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It is safe to use transdermal glyceryl trinitrate to lower blood pressure in patients with acute ischaemic stroke with carotid stenosis

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Stroke & Vascular Neurology 2019年第5期4卷 28-35页

作者： Jason P Appleton Lisa J Woodhouse Andrew Belcher Daniel Bereczki Eivind Berge Valeria Caso Hui Meng Chang Hanne K Christensen Ronan Collins John Gommans Ann C Laska George Ntaios Serefnur Ozturk Gillian M Sare Szabolcs Szatmari Yongjun Wang Joanna M Wardlaw Nikola Sprigg Philip M Bath for the ENOS investigators Stroke Division of Clinical NeurosciencesUniversity of NottinghamNottinghamUK Stroke Nottingham University Hospitals NHS TrustNottinghamUK Department of Neurology Semmelweis UniversityBudapestHungary Department of Internal Medicine and Cardiology Oslo University HospitalOsloNorway Stroke Unit Santa Maria della Misericordia HospitalUniversity of PerugiaPerugiaItaly Department of Neurology Singapore General HospitalSingaporeSingapore Neurology Bispebjerg and Frederiksberg HospitalCopenhagenDenmark Tallaght Hospital Trinity College DublinDublinIreland Department of Medicine Hawke's Bay District Health BoardHastingsNew Zealand Department of Clinical Science Danderyd HospitalKarolinska InstituteStockholmSweden Department of Medicine University of ThessalyLarissaGreece Neurology Selcuk University Faculty of MedicineKonyaTurkey Neurology Nottingham University Hospitals NHS TrustNottinghamUK Department of Neurology Clinical County Emergency HospitalTargu MuresRomania Neurology Beijing Tiantan HospitalBeijingChina Centre for Clinical Brain Sciences EdinburghUK

Background There is concern that blood pressure(BP)lowering in acute stroke may compromise cerebral perfusion and worsen outcome in the presence of carotid *** assessed the effect of glyceryl trinitrate(GTN)in patients with carotid stenosis using data from the Efficacy of Nitric Oxide in Stroke(ENOS)*** ENOS randomised 4011 patients with acute stroke and raised systolic BP(140-220 mm Hg)to transdermal GTN or no GTN within 48 hours of *** on prestroke antihypertensives were also randomised to stop or continue their medication for 7 *** primary outcome was the modified Rankin Scale(mRS)at day *** carotid stenosis was split:<30%;30-<50%;50-<70%;≥70%.Data are ORs with 95%CIs adjusted for baseline prognostic *** 2023(60.5%)ischaemic stroke participants had carotid *** compared with<30%,≥70%ipsilateral stenosis was associated with an unfavourable shift in mRS(worse outcome)at 90 days(OR 1.88,95%CI 1.44 to 2.44,p<0.001).Those with≥70%stenosis who received GTN versus no GTN had a favourable shift in mRS(OR 0.56,95%CI 0.34 to 0.93,p=0.024).In those with 50-<70%stenosis,continuing versus stopping prestroke antihypertensives was associated with worse disability,mood,quality of life and cognition at 90 *** outcomes did not differ across bilateral stenosis *** Following ischaemic stroke,severe ipsilateral carotid stenosis is associated with worse functional outcome at 90 *** appears safe in ipsilateral or bilateral carotid stenosis,and might improve outcome in severe ipsilateral carotid stenosis.

关键词： stenosis carotid hypertensive

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1.5T与3T脑部MRI临床实践和研究应用的系统性回顾

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国际医学放射学杂志 2013年第1期 82-82页

作者： J.M.Wardlaw W.Brindle A.M.Casado K.Shuler M.Henderson B.Thomas 刘丽华 SINAPSE Collaboration Brain Research Imaging CentreDivision of Clinical NeurosciencesWestern General HospitalCrewe RoadEdinburgh EH4 2XUUK

目的 3TMR设备较1.5T的被认为具有更高的准确率,但是因检查费用高和其他的实际差别导致无法确定两者的优劣。方法我们系统回顾比较了3T与1.5T设备的诊断准确率。检索2000年1月1日—2010年10月22日MEDLINE、EMBASE和其他数据库关于1.5T... 详细信息

