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Copper homeostasis and neurodegenerative diseases

Neural Regeneration Research 2025年第11期20卷 3124-3143页

作者： Yuanyuan Wang Daidi Li Kaifei Xu Guoqing Wang Feng Zhang International Research laboratory of Ethnomedicine of Ministry of Education Key Laboratory of Basic Pharmacology of Ministry of EducationLaboratory Animal Center and Key Laboratory of Basic Pharmacology of Guizhou ProvinceZunyi Medical UniversityZunyiGuizhou ProvinceChina

Copper,one of the most prolific transition metals in the body,is required for normal brain physiological activity and allows various functions to work normally through its range of *** homeostasis is meticulously maintained through a complex network of copper-dependent proteins,including copper transporters(CTR1 and CTR2),the two copper ion transporters the Cu-transporting ATPase 1(ATP7A)and Cu-transporting beta(ATP7B),and the three copper chaperones ATOX1,CCS,and *** in copper homeostasis can lead to either the deficiency or accumulation of copper in brain *** evidence suggests that abnormal copper metabolism or copper binding to various proteins,including ceruloplasmin and metallothionein,is involved in the pathogenesis of neurodegenerative ***,the exact mechanisms underlying these processes are not *** is a potent oxidant that increases reactive oxygen species production and promotes oxidative *** reactive oxygen species levels may further compromise mitochondrial integrity and cause mitochondrial *** oxygen species serve as key signaling molecules in copper-induced neuroinflammation,with elevated levels activating several critical inflammatory ***,copper can bind aberrantly to several neuronal proteins,including alphasynuclein,tau,superoxide dismutase 1,and huntingtin,thereby inducing neurotoxicity and ultimately cell *** study focuses on the latest literature evaluating the role of copper in neurodegenerative diseases,with a particular focus on copper-containing metalloenzymes and copper-binding proteins in the regulation of copper homeostasis and their involvement in neurodegenerative disease *** synthesizing the current findings on the functions of copper in oxidative stress,neuroinflammation,mitochondrial dysfunction,and protein misfolding,we aim to elucidate the mechanisms by which copper contributes to a wide range of heredit

关键词： Alzheimer's disease amyotrophic lateral sclerosis disease copper homeostasis copper toxicity Huntington's disease Menkes'disease multiple sclerosis neurodegenerative disease Parkinson's disease Wilson's disease

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Application of the improved dung beetle optimizer,muti-head attention and hybrid deep learning algorithms to groundwater depth prediction in the Ningxia area,China

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 18-23页

作者： Jiarui Cai Bo Sun Huijun Wang Yi Zheng Siyu Zhou Huixin Li Yanyan Huang Peishu Zong Collaborative Innovation Center on forecast and Evaluation of Meteorological Disasters/Key laboratory of Meteorological Disaster Ministry of Education/Joint International Research Laboratory of Climate and Environment ChangeNanjing University of Information Science and TechnologyNanjingChina Southern Marine Science and Engineering Guangdong laboratory(Zhuhai) ZhuhaiChina China Meteorological Administration Key Laboratory of Transportation MeteorologyNanjingChina Jiangsu Meteorological Observatory NanjingChina

Due to the lack of accurate data and complex parameterization,the prediction of groundwater depth is a chal-lenge for numerical *** learning can effectively solve this issue and has been proven useful in the prediction of groundwater depth in many *** this study,two new models are applied to the prediction of groundwater depth in the Ningxia area,*** two models combine the improved dung beetle optimizer(DBO)algorithm with two deep learning models:The Multi-head Attention-Convolution Neural network-Long Short Term Memory networks(MH-CNN-LSTM)and the Multi-head Attention-Convolution Neural network-Gated Recurrent Unit(MH-CNN-GRU).The models with DBO show better prediction performance,with larger R(correlation coefficient),RPD(residual prediction deviation),and lower RMSE(root-mean-square error).Com-pared with the models with the original DBO,the R and RPD of models with the improved DBO increase by over 1.5%,and the RMSE decreases by over 1.8%,indicating better prediction *** addition,compared with the multiple linear regression model,a traditional statistical model,deep learning models have better prediction performance.

关键词： Groundwater depth Multi-head attention Improved dung beetle optimizer CNN-LSTM CNN-GRU Ningxia

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Olfactory receptors in neural regeneration in the central nervous system

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Neural Regeneration Research 2025年第9期20卷 2480-2494页

作者： Rafael Franco Claudia Garrigós Toni Capó Joan Serrano-Marín Rafael Rivas-Santisteban Jaume Lillo Molecular Neurobiology laboratory Department of Biochemistry and Molecular BiomedicineFacultat de BiologiaUniversitat de BarcelonaBarcelonaSpain CiberNed network Center for Biomedical Research in Neurodegenerative Diseases Spanish National Health Institute Carlos ⅢMadridSpain School of Chemistry Universitat de BarcelonaBarcelonaSpain Department of Biochemistry and Physiology School of Pharmacy and Food SciencesUniversitat de BarcelonaBarcelonaSpain laboratory of Computational Medicine Biostatistics UnitFaculty of MedicineAutonomous University of BarcelonaCampus BellaterraBarcelonaSpain

