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第十届全国免疫学学术大会

作者： Ludmila Rodrigues Pinto Ferreira Frederico Moraes Ferreira Monique Andrade Baron Darlan da Silva Candido Laurie Laugier Sandrine Cabantous Amanda Farage Frade Ronaldo Honorato Barros Santos Christophe Chevillard Jorge Kalil Edecio Cunha-Neto Laboratory of Immunology Heart Institute (InCor) University of Sao PauloSchool of Medicine division of Clinical Immunology and Allergy University of Sao Paulo School of Medicine Universidade Santo Amaro (UNISA) INSERM U906 Aix-Marseille University AMU Faculte de Medecine division of Transplantation Heart Institute (InCor) University of Sao PauloSchool of Medicine

Chronic Chagas Cardiomyopathy (CCC) is the severe manifestation of Chagasdisease, caused by infection with the protozoan parasite Trypanosoma *** is characterized by myocardial inflammation, arrhythmias, heart

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加拿大多伦多肺移植新进展(附视频)

中华移植杂志（电子版） 2011年第2期5卷 48-49页

作者： Thomas K. Waddell Toronto Lung Transplant Program Division of ThoracicSurgeryToronto General Hospital

（编者按：本文根据Waddell教授在2010年第5届全国心肺移植高级研讨会上讲课内容归纳整理）自1983年多伦多总院肺移植团队完成世界上第1例成功的肺移植以来,该院肺移植中心每年（1983年至2008年5月）的手术例数稳步增长,受者术后病死率... 详细信息

（编者按：本文根据Waddell教授在2010年第5届全国心肺移植高级研讨会上讲课内容归纳整理）自1983年多伦多总院肺移植团队完成世界上第1例成功的肺移植以来,该院肺移植中心每年（1983年至2008年5月）的手术例数稳步增长,受者术后病死率明显下降。肺移植手术适应证的前三项疾病分别为慢性阻塞性肺疾病（33%）、

关键词：肺移植多伦多禁忌证体外膜肺氧合离体肺灌注供者视频

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氟氯烃替代物的开发现状

世界环境 1990年第3期 39-41页

作者：严珊琴刘大澂 CFCs Planning and Strategy division Bureau of CapitalMinistry of IndustryJapan

1.特定氟氯烃的使用状况在日本,特定的氟氯烃(CFC—11CFC—12、CFC—113、CFC—114,CFC—115)实际消费量,以蒙特利尔议定书规定1986年为基准年时是13.3万吨,1988年为16.4万吨,两年间增加了26％。为此,从1989年7月起,作为第一个氟氯烃控... 详细信息

1.特定氟氯烃的使用状况在日本,特定的氟氯烃(CFC—11CFC—12、CFC—113、CFC—114,CFC—115)实际消费量,以蒙特利尔议定书规定1986年为基准年时是13.3万吨,1988年为16.4万吨,两年间增加了26％。为此,从1989年7月起,作为第一个氟氯烃控制年(1989年7月～1990年6月),全日本将削减26％。图1示出了1986、1988年的实际数据。

关键词：氟氯烃蒙特利尔议定书基准年化学物质亚急性毒性慢性毒性水溶解度 CFCs 地球温室效应臭氧层破坏

Diffuse intrinsic pontine glioma:current insights and future directions

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Chinese Neurosurgical Journal 2021年第4期7卷 289-299页

作者： Dilakshan Srikanthan Michael S.Taccone Randy Van Ommeren Joji Ishida Stacey L.Krumholtz James T.Rutka Cell Biology Program The Hospital for Sick Children686 Bay StTorontoON M5G 0A4Canada The Arthur and Sonia Labatt Brain Tumour Research Centre The Hospital for Sick Children686 Bay StTorontoON M5G 0A4Canada Department of Laboratory Medicine and Pathobiology University of TorontoTorontoONCanada division of Neurosurgery Department of SurgeryThe Ottawa HospitalOttawaONCanada developmental and Stem Cell Biology Program The Hospital for Sick Children686 Bay StTorontoON M5G 0A4Canada Institute of Medical Sciences University of TorontoTorontoONCanada division of Neurosurgery Department of SurgeryThe Hospital for Sick ChildrenSuite 1503555University AvenueTorontoON M5G 1X8Canada

Diffuse intrinsic pontine glioma(DIPG)is a lethal pediatric brain tumor and the leading cause of brain tumor–related death in *** several clinical trials over the past few decades have led to no significant improvements in outcome,the current standard of care remains fractionated focal *** to the recent increase in stereotactic biopsies,tumor tissue availabilities have enabled our advancement of the genomic and molecular characterization of this lethal *** groups have identified key histone gene mutations,genetic drivers,and methylation changes in DIPG,providing us with new insights into DIPG ***,there has been increased development of in vitro and in vivo models of DIPG which have the capacity to unveil novel therapies and strategies for drug *** review outlines the clinical characteristics,genetic landscape,models,and current treatments and hopes to shed light on novel therapeutic avenues and challenges that remain.