目的 3TMR设备较1.5T的被认为具有更高的准确率,但是因检查费用高和其他的实际差别导致无法确定两者的优劣。方法我们系统回顾比较了3T与1.5T设备的诊断准确率。检索2000年1月1日—2010年10月22日MEDLINE、EMBASE和其他数据库关于1.5T与3T脑部成像诊断准确率的文献。按照QUADAS及STARD标准,我们提取关于检查方法、质量标准、技术因素、主观因素、信噪比、诊断准确率及错误等方面的数据。结果在150项(4500例受试者)研究中,多数研究数目较少,并且比较陈旧的1.5T与新的3T技术,仅有22篇(15%)涉及了诊断准确率。3T影像常受到称赞,但是在提高诊断准确率方面的证据却不足。3T的进步主要局限于研究方面,如功能MRI、MR波谱、自动病变检测。理论上的信噪比提高1倍但未确切证实,多数为25%。3T设备的伪影更为严重,采集时间较1.5T略长。结论目前尚缺乏指导MRI购买和常规诊断应用方面的客观证据。为保证医疗干预和保健系统更加有效,应常规严格评价影像诊断技术的准确率和实用性。

关键词： MRI 脑部信噪比

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多发性硬化功能相关的脑白质退变:基于纤维束的空间荟萃分析

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国际医学放射学杂志 2015年第3期 278-278页

作者： T.Welton D.Kent C.S.Constantinescu D.P.Auer R.A.Dineen 陶志刚 Departments of Radiological Sciences Division of Clin ical Neurosciences University of Nottingham Queen 's Medical CentreDerby Rd Nottingham NG7 2UHEngland

目的为了确定已发表的关于多发性硬化(MS)白质纤维束(WM)退变的分布与功能相关性研究是否具有统计学一致性。材料与方法系统地搜索在线数据库,挑选出基于

关键词：多发性硬化纤维束退变荟萃分析

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The Impact of Chronic Pelvic Pain in Women

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International Journal of Clinical Medicine 2013年第10期4卷 421-427页

作者： Adriana Peterson Mariano Salata Romao Ricardo Gorayeb Gustavo Salata Romao Omero Benedicto Poli-Neto Antonio Alberto Nogueira Department of Gynecology and Obstetrics School of Medicine of Ribeirao PretoUniversity of Sao PauloRibeirao PretoSPBra-zil Department of neurosciences and Behavioral Sciences School of Medicine of Ribeirao PretoUniversity of Sao PauloRibeirao PretoSPBrazil Federal University of Sao Carlos SPBrazil Department the Surgery and Anatomy University HospitalFaculty of Medicine of Ribeirao PretoUniversity of São PauloRibeirao PretoSPBrazil Department of the Surgery and Anatomy Uni-versity HospitalFaculty of Medicine of Ribeirao PretoUniversity of Sao PauloRibeirao PretoSPBrazil.

Chronic pelvic pain (CPP) is a prevalent condition with a significant impact on the personal, social, professional and marital life of women. It is a complex condition that may have no specific causal diagnosis or may be associated with multiple diagnoses, frequently involving treatment failure. The definition of health care strategies fundamentally depends on the way women live with this condition. Thus, the objective of the present study is to learn how women with CPP experience their diagnosis and the meaning they attribute to it. A qualitative study was conducted by interviewing a focus group of 11 women. The content of the interviews was recorded and fully transcribed, and the speeches were interpreted by Bardin’s content analysis. The topics most frequently dealt with in the interview were diagnosis, beginning of pain, worsening and improving factors, marital and interpersonal relationships, interference with daily activities, association with emotional aspects, and perspectives for the future. It could be perceived how much these women need to be better heard and how much the association between psychic and physical questions must be visualized by the professionals who provide care for them. The approach used by professionals from different areas, when properly structured, can minimize the problem of the division of a sick person into separate parts. Psychological care is very important, especially in relation to the discovery of more effective strategies for living with pain.

