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Predicting short-term major postoperative complications in intestinal resection for Crohn’s disease:A machine learning-based study

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World Journal of Gastrointestinal Surgery 2024年第3期16卷 717-730页

作者： Fang-Tao Wang Yin Lin Xiao-Qi Yuan Ren-Yuan Gao Xiao-Cai Wu Wei-Wei Xu Tian-Qi Wu Kai Xia Yi-Ran Jiao Lu Yin Chun-Qiu Chen Diagnostic and treatment center for Refractory Diseases of Abdomen Surgery Shanghai Tenth People’s HospitalTongji University School of MedicineShanghai 200072China

BACKGROUND Due to the complexity and numerous comorbidities associated with Crohn’s disease(CD),the incidence of postoperative complications is high,significantly impacting the recovery and prognosis of ***,additional stu-dies are required to precisely predict short-term major complications following intestinal resection(IR),aiding surgical decision-making and optimizing patient *** To construct novel models based on machine learning(ML)to predict short-term major postoperative complications in patients with CD following *** A retrospective analysis was performed on clinical data derived from a patient cohort that underwent IR for CD from January 2017 to December *** study participants were randomly allocated to either a training cohort or a validation *** logistic regression and random forest(RF)were applied to construct models in the training cohort,with model discrimination evaluated using the area under the curves(AUC).The validation cohort assessed the performance of the constructed *** Out of the 259 patients encompassed in the study,5.0%encountered major postoperative complications(Clavien-Dindo≥III)within 30 d following IR for *** AUC for the logistic model was 0.916,significantly lower than the AUC of 0.965 for the RF *** logistic model incorporated a preoperative CD activity index(CDAI)of≥220,a diminished preoperative serum albumin level,conversion to laparotomy surgery,and an extended operation time.A nomogram for the logistic model was *** for the surgical approach,the other three variables ranked among the top four important variables in the novel ML *** Both the nomogram and RF exhibited good performance in predicting short-term major postoperative complic-ations in patients with CD,with the RF model showing more superiority.A preoperative CDAI of≥220,a di-minished preoperative serum albumin level,and an extended operation time might be the most crucial ***

关键词： Crohn’s disease Postoperative complications Nomogram Random forest Intestinal resection

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Clinical implications of the latest advances in gastrointestinal tumor research

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World Journal of Gastrointestinal Oncology 2024年第10期16卷 4055-4059页

作者： Wei Dai Yuan-Qi Li You Zhou Tumor Biological Diagnosis and treatment center The Third Affiliated Hospital of Soochow UniversityChangzhou 213003Jiangsu ProvinceChina

In this editorial,we provide commentary on six articles recently published in the World Journal of Gastrointestinal *** articles collectively present the latest findings in the field of gastric and colorectal cancer(CRC)*** global incidence of gastric cancer varies based on geographical location,age,and *** disease predominantly affects middle-aged and elderly individuals,with a slightly higher prevalence in men than in *** is characterized by a low 5-year survival rate and high mortality *** primarily affects individuals over the age of 50,and the risk of disease increases with *** gastric and CRC pose significant health threats,thus requiring more effective diagnostic,therapeutic,and supportive care strategies to improve patient *** articles discussed in this editorial encompass topics such as screening,diagnosis,mechanisms of progression,and postoperative recovery in gastric and CRC,and the findings offer valuable insights for clinical decision-making in the diagnosis,treatment,and prognosis of gastrointestinal cancers.

关键词： Gastric cancer Colorectal cancer Screening Diagnosis Mechanisms of progression Postoperative recovery

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The key mediator of diabetic kidney disease:Potassium channel dysfunction

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Genes & Diseases 2024年第4期11卷 188-200页

作者： Jia Guo Chaojie Zhang Hui Zhao Yufan Yan Zhangsuo Liu Nephrology Research center The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan 450052China Key Laboratory of Precision Diagnosis and treatment for Chronic Kidney Disease in Henan Province ZhengzhouHenan 450052China Research center for Kidney Disease ZhengzhouHenan 450052China

Diabetic kidney disease is a leading cause of end-stage renal disease,making it a global public health *** molecular mechanisms underlying diabetic kidney disease have not been elucidated due to its complex ***,exploring these mechanisms from new perspectives is the current focus of research concerning diabetic kidney *** channels are important proteins that maintain the physiological functions of cells and *** ion channels,potassium channels stand out,because they are the most common and important channels on eukaryotic cell surfaces and function as the basis for cell *** potassium channel abnormalities have been found to be closely related to diabetic kid-ney disease progression and genetic susceptibility,such as K_(ATP),K_(ca),K_(ir),and K_(v).In this review,we summarized the roles of different types of potassium channels in the occurrence and devel-opment of diabetic kidney disease to discuss whether the development of DKD is due to potas-sium channel dysfunction and present new ideas for the treatment of DKD.

