检索结果-南通市图书馆

Ndfip1 represses cell proliferation by controlling Pten localization and signaling specificity

在线全文

学校读者我要写书评

暂无评论

分子细胞生物学报:英文版 2015年第2期7卷 119-131页

作者： Jason Howitt Ley-Hian Low Ulrich Putz Anh Doan Jenny Lackovic Choo-Peng Goh Jenny Gunnersen John Silke Seong-Seng Tan Brain Development and Regeneration Division Florey Institute of Neuroscience and Mental HealthThe University of MelbourneParkvilleVictoria 3010Australia Department of Anatomy and neuroscience The University of MelbourneParkvilleVictoria 3010Australia Cell signalling and Cell Death laboratory Walter and Eliza Hall InstituteThe University of MelbourneParkvilleVictoria 3010Australia

Pten controls a signaling axis that is implicated to regulate cell proliferation,growth,survival,migration,and metabolism.The molecular mechanisms underlying the specificity of Pten responses to such diverse cellular functions are currently poorly understood.Herewe report the control of Pten activity and signaling specificity during the cell cycle by Ndfip1 regulation of Pten spatial distribution.Genetic deletion of Ndfip1 resulted in a loss of Pten nuclear compartmentalization and increased cell proliferation,despite cytoplasmic Pten remaining active in regulating PI3K/Akt signaling.Cells lacking nuclear Pten were found to have dysregulated levels of Plk1 and cyclin D1 that could drive cell proliferation.In vivo,transgene expression of Ndfip1 in the developing brain increased nuclear Pten and lengthened the cell cycle of neuronal progenitors,resulting in microencephaly.Our results show that local partitioning of Pten from the cytoplasm to the nucleus represents a key mechanism contributing to the specificity of Pten signaling during cell proliferation.

关键词： Akt autism cancer cell cycle microcephaly nuclear trafficking ubiquitin

Decoupling SERT-nNOS Interaction to Generate Fast-Onset Antidepressants

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

神经科学通报:英文版 2023年第8期39卷 1327-1329页

作者： Qing Ye Si‑Si Lin Henning Ulrich Yong Tang International Joint Research Centre on Purinergic signalling/School of Acupuncture and Tuina Chengdu University of Traditional Chinese MedicineChengdu 610075China Department of Biochemistry Institute of ChemistryUniversity of São PauloSão Paulo 05508Brazil Acupuncture and Chronobiology Key laboratory of Sichuan Province/School of Health and Rehabilitation Chengdu University of Traditional Chinese MedicineChengdu 610075China

Major depressive disorder(MDD)is one of the most common psychiatric disorders,and~4.7%of the world's population has an onset of depression in any one-year period.It causes constant distress,impairs social function and physiological health,and even leads to suicide[1].Numerous studies support the classic monoamine hypothesis of depressive episodes.The majority of clinical antidepressants have been developed on the basis of this hypothesis to increase 5-hydroxytryptamine(5-HT).

关键词： distress hypothesis clinical

Astrocyte-derived ATP:A New Etiological Factor for Autism Spectrum Disorder

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

neuroscience Bulletin 2022年第1期38卷 104-106页

作者： Jie Li Patrizia Rubini Yong Tang Peter Illes School of Acupuncture and Tuina Chengdu University of Traditional Chinese MedicineChengdu610075China International Collaborative Centre on Big Science Plan for Purinergic signalling Chengdu University of Traditional Chinese MedicineChengdu610075China Rudolf Boehm Institute for Pharmacology and Toxicology University of Leipzig04109LeipzigGermany

In the central nervous system,purinergic signaling plays an important role in maintaining the functions of neurons,astrocytes,and microglia,thereby regulating brain homeostasis,with consequences for higher-order cognitive processes[1].ATP released from astrocytes in conjunction with several additional signaling molecules modulates neuronal circuits.