关键词： Lived Experience Chronic Pelvic Pain Qualitative Method Women’s Health

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Intracranial Large Artery Occlusive Disease

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中国临床神经科学 2000年第Z1期8卷 5-页

作者： Wong KS Li H Kay R division of Neurology Department of Medicine & Therapeutics The Chinese University of Hong Kong China Division of Neurology Department of Medicine & Therapeutics The Chinese University of Hong Kong China Division of Neurology Department of Medicine & Therapeutics The Chinese University of Hong Kong China

　　Intracranial large artery stenosis is the most commonly found vascular lesion in stroke patient of Chinese, Hispanic and African ancestry. There .have been few studies on the epidemiology, pathophysiology, treatment and prognosis of this important disease. Recent advances in technology provide safe and reliable investigation for studying large number of patients. Transcranial Doppler is an easily accessible, cheap and reliable method to diagnose intracranial stenosis. It is suitable for screening for and monitoring the progress of intracranial stenosis. Magnetic resonance angiography and CT angiography provide the morphology of lumenal stenosis but are less accessible.……

关键词： vascular lesion CT angiography

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隐源性卒中的心电监测策略：2015年卒中诊断和监测专题组的报告

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国际脑血管病杂志 2017年第7期25卷 592-600页

作者： Gregory W. Albers Richard A. Bernstein Johannes Brachmann John Camm J. Donald Easton Peter Fromm Shinya Goto Christopher B. Granger Stefan H. Hohnloser Elaine Hylek Amir K. Jaffer Derk W. Krieger Rod Passman Jesse M. Pines Shelby D. Reed Peter M. Rothwell Peter R. Kowey 地力木拉提·阿米提朱沂李红燕牛晓珊 Department of Neurology and Neurological Sciences Stanford University Stanford CA Davee Department of Neurology Feinberg School of Medicine of Northwestern University Chicago IL Hospital Klinikum Coburg Teaching Hospital of the University of Wurzburg Coburg Germany Cardiovascular and Cell Sciences Research Institute St. George's University of London and Imperial College London LK Department of Neurology University of California San Francisco Sandier Neurosciences Center San Francisco CA Center for Cardiovascular Health South Nassau Communities Hospital Oeeanside NY Department of Medicine Tokai University School of Medicine Isehara Japan Cardiac Care Unit Duke University Medical Center Durham NC division of Clinical Electrophysiology Department of Cardiology J.W. Goethe University Frankfurt Germany Boston University School of Medicine Boston MA Department of Medicine Rush Lhiversity Medical Center Chicago IL Faculty of Health and Medical Science University of Copenhagen Denmark German Neuroscience Center Dubal Healthcare City Dubai UAE Bluhm Cardiovascular Institute Northwestern University Feinberg School of Medicine Chicago IL Office for Clinical Practice Innovation George Washington Lhiversity Washington DC Duke Clinical Research Institute Duke University Durham NC Stroke Prevention Research Unit Nuffield Department of Clinical Neurosciences University of Oxford UK division of Cardiovascular Diseases Lankenau Heart Institute Wyrmewood PA Department of Medicine Jefferson Medical College Philadelphia PA 新疆维吾尔自治区人民医院神经内科乌鲁木齐830001

卒中是一个重要的全球性公共卫生问题。2010年全世界总共发生3300万例卒中，其中1690万为首发卒中。卒中是仅次于心脏病的第二大全球人口死亡原因，占全部死亡的10％以上。卒中是一类异质性疾病，其病因可以是血管破裂（出血性）或血管... 详细信息

卒中是一个重要的全球性公共卫生问题。2010年全世界总共发生3300万例卒中，其中1690万为首发卒中。卒中是仅次于心脏病的第二大全球人口死亡原因，占全部死亡的10％以上。卒中是一类异质性疾病，其病因可以是血管破裂（出血性）或血管闭塞（缺血性）。缺血性卒中约占全部卒中的85％，可根据发病机制进行分类。

关键词：缺血性卒中心电监测隐源性专题诊断公共卫生问题死亡原因异质性疾病

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Distinct molecular profiles of skull bone marrow in health and neurological disorders

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四川生理科学杂志 2023年第9期45卷 1704-1704页

作者： Zeynep Ilgin Kolabas Institute for Tissue Engineering and Regenerative Medicine (iTERM) Helmholtz Center Neuherberg Munich Germany Institute for Stroke and Dementia Research LMU University Hospital Ludwig-Maximilians University Munich Munich Germany Graduate School of Systemic neurosciences (GSN) Munich Germany Sheffield Institute for Translational Neuroscience University of Sheffield Sheffield UK Institute of Computational Biology Helmholtz Zentrum München German Research Center for Environmental Health Neuherberg Germany division of Mental Health in Older Adults and Alzheimer Therapy and Research Center Department of Psychiatry and Psychotherapy University Hospital Ludwig Maximilian University Munich 80336 Munich Germany German Center for Neurodegenerative Diseases (DZNE) Munich Munich Germany Ageing Epidemiology (AGE) Research Unit School of Public Health Imperial College London London UK Munich Cluster for Systems Neurology (SyNergy) Munich Germany Department of Nuclear Medicine University Hospital Ludwig-Maximilians-Universität München Munich Germany Institute for Diabetes and Obesity Helmholtz Center Munich and German Center for Diabetes Research (DZD) 85764 Neuherberg Germany Munich Medical Research School (MMRS) 80336 Munich Germany Helmholtz Pioneer Campus (HPC) Helmholtz Munich Neuherberg Germany Wellcome Sanger Institute Cambridge UK