关键词： Channel dysfunction Diabetic kidney disease End-stage renal disease lon channel Potassium

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Self-assembly multifunctional DNA tetrahedron for efficient elimination of antibiotic-resistant bacteria

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Aggregate 2024年第1期5卷 204-215页

作者： Tiantian Wu Yu Fu Shuang Guo Yanqiang Shi Yuxin Zhang Zhijin Fan Bin Yang Baoquan Ding Yuhui Liao Molecular Diagnosis and treatment center for Infectious Diseases Dermatology HospitalSouthern Medical UniversityGuangzhouChina CAS Key Laboratory of Nanosystem and Hierarchical Fabrication CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijingChina Longgang District Central Hospital of Shenzhen ShenzhenChina

Antibiotic resistance is a major challenge in the clinical treatment of bacterial infectious ***,we constructed a multifunctional DNA nanoplatform as a versatile carrier for bacteria-specific delivery of clinical antibiotic ciprofloxacin(CIP)and classic nanoantibiotic silver nanoparticles(AgNP).In our rational design,CIP was efficiently loaded in the self-assembly double-bundle DNA tetrahedron through intercalation with DNA duplex,and single-strand DNA-modified AgNP was embedded in the cavity of the DNA tetrahedron through *** the site-specific assembly of targeting aptamer in the well-defined DNA tetrahedron,the bacteria-specific dual-antibiotic delivery system exhibited excellent combined bactericidal *** enhanced antibiotic accumulation through breaking the out membrane of bacteria,the antibiotic delivery system effectively inhibited biofilm formation and promoted the healing of infected wounds in *** DNAbased antibiotic delivery system provides a promising strategy for the treatment of antibiotic-resistant infections.

关键词： antibiotic resistance anti-infection therapy biofilm DNA nanotechnology targeted delivery

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High performance photodegradation resistant PVA@TiO_(2)/carboxyl-PES self-healing reactive ultrafiltration membrane

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Chinese Journal of Chemical Engineering 2024年第2期66卷 31-39页

作者： Yu Liang Yuanfang Fan Zhongmin Su Mingxin Huo Xia Yang Hongliang Huo Chi Wang Zhi Geng College of Environment Engineering Research Center of Low-Carbon Treatment and Green Development of Polluted Water in Northeast ChinaMinistry of EducationNortheast Normal UniversityChangchun 130117China School of Science Hainan UniversityHaikou 570225China

The occurrence of ultrafiltration(UF)membrane fouling frequently hampers the sustainable advancement of UF *** self-cleaning UF membranes can effectively alleviate the problem of membrane ***,the self-cleaning process may accelerate membrane *** these concerns,we present an innovative design concept for composite self-healing materials based on self-cleaning UF *** begin,TiO_(2)nanoparticles were incorporated into the polymer molecular structure via molecular design,resulting in the synthesis of TiO_(2)/carboxyl-polyether sulfone(PES)hybrid ***,the nonsolvent-induced phase inversion technique was employed to prepare a novel of UF ***,a polyvinyl alcohol(PVA)hydrogel coating was applied to the hybrid UF membrane surface to create PVA@TiO_(2)/carboxyl-PES self-healing reactive UF *** establishing a covalent bond,the TiO_(2)nanoparticles were effectively and uniformly dispersed within the UF membrane,leading to exceptional self-cleaning ***,the water-absorbing and swelling properties of PVA hydrogel,along with its capacity to form hydrogen bonds with water molecules,resulted in UF membranes with improved hydrophilicity and active self-healing *** results demonstrated that the water contact angle of PVA@5%TiO_(2)/carboxyl-PES UF membrane was 43.1°.Following a 1-h exposure to simulated solar exposure,the water flux recovery ratio increased from 48.16%to 81.03%.Moreover,even after undergoing five cycles of 12-h simulated sunlight exposure,the UF membranes exhibited a consistent retention rate of over 97%,thus fully demonstrating their exceptional self-cleaning,antifouling,and selfhealing *** anticipate that the self-healing reactive UF membrane system will serve as a pioneering and comprehensive solution for the self-cleaning antifouling challenges encountered in UF membranes while also effectively mitigating the aging effects of reactive