关键词： thereby consequences purine

Splicing factor SF3B3,a NS5-binding protein,restricts ZIKV infection by targeting GCH1

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Virologica Sinica 2023年第2期38卷 222-232页

作者： Tanxiu Chen Hao Yang Penghui Liu Moliduer Hamiti Xintian Zhang Yi Xu Wenqi Quan Yong Zhang Wenhai Yu Li Jiao Tingfu Du Juemin Xi Bin Yin Wei Zhou Shuaiyao Lu Xiaozhong Peng Institute of Medical Biology Chinese Academy of Medical Sciences and Peking Union Medical CollegeKunming650031China Department of Science and Education Jiangxi Key Laboratory of Translational Cancer ResearchJiangxi Cancer HospitalNanchang330029China The State Key laboratory of Medical Molecular Biology Department of Molecular Biology and BiochemistryInstitute of Basic Medical SciencesMedical Primate Research CenterNeuroscience CenterChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing100730China

Zika virus(ZIKV),a positive-sense single-stranded RNA virus,causes congenital ZIKV syndrome in children and Guillain-Barre Syndrome(GBS)in adults.ZIKV expresses nonstructural protein 5(NS5),a large protein that is essential for viral replication.ZIKV NS5 confers the ability to evade interferon(IFN)signalling;however,the exact mechanism remains unclear.In this study,we employed affinity pull-down and liquid chromatography-tandem mass spectrometry(LC-MS/MS)analyses and found that splicing factor 3b subunit 3(SF3B3)is associated with the NS5-Flag pull-down complex through interaction with NS5.Functional assays showed that SF3B3 overexpression inhibited ZIKV replication by promoting IFN-stimulated gene(ISG)expression whereas silencing of SF3B3 inhibited expression of ISGs to promote ZIKV replication.GTP cyclohydrolase I(GCH1)is the first and ratelimiting enzyme in tetrahydrobiopterin(BH4)biosynthesis.NS5 upregulates the expression of GCH1 during ZIKV infection.And GCH1 marginally promoted ZIKV replication via the IFN pathway.Additionally,GCH1 expression is related to the regulation of SF3B3.Overexpression of the SF3B3 protein effectively reduced GCH1 protein levels,whereas SF3B3 knockdown increased its levels.These findings indicated that ZIKV NS5 binding protein SF3B3 contributed to the host immune response against ZIKV replication by modulating the expression of GCH1.

关键词： Nonstructural protein 5(NS5) Splicing factor 3b subunit 3(SF3B3) GTP cyclohydrolase I(GCH1) IFN-stimulated gene(ISGs) IFN signalling Pathway

H_(2)S-based therapies for ischaemic stroke:opportunities and challenges

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Stroke & Vascular Neurology 2019年第2期4卷 63-66页

作者： Jia Jia Jie Li Jian Cheng Jiangsu Key laboratory of Neuropsychiatric Diseases and College of Pharmaceutical Sciences Soochow UniversitySuzhouJiangsuChina Jiangsu Key laboratory of Neuropsychiatric Diseases and Institute of neuroscience Soochow UniversitySuzhouJiangsuChina

Stroke is a cerebrovascular disease displaying high mortality and morbidity. Despite extensive efforts, only very few therapies are available for stroke patients as yet. Hydrogen sulfide (H2S) is thought to be a signalling molecule that is endogenously produced and plays functional roles in the central nervous system. Currently, numerous studies show that H2S impacts stroke outcomes in animal and cellular models. Here, we review the recent research regarding the effects of endogenously produced H2S as well as exogenous H2S donors on stroke pathology, focusing on the potential of H2S-based therapies in treating ischaemic stroke. We also discuss the several issues that hinder the clinical translation of H2S-based therapies from the bench. Taken together, we think that H2S-based therapies are promising strategies for treating cerebral ischaemia if we successfully address these issues.

