检索结果-南通市图书馆

NLRP3 inflammasome plays a vital role in the pathogenesis of age-related diseases in the eye and brain

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第7期19卷 1425-1426页

作者： Jack Jonathan Maran Odunayo Omolola Mugisho Buchanan Ocular Therapeutics Unit Department of OphthalmologyNew Zealand National Eye CentreUniversity of AucklandAucklandNew Zealand

Key points:With aging,there is increased nucleotide-binding oligomerization domain-(NOD-)like receptor(NLR) protein-3(NLRP3) activation in neural and ocular *** of the NLRP3 inflammasome appears to be a common denominator in the pathogenesis of age-related diseases of the eye and *** inhibition of the NLRP3 inflammasome may be a potent therapy for preventing the development and progression of age-related eye and brain diseases.

关键词： NLRP3 pathogenesis inflam

Demographic features and visual outcomes of patients presenting to diabetic photo-screening and treated for sight threatening retinopathy in Fiji

在线全文

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2017年第5期10卷 790-795页

作者： Riyaz Bhikoo Neil Murray Biu Sikivou Stephanie Emma Charles McGhee The Fred Hollows Foundation new zealand Auckland 1023New Zealand Department of Ophthalmology New Zealand National Eye Centre University of Auckland Auckland 1023 New Zealand Pacific eye Institute Suva Fiji

AIM：To describe the demographic features and visual outcomes of patients presenting to photo-screening services, and treated for sight threatening retinopathy（STR） in a low resource setting, ***：A retrospective review of all new patients who presented for diabetic photo-screening at the Diabetic eye Clinic, Suva in 2010. Fundus images were graded using standardised guidelines. Patient demographics, retinopathy grading and visual acuity data were extracted from the database and analyzed. Patients that received laser therapy and still attending follow up in 2012 were examined for disease progressionRESULTS：Totally 2236 patients were photo-screened, 87%（3870/4472） of images were gradable. STR was observed in 26%（988/3870） with advanced STR（proliferative retinopathy/severe maculopathy） in 10%（385/3870）. Of those with STR, 59% had BCVA ≥6/18, 31% with advanced STR were 〈6/60. Male gender [odds ratio（OR） 1.59; 1.20-2.12], history of hypertension（OR 1.36; 1.03-1.80） and peripheral neuropathy（OR 1.41; 1.01-1.95） were predictive of advanced STR. In 2012, 32%（315/988） attended follow up with 69% exhibiting advanced STR compared with 53% of the same cohort in 2010. Laser photocoagulation was administered to 212 eyes（212/3870, 5%） with retinopathy and maculopathy progression observed in 52% and 33% respectively. BCVA ≥6/18 was noted in 67%（143/212） of treated eyes. Improved glycaemic control（OR 46.52; 1.50-1441.90） amongst those with advanced STR was predictive of eyes that maintained good ***：In Fiji, a quarter of new patients presenting to photo-screening have STR with a third of those with advanced STR having already loss vision. Improved glycaemic control and timely treatment of patients with sight threatening complications is important in halting disease progression.

关键词： diabetic retinopathy sight threatening photocoagulation pacific islands developing countries

16.48% Efficient solution-processed CIGS solar cells with crystal growth and defects engineering enabled by Ag doping strategy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2025年第1期100卷 59-65页

作者： Mengyu Xu Shaocong Yan Ting Liang Jia Jia Shengjie Yuan Dongxing Kou Zhengji Zhou Wenhui Zhou Yafang Qi Yuena Meng Litao Han Sixin Wu Key Laboratory for Special Functional Materials of MOE National & Local Joint Engineering Research Centre for High-efficiency Display and Lighting Technology School of Nanoscience and Materials Engineering Henan University

Solution-processed Cu（In,Ga）Se2（CIGS） solar cells suffer from serious carrier recombination and power conversion efficiency（PCE） loss because of the poor film properties and easy formation of ***, we propose Ag&Se co-selenization strategy to enhance the crystallization and passivate harmful defects of the CIGS films. The formation of Ag-Se phase during the selenization process enables the formation of large grains and suppresses the deep level defects. It is found that Ag doping can enlarge the depletion region width, lower the Urbach energy and prolong the carrier lifetime. As a result, a champion solution-processed CIGS solar cell presents a high efficiency of 16.48% with the highly improved opencircuit voltage（VOC） of 662 m V and fill factor（FF） of 75.8%. This work provides an efficient strategy to prepare high quality solution-processed CIGS films for high-performance CIGS solar cells.