关键词： Ultrafiltration membrane Self-cleaning Self-healing Poly(aryl ether sulfone)

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Nanosize-effect on the distribution of heavy metals in copper smelting dust:Based on sophisticated dust sorting approach

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Nano Research 2024年第1期17卷 312-320页

作者： Ken Li Zuwu Liao Hengdi Ye Qingzhu Li Fenghua Shen Qian Li Hui Liu Qingwei Wang Xu Yan Zhang Lin Liyuan Chai School of Metallurgy and Environment Central South UniversityChangsha 410083China Chinese National Engineering Research center for Control&treatment of Heavy Metal Pollution Changsha 410083China National Engineering Research center of Sintering and Pelletizing Equipment System Zhongye Changtian International Engineering Co.LtdChangsha 410205China

Dust particles emitted from smelters can be hazardous to ecosystems and humans,as they are often enriched in metallic ***,we combined multi-method mineralogical analysis with a sophisticated size sorting approach for copper smelting dust to study the nanosize-effect on heavy metal distribution,which has hitherto been *** types of dust were collected from a copper flash smelter and then size-sorted using a Dekati low-pressure *** showed that all three samples could easily sort out nanoscale dust particles(<1μm,grades 10–2)and even those smaller than 100 nm(grades 5–2).Especially for electrostatic precipitators dust,the mass fraction of nanoscale dust(<1μm)could reach 10.71%.The presence of heavy metals(Pb,Zn,Cu,and As)and their mineral species in dust was examined at various particle *** was discovered that different heavy metals are enriched on nanoparticles in specific *** micron-sized particles,heavy metals are generally found in discrete phases(e.g.,CuSO_(4),PbSO_(4),and As_(2)O_(3)).In nanoscale particles,the dominant phase is Fe_(3)O_(4),while heavy metals are mostly found in lattice substitution(e.g.,CuFe_(2)O_(4)and ZnFe_(2)O_(4)).Two distinct nano-dust morphologies were found:One with irregular mesh or chain structures consisting of particles of a few nanometers,and the other with polygonal crystals in larger sizes of hundreds of *** enrichment of heavy metals in the latter morphology is more pronounced,possibly because lattice substitution of heavy metals is more likely to occur when polycrystalline particles are formed.

关键词： copper flue dust size-sorted heavy metal distribution morphology nano-sized effects

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High Levels of Vitamin C Intake Modify Effects of Phthalates on Metabolic Dysfunction-associated Steatotic Liver Disease:A Nationally Representative Study

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Journal of Clinical and Translational Hepatology 2024年第10期12卷 892-895页

作者： Ruoqi Zhou Yuwei Wang Xinxin Liu Xia Yu Dajing Xia Yihua Wu Yu Shi State Key Laboratory for Diagnosis and treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiangChina Department of Toxicology of School of Public Health and Department of Gynecologic Oncology of Women’s Hospital Zhejiang University School of MedicineHangzhouZhejiangChina

Metabolic dysfunction-associated steatotic liver disease(MASLD)is a growing cause of chronic liver diseases worldwide,with a global prevalence of 38%.1 Patients with MASLD are at risk of developing liver-related complications,such as cirrhosis,hepatocellular carcinoma,and extra-hepatic adverse events.1 In recent years,endocrine-disrupting chemicals(EDCs)have been linked to the development and progression of MASLD.

关键词： Metabolic liver diseases

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Potential risks of organic contaminated soil after persulfate remediation:Harmful gaseous sulfur release

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Journal of Environmental Sciences 2024年第1期135卷 1-9页

作者： Yuyang Long Zixiao Wu Xiaodong Ding Jiansong Chen Dongsheng Shen Jiali Shentu Cai Hui Zhejiang Provincial Key Laboratory of Solid Waste treatment and Recycling Zhejiang Engineering Research Center of Non-ferrous Metal Waste RecyclingInstrumental Analysis CenterSchool of Environmental Science and EngineeringZhejiang Gongshang UniversityHangzhou 310012China Shangyu Yingtai Fine Chemical Co. Ltd.Shaoxing 312000China Hangzhou Ecological Environment Monitoring center Hangzhou 310007China

