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Commentary for Sequential Therapy Based on Evolvement of Patterns: A New Model for Treatment of Alzheimer's Disease

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Chinese Journal of Integrative Medicine 2019年第8期25卷 563-564页

作者： Gordon Wilcock David Neary Department of Clinical Neuroscience University of Oxford Manchester Centre for Clinical neurosciences Salford Royal NHS Foundation Trust

It has been accepted for many years that Alzheimer’s disease(AD)is the main cause of dementia in most if not all parts of the *** is a very complex disorder and its underlying pathological mechanisms are still poorly... 详细信息

关键词： Alzheimer A New Model for Treatment of Alzheimer’s Disease Commentary for Sequential Therapy Based on Evolvement of Patterns Model

To metabolomics and beyond:a technological portfolio to investigate cancer metabolism

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Signal Transduction and Targeted Therapy 2023年第4期8卷 1721-1742页

作者： Federica Danzi Raffaella Pacchiana Andrea Mafficini Maria TScupoli Aldo Scarpa Massimo Donadelli Alessandra Fiore Department of neurosciences Biomedicine and Movement SciencesSection of BiochemistryUniversity of VeronaVeronaItaly Department of Diagnostics and Public Health University of VeronaVeronaItaly Department of neurosciences Biomedicine and Movement SciencesBiology and Genetics SectionUniversity of VeronaVeronaItaly ARC-NET Research Centre University and Hospital Trust of VeronaVeronaItaly

Tumour cells have exquisite flexibility in reprogramming their metabolism in order to support tumour initiation, progression,metastasis and resistance to therapies. These reprogrammed activities include a complete rewiring of the bioenergetic, biosyntheticand redox status to sustain the increased energetic demand of the cells. Over the last decades, the cancer metabolism field hasseen an explosion of new biochemical technologies giving more tools than ever before to navigate this complexity. Within a cell ora tissue, the metabolites constitute the direct signature of the molecular phenotype and thus their profiling has concrete clinicalapplications in oncology. Metabolomics and fluxomics, are key technological approaches that mainly revolutionized the fieldenabling researchers to have both a qualitative and mechanistic model of the biochemical activities in cancer. Furthermore, theupgrade from bulk to single-cell analysis technologies provided unprecedented opportunity to investigate cancer biology at cellularresolution allowing an in depth quantitative analysis of complex and heterogenous diseases. More recently, the advent offunctional genomic screening allowed the identification of molecular pathways, cellular processes, biomarkers and noveltherapeutic targets that in concert with other technologies allow patient stratification and identification of new treatmentregimens. This review is intended to be a guide for researchers to cancer metabolism, highlighting current and emergingtechnologies, emphasizing advantages, disadvantages and applications with the potential of leading the development ofinnovative anti-cancer therapies.

关键词： metabolism qualitative beyond

Novel translational rat models of dopamine transporter deficiency

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Neural Regeneration Research 2018年第12期13卷 2091-2093页

作者： Damiana Leo Ilya Sukhanov Raul R.Gainetdinov Department of neurosciences University of Mons Institute of Pharmacology Pavlov Medical University Institute of Translational Biomedicine St. Petersburg State University

Dopamine （DA） is one of the brain＇s fundamental neurotransmitters. Despite the fact that the dopaminergic synapses constitute less than 1% of all brain synapses, DA is implicated in a number of critical physiological functions and in the pathogenesis of important psychiatric diseases such as schizophrenia, attention-deficit/hyperactivity disorder （ADHD）, Parkinson＇s disease （PD） and others.

关键词： DAT KO Novel translational rat models of dopamine transporter deficiency

Hearing characteristics of cephalopods: Modeling and environmental impact study

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Integrative Zoology 2015年第1期10卷 141-151页

作者： Yunfeng ZHANG Feng SHI Jiakun SONG Xugang ZHANG Shiliang YU Department of Civil and Environmental Engineering University of MarylandCollege ParkMarylandUSA Institute for Marine Biosystem and neurosciences Shanghai Ocean UniversityShanghaiChina

Cephalopods(octopus,squid and cuttlefish)are some of the most intriguing molluscs,and they represent economically important commercial marine species for *** studies have shown that cephalopods are sensitive to underwater particle motion,especially at low frequencies in the order of 10 *** present paper deals with quantitative modeling of the statocyst system in three cephalopod species:Octopus vulgaris,Sepia officinalis and Loligo *** octopus’s macula/statolith organ was modeled as a 2nd-order dynamic oscillator using parameter values estimated from scanning electron micrograph *** modeling results agree reasonably well with experimental data(acceleration threshold)in the three cephalopod *** made from quantitative modeling and simulating the particle motion sensing mechanism of cephalopods elucidated their underwater particle motion detection *** to emerging environmental issues,such as low frequency noise caused by near-shore wind farms and increasing levels of carbon dioxide in the ocean,and sensitivity to sounds produced by impending landslides were investigated in octopus using the model.

关键词： cephalopod hearing threshold octopus particle motion

Focus on the gut-brain axis: multiple sclerosis, the intestinal barrier and the microbiome

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World Journal of Gastroenterology 2018年第37期24卷 4217-4223页

作者： Carlos R Camara-Lemarroy Luanne M Metz V Wee Yong Department of Clinical neurosciences Cumming School of Medicine University of Calgary Hotchkiss Brain Institute Cumming School of Medicine University of Calgary

The brain-gut axis serves as the bidirectional connection between the gut microbiome, the intestinal barrier and the immune system that might be relevant for the pathophysiology of inflammatory demyelinating diseases. People with multiple sclerosis have been shown to have an altered microbiome, increased intestinal permeability and changes in bile acid metabolism. Experimental evidence suggests that these changes can lead to profound alterations of peripheral and central nervous system immune regulation. Besides being of pathophysiological interest, the brain-gut axis could also open new avenues of therapeutic targets. Modification of the microbiome, the use of probiotics, fecal microbiota transplantation, supplementation with bile acids and intestinal barrier enhancers are all promising candidates. Hopefully, pre-clinical studies and clinical trials will soon yield significant results.

