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Psychophysiological Effects of Sideritis and Bacopa Extract and Three Combinations Thereof—A Quantitative EEG Study in Subjects Suffering from Mild Cognitive Impairment (MCI)

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Advances in Alzheimer's Disease 2016年第1期5卷 1-22页

作者： Wilfried Dimpfel Leonie Schombert Andreas Biller Justus-Liebig-University Giessen Giessen Germany neuro code ag Wetzlar Germany Dr. Loges GmbH Winsen Germany

Mild cognitive impairment (MCI) is regarded as a transitional stage during the development of Alzheimer’s disease. Diagnosis of MCI can be obtained by the questionnaire “DemTect” in German speaking countries. Quantitative assessment has been successfully performed using psychometric testing concomitantly with quantitative EEG recording. The present investigation aimed at the possible treatment of MCI with two botanicals, namely extracts from Sideritis scardica (500 mg) or Bacopa monnieri (320 mg) and three combinations thereof using this method in order to find a new treatment. The performance of the d2-test, an arithmetic calculation test (CPT) and a memory-test revealed better performance for the d2-test only in the presence of Sideritis extract or the combinations with Bacopa extract. Quantitative EEG assessment during the different experimental conditions showed massive differences between both extracts. Whereas Sideritis extract and its combination with a low amount of Bacopa extract (160 mg) induced increases of spectral power in fronto-temporal brain areas, Bacopa and the combination of Sideritis with high amounts of Bacopa extract produced attenuation of all waves except for delta in fronto-temporal brain areas. These differences were also documented by quantitative EEG maps in comparison to Placebo. A different action of both extracts was confirmed by discriminant analysis, where Sideritis extract and its combination with low Bacopa grouped together quite at distance to Bacopa and the combination of Sideritis with high Bacopa. A combination of Sideritis extract with a low amount of Bacopa should be tested with daily repetitive dosing for at least 4 weeks as a consequence.

关键词： DemTect Cognition Psychometry EEG Source density Mild Cognitive Impairment (MCI) Alzheimer’s Disease CATEEM Sideritis Bacopa

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Tubulin glutamylation: a skeleton key for neurodegenerative diseases

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Neural Regeneration Research 2019年第11期14卷 1899-1900页

作者： Siem van der Laan Geronimo Dubra Krzysztof Rogowski Institute of Human Genetics (IGH) Tubulin Code Team Centre National de la Recherche Scientifique (CNRS)-University of Montpellier

Microtubules (MTs) are cytoskeletal elements formed by a non-covalent association of α- and β-tubulin heterodimers. They provide structure and shape to all eukaryotic cells and are implicated in a variety of fundamental cellular processes including cell motility, cell division, mechanotransduction as well as long-distance intracellular cargo transport. In neurons, they constitute the molecular frame that maintains the lengthy axonal projections. In view of the relative size of some axons in the human body, which can reach up to 1 m, the active transport of e.g., vesicles over the MT arrays to the synaptic cleft, is of particular importance.

关键词： neurodegenerative diseases Microtubules(MTs) cellular processes

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Metadata requirements analysis for the emerging Sensor Web

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International Journal of Digital Earth 2009年第S01期2卷 3-17页

作者： Liping Di Karen L.Moe Genong(Eugene)Yu Center for Spatial Information Science and Systems(CSISS) George Mason University6301 Ivy LnSuite 620GreenbeltMD 20770USA Earth System Technology Office NASA/GSFC MS Code 407GreenbeltMD 20771USA

The Sensor Web has emerged from Earth Science research with the development of Web technology,to achieve process automation,sensor interoperation,and service *** promises require the discovery of the right sensor at the right time and the right location with the right ***,for sensor,platform,and data,are crucial for achieving such ***,analysis and practical use of these metadata reveals that the metadata and their associations are not applicable or suitable for the Sensor *** shortfalls are(1)the nonstandard metadata expression language;(2)the missing link between sensor and domain knowledge;(3)the insufficiency in the information for geographic locating and sensor tasking;and(4)the enhanced requirements on the quality,security,and ownership of both sensors and their sensed *** paper reviews the current standards that have metadata components for the sensor and its platform,especially those from ISO TC211,Open Geospatial Consortium Inc.,and The National Aeronautics and Space Administration Global Change Master Directory.A recommendation on metadata that meets the requirement of crossmission sensor discovery in a pervasive Web environment is derived from *** recommendation addresses issues on language formalization,sensor geolocation,semantics,quality,and *** of the emerging semantic Web technology for enabling robust discovery of sensor are discussed.

