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Anatomical and Functional Diversity in Amygdala Circuits

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Anatomical and Functional Diversity in Amygdala Circuits

Paracrine actions of glucagon-like peptide 1 in the gut unraveled

中国神经科学学会第十二届全国学术会议

作者： Anna Beyeler neurocentre magendie INSERM University of Bordeaux

Inappropriate assignment of emotional valence and dysfunctions of the circuits that govern valence processing are thought to underlie many psychiatric diseases including anxiety, depression and addiction. The basolateral amygdala（BLA） is known to play a critical role in the formation of associative memories of both positive and negative valence and contains multiple populations of projection neurons, including populations targeting the ventral hippocampus（BLA-v HPC）, the nucleus accumbens（BLA-NAc） and the central nucleus of the amygdala（BLA-Ce A）. To define the critical yet unknown role of these neural populations we used a combination of cutting edge technologies in mice models. Using optogenetics to activate or inhibit these populations in vivo, we found that BLA-v HPC projection regulates anxiety-related behaviors, while BLA-NAc population support reward seeking and BLA-Ce A population induce avoidance. By combining large-scale single-unit recordings and optogenetic photoidentification in vivo, we identified that despite the heterogeneity of single-cell coding, BLA-NAc and BLA-Ce A populations differentially encode the retrieval of positive and negative associations. Consistently, we provided evidences that experiences of opposite valence differentially regulate the synaptic inputs onto BLA-NAc and BLA-Ce A populations. Surprisingly, the BLA-v HPC population did not preferentially code for learned valence, supporting a model of distinct routing for innate and learned valencerelated information. Finally, we identified a topographical organization of the three populations within the amygdala and mapped their local connectivity using ex vivo whole-cell patch-clamp recordings. Together, our findings reveal that valence encoding in the amygdala is at least partially accomplished through the divergent activity of anatomically defined neural populations.

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Life Metabolism 2022年第1期1卷 6-7页

作者： Camille Allard Daniela Cota University of Bordeaux INSERMNeurocentre MagendieU1215 BordeauxFrance

In the last issue of Cell,Zhang et *** pinpointed in male mice how endogenous glucagon-like peptide 1(GLP-1)production by intestinal L cells triggers a coordinated interorgan crosstalk to mediate stomach distension and appetite ***-1 was originally described at the beginning of the 20th century as a peptide deriving from pre-proglucagon,and then officially named in the 1980s[1].GLP-1 has a large number of metabolic actions,the most studied ones being its capacity to inhibit gastric emptying,suppress food intake,and reduce glycemia[1].GLP-1 receptor(GLP-1R)agonists are effective drugs for the treatment of type 2 diabetes and obesity[1].

关键词： stomach al. endogenous

维普期刊数据库

Vangl2 regulation in a mammalian model for planar polarity

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Vangl2 regulation in a mammalian model for planar polarity

Regulation of synapse activity by the scaffolding planar cell polarity protein Scribblel

中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Arnaud Giese La Lasvaux Claire Mazzocco Elodie Richard Matthew W.Kelley Nathalie Sans John Brigande Mireille Montcouquiol INSERM U862 Neurocentre MagendiePlanar Polarity and Plasticity groupBordeauxFrance University of Bordeaux France

Vangl2 is one of the central proteins controlling the establishment of Planar Cell Polarity in different tissues and ***,results in both flies and mammals suggest that that the localization of Vangl2 protein to specific intracellular microdomains is crucial for normal ***,the molecular mechanisms that control Vangl2 trafficking within a cell are largely ***,we identify a new binding partner for Vangl2,G-protein signaling-GAIP -interacting protein 1(GIPC1).We show that the central PDZ domain of GIPC1 directly associates with the last 12 amino acids of Vangl2,and that GIPC1,along with the motor protein MyosinⅥ(MyoⅥ),co-localizes with Vangl2 in endosomal *** show that a GIPC1/MyoⅥcomplex regulates the levels of Vangl2 at the plasma membrane. Consistent with this result,high resolution imaging by STED microscopy reveals a depletion of Vangl2 in the proximal membrane of hair cells,a location with a large accumulation of ***,downregulation of GIPC1 in hair cells by shRNA in vitro or in utero leads to hair cell maturation defects,including defects in hair bundle orientation and *** results demonstrate a role for GIPC1 in the regulation of Vangl2 protein within developing hair cells. Moreover,morphological analysis of the effects of depletion of GIPC1 indicates a broader role for this molecule in the development of both stereociliary bundles and planar cell polarization.

关键词： planar polarity inner ear traffic cochlea Van Gogh-like 2

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Regulation of synapse activity by the scaffolding planar cel...

