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The role of microglia versus peripheral macrophages in maladaptive plasticity after nerve injury

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Neural Regeneration Research 2021年第6期16卷 1202-1203页

作者： Thomas A.Szabo-Pardi Nilesh M.Agalave Michael D.Burton neuroimmunology and behavior laboratory Department of NeuroscienceSchool of Behavioral and Brain SciencesCenter for Advanced Pain StudiesUniversity of Texas at DallasRichardsonTXUSA

Microglia and macrophages in the development of maladaptive plastic changes after peripheral nerve injury:Microglia and macrophages encompass the innate immune response to injury in the central and peripheral nervous systems,respectively,and are intimately involved in the pathogenesis of maladaptive changes(Tsuda,2019).These dynamic cells can influence neuronal activity in active and quiescent *** findings argue that peripheral macrophages facilitate the development of nerve injury-induced neuropathic pain,as opposed to central microglia(Lopes et al.,2017;Yu et al.,2020).

关键词： al. injury peripheral

Utilizing multiphoton imaging and integrative clearing to reveal sex differences in neuroimmune interactions after nerve injury

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Neural Regeneration Research 2022年第11期17卷 2429-2430页

作者： Zachary W.Castillo Michael D.Burton neuroimmunology and behavior laboratory Department of NeuroscienceSchool of Behavioral and Brain SciencesCenter for Advanced Pain StudiesUniversity of Texas at Dallas

With the constant development of multiphoton microscopy,our ability to observe complex and dynamic biological processes deeper within living tissue,is steadily *** use multiphoton microscopy,because experiments can be conducted with little to no invasiveness or tissue damage over a long period of time with no photodamage(Mancuso et al.,2009).This allows for the introduction of tissue into the context of a three-dimensional 3D environment in which visualization of cellular activation and interaction is *** circumventing a distorted reconstruction with limited z-stacks,multiphoton imaging provides enhanced spatiotemporal resolution.

关键词： resolution. multiphoton distorted

Differential response of injured and healthy retinas to syngeneic and allogeneic transplantation of a clonal cell line of immortalized olfactory ensheathing glia:a double-edged sword

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Neural Regeneration Research 2025年第8期20卷 2395-2407页

作者： María Norte-Muñoz María Portela-Lomba Paloma Sobrado-Calvo Diana Simón Johnny Di Pierdomenico Alejandro Gallego-Ortega Mar Pérez JoséMCabrera-Maqueda Javier Sierra Manuel Vidal-Sanz María Teresa Moreno-Flores Marta Agudo-Barriuso Grupo de Investigación Oftalmología Experimental Departamento de OftalmologíaOptometríaOtorrinolaringología y Anatomía PatológicaFacultad de MedicinaUniversidad de MurciaInstituto Murciano de Investigación Biosanitaria(IMIB)Campus de Ciencias de la SaludMurciaSpain Experimental Sciences Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain Anatomy Histology and Neuroscience DepartmentMedicine FacultyUniversidad Autónoma de MadridMadridSpain Center of neuroimmunology Service of NeurologyLaboratory of Advanced Imaging in Neuroimmunological DiseasesHospital Clínic of BarcelonaInstitut d’Investigacions Biomèdiques August Pi i Sunyer(IDIBAPS)and Universitat de BarcelonaBarcelonaSpain Medicine Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain

Olfactory ensheathing glia promote axonal regeneration in the mammalian central nervous system,including retinal ganglion cell axonal growth through the injured optic ***,it is unknown whether olfactory ensheathing glia also have neuroprotective *** ensheathing glia express brain-derived neurotrophic factor,one of the best neuroprotectants for axotomized retinal ganglion ***,we aimed to investigate the neuroprotective capacity of olfactory ensheating glia after optic nerve *** ensheathing glia cells from an established rat immortalized clonal cell line,TEG3,were intravitreally injected in intact and axotomized retinas in syngeneic and allogeneic mode with or without microglial inhibition or immunosuppressive *** and gene expression analyses were *** bulb-derived primary olfactory ensheathing glia and TEG3 express major histocompatibility complex classⅡ*** and syngenically transplanted TEG3 cells survived in the vitreous for up to 21 days,forming an *** axotomized retinas,only the allogeneic TEG3 transplant rescued retinal ganglion cells at 7 days but not at 21 *** these retinas,microglial anatomical activation was higher than after optic nerve crush *** intact retinas,both transplants activated microglial cells and caused retinal ganglion cell death at 21 days,a loss that was higher after allotransplantation,triggered by pyroptosis and partially rescued by microglial inhibition or ***,neuroprotection of axotomized retinal ganglion cells did not improve with these *** different neuroprotective properties,different toxic effects,and different responses to microglial inhibitory treatments of olfactory ensheathing glia in the retina depending on the type of transplant highlight the importance of thorough preclinical studies to explore these variables.