关键词： Sensor Web geospatial standards metadata interoperation semantic web

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On the parity-check matrix of generalized concatenated code

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Science China(Information Sciences) 2020年第4期63卷 233-235页

作者： Sha SHI Yang LIU Junzhi YAN Jingliang GAO Yunjiang WANG Engineering Research Center of Molecular and neuro Imaging Ministry of Education School of Life Science and Technology Xidian University National Computer Network Emergency Response Technical Team/Coordination Center of China China Mobile Research Institute State Key Laboratory of Integrated Services Networks Xidian University

Dear editor,Single-level concatenation using a nonbinary code as outer code and a binary code as inner code is widely used in communication and digital data storage systems to achieve high reliability with reduced decoding complexity [1]. Moreover, concatenation can be multilevel, where multiple outer codes are concatenated with multiple inner codes

关键词： On the parity-check matrix of generalized concatenated code

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How small could a pup sound？ The physical bases of signaling body size in harbor seals

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Current Zoology 2017年第4期63卷 457-465页

作者： Andrea RAVIGNANI Stephanie GROSS Maxime GARCIA Ana RUBIO-GARCIA Bart DE BOER Veterinary & Research Department Sealcentre Pieterburen Hoofdstraat 94a Pieterburen AG 9968 The Netherlands Artificial Intelligence Laboratory Vrije Universiteit Brussel Pleinlaan 2 Brussels 1050 Belgium Language and Cognition Department Max Planck Institute for Psycholinguistics Wundtlaan 1 Nijmegen XD 6525 The Netherlands Institute for Terrestrial and Aquatic Wildlife Research University of Veterinary Medicine Hannover Foundation Werftstrasse 6 Buesum 25761 Germany ENES Lab/neuro-PSI CNRS UMR9197 University of Lyon/Saint Etienne 23 rue Paul Michelon 42023 Saint-Etienne cedex 2 France

Vocal communication is a crucial aspect of animal behavior. The mechanism which most mam- mals use to vocalize relies on three anatomical components. First, air overpressure is generated in- side the lower vocal tract. Second, as the airstream goes through the glottis, sound is produced via vocal fold vibration. Third, this sound is further filtered by the geometry and length of the upper vocal tract. Evidence from mammalian anatomy and bioacoustics suggests that some of these three components may covary with an animal＇s body size. The framework provided by acoustic al- Iometry suggests that, because vocal tract length （VTL） is more strongly constrained by the growth of the body than vocal fold length （VFL）, VTL generates more reliable acoustic cues to an animal＇s size. This hypothesis is often tested acoustically but rarely anatomically, especially in pinnipeds. Here, we test the anatomical bases of the acoustic allometry hypothesis in harbor seal pups Phoca vitulina. We dissected and measured vocal tract, vocal folds, and other anatomical features of 15 harbor seals post-mortem. We found that, while VTL correlates with body size, VFL does not. This suggests that, while body growth puts anatomical constraints on how vocalizations are filtered by harbor seals＇ vocal tract, no such constraints appear to exist on vocal folds, at least during puppy- hood. It is particularly interesting to find anatomical constraints on harbor seals＇ vocal tracts, the same anatomical region partially enabling pups to produce individually distinctive vocalizations.

关键词： acoustic allometry honest signaling larynx pinniped vocal tract.

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European Research Project’s Contributions to a Safer Automated Road Traffic

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Automotive Innovation 2023年第4期6卷 521-530页

作者： Felix Fahrenkrog Susanne Reithinger Burak Gülsen Florian Raisch BMW ag Konzepte Integrale Sicherheit(EG-34)KnorrstraBe 14780788 MunichGermany

Automated driving is poised to become a pivotal technology in the future automotive ***,it is evident that the implementation of automated driving presents significant technical *** accelerate the development and deployment of automated driving the European Commission initiated the research project L3Pilot in *** a budget of 65 million Euros and the involvement of 13 car manufacturers,L3Pilot stands as the largest European project on automated driving(AD).This paper serves as a comprehensive account of BMW’s main activities in the L3Pilot project that ended in *** research questions addressed in this project are related to the following topics:what are the guidelines for the development of AD?How do potential customers interact with AD?And what is the safety impact assessment of AD?The paper presents the findings related to all three research questions to contribute to the further development of automated *** this purpose together with other partners the code of Practice of AD was defined as a guideline for the development of future AD *** to the second question,BMW conducted tests with AD systems on motorways and in parking scenarios,with over 100 test subjects experiencing *** studies provide input and considerations for future AD ***,in the safety impact assessment,BMW investigated with other project partners the potential safety benefits of AD through *** results show a potential to improve road *** conclusion,the exploration of all three research questions has led to a deeper understanding of SAE Level 3 AD.

关键词： Automated driving L3Pilot code of Practice Pilot Safety impact assessment User acceptance

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MILI:Multi-person inference from a low-resolution image

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Fundamental Research 2023年第3期3卷 434-441页

作者： Kun Li Yunke Liu Yu-Kun Lai Jingyu Yang Tianjin University Tianjin 300350China CardiffUniversity CardiffCF244AGUnited Kingdom

Existing multi-person reconstruction methods require the human bodies in the input image to occupy a considerable portion of the ***,low-resolution human objects are ubiquitous due to trade-offbetween the field of view and target distance given a limited camera *** this paper,we propose an end-to-end multi-task framework for multi-person inference from a low-resolution image(MILI).To perceive more information from a low-resolution image,we use pair-wise images at high resolution and low resolution for training,and design a restoration network with a simple loss for better feature extraction from the low-resolution *** address the occlusion problem in multi-person scenes,we propose an occlusion-aware mask prediction network to estimate the mask of each person during 3D mesh *** results on both small-scale scenes and large-scale scenes demonstrate that our method outperforms the state-of-the-art methods both quantitatively and *** code is available at http://***/faculty/likun/projects/MILI.