Novel insights into D-Pinitol based therapies:a link between tau hyperphosphorylation and insulin resistance

中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Nathalie Sans "Planar Polarity and Plasticity" Group INSERMNeurocentre MagendieLaboratory of "Pathophysiology of Neural Plasticity" U862University of Bordeaux33077 Bordeaux CedexFrance

＜正＞A strong relationship exists between the structure,maintenance and function of dendritic spines and activity-dependent spine remodeling is believed to underlie physiological processes such as synaptic transmission and ***,structural and/or functional changes at the level of dendritic spines will be sensed by, and affect,all the local neuronal networks,and ultimately,behavior such as learning and memory.A broad variety of psychiatric and neurologic disorders are accompanied by patterns of altered ***,the molecular mechanisms that control spine morphology and pathology have been studied for many *** have focused our studies on Scribble1,which is a crucial regulator of spine development,as well as structural and functional plasticity. Our data suggested that the circletail mutant,a mouse model for planar cell polarity（PCP） defects,might be a model for studying synaptic dysfunction and human psychiatric disorders such as autism syndrome disorders.

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Neural Regeneration Research 2024年第2期19卷 289-295页

作者： Dina Medina-Vera Antonio Jesús López-Gambero Juan Antonio Navarro Carlos Sanjuan Elena Baixeras Juan Decara Fernando Rodríguez de Fonseca Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND UGC Salud MentalMálagaSpain Facultad de Ciencias Universidad de MálagaMálagaSpain CIBER Enfermedades Cardiovasculares(CIBERCV) Hospital Universitario Virgen de la VictoriaUGC del CorazónMálagaSpain University of Bordeaux INSERMNeurocentre MagendieBordeauxFrance Euronutra S.L.Calle Johannes Kepler MálagaSpain Departamento de Bioquímica y Biología Molecular Facultad de MedicinaUniversidad de MálagaMálagaSpain

Alzheimer’s disease is a neurodegenerative disorder characterized by the amyloid accumulation in the brains of patients with Alzheimer’s *** pathogenesis of Alzheimer’s disease is mainly mediated by the phosphorylation and aggregation of tau *** the multiple causes of tau hyperphosphorylation,brain insulin resistance has generated much attention,and inositols as insulin sensitizers,are currently considered candidates for drug *** present narrative review revises the interactions between these three elements:Alzheimer’s disease-tau-inositols,which can eventually identify targets for new disease modifiers capable of bringing hope to the millions of people affected by this devastating disease.

关键词： Alzheimer’s disease cyclin-dependent kinase 5 diabetes D-Pinitol inositols insulin resistance kinases phosphorylation PI3K/Akt tau

维普期刊数据库

小胶质细胞在光/暗周期过程中调节海马突触传递和睡眠持续时间

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神经损伤与功能重建 2022年第5期17卷 310-310页

作者：杜一星(编译) Department of Physiology and Pharmacology Sapienza University of Rome Axe Neurosciences Centre de Recherche du CHU de Québec Université Laval Quebec City Department of Neurology San Raffaele of Cassino National Research Council Institute of Biochemistry and Cell Biology (EMMA/Infrafrontier/IMPC ) International Campus "A. Buzzati-Traverso" INRAE Bordeaux INP NutriNeuro UMR 1286 Bordeaux University Tecniplast S.P.A. Buguggiate Department of Molecular Medicine Sapienza University INSERM Neurocentre Magendie Physiopathologie de la Plasticité Neuronale Division of Medical Sciences University of Victoria The Department of Biochemistry and Molecular Biology The University of British Columbia Department of Physiology and Pharmacology Sapienza University Laboratory affiliated to Istituto Pasteur Italia Department of Neurophysiology Neuropharmacology Inflammaging IRCCS Neuromed

小胶质细胞是大脑的常驻巨噬细胞,通过感知神经元活动并支持突触重塑和可塑性积极促进脑实质的稳态。虽然已有研究表明星形胶质细胞在睡眠中的不同作用,但小胶质细胞在调节睡眠/觉醒周期和白天不同阶段调节突触活动中的作用尚未深入研... 详细信息

小胶质细胞是大脑的常驻巨噬细胞,通过感知神经元活动并支持突触重塑和可塑性积极促进脑实质的稳态。虽然已有研究表明星形胶质细胞在睡眠中的不同作用,但小胶质细胞在调节睡眠/觉醒周期和白天不同阶段调节突触活动中的作用尚未深入研究。以光作为授时提示,我们研究了用集落刺激因子-1受体拮抗剂PLX5622消除小胶质细胞对雄性小鼠睡眠/觉醒周期和海马突触传递的影响。我们的数据表明,小胶质细胞几乎完全的耗竭会增加NREM睡眠的持续时间并减少海马兴奋性神经传递。由于cx3cr1GFP/GFP小鼠显现与PLX5622处理的小鼠中发现的相同情况,趋化因子fractalkine受体CX3CR1在这些效应中起相关作用。此外,在光照阶段小胶质细胞表达较低水平的cx3cr1;当培养的小胶质细胞受到ATP(一种在睡眠期间释放的嘌呤能分子)的刺激时其cx3cr1表达降低。我们的研究结果表明,小胶质细胞参与调节睡眠,调整其cx3cr1表达以响应光/暗阶段,并以时相依赖性方式调节突触活动。

关键词： cx3cr1 脑电图长期增强小胶质细胞耗竭微型兴奋性突触后电流睡觉眠自发兴奋性突触后电流

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