关键词： Diffuse intrinsic pontine glioma Molecular genetics Neuro-oncology Therapeutics Disease models Pediatrics Neurosurgery

Carrageenan-Induced Non-Painful Inflammation Reduces Voluntary Sucrose Consumption in a Two-Bottle Choice Paradigm: A new Model of Inflammation Induced Anhedonia

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Journal of Behavioral and Brain Science 2020年第3期10卷 153-164页

作者： Marco A. Sotomayor-Sobrino Abraham Ochoa-Aguilar Ulises R. Coffeen-Medina Roberto Velasco-González Gilberto Pérez-Sánchez Gloria M. Capula-León Israel Luna-Mendoza Lenin Pavón-Romero Claudia Gómez-Acevedo Pharmacology Department Faculty of Medicine National University of Mexico Mexico City Mexico Neuroscience division National Institute og Psychiatry “Ramón de la Fuente Muñiz” Mexico City Mexico

Anhedonia, the presence of diminished pleasure or decreased motivation for rewards is considered one of the core symptoms of depression. Studies have shown that anhedonia and reduced reward learning predict a poor prognosis with a higher prevalence of treatment failure among patients. Several mechanisms have been implicated in the onset and progression of depression;furthermore, an important amount of evidence supports not only the importance of the reward circuitry in the development of depressive anhedonia but also, that it is closely related with the presence of inflammation. In the current paper we show that 500 ul carrageenan administration in the right hind paw after deafferentation surgery leads to anhedonia, which is evident by a decrease in saccharine consumption in a two-bottle choice test;these findings suggest that carrageenan mediated inflammation is a reliable model of anhedonia that could lead to a better understanding of the immune-neural axis in motivation.

关键词： Anhedonia Inflammation Animal Model Motivation

TNF<i>α</i>and IL1<i>β</i>Stimulate Differential Gene Expression in Endometrial Stromal Cells

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Advances in Biological Chemistry 2015年第2期5卷 126-141页

作者： Abha J. Chalpe Chad D. Law Jennifer N. Dumdie Keith A. Hansen Kathleen M. Eyster division of Basic Biomedical Sciences Sanford School of Medicine The University of South Dakota Vermillion SD USA Department of Obstetrics and Gynecology Sanford School of Medicine The University of South Dakota Sioux Falls SD USA

The purpose of this study was to test the hypothesis that specific macrophage-secreted cytokines cause gene expression changes in endometrial stromal cells that reproduce the effects of macro-phages in the development of endometriosis. Telomerase-immortalized human endometrial stromal cells (T-HESC) were treated with tumor necrosis factor α (TNFα, 5 ng/ml) and interleukin 1β (IL1β, 1 ng/ml). Differential expression of 249 genes was identified by DNA microarray. Ontologies such as peptidases, cell adhesion, cell death/cell cycle, growth factors, cytoskeletal organization, defense/immune system, signal transduction, and transcriptional regulation which are related to the development of endometriosis were represented by these genes. The up-regulation of interleukin 8 (IL8), interleukin 6 (IL6), IL1β and matrix metallopro-teinase 3 (MMP3) in response to TNFα ± ILIβ in T-HESC cells was confirmed by real time RT-PCR. TNFα ± ILIβ did not affect the migration or invasion of T-HESC cells. This study reinforces our previous investigations on communication between cells of the immune system and endometrial stromal cells and their potential role in the development of endometriosis.

关键词： Cytokines Endometriosis Endometrium Endometrial Stromal Cells Microarray Gene Expression

Factors Affecting the Perception of Family Functioning among Couples in Child-Rearing Japanese Families

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Open Journal of Nursing 2015年第5期5卷 407-415页

作者： Junko Honda Yuuri Nakai Shota Kakazu Naohiro Hohashi division of Family Health Care Nursing Department of Nursing Graduate School of Health Sciences Kobe University Hyogo Japan Department of Nursing Faculty of Health Sciences School of Medicine Kobe University Hyogo Japan

In family healthcare nursing, the family system unit (i.e., a group in which the members, seen as a whole, mutually interact) is the target of care. As nurses tend to obtain family-related information from particular family members in the clinical setting, when assessing families, they often confront the issue of the differences between the theoretical level and methodological level. Although this issue needs resolving for evidence-based family nursing practice, sufficient research is lacking on the methodology related to family assessment. The present study aimed to clarify the factors that affected evaluation of family functioning among couples. Semi-structured interviews were conducted with 10 child-rearing families (couples) using the Survey of Family Environment (SFE) as a family functioning scale. Content analysis identified 12 factors that affected discrepancies in the couples’ evaluations and eight factors that affected agreement in those evaluations. These factors were classified into three categories: factors concerning family or family members;factors concerning questions related to the SFE;and factors concerning the view of the family as a whole. The results of this study should contribute to the development of family assessment tools and effective methods for evaluation of family care.