关键词： cell therapy immune recognition major histocompatibility complex class II(MHCII) neuroprotection olfactory ensheathing glia retinal ganglion cells

Comparative immunology

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Integrative Zoology 2006年第1期1卷 32-43页

作者： Edwin L.COOPER laboratory of Comparative neuroimmunology Department of NeurobiologyDavid Geffen School of Medicine at UCLAUniversity of CaliforniaLos AngelesCaliforniaUSA

As a discipline,comparative immunology enhances zoology and has gained wide acceptance in the biological *** is an offshoot of the parent field,immunology,and is an amalgam of immunology and *** animals from protozoans to humans have solved the threat of extinction by having evolved an immune-defense strategy that ensures the capacity to react against foreign,non-self microorganisms and cancers that disturb the homeostatic ***-type innate immune responses evolved first and they characterize the *** rapid natural responses act immediately and are often essential for the occurrence of slower,more specific,adaptive vertebratetype immune *** components of the innate immune system,there is an emphasis on several major steps in the evolutionary process:(i)recognition;(ii)the phagocytic cell;and(iii)the natural killer *** vertebrates evolved,beginning with fish,thymus-controlled T cells first appeared,as did bone marrow-derived B cells(first found in amphibians with long bones).These were the precursors of the plasma cells that synthesize and secrete *** the concept of self/non-self,invertebrates possess natural,non-adaptive,innate,non-clonal,non-anticipatory immune responses,whereas vertebrates possess adaptive,acquired,clonal,and anticipatory *** symposium concerns:(i)aspects of the immune spectrum in representative groups;(ii)specific findings(in particular models;***);(iii)clues as to the possible biomedical application of relevant molecules derived from animals,notably invertebrates;and(iv)some views on the more practical applications of understanding immune systems of invertebrates and ectotherms,and their possible role in survival.

关键词： adaptive immunity immunology innate invertebrates

Autophagy and neurodegenerative disorders

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Neural Regeneration Research 2013年第24期8卷 2275-2283页

作者： Evangelia Kesidou Roza Lagoudaki Olga Touloumi Kyriaki-Nefeli Poulatsidou Constantina Simeonidou laboratory of Experimental Neurology and neuroimmunology Second Department of Neurology AHEPA University Hospital Aristotle University of Thessaloniki Department of Experimental Physiology Medical School Aristotle University of Thessaloniki

Accumulation of aberrant proteins and inclusion bodies are hallmarks in most neurodegenerative diseases. Consequently, these aggregates within neurons lead to toxic effects, overproduction of reactive oxygen species and oxidative stress. Autophagy is a significant intracellular mechanism that removes damaged organelles and misfolded proteins in order to maintain cell homeostasis. Excessive or insufficient autophagic activity in neurons leads to altered homeostasis and influences their survival rate, causing neurodegeneration. The review article provides an update of the role of autophagic process in representative chronic and acute neurodegenerative disorders.

关键词： neural regeneration reviews oxidative stress autophagy autophagy-related genes apoptosis Parkinson's disease amyotrophic lateral sclerosis multiple sclerosis acute and chronic neurode-generation neuroregeneration

Rehabilitation following spinal cord injury:how animal models can help our understanding of exercise-induced neuroplasticity

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Neural Regeneration Research 2019年第3期14卷 405-412页

作者： Kristina Loy Florence M.Bareyre Institute of Clinical neuroimmunology Ludwig-Maximilians Universitat Munchen Munich Cluster of Systems Neurology (SyNergy)

Spinal cord injury is a devastating condition that is followed by long and often unsuccessful recovery after trauma. The state of the art approach to manage paralysis and concomitant impairments is rehabilitation, which is the only strategy that has proven to be effective and beneficial for the patients over the last decades. How rehabilitation influences the remodeling of spinal axonal connections in patients is important to understand, in order to better target these changes and define the optimal timing and onset of training. While clinically the answers to these questions remain difficult to obtain, rodent models of rehabilitation like bicycling, treadmill training, swimming, enriched environments or wheel running that mimic clinical rehabilitation can be helpful to reveal the axonal changes underlying motor recovery. This review will focus on the different animal models of spinal cord injury rehabilitation and the underlying changes in neuronal networks that are improved by exercise and rehabilitation.

