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Endoscopic management of obstructing pouch twist

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Gastroenterology Report 2022年第1期10卷 659-660页

作者： Sriya Pokala Bo Shen Division of Colorectal Surgery and center for Inflammatory Bowel Disease Columbia University Irving Medical CenterNew York Presbyterian HospitalNew YorkNYUSA

Introduction Restorative proctocolectomy with ileal pouch–anal anastomosis(IPAA)has been a standard of surgical management of medically refractory ulcerative colitis(UC),UC with neoplasia,or familial adenomatous *** IPAA significantly improves patients’health-related quality of life,complications are *** complications include anastomotic leaks,abscesses,pouch strictures,pouchitis,and fistulas[2,3].

关键词： anastomosis twist patients

Surgery for Crohn’s disease:upfront or last resort?

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Gastroenterology Report 2022年第1期10卷 188-194页

作者： U.Ahmed Ali Ravi P.Kiran Division of Colorectal Surgery New York–Presbyterian/Columbia University Medical CenterNew YorkUSA

Crohn’s disease(CD)can involve the entire gastrointestinal tract from the mouth to the anus and can lead to a constellation of *** the advancement of effective medical treatments for CD,a tendency has emerged to consider surgical treatment as a last *** potentially has the disadvantage of delaying surgery and if it fails might leave patients sicker,less well nourished,and with more severe *** with most non-malignant diseases,the choice of surgery vs medical treatment is a patient’s personal preference under the guidance of the treating physician,except in extreme situations where surgery might be the only *** this article,we will discuss the available evidence regarding the optimal timing of surgery in CD,focusing on whether early surgery can bring benefits in terms of disease control,symptom relief,and quality of life.

关键词： surgery timing Crohn’s disease outcome

Circulating microRNA expression and nonalcoholic fatty liver disease in adolescents with severe obesity

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World Journal of Gastroenterology 2024年第4期30卷 332-345页

作者： Yi-Jie Li Brittney O Baumert Nikos Stratakis Jesse A Goodrich Hao-Tian Wu Jing-Xuan He Yin-Qi Zhao Max T Aung Hong-Xu Wang Sandrah P Eckel Douglas I Walker Damaskini Valvi Michele A La Merrill Justin R Ryder Thomas H Inge Todd Jenkins Stephanie Sisley Rohit Kohli Stavra A Xanthakos Andrea A Baccarelli Rob McConnell David V Conti Lida Chatzi Department of Population and Public Health Sciences Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCA 90032United States Barcelona Institute of Global Health Barcelona Institute of Global HealthBarcelona 08036Spain Department of Environmental Health Sciences Mailman School of Public HealthColumbia UniversityNew YorkNY 10032United States Gangarosa Department of Environmental Health Rollins School of Public HealthEmory UniversityAtlantaGA 30329United States Department of Environmental Medicine and Public Health Icahn School of Medicine at Mount SinaiNew YorkNY 10029United States Department of Environmental Toxicology University of CaliforniaDavisCA 95616United States Department of Surgery Lurie Children’s Hospital of ChicagoChicagoIL 60611United States Northwestern university Feinberg School of Medicine Northwestern UniversityChicagoIL 60611United States Division of Biostatistics and Epidemiology Cincinnati Children's Hospital Medical CenterCincinnatiOH 45229United States Department of Pediatrics University of Cincinnati College of MedicineCincinnatiOH 45229United States Department of Pediatrics Children’s Nutrition Research Center USDA/ARSBaylor College of MedicineHoustonTX 77030United States Department of Gastroenterology Children’s Hospital Los AngelesLos AngelesCA 90027United States Division of Gastroenterology Hepatology and NutritionCincinnati Children's Hospital Medical CenterCincinnatiOH 45229United States

BACKGROUND Nonalcoholic fatty liver disease(NAFLD)is one of the most common chronic liver diseases in children and *** ranges in severity from isolated hepatic steatosis to nonalcoholic steatohepatitis(NASH),wherein hepatocellular inflammation and/or fibrosis coexist with *** microRNA(miRNA)levels have been suggested to be altered in NAFLD,but the extent to which miRNA are related to NAFLD features remains *** analysis tested the hypothesis that plasma miRNAs are significantly associated with histological features of NAFLD in *** To investigate the relationship between plasma miRNA expression and NAFLD features among adolescents with *** This study included 81 adolescents diagnosed with NAFLD and 54 adolescents without NAFLD from the Teen-Longitudinal Assessment of Bariatric Surgery ***-operative core liver biopsies were collected from participants and used to characterize histological features of *** samples were collected during surgery for miRNA profiling.A total of 843 plasma miRNAs were profiled using the HTG EdgeSeq *** examined associations of plasma miRNAs and NAFLD features using logistic regression after adjusting for age,sex,race,and other key *** Pathways Analysis was used to identify biological functions of miRNAs that were associated with multiple histological features of *** We identified 16 upregulated plasma miRNAs,including miR-193a-5p and miR-193b-5p,and 22 downregulated plasma miRNAs,including miR-1282 and miR-6734-5p,in adolescents with ***,52,16,15,and 9 plasma miRNAs were associated with NASH,fibrosis,ballooning degeneration,and lobular inflammation,***,16 miRNAs were associated with two or more histological features of *** those miRNAs,miR-411-5p was downregulated in NASH,ballooning,and fibrosis,while miR-122-5p,miR-1343-5p,miR-193a-5p,miR-193b-5p,and miR-7845-5p were consistently and posi

