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Olfactory proteotyping: towards the enlightenment of the neurodegeneration

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Neural Regeneration Research 2019年第6期14卷 979-981页

作者： Joaquín Fernández-Irigoyen Enrique Santamaría Proteored-Institute of Health Carlos Ⅲ (ISCⅢ) Clinical Neuroproteomics UnitNavarrabiomedNavarra Health DepartmentPublic University of NavarraNavarra Institute for Health Research (IdiSNA)

Although phylogenetically ancient,the olfactory system has received less attention than other sensorial ***,olfactory dysfunction is considered an early prodromal event in neurodegenerative diseases(NDs)(Doty,2012;Attems et al.,2014),which may vary from severe smell loss(e.g.,Alzheimer’s and Parkinson’s diseases)to relatively moderate loss(e.g.,progressive supranuclear palsy)(Doty,2017).Recently,a cluster of neuropathological and functional discoveries has evidenced the relevant role of the olfactory bulb(OB)during the neurodegenerative process(Attems et al.,2014;Rey et al.,2018).For instance,the double-transgenic APP/PS1 mouse model of Alzheimer’s disease(AD)develops early proteomic disturbances accompanied by a specific modulation of the focal adhesion kinase(FAK)and mitogen-activated protein kinase(MAPK)dynamics at the level of the OB,demonstrating that olfactory molecular alterations occur prior toβ-amyloid plaque appearance and memory impairments in APP/PS1 transgenic mice(Lachen-Montes et al.,2016).

关键词： Although phylogenetically olfactory system considered

Nanoplasmonic mid-infrared biosensor for in vitro protein secondary structure detection

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Light(Science & Applications) 2017年第1期6卷 656-665页

作者： Dordaneh Etezadi John B Warner IV Francesco S Ruggeri Giovanni Dietler Hilal A Lashuel Hatice Altug Bionanophotonic Systems Laboratory École Polytechnique Fédérale de Lausanne(EPFL)Lausanne CH-1015Switzerland Laboratory of Molecular Neurobiology and neuroproteomics EPFLLausanne CH-1015Switzerland Institute of Physics Laboratory of the Physics of Living MatterEPFLLausanne CH-1015Switzerland Department of Chemistry Lensfield roadUniversity of CambridgeCambridge CB21EWUK

Plasmonic nanoantennas offer new applications in mid-infrared(mid-IR)absorption spectroscopy with ultrasensitive detection of structural signatures of biomolecules,such as proteins,due to their strong resonant *** amide I fingerprint of a protein contains conformational information that is greatly important for understanding its function in health and ***,we introduce a non-invasive,label-free mid-IR nanoantenna-array sensor for secondary structure identification of nanometer-thin protein layers in aqueous solution by resolving the content of plasmonically enhanced amide I *** successfully detect random coil to crossβ-sheet conformational changes associated withα-synuclein protein aggregation,a detrimental process in many neurodegenerative ***,our experimental results demonstrate high conformational sensitivity by differentiating subtle secondary-structural variations in a nativeβ-sheet protein monolayer from those of crossβ-sheets,which are characteristic of pathological *** nanoplasmonic biosensor is a highly promising and versatile tool for in vitro structural analysis of thin protein layers.

关键词： label-free biosensing nanoantennas plasmonics protein secondary structure surface-enhanced infrared absorption spectroscopy

Stem cells in neuroinjury and neurodegenerative disorders: challenges and future neurotherapeutic prospects

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Neural Regeneration Research 2014年第9期9卷 901-906页

作者： Tarek H.Mouhieddine Firas H.Kobeissy Muhieddine Itani Amaly Nokkari Kevin K.W.Wang Faculty of Medicine American University of Beirut Medical Center Center for neuroproteomics and Biomarkers Research Department of Psychiatry Gainesville Division of Addiction Medicine Department of Psychiatry University of Florida Faculty of Medicine Saint George University of London Department of Biochemistry and Molecular Genetics American University of Beirut

The prevalence of neurodegenerative diseases and neural injury disorders is increasing worldwide. Research is now focusing on improving current neurogenesis techniques including neural stem cell therapy and other biochemical drug-based approaches to ameliorate these disorders. Unfortunately, we are still facing many obstacles that are rendering current neurotherapies ineffective in clinical trials for reasons that are yet to be discovered. That is why we should start by fully understanding the complex mechanisms of neurogenesis and the factors that affect it, or else, all our suggested therapies would fail since they would not be targeting the essence of the neurological disorder but rather the symptoms. One possible paradigm shift is to switch from neuroprotectant therapies towards neurodegeneration/neurorestorative approaches. In addition, other and our laboratories are increasingly focusing on combining the use of pharmacological agents（such as Rho-associated kinase（ROCK） inhibitors or other growth factors（such as brain-derived neurotrophic factor（BDNF）） and stem cell treatment to enhance the survivability and/or differentiation capacity of transplanted stem cells in neurotrauma or other neurodegeneration animal models. Ongoing stem cell research is surely on the verge of a breakthrough of multiple effective therapeutic options for neurodegenerative disorders. Once, we fully comprehend the process of neurogenesis and its components, we will fully be capable of manipulating and utilizing it. In this work, we discuss the current knowledge of neuroregenerative therapies and their associated challenges.