Persulfate is considered a convenient and efficient remediation agent for organic contaminated ***,the potential risk of sulfur into the soil remediation by persulfate remains *** this study,glass bottles with different persulfate dosages and groundwater tables were set up to simulate persulfate remediation of organic pollutants(aniline).The results found sulfate to be the main end-product(83.0%–99.5%)of persulfate remediation after10 ***,H_(2)S accounted for 93.4%–99.4%of sulfur reduction end-products,suggesting that H_(2)S was the final fate of sulfur.H_(2)S was released rapidly after one to three days at a maximum concentration of 33.0 ppm,which is sufficient to make a person *** to the fitted curve results,H_(2)S concentration decreased to a safe concentration(0.15 ppm)after 20–85 ***,the maximum concentration of methanethiol reached 0.6 *** results indicated that secondary pollution from persulfate remediation could release harmful gases over a long ***,persulfate should be used more carefully as a remediation agent for soil contamination.

关键词： Gaseous sulfur release H_2S Long period potential risk Organic contaminated soil remediation Persulfate

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Correlation of Oral Microbiota With Different Immune Responses to Antiretroviral Therapy in People Living With HIV

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Infectious Microbes & Diseases 2024年第2期6卷 85-92页

作者： Jingying Pan Xiaodi Zhang Danrong Shi Xuebin Tian Lijun Xu Xiangyun Lu Mingqing Dong Peng Yao Zhaoyi Pan Nanping Wu Hangping Yao State Key Laboratory for Diagnosis and treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhouChina Department of Infectious Disease Zhejiang Qingchun HospitalZhejiang UniversityHangzhouChina Jinan Microecological Biomedicine Shandong Laboratory JinanChina

Both HIV infection and antiretroviral therapy(ART)affect the oral *** successful treatment with ART in people living with HIV(PLWH),which leads to a significant decline in viral loads and immune reconstitution,is associated with changes in or recovery of the oral microbiome remains ***,we performed a cross-sectional study of 118 PLWH receiving regular ART and 40 healthy controls(HCs).Among the 118 PLWH,18 immunological nonresponders(INRs;<200 CD4^(+)T cells/μL)and 30 immunological responders(IRs;≥500 CD4^(+)T cells/μL)were *** oral microbiota composition of all participants was analyzed using 16S rRNA gene sequencing of throat swab *** abundance of bacterial genera was compared between IRs and INRs,and Pearson correlations between bacterial abundance and peripheral blood immune cell counts were *** INR group showed lower alpha diversity than the IR and HC groups,which displayed similar alpha *** genera Alloprevotella,Prevotella and Neisseria were more abundant in PLWH than in HCs,whereas the genera Rothia,Streptococcus and Fusobacterium were more abundant in HCs than in *** genus Rothia was more abundant in the INR group,whereas Prevotella,Alloprevotella,Porphyromonas and Haemophilus were more abundant in the IR *** genera Rothia and Alloprevotella were negatively and positively associated with CD4^(+)T cell counts,***,an increased abundance of Rothia in the oral microbiome is associated with unfavorable outcomes regarding immune reconstitution in PLWH receiving regular ART,whereas Prevotella,Alloprevotella,Porphyromonas and Haemophilus are associated with favorable outcomes.

关键词： HIV oral microbiome antiretroviral therapy immunological nonresponders immunological responders

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Quantitative assessment of the impact of a triage physician on the Accreditation Council for Graduate Medical Education resident milestones in the emergency department

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World Journal of Emergency Medicine 2024年第3期15卷 220-222页

作者： Julie Cueva Duncan Grossman Vishnu Muppala Arlene Chung Mahlaqa Butt Jefferson Drapkin Antonios Likourezos Errel Khordipour Department of Emergency Medicine Maimonides Medical CenterNew York 11219USA

The “door-to-doctor” time for patients to be seen by a physician is an increasingly studied *** may shorten this time by implementing a triage physician (TP).The exact role of a TP may vary across *** put in preliminary orders for lab work,imaging,and treatment,and decide treatment location for further *** the prevalence of TPs grows,its effect on resident education in academic emergency departments (EDs) remains *** implemented a TP in the spring of 2016 and assessed resident physicians before and after implementation.

关键词： physician doctor treatment

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