检索结果-南通市图书馆

Interdisciplinary management of central nervous system metastasis and neoplastic meningitis:recent developments and future perspectives

引用

Journal of Cancer Metastasis and Treatment 2016年第1期2卷 163-175页

作者： Ghazaleh Tabatabai Marilin Koch Cristiana Roggia Juliane Ebert Claus Garbe Friedegund Meier Sara Brucker Eva Maria Grischke Diethelm Wallwiener Robert Möhle Lothar Kanz Walter Erich Aulitzky Ulrike Ernemann Christian laFougere Konstantin Nikolaou Bernd Pichler Jens Schittenhelm Manuela Neumann Falko Fend Stefan Czemmel Sven Nahnsen Frank Paulsen Daniel Zips Maike van Lessen Hans-Otto Karnath Ulf Ziemann Constantin Roder Marco Skardelly Jürgen Bernd Honegger Marcos Tatagiba Interdisciplinary Division of neuro-Oncology Departments of Vascular Neurology and NeurosurgeryUniversity Hospital TübingenHertie Institute for Clinical Brain ResearchEberhard Karls University72076 TübingenGermany Division of Dermato-Oncology Department of DermatologyUniversity Hospital TübingenEberhard Karls University72076 TübingenGermany Department of Gynecology and Ostetrics University Hospital TübingenEberhard Karls University72076 TübingenGermany Department of Internal Medicine(II) University Hospital TübingenEberhard Karls University72076 TübingenGermany Department of Hematology and Oncology Robert Bosch Hospital StuttgartStuttgartGermanyComprehensive Cancer CenterTübingen StuttgartGermany Department of Diagnostic and Interventional neuroradiology University Hospital TübingenEberhard Karls University72076 TübingenGermany Department of Nuclear Medicine University Hospital TübingenEberhard Karls University72076 TübingenGermany Department of Diagnostic and Interventional Radiology University Hospital TübingenEberhard Karls University72076 TübingenGermany Department of Preclinical Imaging and Radiopharmacy University Hospital TübingenEberhard Karls University72076 TübingenGermany Department of Pathology and neuropathology University Hospital TübingenEberhard Karls University72076 TübingenGermany Department of Radiation Oncology University Hospital TübingenEberhard Karls University72076 TübingenGermany Division of neuropsychology University Hospital TübingenHertie Institute for Clinical Brain ResearchEberhard Karls University72076 TübingenGermany Center for CNS tumors Comprehensive Cancer Center Tübingen StuttgartGermany Center for Personalized Medicine University Hospital TübingenEberhard Karls UniversityTübingenGermany Center for Dermato-Oncology University Hospital DresdenGermany Quantitative Biology Center(QBiC) Eberhard Karls UniversityTübingenGermany DKTK DKFZ partner site Tübingen.18Department of ImmunologyEberhard Karls University TübingenGermany

The incidence of metastatic disease in the central nervous system(CNS)is *** to current estimates,up to a third of adult cancer patients will suffer from CNS *** evidence-based data from prospective randomized trials are rare,however,because CNS metastasis patients were often excluded from clinical trial *** management of CNS metastasis patients is therefore rather ill-defined and an interdisciplinary *** basic and translational science data have begun contributing to a more profound understanding of the molecular mechanisms leading to invasion of tumor cells into the *** report reviews advances,challenges,and perspectives in this field.

关键词： Brain tumor central nervous system metastases interdisciplinary management

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

卒中介入治疗培训指南：国际多学会共识文件

引用

国际脑血管病杂志 2017年第5期25卷 396-399页

作者： Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩孙瑞郭芮兵 From the American Association of neurological Surgeons/Congress of neurological Surgeons (AANS/CNS) Rolling Meadows IL USA American Society of neuroradiology (ASNR) Oak Brook IL USA Asian Australasian Federation of lnterventional and Therapeutic neuroradiology (AAFITN) Bali Indonesia Australian and New Zealand Society of neuroradiobgy-Conjomt Committee for Recognition of Training in Interventional neuroradiology (CCINR) representing the RANZCR (ANZSNR) ANZAN and NSA Sydney Australia Canadian Interventional neuro Group (CING) Edmonton AB Canada World Federation of Interventional and Therapeutic neuroradiology (WFITN) Gold Coast Australia European Society of neuroradiology (ESNR) Milan Italy European Society of Minimally Invasive neurologic Therapy (ESMINT) Nice France Japanese Society for neuroendovascular therapy (JSNET) Okayama Japan Sociedad Ibero Latino Americana de neuroradiologica (SILAN) Cartagena Colombia Society of neurolnterventional Surgery (SNIS) Washington DC USA Society of Vascular and Interventional neurology (SVIN) Brooklyn NY USA 南京大学医学院附属金陵医院(南京军区南京总医院)神经内科 210002 解放军第一0一医院(无锡太湖医院)神经内科无锡214004