关键词： MicroRNA Nonalcoholic fatty liver disease Non-alcoholic steatohepatitis Liver fibrosis Lobular inflammation Ballooning degeneration

Exclusively endoscopic surgical resection of esthesioneuroblastoma: A systematic review

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2022年第1期8卷 66-72页

作者： Daniel B.Spielman Andi Liebowitz Maeher Grewal Chetan Safi Jonathan B.Overdevest Alfred M.Iloreta Brett E.Youngerman David A.Gudis Department of Otolaryngology-Head and Neck Surgery New York-Presbyterian Hospital-Columbia University Irving Medical CenterNew YorkNew YorkUSA Department of Otolaryngology-Head and Neck Surgery The Mount Sinai Hospital/lcahn School of Medicine at Mount SinaiNew YorkNew York.USA Department of Neurological Surgery New York-Presbyterian Hospital-Columbia University Irving Medical CenterNew YorkNew YorkUSA

Background:Historically sinonasal malignancies were always addressed via open craniofacial surgery for an oncologic *** esthesioneuroblastomas are excised using an exclusively endoscopic approach,however,the rarity of this disease limits the availability of long-term and large scale outcomes ***:The primary objective is to evaluate the treatment modalities used and the overall survival of patients with esthesioneuroblastoma managed with exclusively endoscopic ***:In accordance with PRISMA guidelines,PubMed was queried to identify studies describing outcomes associated with endoscopic management of ***:Forty-four out of 2462 articles met inclusion criteria,totaling 399 patients with esthesioneuroblastoma treated with an exclusively endoscopic ***-two patients(18.0%)received adjuvant chemotherapy and 331 patients(83.0%)received postoperative radiation *** average age was 50.6 years old(range 6-83).Of the 399 patients,57(16.6%)were Kadish stage A,121(35.2%)were Kadish stage B,145(42.2%)were Kadish stage C,and 21(6.1%)were Kadish stage *** analysis demonstrated that 66.0%of patients had Hyams histologic GradeⅠorⅡ,while 34.0%of patients had GradeⅢorⅣ*** surgical margins were achieved in 86.9%of patients,and recurrence was identified in 10.3%of *** those with 5-year follow-up,reported overall survival was 91.1%.Conclusion:Exclusively endoscopic surgery for esthesioneuroblastoma is performed for a wide range of disease stages and grades,and the majority of these patients are also treated with adjuvant chemotherapy or radiation *** overall recurrence rate is 10.3%and 5-year survival is 91.1%.

关键词： anterior skull base endoscopic skull base surgery esthesioneuroblastoma olfactory neuroblastoma skull base

Simulation training in endoscopic skull base surgery: A scoping review

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2022年第1期8卷 73-81页

作者： Joel James Alexandria L.I race David A.Gudis Jonathan B.Overdevest City university of new york School of Medicine New YorkNew YorkUSA Department of Otolaryngology-Head and Neck Surgery Columbia University Vagelos College of Physicians and SurgeonsColumbia University Irving Medical CenterNew York-Presbyterian HospitalNew YorkNew YorkUSA

Objective:Proficiency in endoscopic endonasal skull base surgery requires both substantial baseline training and progressive lifelong *** simulation models continue to evolve in an effort to optimize trainee education and preoperative preparation and improve surgical *** current scoping review systematically reviews all available literature and synthesizes the current paradigms of simulation models for endoscopic skull base surgery training and skill ***:In accordance with Preferred Reporting Items for Systemic Review and Meta-Analyses guidelines,we systematically searched PubMed,Embase,CINAHL,and Cochrane *** were categorized according to the type of simulation models ***:We identified 238 unique references,with 55 studies ultimately meeting inclusion *** these,19 studies described cadaveric dissection models,17 discussed three-dimensional(3D)printed models,14 examined virtual surgical planning and augmented reality-based models,and five 5 articles described task ***:There are a wide variety of simulation models for endoscopic skull base surgery,including high-fidelity cadaveric,virtual reality,and 3D-printed *** models are an asset for trainee development and preoperative surgical preparation.