关键词： Family Functioning Discrepancy Survey of Family Environment (SFE) Japan Concentric Sphere Family Environment Theory (CSFET)

在肺结核诊断中应用系列痰涂片的结果:系统综述

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国际结核病与肺部疾病杂志 2007年第3期2卷 71-80页

作者： S.R.Mase A.Ramsay V.Ng M.Henry P.C.Hopewell J.Cunningham R.Urbanczik M.D.Perkins M.A.Aziz M.Pai 张宗德张立兴 division of Pulmonary and Critical Care Medicine San Francisco General HospitalUniversity of California Francis J Curry National Tuberculosis Center University of California United Nations Children's Fund/United Nations development Programme/World Bank/World Health Organization(WHO)Special Programme for Research and Training in Tropical Diseases(TDR) WHO Albany Medical College County of Sacramento Department of Health and Human Services Sacramento WHO Tuberculosis Laboratory Consultants Group Foundation for Innovative new Diagnostics(FIND) GenevaStop TB DepartmentWHO Stop TB Department WHO Department of Epidemiology & Biostatistics McGill University

目前的国际结核病(TB)指南推荐在对肺结核可疑患者评价时应用3次痰涂片镜检以寻找结核菌。我们对符合3次痰标本结果标准的研究进行了系统的评价。通过对多个数据库和资源的检索,我们确定了共37个合格的研究。第3份标本中涂阳结果的增加... 详细信息

目前的国际结核病(TB)指南推荐在对肺结核可疑患者评价时应用3次痰涂片镜检以寻找结核菌。我们对符合3次痰标本结果标准的研究进行了系统的评价。通过对多个数据库和资源的检索,我们确定了共37个合格的研究。第3份标本中涂阳结果的增加(所有培阳病例作为分母的研究)和敏感性的增高(所有培阳病例作为分母的研究)是我们关注的主要结果。虽然各研究的方法和结果不同对数据综合构成了挑战,但亚组的分析提示对第3份标本的检查使结果和/或敏感性平均增加了2%～ 5%。把推荐的标本检查数量从3份减至2份(特别是在同一天收集的2份标本)对结核控制项目有利。有很多理由可潜在增加病例检出;许多实施性研究问题需要强调。如果按照国际间协调和标准化的方法,在痰标本镜检时应用现行技术检验哪种方法最有效,这样的研究会是最有用的,既可以增加本国的数据,又可进行研究之间的对比。

关键词：结核痰显微镜检查结果增加抗酸菌系列痰标本

Polymorphism AGT2(rs4762)is involved in the development of dermatologic events:Proof-of-concept in hepatocellular carcinoma patients treated with sorafenib

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World Journal of Hepatology 2022年第7期14卷 1438-1458页

作者： Víctor Sapena Massimo Iavarone Loreto Boix Floriana Facchetti Maria Guarino Marco Sanduzzi Zamparelli Alessandro Granito Esther Samper Mario Scartozzi Josep Corominas Giorgia Marisi Alba Díaz Andrea Casadei-Gardini Laura Gramantieri Pietro Lampertico Filomena Morisco Ferran Torres Jordi Bruix María Reig Barcelona Clinic Liver Cancer Group Liver UnitHospital Clínic de BarcelonaInstitut d'Investigacions Biomèdiques August Pi SunyerCentro de Investigación Biomédica en Red Enfermedades Hepáticas y DigestivasBarcelona 08036Spain Universidad de Barcelona Barcelona 08036Spain division of Gastroenterology and Hepatology Foundation Istituto di Ricovero e Cura a Carattere Scientifico di Natura Pubblica Ca’Granda Ospedale Maggiore PoliclinicoMilano 20122Italy Department of Clinical Medicine and Surgery Gastroenterology UnitUniversity of Naples Federico IINaples 80131Italy Gastroenterology and Hepatology Unit Fondazione Istituto di Ricovero e Cura a Carattere Scientifico di Natura Pubblica CàGranda Ospedale Maggiore PoliclinicoUniversity of MilanMilan 20100Italy Department of Clinical Medicine and Surgery Gastroenterology UnitUniversity of Naples"Federico II"Napoli 80100Italy Department of Clinical Medicine and Surgery Gastroenterology and HepatologyFederico II University of NaplesNaples 80131Italy division of Internal Medicine Hepatobiliary and Immunoallergic DiseasesIstituto di Ricovero e Cura a Carattere Scientifico di Natura Pubblica Azienda Ospedaliero-Universitaria di BolognaBologna 40139Italy Department of Medical and Surgical Sciences University of BolognaBologna 40139Italy Department of Medical Oncology University of CagliariCagliari 45698Italy Biosciences Laboratory Istituto di Ricovero e Cura a Carattere Scientifico di Natura PubblicaIstituto Romagnolo per lo Studio dei Tumori“Dino Amadori”Meldola 47014Italy Department of Pathology Hospital Clínic de BarcelonaUniversitat de BarcelonaBarcelona 08036Spain School of Medicine Vita-Salute San Raffaele UniversityMilan 20132Italy Unit of Oncology UniversitàVita-SaluteIstituto di Ricovero e Cura a Carattere Scientifico di Natura Pubblica-San Raffaele Scientific InstituteMilan 20132Italy division of Internal Medicine Hepatobiliary and Immunoallergic DiseasesIstituto di Ricovero e Cura a Carattere Scientifico di Natura Pubblica Aziend

