检索结果-南通市图书馆

Glibenclamide pretreatment attenuates early hematoma expansion of warfarin-associated intracerebral hemorrhage in rats by alleviating perihematomal blood-brain barrier dysfunction

引用

Chinese Neurosurgical Journal 2024年第1期10卷 8-19页

作者： Zongwei Zeng Liang Liang Zhou Feng Peiwen Guo Xiaoke Hao Jishu Xian Hua Feng Yujie Chen Zhi Chen department of neurosurgery and State Key Laboratory of Trauma Burn and Combined InjurySouthwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China department of neurosurgery The 945Th Hospital of PLAYaanSichuan Province 625099China department of Rehabilitation Southwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China Chongqing Key Laboratory of Precision Neuromedicine and Neuroregeneration Southwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China Chongqing Clinical Research Center for neurosurgery Southwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China

Background Hematoma expansion is a determinant of poor outcome of intracerebral hemorrhage but occurs frequently,especially in warfarin-associated intracerebral hemorrhage(W-ICH).In the present study,we employ the warfarin-associated intracerebral hemorrhage(W-ICH)rat model,to explore the efficacy and potential mechanism of glibenclamide pretreatment on hematoma expansion after intracerebral hemorrhage,hoping to provide proof of concept that glibenclamide in stroke primary and secondary prevention is also potentially beneficial for intracerebral hemorrhage patients at early *** In the present study,we tested whether glibenclamide,a common hypoglycemic drug,could attenuate hematoma expansion in a rat model of *** expansion was evaluated using magnetic resonance imaging;brain injury was evaluated by brain edema and neuronal death;and functional outcome was evaluated by neurological *** blood-brain barrier integrity was assessed using Evans blue extravasation and tight junction-related *** The data indicated that glibenclamide pretreatment significantly attenuated hematoma expansion at 24 h after W-ICH,thus mitigating brain edema and neuronal death and promoting neurological function recovery,which may benefit from alleviating blood-brain barrier disruption by suppressing matrix *** The results indicate that glibenclamide pretreatment in stroke primary and secondary prevention might be a promising therapy for hematoma expansion at the early stage of W-ICH.

关键词： Intracerebral hemorrhage Warfarin Glibenclamide Hematoma expansion Blood-brain barrier Matrix metallopeptidase-9

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The Traf2 and NcK interacting kinase inhibitor NCB-0846 suppresses seizure activity involving the decrease of GRIA1

引用

Genes & Diseases 2024年第3期11卷 452-467页

作者： Min Wang Yixue Gu Qiubo Li Bangzhe Feng Xinke Lv Hao Zhang Qingxia Kong Zhifang Dong Xin Tian Yanke Zhang department of Neurology Affiliated Hospital of Jining Medical UniversityJiningShandong 272000China department of Neurology The First Affiliated Hospital of Chongqing Medical UniversityChongqing Key Laboratory of NeurologyChongqing 400016China department of Pediatrics Affiliated Hospital of Jining Medical UniversityJiningShandong 272000China department of neurosurgery Affliated Hospital of Jining Medical UniversityJiningShandong 272000China Pediatric Research Institute Ministry of Education Key Laboratory of Child Development and DisordersNational Clinical Research Center for Child Health and DisordersChongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory DisordersChildren's Hospital of Chongqing Medical UniversityChongqing 400014China Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of SciencesShanghai 200031China

Epilepsy,one of the most common neurological disorders,is characterized by spon-taneous recurrent *** lobe epilepsy(TLE)is one of the most common medically intractable seizure ***2-and NcK-interacting kinase(TNIK)has recently attracted attention as a critical modulation target of many neurological and psychiatric disorders,but its role in epilepsy remains *** this study,we hypothesized the involvement of TNIK in epilepsy and investigated TNIK expression in patients with intractable TLE and in a pilocarpineinduced rat model of epilepsy by western blotting,immunofluorescence,and immunohistochemistry.A pentylenetetrazole(PTZ)-induced epilepsy rat model was used to determine the effect of the TNIK inhibitor NCB-0846 on behavioral manifestations of ***(Co-IP)/mass spectrometry(MS)was used to identify the potential *** Co-IP,we detected and confirmed the main potential TNIK *** fractionation was used to establish the effect of NCB-0846 on the expression of the main interactors in postsynaptic density(PSD)*** found that TNIK was primarily located in neurons and decreased significantly in epilepsy model rats and TLE patients compared with ***-0846 delayed kindling progression and decreased seizure ***-IP/MS identified 63 candidate TNIK interactors in rat hippocampi,notably ***-IP showed that TNIK might correlate with endogenous GRIA1,SYN2,PSD-95,CaMKIV,GABRG1,and *** addition,the significant decrease in GRIA1 in hippocampal total lysate and PSDs after NCB-0846 treatment might help modify the progression of PTZ *** results suggest that TNIK contributes to epileptic pathology and is a potential antiepileptic drug target.