1背景缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞（emergent large vesselocclusion，ELVO）患者都会遗留长期残疾。事实上，这些颅内大动脉闭塞经常会导致大面积脑损伤，进而造成患者死亡或严重致残。

关键词：缺血性卒中培训指南介入治疗文件学会国际血管闭塞动脉闭塞

来源：

维普期刊数据库

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

小胶质细胞控制成年小鼠海马中的谷氨酸能突触

引用

神经损伤与功能重建 2021年第10期16卷 F0003-F0003页

作者： Bernadette Basilico Laura Ferrucci Patrizia Ratano Maria T Golia Alfonso Grimaldi Maria Rosito Valentina Ferretti Ingrid Reverte Caterina Sanchini Maria C Marrone Maria Giubettini Valeria De Turris Debora Salerno Stefano Garofalo Marie-Kim St-Pierre Micael Carrier Massimiliano Renzi Francesca Pagani Brijesh Modi Marcello Raspa Ferdinando Scavizzi Cornelius T Gross Silvia Marinelli Marie-Ève Tremblay Daniele Caprioli Laura Maggi Cristina Limatola Silvia Di Angelantonio Davide Ragozzino Department of Physiology and Pharmacology Sapienza University of RomeRomeItaly. neurophysiology and neuropharmacology Inflammaging unit IRCCS NeuromedMediterranean Neurological InstitutePozzilliISItaly. Center for Life Nano-and neuro-science Istituto Italiano di TecnologiaRomeItaly. Dipartimento di Biologia e Biotecnologie“Charles Darwin” Sapienza University of RomeRomeItaly. Santa Lucia Foundation(IRCCS Fondazione Santa Lucia) RomeItaly. European Brain Research Institute(EBRI)‘Rita Levi-Montalcini’ RomeItaly. CrestOptics S.p.A RomeItaly. Centre de Recherche du CHU de Québec Axe Neurosciences QuébecQuebec CityCanada. Département de Médecine Moléculaire UniversitéLaval QuébecQuebec CityCanada.1 National Research Council Institute of Biochemistry and Cell Biology(CNR-IBBC/EMMA/Infrafrontier/IMPC)International Campus“A.Buzzati-Traverso”Monterotondo(Rome)Italy.1 Epigenetics and neurobiology unit European Molecular Biology Laboratory(EMBL)MonterotondoItaly.1 Division of Medical Sciences University of VictoriaVictoriaCanada.1 Department of Physiology and Pharmacology Sapienza UniversityLaboratory affiliated to Istituto Pasteur ItaliaRomeItaly.

小胶质细胞是调节大脑突触发育和可塑性的重要细胞类型,但其影响突触的正常功能的机制尚不清楚。在本研究中,我们通过PLX5622造成小胶质细胞耗竭,并观察其对成年野生型小鼠海马CA3-CA1突触的影响。在小胶质细胞耗竭后,与树突棘密度降低... 详细信息

小胶质细胞是调节大脑突触发育和可塑性的重要细胞类型,但其影响突触的正常功能的机制尚不清楚。在本研究中,我们通过PLX5622造成小胶质细胞耗竭,并观察其对成年野生型小鼠海马CA3-CA1突触的影响。在小胶质细胞耗竭后,与树突棘密度降低相关的自发和诱发谷氨酸能活动的减少,出现未成熟突触特征以及突触的可塑性提高。小胶质细胞耗竭的小鼠在新物体识别任务的获取方面表现出缺陷。海马星形胶质细胞出现增生,但并没有神经炎症反应。在Cx3cr1-/-小鼠中,PLX不能导致海马出现上述改变。这说明CX3CL1/CX3CR1轴在小胶质细胞对突触功能的控制中有重要作用。PLX5622停用后,小胶质细胞的重新增殖,海马突触恢复,小鼠的学习功能也出现恢复。综上所述,小胶质细胞对维持成人大脑的突触的正常功能用重要的作用,去除小胶质细胞会导致谷氨酸能突触组织和活动的可逆变化。

关键词：谷氨酸能传递海马体学习小胶质细胞神经元-小胶质细胞相互作用突触

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Join us on an amazing journey towards next-generation treatments for CNS disorders:Launch of neuroprotection,a new high-quality journal in translational neuroscience