关键词： therapies endogenous mortality

The pleiotropic effects of tissue plasminogen activator in the brain:implications for stroke recovery

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2016年第9期11卷 1401-1402页

作者： Julia A.Grummisch Nafisa M.Jadavji Patrice D.Smith Department of neuroscience Carleton University

Tissue plasminogen activator （tPA） use in the treatment of isch- emic stroke： tPA is a serine protease that catalyzes the breakdown of blood dots. Because of its thrombolytic properties, tPA is used to treat specific types of stroke, including ischemia, but is contra- indicated for treatment of hemorrhagic stroke or head trauma. Although a life saving and powerful ＇dot buster＇, tPA has a short therapeutic window. When administered outside of this prescribed timeframe, research suggests that tPA can produce neurotoxic ef- fects in the brain, due in part to activation of several signalling pro- cesses associated with cell apoptosis, degradation of the extracel- lular matrix, and increase in the permeability of the neurovascular unit （Yepes et al., 2009）. Concerted research has been dedicated to- ward understanding the mechanisms mediating the impact of tPA on the brain, using both in vivo and in vitro animal models.

关键词： The pleiotropic effects of tissue plasminogen activator in the brain PA

The suppressor of cytokine signalling 2(SOCS2),traumatic brain injury and microglial/macrophage regulation

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2016年第9期11卷 1405-1406页

作者： Harleen S.Basrai Ann M.Turnley Department of Anatomy and neuroscience The University of Melbourne

Traumatic brain injury （TBI） results in a range of neuroinflam- matory events that vary depending on the type and extent of in- jury. Central to this is the activation of tissue resident microglia and infiltration of peripheral macrophages, which phagocytose debris and/or secrete a range of cytokines, chemokines and oth- er factors which modify the injured environment to promote or inhibit repair （Schwartz et al., 2013）. The reactive macro- phages/microglia are broadly divided into two categories.

关键词： SOCS2 Tg WT TBI The suppressor of cytokine signalling 2 traumatic brain injury and microglial/macrophage regulation

Melatonin in drug addiction and addiction management: Exploring an evolving multidimensional relationship

在线全文

学校读者我要写书评

暂无评论

World Journal of Psychiatry 2018年第2期8卷 64-74页

作者： Olakunle J Onaolapo Adejoke Y Onaolapo Behavioural neuroscience/Neuroph- armacology Unit Department of Pharmacology and Therapeutics Ladoke Akintola University of Technology Behavioural neuroscience/Neurobiology Unit Department of Anatomy Ladoke Akintola University of Technology

Melatonin is a pleiotropic signalling molecule that regulates several physiological functions, and synchronises biological rhythms. Recent evidences are beginning to reveal that a dysregulation of endogenous melatonin rhythm or action may play a larger role in the aetiology and behavioural expression of drug addiction, than was previously considered. Also, the findings from a number of animal studies suggest that exogenous melatonin supplementation and therapeutic manipulation of melatonin/melatonin receptor interactions may be beneficial in the management of behavioural manifestations of drug addiction. However, repeated exogenous melatonin administration may cause a disruption of its endogenous rhythm and be associated with potential drawbacks that might limit its usefulness. In this review, we examine the roles of melatonin and its receptors in addictive behaviours; discussing how our understanding of melatonin's modulatory effects on the brain rewards system and crucial neurotransmitters such as dopamine has evolved over the years. Possible indications(s) for melatonergic agents in addiction management, and how manipulations of the endogenous melatonin system may be of benefit are also discussed. Finally, the potential impediments to application of melatonin in the management of addictive behaviours are considered.

关键词： Dopamine Drug dependence Biological rhythms Neuroplasticity Brain reward

A role for mitogen-activated protein kinase phosphatase 1(MKP1) in neural cell development and survival

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2015年第11期10卷 1748-1749页

作者： André Toulouse Yvonne M.Nolan Department of Anatomy and neuroscience University College Cork

The mitogen-activated protein kinase（MAPK）pathways are a group of conserved intracellular signalling pathways present in most cells including neurons and glia.These pathways respond to a variety of stimuli including growth factors,cytokines and oxidative stress to generate appropriate cellular responses such as modulation of gene expression,cell proliferation,differentiation and survival as well as the stress response（Korhonen and Moilanen,2014）.

关键词： MKP1 A role for mitogen-activated protein kinase phosphatase 1 in neural cell development and survival cell