关键词： Multi-person reconstruction Low-resolution human objects End-to-end Multi-task learning Occlusion-aware prediction

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STATE:Learning structure and texture representations for novel view synthesis

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Computational Visual Media 2023年第4期9卷 767-786页

作者： Xinyi Jing Qiao Feng Yu-Kun Lai Jinsong Zhang Yuanqiang Yu Kun Li College of Intelligence and Computing Tianjin UniversityTianjin 300350China School of Computer Science and Informatics Cardiff UniversityCardiff CF244AGUK

Novel viewpoint image synthesis is very challenging,especially from sparse views,due to large changes in viewpoint and *** image-based methods fail to generate reasonable results for invisible regions,while geometry-based methods have difficulties in synthesizing detailed *** this paper,we propose STATE,an end-to-end deep neural network,for sparse view synthesis by learning structure and texture *** is encoded as a hybrid feature field to predict reasonable structures for invisible regions while maintaining original structures for visible regions,and texture is encoded as a deformed feature map to preserve detailed *** propose a hierarchical fusion scheme with intra-branch and inter-branch aggregation,in which spatio-view attention allows multi-view fusion at the feature level to adaptively select important information by regressing pixel-wise or voxel-wise confidence *** decoding the aggregated features,STATE is able to generate realistic images with reasonable structures and detailed *** results demonstrate that our method achieves qualitatively and quantitatively better results than state-of-the-art *** method also enables texture and structure editing applications benefiting from implicit disentanglement of structure and *** code is available at http://***/faculty/likun/projects/STATE.

关键词： novel view synthesis sparse views spatioview attention structure representation texture representation

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Quantitative Objective Assessment of Websites by neurocode-Tracking in Combination with Eye-Tracking

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Journal of Behavioral and Brain Science 2014年第8期4卷 384-395页

作者： Wilfried Dimpfel Andrè Morys Justus-Liebig-University Giessen c/o neurocode ag Wetzlar Germany Web Arts ag Bad Homburg v. d. Hohe Germany

Assessment of websites remains a definite challenge within advertisement research. In order to gather objective information, one possibility exists in using Eye-Tracking. This method allows for determination of where and how long particular areas of a website are fixed. However, longer fixation values do not necessarily reflect higher attention or even memorizing of the content. It could also mean that the content is too complicated. Therefore more information can be obtained by addition of quantitative analysis of brain electricity. Following the changes of the frequency content of electric brain activity has been recently introduced as “neurocode-Tracking”. In the present study, quantitative assessment of websites has been performed by the combination of neuro-code-Tracking with Eye-Tracking. Fast dynamic quantitative EEG recording with a time resolution of nearly 3 images/second provided electric power values according to frequency analysis in 17 brain regions (electrode positions). Particular values represented changes of electric brain activity, which were interpreted to represent visual perception, mental activation, concentration, stimulation, memory and tension according to earlier experience. Eye-Tracking was performed in a conventional manner by defining special areas of interest for detection of fixation lengths and time to first awareness. Ten male subjects (aged 36 ± 4.4 years) entered the study. They were asked to view Internet landing pages of five bank institutions: ComDirect, DKB, INGDiBa, Postbank and Targo-Bank. According to Eye-Track analysis, ComDirect was recognized to have the shortest time-to-awareness with respect to conditions, bonus, faces and application or address form. With respect to region of interest “service”, INGDiBa showed the shortest time-to-awareness. neurocode-Tracking provided best results for INGDiBa with respect to mental activation and concentration. Stimulation and memory values were headed by Targo-Bank. Lowest tension w

关键词： neurocode-Tracking Eye-Tracking Quantitative EEG Internet Surfing CATEEM

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Static Analysis and code Complexity Metrics as Early Indicators of Software Defects

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Journal of Software Engineering and Applications 2018年第4期11卷 153-166页

作者： Safa Omri Pascal Montag Carsten Sinz Daimler ag Boeblingen Germany Karlsruhe Institute of Technology Karlsruhe Germany

Software is an important part of automotive product development, and it is commonly known that software quality assurance consumes considerable effort in safety-critical embedded software development. Increasing the effectiveness and efficiency of this effort thus becomes more and more important. Identifying problematic code areas which are most likely to fail and therefore require most of the quality assurance attention is required. This article presents an exploratory study investigating whether the faults detected by static analysis tools combined with code complexity metrics can be used as software quality indicators and to build pre-release fault prediction models. The combination of code complexity metrics with static analysis fault density was used to predict the pre-release fault density with an accuracy of 78.3%. This combination was also used to separate high and low quality components with a classification accuracy of 79%.

关键词： Static Analysis Tools Complexity Metrics Software Quality Assurance Statistical Methods Fault Proneness

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