关键词： Epilepsy NCB-0846 Rat TLE TNIK Traf2-and NcK-interacting kinase

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Role of Dicer on tumorigenesis in glioma cells

引用

Neural Regeneration Research 2010年第17期5卷 1324-1329页

作者： Anling Zhang Lei Han Guangxiu Wang Zhifan Jia Peiyu Pu Chunsheng Kang department of neurosurgery Tianjin Medical University General Hospital and Laboratory of Neuro-OncologyTianjin Neurological InstituteTianjin 300052China

Micro RNAs（miRNAs）are non-coding,single-stranded RNAs that regulate target gene expression by repressing translation or promoting RNA *** studies show that miRNA expression is globally decreased in some human *** is an essential component of the miRNA processing *** determine whether global reduction of miRNA effects tumorigenesis,small interfering RNA were designed to target Dicer to restrain whole miRNA expression in the glioblastoma cell *** effective knock-down of Dicer,tumor cells were invasive and proliferative,and globally impaired miRNA processing enhanced proliferation and invasiveness of glioma cells in *** of Dicer expression resulted in a more aggressive glioma phenotype,which suggests that global reduction of miRNA expression could have an oncogenic role in glioblastoma cells.

关键词： Dicer glioma tumorigenesis small interfering RNA micro RNAs

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

PED Flex with Shield Technology:a feasible alternative for fusiform MCA aneurysms

引用

Stroke & Vascular Neurology 2018年第3期3卷 185-188页

作者： Guilherme J.Agnoletto Pedro Aguilar-Salinas Roberta Santos Eric Sauvageau Ricardo A.Hanel Lyerly neurosurgery Baptist Neurological InstituteJacksonvilleFLUSA

BACKGROUND The advent of flow diverters(FDs)has changed the scope of endovascular treatment options for intracranial aneurysms(IAs).FDs can effectively treat complex aneurysms in which both microsurgical and conventional endovascular options are less than ideal.12 The Pipeline Flex Embolization Device(PED;Medtronic,Irvine,California,USA)has been available in the USA for several years demon-strating positive *** recently,the PED Flex with enhanced delivery features has been introduced,and although decreased,thromboembolic complications are still a potential risk.3 In light of this,a new surface modification was applied to the PED Flex known as Shield Technology consisting of a phosphorylcholine layer covalently bound to its metal braids potentially reducing its thrombogenicity.4 Herein,we report our initial experience using the PED Flex with Shield Technology in the treatment of an unruptured fusiform aneurysm located in the middle cerebral artery(MCA)using dual-an-tiplatelet therapy.

关键词： Flex PED MCA treatment

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Thrombus migration in patients with acute ischaemic stroke undergoing endovascular thrombectomy

引用

Stroke & Vascular Neurology 2024年第2期9卷 126-133,I0006-I0395页

作者： ZeFeng Tan Lei Zhang Li'an Huang Hongyu Qiao Min Guan Bing Yang Pengfei Yang Yongwei Zhang Hongjian Shen Yu Zhou Bo Hong Huaizhang Shi Hongxing Han Xinyi Leng Yi Dong Changlin Lian Wenhuo Chen Anding Xu Jianmin Liu Neurology First People's Hospital of FoshanFoshanGuangdongChina department of Neurology Jinan University First Affiliated HospitalGuangzhouGuangdongChina Neurovascular Center Changhai HospitalNaval Medical UniversityShanghaiChina department of neurosurgery First Affiliated Hospital of Harbin Medical UniversityHarbinChina department of Neurology Linyi People's HospitalLinyiShandongChina Medicine&Therapeutics The Chinese University of Hong KongHong KongChina Neurology Huashan Hospital Fudan UniversityShanghaiChina Neurology Zhangzhou Municipal Hospital of Fujian Province and Zhangzhou Affiliated Hospital of Fujian Medical UniversityZhangzhouFujianChina Stroke Center Jinan University First Affiliated HospitalGuangzhouGuangdongChina