关键词： CIGS solar cells Solution-processed method Ag doping Crystal growth Defects engineering

Modified endoscopic transnasal orbital apex decompression in dysthyroid optic neuropathy

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

eye and Vision 2021年第1期8卷 183-191页

作者： Yunhai Tu Mingna Xu Andy D.Kim Michael T.M.Wang Zhaoqi Pan Wencan Wu The eye Hospital of Wenzhou Medical University No.270 Xueyuan Xi RoadWenzhouZhejiang 325027P.R.China Department of Ophthalmology New Zealand National Eye CentreThe University of AucklandAucklandNew Zealand

Background:To describe the surgical technique and assess the clinical efficacy and safety of modified endoscopic transnasal orbital apex decompression in the treatment of dysthyroid optic ***:In this retrospective research,forty-two subjects(74 orbits)who underwent modified endoscopic transnasal orbital apex decompression for the treatment of dysthyroid optic neuropathy were *** and postoperative best-corrected visual acuity(BCVA),visual field mean deviation(MD),Hertel exophthalmometry,and new onset diplopia were assessed before and after the *** Wilcoxon test was used for differential *** mixed-models’analyses were conducted to assess the potential predictors for BCVA ***:Postoperatively,the mean BCVA improved from 0.70±0.62 logMAR to 0.22±0.33 *** significantly improved in 69 eyes(93%),remained stable in 4 eyes(5%)and deteriorated in 1 eye(1%).MD of visual fields improved from−13.73±9.22 dB to−7.23±7.04 *** decreased from 19.57±3.38mm to 16.35±*** BCVA,MD of visual fields and medical rectus diameter were independent factors associated with improvements in BCVA(Pnew diplopia ***:Modified endoscopic transnasal orbital apex decompression effectively restores vision in dysthyroid optic neuropathy.

关键词： Endoscopic transnasal orbital decompression Dysthyroid optic neuropathy Thyroid-associated ophthalmopathy Visual acuity Visual field

Development of a novel stability indicating RP-HPLC method for quantification of Connexin43 mimetic peptide and determination of its degradation kinetics in biological fluids

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Pharmaceutical Analysis 2017年第6期7卷 365-373页

作者： Rohit Bisht Ilva D. Rupenthal Sreevalsan Sreebhavan Jagdish K. Jaiswal Buchanan Ocular Therapeutics Unit(BOTU) Department of OphthalmologyNew Zealand National Eye CentreFaculty of Medical and Health SciencesUniversity of AucklandAuckland 1142New Zealand Auckland Cancer Society Research centre Faculty of Medical and Health SciencesUniversity of AucklandAuckland 1142New Zealand

Connexin43 mimetic peptide （Cx43MP） has been intensively investigated for its therapeutic effect in the management of inflammatory eye conditions, spinal cord injury, wound healing and iscbemia-induced brain damage. Here, we report on a validated stability-indicating reversed-phase high performance liquid chromatography （RP-HPLC） method for the quantification of Cx43MP under stress conditions. These included exposure to acid/base, light, oxidation and high temperature. In addition, the degradation kinetics of the peptide were evaluated in bovine vitreous and drug-free human plasma at 37℃. Detection of Cx43MP was carried out at 214 nm with a retention time of 7.5 min. The method showed excellent linearity over the concentration range of 0.9-250μg/mL （R2a0.998）, and the limits of detection （LOD） and quantification （LOQ） were found to be 0.90 and 2.98 μg/mL, respectively. The accuracy of the method determined by the mean percentage recovery at 7.8, 62.5 and 250μg/mL was 96.79%, 98.25% and 99.06% with a RSD of〈 2.2%. Accelerated stability studies revealed that Cx43MP was more sensitive to basic conditions and completely degraded within 24 h at 37℃（0% recovery） and within 12 h at 80℃ （0.34% recovery）. Cx43MP was found to be more stable in bovine vitreous （t1/2 slow= 171.8 min） compared to human plasma （t1/2slow = 39.3 min） at 37℃ according to the two phase degradation kinetic model. These findings are important for further pre-clinical development of Cx43MP.

关键词： RP-HPLC determination biological fluids

Connexin therapeutics:blocking connexin hemichannel pores is distinct from blocking pannexin channels or gap junctions

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2021年第3期16卷 482-488页

作者： Monica L.Acosta Mohd N.Mat Nor Cindy X.Guo Odunayo O.Mugisho Frazer P.Coutinho Ilva D.Rupenthal Colin R.Green School of Optometry and Vision Science University of AucklandAucklandNew Zealand Faculty of Medicine Universiti Sultan Zainal AbidinTerengganuMalaysia Department of Ophthalmology University of AucklandAucklandNew Zealand Buchanan Ocular Therapeutics Unit Department of OphthalmologyAucklandNew Zealand new zealand national eye centre University of AucklandAucklandNew Zealand centre for Brain Research Faculty of Medical and Health SciencesThe University of AucklandAucklandNew Zealand Brain Research new zealand–Rangahau Roro Aotearoa AucklandNew Zealand

Compounds that block the function of connexin and pannexin protein channels have been suggested to be valuable therapeutics for a range of *** of these compounds are now in clinical trials,but for many of them,the literature is inconclusive about the molecular effect on the tissue,despite evidence of functional *** the different channel types has distinct physiological and pathological implications and this review describes current knowledge of connexin and pannexin protein channels,their function as channels and possible mechanisms of the channel block effect for the latest therapeutic *** summarize the evidence implicating pannexins and connexins in disease,considering their homeostatic versus pathological roles,their contribution to excesive ATP release linked to disease onset and progression.

