反应性细胞增生（exaggeratedplacentalsitereaction）具有植入部位的中间型滋养细胞特征，而上皮样滋养叶细胞肿瘤和胎盘部位结节性病变起源于平滑绒毛膜的中间型滋养细胞。

关键词：完全性葡萄胎遗传学基础胎盘部位滋养叶细胞肿瘤滋养叶细胞疾病滋养层细胞增生中间型滋养细胞绒毛膜癌流行病学特征