BACKGROUND Dermatologic adverse events(DAEs)are associated with a better outcome in patients with hepatocellular carcinoma(HCC)irrespective of the therapeutic agent *** exact mechanisms associated with the development of DAEs are unknown although several studies point to direct toxicity of tyrosine kinase inhibitors(TKIs)to the skin or an immune-mediated reaction triggered by the oncologic *** is the case in other conditions,individual genetic variants may partially explain a higher risk of *** To evaluate the contribution of several gene variants to the risk of developing DAEs in HCC patients treated with *** We first analyzed 27 single-nucleotide polymorphisms(SNPs)from 12 genes selected as potential predictors of adverse event(AE)development in HCC patients treated with sorafenib[Barcelona Clinic Liver Cancer 1(BCLC1)cohort].Three additional cohorts were analyzed for AGT1(rs699)and AGT2(rs4762)polymorphisms-initially identified as predictors of DAEs:BCLC2(n=79),Northern Italy(n=221)and Naples(n=69)cohorts,*** relation between SNPs and DAEs and death were assessed by univariate and multivariate Cox regression models,and presented with hazard ratios and their 95%confidence intervals(95%CI).RESULTS The BCLC1 cohort showed that patients with arterial hypertension(AHT)(HR=1.61;P value=0.007)and/or AGT SNPs had an increased risk of ***,AGT2(rs4762)AA genotype was found to be linked to a statistically significant increased probability of DAEs(HR=5.97;P value=0.0201,AA vs GG)in the Northern Italy cohort by multivariate analysis adjusted for BCLC stage,ECOG-PS,diabetes and *** value of this genetic marker was externally validated in the cohort combining the BCLC1,BCLC2 and Naples cohorts[HR=3.12(95%CI:1.2-8.14),P value=0.0199,AGT2(rs4762)AA vs AG genotype and HR=2.73(95%CI:1.18-6.32)P value=0.0188,AGT2(rs4762)AA vs GG genotype].None of the other gene variants tested were found to be associated with the risk of D

关键词： HCC Early DAE Single-nucleotide polymorphisms AGT1(rs699) AGT2(rs4762),Tyrosine kinase inhibitors

一亚热带蜚蠊(Periplaneta japanna)两地理种群间相异的光周期反应模式(英文)

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生态学报 2007年第9期27卷 3687-3693页

作者：朱道弘 Seiji Tanaka 中南林业科技大学资源与环境学院湖南长沙410004 Laboratory of Insect Life Cycles and Physiology Division of Insect and Animal SciencesIndependent Administrative InstitutionTsukubaJapan

为弄清光周期对一种亚热带蜚蠊(Periplaneta japanna)若虫发育的控制机理,检测了光周期对冲绳(26°N)和八丈岛(33°N)两个地理种群若虫发育的影响。结果表明,光周期显著影响两地理种群的若虫发育,然而,冲绳和八丈岛种群间显示不同的光... 详细信息

为弄清光周期对一种亚热带蜚蠊(Periplaneta japanna)若虫发育的控制机理,检测了光周期对冲绳(26°N)和八丈岛(33°N)两个地理种群若虫发育的影响。结果表明,光周期显著影响两地理种群的若虫发育,然而,冲绳和八丈岛种群间显示不同的光周期反应模式。冲绳种群在长日条件下(LD16∶8h)若虫发育显著快于中间日长(LD14∶10h)和短日条件下(LD12∶12h)的若虫发育,孵化后60d或120d将若虫自LD16∶8h向LD12∶12h转移,若虫发育受到抑制,而自LD12∶12h向LD16∶8h转移,则促进若虫发育。八丈岛种群的若虫在短日条件下发育最快,其次是中间日长,长日条件下若虫发育最慢,孵化后60d或120d将若虫自LD16∶8h向LD12∶12h转移抑制若虫发育,反方向转移的若虫快速发育。两地理种群间不同的光周期反应模式可以认为是趋异进化的结果。

关键词：蜚蠊光周期地理变异滞育亚热带 Periplaneta japanna