关键词： Multiple sclerosis Microbiome Intestinal barrier Bile acids Gut-brain axis

Protective effects of Batroxobin on spinal cord injury in rats

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Neuroscience Bulletin 2013年第4期29卷 501-508页

作者： Hong Fan Xia Liu Hai-Bin Tang Peng Xiao Ya-Zhou Wang Gong Ju Institute of neurosciences Fourth Military Medical University Department of Rehabilitation PLA General Hospital of Air Force Department of Laboratory Medicine Xi'an Central Hospital

Expansion of the secondary injury following primary spinal cord injury is a major pathological event that increases destruction in the spinal cord, so measures to reduce secondary injury are needed. Our previous study demonstrated that, at the front of the expanding secondary injury in the spinal cord, there is an ischemic area in which many neurons can still be rescued. Therefore, enhancement of blood circulation in the cord may be helpful, and indeed, we found that a traditional Chinese medicine, shu-xue-tong, efficiently reduces the secondary injury. The aim of the present study was to investigate the effect of reducing fibrinogen with Batroxobin, a drug widely used clinically for ischemia, in rats with spinal cord contusion. We found that both 2 and 4 Batroxobin units （BU）/kg efficiently decreased the plasma fibrinogen, and 2 BU/kg significantly increased spinal blood flow, enhanced neuronal survival, mitigated astrocyte and microglia activation, and improved locomotor recovery. However, 4 BU/kg had no effect on the secondary spinal cord injury. These data suggest that Batroxobin has multiple beneficial effects on spinal cord injury, indicating a potential clinical application.

关键词： spinal cord injury secondary injury fibrinogen Batroxobin

Optical coherence tomography angiography in incomplete acute Vogt-Koyanagi-Harada disease

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International Journal of Ophthalmology(English edition) 2017年第4期10卷 661-662页

作者： gilda cennamo mario r.romano claudio iovino giuseppe de crecchio giovanni cennamo Eye Clinic Department of Neurosciences Reproductive Sciences and Dentistry University of Naples Federico ⅡNaples 80100 Italy

Dear Editor,Vogt-Koyanagi-Harada（VKH）disease is a cell-mediated autoimmune syndrome directed against *** is considered a multisystem disorder characterized by granulomatous panuveitis often associated with neurologi... 详细信息

关键词： area Figure Optical coherence tomography angiography in incomplete acute Vogt-Koyanagi-Harada disease

(Phospho)creatine:the reserve and merry-go-round of brain energetics

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Neural Regeneration Research 2023年第2期18卷 327-328页

作者： Hong-Ru Chen Ton DeGrauw Chia-Yi Kuan Department of neurosciences University of Virginia School of MedicineCharlottesvilleVAUSA Department of Pediatrics Division of NeurologyEmory UniversityAtlantaGAUSA

Creatine transporter(CrT)-deficiency,the most common form of the cerebral creatine deficiency syndromes,causes cognition impairments and severe reduction of the brain creatine(Cr)and phosphocreatine(PCr)levels,and responds poorly to oral Cr supplement as a treatment *** ca uses of cognitive impairments in CrT-deficient children remain *** recently use gene-targeting to create a mouse model of CrT-deficiency to assess the impacts of Cr/PCr deficiency on brain energetics and stress-adaptation responses(Chen et al.,2021).

关键词： impairment cerebral creatine

Stem cell therapy for Parkinson’s disease: safety and modeling

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Neural Regeneration Research 2020年第1期15卷 36-40页

作者： Theo Stoddard-Bennett Renee Reijo Pera Department of Cell Biology and neurosciences Montana State UniversityBozemanMTUSA Department of Chemistry and Biochemistry Montana State UniversityBozemanMTUSA

For decades,clinicians have developed medications and therapies to alleviate the symptoms of Parkinson’s disease,but no treatment currently can slow or even stop the progression of this localized ***,sparked by the genetic revolution,stem cell reprogramming research and the advancing capabilities of personalization in medicine enable forward-thinking to unprecedented patient-specific modeling and cell therapies for Parkinson’s disease using induced pluripotent stem cells(iPSCs).In addition to modeling Parkinson’s disease more accurately than chemically-induced animal models,patient-specific stem cell lines can be created,elucidating the effects of genetic susceptibility and sub-populations’differing responses to in vitro *** cell therapy with iPSC lines provides ethical advantages because these stem cell lines do not require the sacrifice of human zygotes and genetically-specific drug trails can be tested in vitro without lasting damage to *** hopes of finally slowing the progression of Parkinson’s disease or re-establishing function,iPSC lines can ultimately be corrected with gene therapy and used as cell sources for neural transplantation for Parkinson’s *** relatively localized neural degeneration,similar to spinal column injury,Parkinson’s disease presents a better candidacy for cell therapy when compared to other diffuse degeneration found in Alzheimer’s or Huntington’s *** implantation of pluripotent cells poses the risk of an innate immune response and ***,therefore,must be taken to ensure cell line quality before *** cell quality can be quantified using a number of assays,a yielding a high percentage of therapeutically relevant dopaminergic neurons,minimal de novo genetic mutations,and standard chromosomal structure is of the utmost *** techniques focus on iPSCs because they can be matched with donors using human leukocyte antig

关键词： alpha synuclein animal model cell therapy dopaminergic neurons induced pluripotent stem cells neurodegeneration Parksinson’s disease stem cells