引用

neuroprotection 2023年第1期1卷 5-8页

作者： Xunming Ji Piotr Walczak Heleen M.M.van Beusekom Ana I.Casas Andrew Clarkson Tracy Farr Jukka Jolkkonen Yajie Liang Michel M.Modo Paulo H.Rosado-de-Castro Karsten Ruscher Yan-Jiang Wang Haitao Wu Marietta Zille Shen Li Johannes Boltze Beijing Institute of Brain Disorders Capital Medical UniversityBeijingChina Department of Diagnostic Radiology and Nuclear Medicine Center for Advanced Imaging ResearchUniversity of MarylandBaltimoreMarylandUSA Department of Cardiology Erasmus MC RotterdamUniversity Medical Center RotterdamRotterdamThe Netherlands Department of neurology Center for Translational Neuro‐and Behavioral Sciences(C‐TNBS)University Clinics EssenEssenGermany Department of Anatomy Brain Health Research Center and Brain Research New ZealandDunedinNew Zealand Medical School Queen's Medical CentreUniversity of NottinghamNottinghamUK A.I.Virtanen Institute for Molecular Sciences University of Eastern FinlandKuopioFinland McGowan Institute for Regenerative Medicine University of PittsburghPittsburghPennsylvaniaUSA Department of Radiology University of PittsburghPittsburghPennsylvaniaUSA Department of Bioengineering University of PittsburghPittsburghPennsylvaniaUSA Department of Anatomy and Department of Radiology School of MedicineInstitute of Biomedical SciencesFederal University of Rio de JaneiroRio de JaneiroBrazil Laboratory for Experimental Brain Research University of LundLundSweden Department of neurology Daping HospitalCenter for Clinical NeuroscienceChongqingChina Department of neurobiology Beijing Institute of Basic Medical SciencesBeijingChina Department of Pharmaceutical Sciences Division of Pharmacology and ToxicologyUniversity of ViennaViennaAustria Department of neurology and Psychiatry Beijing Shijitan HospitalCapital Medical UniversityBeijingChina School of Life Sciences University of WarwickCoventryUK

Translational medicine in neurodegenerative and neurovascular diseases is approaching a breakthrough *** years have led to dramatic progress in both experimental and clinical *** on a much better and continuously increasing understanding of disease mechanisms,progression and pathophysiology,new therapies with an improved translational potential to protect tissue either against acute or chronic degeneration and even approaches potentially capable of repairing damaged brain tissue are emerging.

关键词： cytoprotection nervous system repair neurodegeneration neuroprotection neurovasculardiseases translational research

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Aging impairs the neurovascular interface in the heart

引用

四川生理科学杂志 2023年第9期45卷 1661-1661页

作者： Julian U G Wagner Institute of Cardiovascular Regeneration Centre for Molecular Medicine Goethe University Frankfurt 60590 Frankfurt Germany. German Center for Cardiovascular Research (DZHK) Partner Site Rhein-Main 60590 Frankfurt Germany. Cardiopulmonary Institute (CPI) 60590 Frankfurt Germany. Institute for Cardiovascular Physiology Goethe University Frankfurt 60590 Frankfurt Germany. Institute for Cardiovascular Prevention Ludwig-Maximilians-Universität München (LMU) 80336 Munich Germany. Munich Cluster for Systems neurology (SyNergy) 81377 Munich Germany. German Center for Cardiovascular Research (DZHK) Partner Site Munich Munich Heart Alliance (MHA) 80802 Munich Germany. Department of Biochemistry Cardiovascular Research Institute Maastricht (CARIM) Maastricht University Maastricht Netherlands. Department of Cardiology Pulmonology and Vascular Medicine Medical Faculty Heinrich-Heine-University Düsseldorf 40225 Düsseldorf Germany. Institute of Neural and Sensory Physiology Medical Faculty and University Hospital Düsseldorf Heinrich-Heine-University Düsseldorf 40225 Düsseldorf Germany. Division of Cardiology/Angiology/Intensive Care EVK Düsseldorf cNEP cardiac Neuro- and Electrophysiology Research Consortium 40217 Düsseldorf Germany. Cardiovascular Research Institute Düsseldorf (CARID) Medical Faculty and University Hospital of Düsseldorf Heinrich-Heine University Düsseldorf 40225 Düsseldorf Germany. Department of Medicine I University Hospital Munich Ludwig Maximilian University 81377 Munich Germany. Institute of Surgical Research at the Walter-Brendel-Centre of Experimental Medicine University Hospital LMU Munich 81377 Munich Germany. Interfaculty Center for Endocrine and Cardiovascular Disease Network Modelling and Clinical Transfer (ICON) LMU Munich 80539 Munich Germany. Max Planck Institute for Heart and Lung Research 61231 Bad Nauheim Germany. Institute of Molecular and Translational Therapeutic Strategies (IMTTS) Hannover Medical School 30625 Hannover Germany. RE

Aging is a major risk factor for impaired cardiovascular *** the aging myocardium is characterized by microcirculatory dysfunction,and because nerves align with vessels,we assessed the impact of aging on the cardiac neurovascular *** report that aging reduces nerve density in the ventricle and dysregulates vascular-derived neuroregulatory *** down-regulates microRNA 145(miR-145)and derepresses the neurorepulsive factor ***-145 deletion,which increased Sema3a expression or endothelial Sema3a overexpression,reduced axon density,mimicking the aged-heart *** of senescent cells,which accumulated with chronological age in parallel to the decline in nerve density,rescued age-induced denervation,reversed Sema3a expression,preserved heart rate patterns,and reduced electrical *** data suggest that senescence-mediated regulation of nerve density contributes to age-associated cardiac dysfunction.

关键词： reversed aging interface

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：