关键词： resident education skull base surgery surgical simulation training virtual reality virtual surgical planning

KLF17 promotes human naive pluripotency through repressing MAPK3 and ZIC2

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Science China(Life Sciences) 2022年第10期65卷 1985-1997页

作者： Shao-Hua Wang Jing Hao Chao Zhang Fei-Fei Duan Ya-Tzu Chiu Ming Shi Xin Huang Jihong Yang Huiqing Cao Yangming Wang Institute of Molecular Medicine College of Future TechnologyPeking UniversityBeijing 100871China Department of Medicine Columbia Center for Human DevelopmentColumbia Stem Cell InitiativeHerbert Irving Comprehensive Cancer CenterColumbia University Irving Medical CenterNew YorkNY 10032USA

The pluripotent state of embryonic stem cells(ESCs)is regulated by a sophisticated network of transcription *** expression of KLF17 has recently been identified as a hallmark of naive state of human ESCs(h ESCs).However,the functional role of KLF17 in naive state is not ***,by employing various gain and loss-of-function approaches,we demonstrate that KLF17 is essential for the maintenance of naive state and promotes the primed to naive state transition in h ***,we identify MAPK3 and ZIC2 as two direct targets repressed by *** of MAPK3 or ZIC2 partially blocks KLF17 from promoting the naive ***,we find that human and mouse homologs of KLF17 retain conserved functions in promoting naive pluripotency of both ***,we show that Klf17 may be essential for early embryo development in *** findings demonstrate the important and conserved function of KLF17 in promoting naive pluripotency and reveal two essential transcriptional targets of KLF17 that underlie its function.

关键词： KLF17 human embryonic stem cell naive pluripotency primed to naive state transition ZIC2

Stem cell therapy:light in the tunnel for penetrating Crohn’s disease

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Gastroenterology Report 2023年第1期11卷 78-87页

作者： Nan Lan Xianrui Wu Bo Shen center for Inflammatory Bowel Disease Columbia University Irving Medical Center/NewYork Presbyterian HospitalNew YorkNYUSA Department of Colorectal Surgery The 6th Hospital of Sun Yat-Sen UniversityGuangzhouGuangdongP.R.China

Patients with Crohn’s disease frequently suffer from fistula resulting from adverse sequelae of persistent complicated active disease or surgical *** affects a patient’s quality of life and is directly associated with the need for surgical *** of fistula can be made through CT enterography,MR enterography,gastrograffin-based imaging,and transanal *** for fistula mainly consists of medication,endoscopic procedures,and *** are emerging approaches under current investigation,such as stem cell *** results showed a decent response in patients with perianal and rectovaginal fistula with minimal side *** investigation is still needed for other internal fistula.

关键词： Crohn’s disease fistula perianal disease stem cells therapy

Carotid artery injury in endoscopic endonasal surgery: Risk factors, prevention, and management

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2022年第1期8卷 54-60页

作者： Rahul K.Sharma Alexandria L.I race Jonathan B.Overdevest David A.Gudis Department of Otolaryngology-Head and Neck Surgery Columbia University Irving Medical CenterNewYork-Presbyterian HospitalNew YorkNew YorkUSA Department of Otolaryngology-Head and Neck Surgery Vanderbilt University Medical CenterNashvilleTennesseeUSA

Objective:Endoscopic approaches for sinus and skull base surgery are increasing in *** objective of this narrative review is to characterize risk factors for internal carotid artery injury in endoscopic endonasal surgery(EES),highlight preventative measures,and illustrate key management *** Sources:Comprehensive literature ***:Relevant literature was reviewed using PubMed/***:Carotid artery injury in EES is rare,with most studies reporting an incidence below 0.1%.Anatomic aberrancies,wide dissection margins,as well as specific provider and hospital factors,may increase the risk of *** teams,comprehensive preoperative imaging,patient risk assessment,and formal training in vascular emergencies may reduce the *** protocols should emphasize proper visualization of the injury site,fluid replacement,rapid packing,angiography,and endovascular techniques to achieve ***:While EES is a relatively safe procedure,carotid artery injury is a devastating complication that warrants full consideration in surgical *** preventative measures include identifying patients with notable risk factors and obtaining preoperative *** teams and management protocols are ultimately necessary to reduce morbidity and mortality.

关键词： carotid injury complications internal carotid pituitary pituitary adenoma pituitary tumor skull base surgery surgical outcomes transphenoidal

Post-operative prevention and monitoring of Crohn’s disease recurrence

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Gastroenterology Report 2022年第1期10卷 217-226页

作者： Kate E.Lee Sarah Cantrell Bo Shen Adam S.Faye Department of Medicine Duke University Medical CenterDurhamNCUSA Duke university medical center Library&Archives Duke University School of MedicineDurhamNCUSA center for Inflammatory Bowel Diseases NewYork-Presbyterian/Columbia University Irving Medical CenterNew YorkNYUSA Division of Gastroenterology NYU Grossman School of MedicineNew YorkNYUSA

Crohn’s disease(CD)and ulcerative colitis(UC)are relapsing and remitting chronic inflammatory diseases of the gastrointestinal *** surgery for UC can provide a cure,surgery for CD is rarely *** the past few decades,research has identified risk factors for postsurgical CD recurrence,enabling patient risk stratification to guide monitoring and prophylactic treatment to prevent CD recurrence.A MEDLINE literature review identified articles regarding post-operative monitoring of CD recurrence after resection *** this review,we discuss the evidence on risk factors for postoperative CD recurrence as well as suggestions on post-operative management.

关键词： post-operative Crohn’s management recurrence biologics