关键词： connexin gap junction gap19 hemichannel pannexin retina tonabersat

Genotyping-by-sequencing of pear (Pyrus spp.) accessions unravels novel patterns of genetic diversity and selection footprints

在线全文

学校读者我要写书评

暂无评论

Horticulture Research 2017年第1期4卷 301-310页

作者： Satish Kumar Chris Kirk Cecilia Deng Claudia Wiedow Mareike Knaebel Lester Brewer The new zealand Institute for Plant&Food Research Limited Hawke’s Bay Research CentreHavelock NorthNew Zealand Palmerston North Research centre Palmerston NorthNew Zealand Mount Albert Research centre AucklandNew Zealand Motueka Research centre MotuekaNew Zealand

Understanding of genetic diversity and marker-trait relationships in pears(Pyrus spp.)forms an important part of gene conservation and cultivar *** of Asian and European pear species,and interspecific hybrids were planted in a common garden ***-by-sequencing(GBS)was used to genotype 214 accessions,which were also phenotyped for fruit quality traits.A combination of selection scans and association analyses were used to identify signatures of *** of genetic diversity,population structure and introgression were also *** 15000 high-quality SNP markers were identified from the GBS data,of which 25%and 11%harboured private alleles for European and Asian species,*** clustering analysis suggested negligible gene flow,resulting in highly significant population differentiation(Fst=0.45)between Asian and European *** hybrids displayed an average of 55%and 45%introgression from their Asian and European ancestors,***(firmness,acidity,shape and so on)variation between accessions was significantly associated with genetic *** frequencies at large-effect SNP loci were significantly different between genetic groups,suggesting footprints of directional *** scan analyses identified over 20 outlier SNP loci with substantial statistical support,likely to be subject to directional selection or closely linked to loci under selection.

关键词： planted directional likely

Hierarchical hollow microspheres assembled from carbon nanosheets integrated with molybdenum carbide nanoparticles for boosting microwave absorption properties

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano Research 2025年第1期18卷 10-20页

作者： Zongsheng Chen Yahui Wang Yi Liu Zhigang Li Xiangyin Lv Liping Liu Yajing Chang Jiaming Shi Xiao Zhang State Key Laboratory of Pulsed Power Laser Technology School of Electronic EngineeringNational University of Defense TechnologyHefei 230037China Anhui Provincial Laboratory of Advanced Laser Technology School of Electronic EngineeringNational University of Defense TechnologyHefei 230037China centre for Environmental and Energy Nanomaterials Anhui Key Laboratory of Nanomaterials and NanotechnologyCAS Centre for Excellence in NanoscienceInstitute of Solid State PhysicsHefei Institutes of Physical ScienceChinese Academy of SciencesHefei 230031China

Hierarchical hollow structure has demonstrated potential for enhancing electromagnetic(EM)attenuation and improving impedance matching,garnering significant attention for ***,we have successfully implemented compositional and structural engineering to fabricate hollow Mo2C/C microspheres with controllable composition by coupling interaction between dopamine hydrochloride and ammonium *** the synergistic effect of composition and hollow structure,the strongest reflection loss intensity and broadest effective absorption of the optimized sample reach-70.2 dB and 6.2 GHz,*** formation of hollow heterogeneous structures not only favors impedance matching feature,but also generates considerable contribution to EM attenuation ***,radar cross-section simulation data indicate that hollow Mo2C/C microspheres with compositional optimization and heterogeneous structures have broad prospects for practical applications.

关键词： electromagnetic absorption Mo2C/C microwave absorption hollow structure

Structural and microwave absorption properties of CoFe_(2)O_(4)/residual carbon composites

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 221-232页

作者： Yuanchun Zhang Shengtao Gao Xingzhao Zhang Dacheng Ma Chuanlei Zhu Jun He Joint national-Local Engineering Research centre for Safe and Precise Coal Mining Anhui University of Science and TechnologyHuainan 232001China School of Chemical and Blasting Engineering Anhui University of Science and TechnologyHuainan 232001China

Electromagnetic interference,which necessitates the rapid advancement of substances with exceptional capabilities for bsorbing electromagnetic waves,is of urgent concern in contemporary *** this work,CoFe_(2)O_(4)/residual carbon from coal gasification fine slag(CFO/RC)composites were created using a novel hydrothermal *** mechanisms for microwave absorption,including conductive loss,natural resonance,interfacial dipole polarization,and magnetic flux loss,are involved in these ***,compared with pure residual carbon materials,this composite offers superior capabilities in microwave *** 7.76GHz,the CFO/RC-2 composite achieves an impressive minimum reflection loss(RL_(min))of-43.99 dB with a thickness of 2.44 ***,CFO/RC-3 demonstrates an effective absorption bandwidth(EAB)of up to 4.16 GHz,accompanied by a thickness of *** study revealed the remarkable capability of the composite to diminish electromagnetic waves,providing a new generation method for microwave absorbing materials of superior quality.

关键词： coal gasification slag residual carbon hydrothermal method microwave absorption CoFe_(2)O_(4)