Objective The impact of thrombus migration(TM)prior to endovascular thrombectomy(EVT)on clinical outcomes and revascularisation rates remains *** aimed to examine whether preinterventional TM modifies the treatment effects of direct EVT versus bridging EVT in acute large vessel occlusion *** All patients undergoing catheter angiography in the Direct Intra-arterial thrombectomy in order to Revascularise acute ischaemic stroke patients with large vessel occlusion Efficiently in Chinese Tertiary hospitals:A Multicentre randomised clinical Trial were *** was determined by radiologists unaware of the study by analysing discrepancies between computed tomographic angiography at baseline and first-run digital subtraction angiography before *** primary outcome was the score on the modified Rankin scale(mRS)assessed at 90 *** Of 627 included patients,the TM rate was 11.3%(71/627).In the multivariable logistic regression model,baseline National Institutes of Health Stroke Scale score(adjusted OR 0.956,95%CI 0.916 to 0.999;p=0.043)and intravenous thrombolysis(adjusted OR 2.614,95%CI 1.514 to 4.514;p<0.001)were independently associated with *** patients with TM were less likely to be completely recanalised than those without TM(21.27%vs 36.23%,p=0.040).The interaction of TM and the EVT treatment effect did not significantly affect mRS shift analysis(p=0.687)or mRS scores of 0 to 1(p=0.436).Conclusion Preinterventional TM does not modify the treatment effects of direct versus bridging EVT on functional outcomes in patients with acute ischaemic stroke with anterior large vessel *** leads to a lower complete recanalisation rate.

关键词： patients throm acute

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Posteroinferior Cerebellar Artery (PICA) Fusiform Aneurysm Ruptured Related with a Pure Arterial Malformation: Case Report and Technical Note (NBCA Embolization under Roadmap-Fluoroscopy)

引用

Open Journal of Modern neurosurgery 2021年第3期11卷 137-143页

作者： Maria Del Rosario Sosa-Martinez Guy G. Broc-Haro Javier Valdes-Garcia Christopher Mader-Alba Daniel Juarez-Rebollar neurosurgery and neurological endovascular therapy department “Lic. Adolfo López Mateos” Regional Hospital of the Security and Social Institute of the State Workers Mexico City Mexico

Background: The pure arterial malformation (PAM) lesion has been recently described as a vascular pathology characterized by the sole presence of coiled, sometimes ectatic, arterial loops. 2% of the fusiform aneurysms are located in the vertebral-posterior inferior cerebellar arteries. Case Presentation: A 60 years old female with subarachnoid hemorrhage was diagnosed with a fusiform aneurysm in the right PICA related with a PAM in the digital subtraction angiography (DSA). With a negative super-selective Wada test, the patient was treated with embolization of the two lesions and the PICA for being in the same arterial territory with adhesive embolic liquid under roadmap fluoroscopy technique. The patient had a satisfactory clinical evolution and no added neurological deficit, so she was discharged 3 days after the treatment. Conclusion: These two vascular lesions located in the same artery are very rare and more in the PICA territory. It is important to make the best decision to treat them because of the potential complications;that’s why the procedure was supported with super-selective Wada test and neuromonitoring of the PICA territory. The injection of the mixture of NBCA and Lipiodol® under roadmap fluoroscopy is very safe.