The bone marrow in the skull is important for shaping immune responses in the brain and meninges, but its molecular makeup among bones and relevance in human diseases remain unclear. Here, we show that the mouse skull has the most distinct transcriptomic profile compared with other bones in states of health and injury, characterized by a late-stage neutrophil phenotype. In humans, proteome analysis reveals that the skull marrow is the most distinct, with differentially expressed neutrophil-related pathways and a unique synaptic protein signature. 3D imaging demonstrates the structural and cellular details of human skull-meninges connections (SMCs) compared with veins. Last, using translocator protein positronemission tomography (TSPO-PET) imaging, we show that the skull bone marrow reflects inflammatory brain responses with a disease-specific spatial distribution in patients with various neurological disorders. The unique molecular profile and anatomical and functional connections of the skull show its potential as a site for diagnosing, monitoring, and treating brain diseases.

关键词： neurological disorders diseases

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Molecular landscapes of human hippocampal immature neurons across lifespan

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四川生理科学杂志 2022年第6期44卷 944-944页

作者： Yi Zhou Department of Neuroscience and Mahoney Institute for neurosciences Perelman School of Medicine University of Pennsylvania Philadelphia PA USA Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education Co-innovation Center of Neuroregeneration Nantong University Nantong China Institute for Regenerative Medicine University of Pennsylvania Philadelphia PA USA Department of Cell and Developmental Biology Perelman School of Medicine University of Pennsylvania Philadelphia PA USA Department of Psychiatry Perelman School of Medicine University of Pennsylvania Philadelphia PA USA The Epigenetics Institute Perelman School of Medicine University of Pennsylvania Philadelphia PA USA division of Neurosurgery Children’s Hospital of Philadelphia Philadelphia PA USA Department of Neurosurgery Perelman School of Medicine University of Pennsylvania Philadelphia PA USA Biochemistry and Molecular Biophysics Graduate Group Perelman School of Medicine University of Pennsylvania Philadelphia PA USA Neuroscience Graduate Group Perelman School of Medicine University of Pennsylvania Philadelphia PA USA Department of Genetics Perelman School of Medicine University of Pennsylvania Philadelphia PA USA Department of Pathology and Laboratory Medicine Children’s Hospital of Philadelphia Philadelphia PA USA division of Neurology Children’s Hospital of Philadelphia Philadelphia PA USA The Epilepsy NeuroGenetics Initiative (ENGIN) Children’s Hospital of Philadelphia Philadelphia PA USA Department of Biomedical and Health Informatics (DBHi) Children’s Hospital of Philadelphia Philadelphia PA USA Department of Neurology Perelman School of Medicine University of Pennsylvania Philadelphia PA USA Lieber Institute for Brain Development The Solomon H. Snyder Department of Neuroscience Department of Neurology and Department of Psychiatry School of Medicine Johns Hopkins University Baltimore MD USA Department of Pathology Johns Hopkins University School of Medic

Immature dentate granule cells(imGCs)arising from adult hippocampal neurogenesis contribute to plasticity and unique brain functions in rodents1,2 and are dysregulated in multiple human neurological *** is known about... 详细信息

关键词： plasticity Molecular 1,2

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TSC1-mTOR-PLK轴以阶段特异性方式调节从施旺细胞增殖到髓鞘形成的内稳态开关

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神经损伤与功能重建 2018年第5期13卷 271-271页

作者： Jiang M Rao R Wang J Wang J1 Xu L Wu LM Chan JR Wang H Lu QR 聂昊(编译) Department of Pediatrics Division of Experimental Hematology and Cancer BiologyCincinnati Children's Hospital Medical CenterUniversity of CincinnatiCicinnatiOhio The Institute of Cognitive Neuroscience East China Normal UniversityShanghaiChina Key Laboratory of Birth Defects Children's Hospital of Fudan UniversityShanghaiChina Department of Neurology and Programs in Biomedical and neurosciences University of CaliforniaSan FranciscoCalifornia 不详