关键词： remodeling exercise wheel running treadmill detour circuit propriospinal neuron corticospinal tract raphespinal tract reticulospinal tract activity recovery central nervous system

Inflammation and dysregulation of immune response in Alzheimer disease,the drug target for the future

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Inflammation and dysregulation of immune response in Alzheim...

Forkhead box protein P1, a key player in neuronal development?

2019全国老年痴呆与认知障碍相关疾病学术大会

作者： ZHU Jie neuroimmunology laboratory Karolinska Institute of Medicine

It has been demonstrated that inflammation and dysregulation of immune response are involved in the pathogenesis of Alzheimer disease(AD).Inflammation is an early event in AD development,especially inflammasome and pro-inflammatory molecules are pathogenic factor in *** data showed that activated immune cells may contribute to the pathogenesis of AD,since the mice with immune cells knock out demonstrated differentsings in the neurodegenerative process and T cells aid clearance of plaques in mice and infiltrating parenchymal T-cell in AD brain mainly in the light of amyloid pathology,and immune treatment is effective,***,the direct evidence on T and B cells infiltrating into the brain of APP transgenic mice have not yet *** aged T cells are pathogenic in AD?How is role of aged B cells?These questions are still *** conclusion,activated immune cells,and inflammatory molecules may play important roles in neurodegenerative disorders,such as *** mechanisms of behind this are needed to further *** inflammation in the early phase of AD and restore normal immune regulation are new drug target for the future.

关键词： inflammation immune response drug target neurodegenerative disorders

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Neural Regeneration Research 2018年第5期13卷 801-802页

作者： Luca Braccioli Cora H.Nijboer Paul J.Coffer laboratory of neuroimmunology and Developmental Origins of Disease (NIDOD) University Medical Center Utrecht University Regenerative Medicine Center University Medical Center Utrecht Utrecht University Center for Molecular Medicine and Division of Pediatrics University Medical Center Utrecht Utrecht University

Forkhead box protein P1（FOXP1）is a transcription factor belonging to the forkhead box（FOX）proteins,a family of transcriptional regulators sharing a highly conserved forkhead DNA-binding domain（Bacon and Rappold,2012）.Previous reports have proposed a role for FOXP1 in functionally regulating the central nervous system（CNS）,while mutations in FOXP1 have been implicated in cognitive abnormalities（Bacon and Rappold, 2012）.

关键词： a key player in neuronal development Forkhead box protein P1

Glucocorticosteroid therapy in inflammatory bowel diseases: From clinical practice to molecular biology

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World Journal of Gastroenterology 2017年第36期23卷 6628-6638页

作者： Karen Dubois-Camacho Payton A Ottum Daniel Franco-Munoz Marjorie De la Fuente Alejandro Torres-Riquelme David Díaz-Jiménez Mauricio Olivares-Morales Gonzalo Astudillo Rodrigo Quera Marcela A Hermoso Innate Immunity laboratory Immunology ProgramInstitute of Biomedical SciencesFaculty of MedicineUniversidad de Chile neuroimmunology laboratory Immunology ProgramInstitute of Biomedical SciencesFaculty of MedicineUniversidad de Chile Division of Research Clínica Las Condes Gastroenterology Department Inflammatory Bowel Disease ProgramClínica Las Condes

Inflammatory bowel diseases(IBDs),such as ulcerative colitis and Crohn's disease,are chronic pathologies associated with a deregulated immune response in the intestinal mucosa,and they are triggered by environmental factors in genetically susceptible *** glucocorticoids(GCs)are widely used as anti-inflammatory therapy in *** the past,patients with moderate or severe states of inflammation received GCs as a first line therapy with an important effectiveness in terms of reduction of the disease activity and the induction of ***,this treatment often results in detrimental side *** downside drove the development of second generation GCs and more precise(non-systemic)drugdelivery *** clinical trials show that most of these new treatments have similar effectiveness to first generation GCs with fewer adverse *** remaining challenge in successful treatment of IBDs concerns the refractoriness and dependency that some patients encounter during GCs treatment.A deeper understanding of the molecular mechanisms underlying GC response is key to personalizing drug choice for IBDs patients to optimize their response to *** this review,we examine the clinical characteristics of treatment with GCs,followed by an in depth analysis of the proposed molecular mechanisms involved in its resistance and dependence associated with *** thorough analysis of current clinical and biomedical literature may help guide physicians in determining a course of treatment for IBDs patients and identifies important areas needing further study.

关键词： Inflammatory bowel diseases Ulcerative colitis Crohn's disease Glucocorticoid dependence Glucocorticoid resistance