关键词： Fusiform Aneurysm Pure Arterial Malformation N-Butyl Cyanoacrylate Roadmap Fluoroscopy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Angioarchitecture and prognosis of pediatric intracranial pial arteriovenous fistula

引用

Stroke & Vascular Neurology 2023年第4期8卷 292-300页

作者： Jingwei Li Zhenlong Ji Jiaxing Yu Jian Ren Fan Yang Lisong Bian Xinglong Zhi Guilin Li Hongqi Zhang department of neurosurgery Xuanwu HospitalCapital Medical UniversityBeijingChina National Center for neurological Disorders BeijingChina China International Neuroscience Institute BeijingChina department of neurosurgery Affiliated Hospital of Beihua UniversityJilin provinceChina department of neurosurgery Beijing United Family HospitalBeijingChina department of neurosurgery Beijing Haidian HospitalBeijingChina

Objective Pial arteriovenous fistulas(PAVFs)are rare and mostly observed in ***,the overall angioarchitecture,clinical features,treatments and long-term prognosis for pediatric patients remain *** Clinical data of consecutive 42 pediatric PAVFs were documented and *** to the differences of age distribution and clinical features,they were split into a younger group(≤3 years old;20 cases)and an older group(3-14 years old;22 cases).Results Their mean age was 4.9±3.9 years,and the mean preoperative modified Rankin Scale(mRS)score was 1.64±*** patients(33.3%)were asymptomatic,followed by epilepsy(21.4%),intracranial haemorrhage(16.7%),hydrocephalus(9.5%),developmental delay(7.1%),intermittent headache(7.1%)and congestive heart failure(4.8%).Annual bleeding rate and rebleeding rate before treatment reached 3.86%and 3.17%.Poor venous drainage including sinus dynamic obstruction(21 cases,50.0%)and sinus occlusion(17 cases,40.48%)were found with high frequency among these ***,33 cases were cured(78.57%),and 4 cases faced surgery-related complications(9.52%).During 24-140 months’follow-up,the mean mRS score reduced to 0.57±***,only 22 cases(52.38%)recovered to absolutely normal,and poor venous drainage was the risk factor for patients’incomplete recovery(p=0.028,Exp(B)=14.692,95%CI 1.346 to 160.392).Compared with the older group,younger group showed more chronic symptoms,more secondary pathological changes,more times treatment and worse prognosis(p=0.013,0.002,0.000 and 0.032,respectively).Conclusions Pediatric PAVF has different angioarchitectures,clinical features and prognoses in different age *** venous drainage is an important factor leading to poor prognosis,and it accounts for incomplete recovery in nearly half of patients.

关键词： pediatric prognosis epilepsy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

siRNA epidermal growth factor receptor silencing in U251 glioma cells

引用

Neural Regeneration Research 2008年第6期3卷 652-655页

作者： Chunsheng Kang Zhiyong Zhang Zhifan Jia Qiang Huang Guangxlu Wang Mingzhe Qiu Peiyu Pu department of neurosurgery Tianjin Medical University General Hospital and Laboratory of Neuro-Oncology Tianjin Neurological Institute Tianjin 300052 China

BACKGROUND： Dicer, a large multidomain ribonuclease, is responsible for processing double-stranded RNAs （dsRNAs） to 20-bp-long small interfering RNAs （siRNAs）, which act as effectors during RNA interference （RNAi）. OBJECTIVE： To observe the efficacy of siRNA cocktails generated by recombinant human Dicer on the down-regulation of epidermal growth factor receptor （EGFR） expression in human glioma cells. DESIGN, TIME AND SETTING： The following in vitro experiment was performed at the department of neurosurgery, Tianjin Medical University General Hospital and Laboratory of Neuro-Oncology, Tianjin neurological Institute. MATERIALS： Mini-RNA isolation kit, human placenta complimentary DNA （cDNA） was produced by Tiangen Biotech （Beijing, China）, human glioblastoma U251-MG cells were produced by the Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences. METHODS： A PCR product from the human EGFR, which corresponded to the tyrosine kinase domain of the 3＇-end fragment, was used as the T7-promotor for in vitro transcription. siRNA cocktails were generated by in vitro dicing of double stranded RNA. A total of 500, 250 and 125 μg siRNA cocktails were transiently transfected into U251 glioma cells through the use of the GeneSilencer. MAIN OUTCOME MEASURE： Expression of EGFR was detected by real-time PCR. RESULTS： The total PCR product of the human EGFR, corresponding to the tyrosine kinase domain, is approximately 680 bp in length. The PCR transcriptants included GCC leader sequences and a T7 promoter sequence, with a fragment of EGFR cDNA at the center. The T7 promoter was prepared for in vitro transcription of dsRNA. After dicing for 24 hours, the 21-nt siRNA cocktails were verified by 4% agarose gel. The difference between threshold cycle of a sample assay and threshold cycle of the corresponding endogenous reference （ΔCt） among parental U251 cells and cells transfected with different doses of siRNA cocktails were determined to be 3.06, 7.35, and 10.31 cycl