恰如其分的外周髓鞘形成取决于雪旺细胞增殖与分化进程间的平衡。丝氨酸/苏氨酸激酶(mTOR)整合多种环境因素,是细胞生长、代谢、发挥作用的中枢调节者。本文报道了一种mTOR的负性调节剂——结节性硬化复合体(TSC1),通过控制细胞增殖和... 详细信息

恰如其分的外周髓鞘形成取决于雪旺细胞增殖与分化进程间的平衡。丝氨酸/苏氨酸激酶(mTOR)整合多种环境因素,是细胞生长、代谢、发挥作用的中枢调节者。本文报道了一种mTOR的负性调节剂——结节性硬化复合体(TSC1),通过控制细胞增殖和髓鞘稳态,建立了雪旺细胞谱系进展和髓鞘形成的阶段依赖性程序。小鼠雪旺细胞祖细胞中TSC1的解离导致mTOR信号通路激活,继而导致雪旺细胞过量增殖,分化受阻,髓鞘形成减少。转录组分析显示,TSC1突变体中的mTOR活化使得polo样激酶(PLK)依赖性通路和细胞周期调节剂上调。弱化mTOR或者对PLK进行药理抑制部分挽救了因TSC1缺失导致的外周神经发育过程中的髓鞘形成减少。相较之下,成年小鼠成熟雪旺细胞中TSC1缺失可导致髓鞘的过度增殖和过度生长。本文的发现提示了TSC1-mTOR-PLK信号轴在控制雪旺细胞的发育过程中,从增殖到分化和髓鞘内稳态中起到的阶段特异性功能。

关键词：雪旺细胞结节性硬化复合体丝氨酸/苏氨酸激酶信号通路髓鞘形成 polo样激酶增殖肿瘤抑制

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三叉神经节离体培养后降钙素基因相关肽调变的细胞内信号转导机制研究

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中国临床神经科学 2010年第2期18卷 113-118页

作者：罗国刚雷莉樊文静吕社民徐仓宝西安交通大学医学院第一附属医院神经内科遗传学与分子生物系 710061 division of Experimental Vascular Research Institution of MedicineLund University

目的:探讨大鼠三叉神经节(TG)离体培养后降钙素基因相关肽(CGRP)表达增高的细胞内信号转导通路。方法:成年雄性SD大鼠TG在DMEM培养液离体培养12、24和48 h,应用免疫组化和实时定量PCR法分别检测CGRP阳性细胞数和mRNA表达水平变化。在培... 详细信息

目的:探讨大鼠三叉神经节(TG)离体培养后降钙素基因相关肽(CGRP)表达增高的细胞内信号转导通路。方法:成年雄性SD大鼠TG在DMEM培养液离体培养12、24和48 h,应用免疫组化和实时定量PCR法分别检测CGRP阳性细胞数和mRNA表达水平变化。在培养液中分别加入一定浓度的炎症抑制剂地塞米松、转录水平特异性抑制剂放线菌素D、蛋白翻译水平特异性抑制剂环己酰胺,以及细胞内丝裂原激活的蛋白激酶(MAPK)信号转导系统ERK1/2、JNK、P38的3条信号通路上关键激酶的特异性阻断剂U0126、SP600125、SB239063与三叉神经节共同培养24 h,免疫组化和实时定量PCR法分别检测CGRP阳性反应细胞数和mRNA表达水平变化。结果:TG离体培养后12、24和48 h后CGRP阳性反应细胞数、平均吸光度和累积吸光度值均比新鲜组织明显增高,CGRP mRNA表达水平也明显增高。浓度为1×10^(-5)mol·L^(-1)的地塞米松、放线菌素D、环己酰胺以及U0126、SP600125分别与三叉神经节共同孵育24 h后,CGRP mRNA表达水平都显著降低。结论:TG离体培养后CGRP表达水平增高是通过细胞核内转录因子上调mRNA转录和蛋白翻译水平,是TG内非特异性炎症反应的结果,细胞内MAPK信号转导的ERK1/2通路和JNK信号通路参与了上调过程。

关键词：降钙素基因相关肽三叉神经节离体培养信号转导

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