关键词： neural stem cells neurodegeneration neuroinjury TBI rho-associated kinase(ROCK) inhibitor BDNF growth factors stem cell therapy

SARS-CoV-2 involvement in central nervous system tissue damage

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Neural Regeneration Research 2022年第6期17卷 1228-1239页

作者： Muhammad Ali Haidar Zaynab Shakkour Mohammad Amine Reslan Nadine Al-Haj Perla Chamoun Karl Habashy Hasan Kaafarani Shima Shahjouei Sarah HFarran Abdullah Shaito Esber SSaba Bassam Badran Mirna Sabra Firas Kobeissy Maya Bizri Department of Biochemistry and Molecular Genetics Faculty of MedicineAmerican University of BeirutBeirutLebanon Faculty of Health Sciences University of BalamandBeirutLebanon Faculty of Medicine University of BalamandKouraLebanon Faculty of Science Lebanese UniversityBaabdaLebanon Program for Neurotrauma Neuroproteomics&Biomarkers ResearchDepartments of Emergency MedicineUniversity of FloridaGainesvilleFLUSA Department of Pathology and Laboratory Medicine American University of Beirut Medical CenterBeirutLebanon Biomedical Research Center Qatar UniversityDohaQatar Department of Experimental Pathology Immunology and MicrobiologyFaculty of MedicineAmerican University of BeirutBeirutLebanon Laboratory of Cancer Biology and Molecular Immunology Faculty of Sciences ILebanese UniversityHadathBeirutLebanon Faculty of Medicine Lebanese UniversityNeuroscience Research Center(NRC)BeirutLebanon Neuroscience Institute Neurology DepartmentGeisinger Health SystemPAUSA Department of Psychiatry American University of BeirutBeirutLebanon

As the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)continues to spread globally,it became evident that the SARS-CoV-2 virus infects multiple organs including the *** clinical studies revealed that patients with COVID-19 infection experience an array of neurological signs ranging in severity from headaches to life-threatening *** the exact mechanism by which the SARS-CoV-2 virus directly impacts the brain is not fully understood,several theories have been suggested including direct and indirect pathways induced by the *** possible theory is the invasion of SARS-CoV-2 to the brain occurs either through the bloodstream or via the nerve endings which is considered to be the direct *** findings are based on studies reporting the presence of viral material in the cerebrospinal fluid and brain ***,the indirect mechanisms,including blood-clotting abnormalities and prolonged activation of the immune system,can result in further tissue and organ damages seen during the course of the *** overview attempts to give a thorough insight into SARS-CoV-2 coronavirus neurological infection and highlights the possible mechanisms leading to the neurological manifestations observed in infected patients.

关键词： autoantibodies CNS infection coagulopathy COVID-19 encephalitis neuroinflammation renin-angiotensin system viral encephalopathy

Spatial proteomics in three-dimensional intact specimens

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四川生理科学杂志 2022年第12期44卷 2202-2202页

作者： Harsharan Singh Bhatia Insititute for Tissue Engineering and Regenerative Medicine (iTERM) Helmholtz Zentrum München 85764 Neuherberg Germany Institute for Stroke and Dementia Research Klinikum der Universität München Ludwig-Maximilians University Munich 81377 Munich Germany Department for Proteomics and Signal Transduction Max Planck Institute of Biochemistry 82152 Martinsried Germany Boehringer Ingelheim Pharma GmbH & Co. KG Drug Discovery Sciences Birkendorfer Str. 65 D-88400 Biberach Riss Germany Graduate School of Neuroscience (GSN) 82152 Munich Germany Munich Cluster for Systems Neurology (SyNergy) 81377 Munich Germany Center for Translational Cancer Research (TranslaTUM) of the TUM 81675 Munich Germany Image-Based Biomedical Modeling Department of Informatics Technical University of Munich 85748 Garching Germany Helmholtz AI Helmholtz Zentrum München 85764 Neuherberg Germany Biomedical Image Analysis Group Department of Computing Imperial College London London SW7 2AZ UK Department for Quantitative Biomedicine University of Zurich 8006 Zurich Switzerland Department of Neuroradiology Klinikum rechts der Isar 81675 Munich Germany Munich Medical Research School (MMRS) 80336 Munich Germany Institute for Diabetes and Cancer Helmholz Zentrum München 85764 Neuherberg Germany Institute for Diabetes and Obesity Helmholz Zentrum München 85764 Neuherberg Germany German Center for Diabetes Research Helmholz Zentrum München 85764 Neuherberg Germany German Center for Neurodegenerative Diseases (DZNE) 81377 Munich Germany neuroproteomics School of Medicine Klinikum Rechts der Isar Technical University of Munich 81675 Munich Germany Institute of Anatomy University of Leipzig 04109 Leipzig Germany Institute of Computational Biology Helmholz Zentrum München 85764 Neuherberg Germany TUM School of Life Sciences Weihenstephan Technical University of Munich 85354 Freising Germany Department of Mathematics Technical University of Munich 85748 Garching Germany NNF Center for Protein Res

Spatial molecular profiling of complex tissues is essential to investigate cellular function in physiological and pathological ***,methods for molecular analysis of large biological specimens imaged in 3D are ***,we present DISCO-MS,a technology that combines whole-organ/whole-organism clearing and imaging,deep-learning-based image analysis,robotic tissue extraction,and ultra-high-sensitivity mass spectrometry.

关键词： Spatial combine analysis