关键词： siRNA epidermal growth factor receptor, glioma gene expression

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Targeting harmful effects of non-excitatory amino acids as an alternative therapeutic strategy to reduce ischemic damage

引用

Neural Regeneration Research 2025年第9期20卷 2454-2463页

作者： Victoria Jiménez Carretero IrisÁlvarez-Merz Jorge Hernández-Campano Sergei A.Kirov Jesús M.Hernández-Guijo department of Pharmacology and Therapeutic School of MedicineUniv.Autónoma de MadridMadridSpain Ramón y Cajal Institute for Health Research(IRYCIS) Neurobiology-Research ServiceHospital Ramón y CajalMadridSpain Institute of Neurobiology Faculty of Mathematics and Natural SciencesHeinrich Heine University DüsseldorfDüsseldorfGermany department of Neuroscience and Regenerative Medicine&department of neurosurgery Medical College of Georgia at Augusta UniversityAugustaGAUSA

The involvement of the excitatory amino acids glutamate and aspartate in ce rebral ischemia and excitotoxicity is ***,the role of non-excitatory amino acids in brain damage following a stroke or brain trauma remains largely *** release of amino acids by necrotic cells in the ischemic core may contribute to the expansion of the *** findings indicated that the reversible loss of field excitato ry postsynaptic potentials caused by transient hypoxia became irreversible when exposed to a mixture of just four non-excitatory amino acids(L-alanine,glycine,L-glutamine,and L-serine)at their plasma *** amino acids induce swelling in the somas of neurons and astrocytes during hypoxia,along with permanent dendritic damage mediated by N-methyl-D-aspartate *** N-methyl-D-aspartate receptors prevented neuronal damage in the presence of these amino acids during *** is likely that astroglial swelling caused by the accumulation of these amino acids via the alanine-serine-cysteine transporter 2 exchanger and system N transporters activates volume-regulated anion channels,leading to the release of excitotoxins and subsequent neuronal damage through N-methyl-D-aspartate receptor ***,previously unrecognized mechanisms involving non-excitatory amino acids may contribute to the progression and expansion of brain injury in neurological emergencies such as stroke and traumatic brain *** these pathways co uld highlight new therapeutic targets to mitigate brain injury.

关键词： cell swelling N-methyl-D-aspartate receptor non-excitatory amino acids stroke synaptic transmission

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Targeting 14-3-3 adaptor protein-protein interactions to stimulate central nervous system repair

引用

Neural Regeneration Research 2017年第7期12卷 1040-1043页

作者： Andrew Kaplan Alyson E.Fournier department of Neurology and neurosurgery Montreal Neurological Institute McGill University Montr6al Qu4bec Canada

The goal of developing treatments for central nervous system（CNS）injuries is becoming more attainable with the recent identification of various drugs that can repair damaged *** discoveries have stemmed from screening efforts,large expression datasets and an improved understanding of the cellular and molecular biology underlying axon *** will be important to continue searching for new compounds that can induce axon *** we describe how a family of adaptor proteins called 14-3-3s can be targeted using small molecule drugs to enhance axon outgrowth and regeneration.14-3-3s bind to many functionally diverse client proteins to regulate their *** highlight the recent discovery of the axon-growth promoting activity of fusicoccin-A,a fungus-derived small molecule that stabilizes 14-3-3 interactions with their client *** we discuss how fusicoccin-A could serve as a starting point for the development of drugs to induce CNS repair.

关键词： axon regeneration 14-3-3 gcnl, fusicoccin optic nerve spinal cord injury

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：