Olfactory receptors are crucial for detecting odors and play a vital role in our sense of smell,influencing behaviors from food choices to emotional *** receptors also contribute to our perception of flavor and have potential applications in medical diagnostics and environmental *** ability of the olfactory system to regenerate its sensory neurons provides a unique model to study neural regeneration,a phenomenon largely absent in the central nervous *** gained from how olfactory neurons continuously replace themselves and reestablish functional connections can provide strategies to promote similar regenerative processes in the central nervous system,where damage often results in permanent *** the molecular and cellular mechanisms underpinning olfactory neuron regeneration could pave the way for developing therapeutic approaches to treat spinal co rd injuries and neurodegenerative diseases like Alzheimer's *** ctory receptors are found in almost any cell of eve ry orga n/tissue of the mammalian *** ectopic expression provides insights into the chemical structures that can activate olfactory *** addition to odors,olfactory receptors in ectopic expression may respond to endogenous compounds and molecules produced by mucosal colonizing *** analysis of the function of olfactory receptors in ectopic expression provides valuable information on the signaling pathway engaged upon receptor activation and the receptor's role in proliferation and cell differentiation *** review explo res the ectopic expression of olfa ctory receptors and the role they may play in neural regeneration within the central nervous system,with particular attention to compounds that can activate these receptors to initiate regenerative *** suggests that olfactory receptors could serve as potential therapeutic targets for enhancing neural repair and recovery following central nervous syste

关键词： adenosine receptors adrenergic receptors ectopic expression G proteincoupled receptors glia neurons

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A Study on Influential User Identification in Online Social networks

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Chinese Journal of Electronics 2016年第3期25卷 467-473页

作者： WANG Nan SUN Qindong ZHOU Yadong SHEN Si Shaanxi Key laboratory of network Computing and Security Xi'an University of Technology Ministry of Education Key laboratory For Intelligent network and network Security Xi'an Jiaotong University

Influential user evaluation is great importance in many application areas of online social *** order to identify influential users in a more adequate and practical way, we propose a Dynamic regional interaction model(DRI) to evaluate user influence in online social networks. Influential users can be identified by the influence effect on different distance users based on dynamic regional interaction model. We have applied the influential user identification method to Sina Weibo and the experimental results show that compared with the existing methods the proposed method can identify the influence users in a more accuracy and efficiency way.

关键词： Online social networks Influential user identification Dynamic regional interaction model(DRI) User influence evaluation

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Research on Loophole with Second Distribution of Real Value Detectors

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Chinese Journal of Electronics 2016年第6期25卷 1141-1150页

作者： WANG Tianbo ZHANG Fengbin XIA Chunhe Beijing Key laboratory of network Technology Beihang University network and Information Security laboratory Harbin University of Science and Technology

Traditional anomaly detection algorithm has improved to some degree the mechanism of negative selection. There still remain many problems such as the randomness of detector generation, incompleteness of selfset and the generalization ability of detectors, which would cause a lot of loopholes in non-self space. A heuristic algorithm based on the second distribution of real value detectors for the remains of loopholes of the non-self space in the first distribution and the mutation regions of self space is proposed. The algorithm can distribute real value detectors through omission data based on the methods of partition and movement. A method is proposed to solve the problem on how to get the optimal solutions to the parameters related in the algorithm. Theoretical analysis and experimental results prove the universality and effectiveness of the method. It is found that our algorithm can effectively avoid the generation of loopholes and thus reduce the omission rate of detector sets.

关键词： Artificial immune Anomaly detection Loophole Parameter estimation Detector

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Spectral analysis of the UFBG-based acousto optical modulator in V–I transmission matrix formalism

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Chinese Physics B 2014年第11期23卷 251-256页

作者：吴良英裴丽刘超王一群翁思俊王建帅 Key laboratory of All Optical network & Advanced Telecommunication network of EMC Beijing Jiaotong Univcnersity

In this study, the V –I transmission matrix formalism(V –I method) is proposed to analyze the spectrum characteristics of the uniform fiber Bragg grating(FBG)-based acousto–optic modulators(UFBG-AOM). The simulation results demonstrate that both the amplitude of the acoustically induced strain and the frequency of the acoustic wave(AW) have an effect on the spectrum. Additionally, the wavelength spacing between the primary reflectivity peak and the secondary reflectivity peak is proportional to the acoustic frequency with the ratio 0.1425 nm/MHz. Meanwhile, we compare the amount of calculation. For the FBG whose period is M, the calculation of the V –I method is 4 ×(2M-1) in addition/subtraction,8 ×(2M- 1) in multiply/division and 2M in exponent arithmetic, which is almost a quarter of the multi-film method and transfer matrix(TM) method. The detailed analysis indicates that, compared with the conventional multi-film method and transfer matrix(TM) method, the V –I method is faster and less complex.

关键词： uniform fiber bragg grating(UFBG) acousto–optic modulator(AOM) V–I transmission matrix formalism spectrum

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Switchable multi-wavelength fiber laser based on modal interference

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Chinese Physics B 2015年第8期24卷 317-322页

作者：马林孙将齐艳辉康泽新简水生 Key laboratory of All Optical network & Advanced Telecommunication network of EMC Beijing Jiaotong University

A comb fiber filter based on modal interference is proposed and demonstrated in this paper. Here two cascaded uptapers are used to excite the cladding mode, and a core-offset jointing point is used to act as an interference *** results show that this kind of structure possesses a comb filter property in a range of the C-band. The measured extinction ratio is better than 12 dB with an insertion loss of about 11 dB. A switchable multi-wavelength erbium-doped fiber laser based on this novel comb filter is demonstrated. By adjusting the polarization controller, the output laser can be switched among single-, dual-, and three-wavelengths with a side mode suppression ratio of better than 45 dB.

关键词： fiber laser up-taper core-offset modal interferometer

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Influence of group-delay ripple on timing jitter induced by SPM and IXPM in systems with dispersion compensated by CFBG

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Chinese Optics Letters 2007年第8期5卷 441-444页

作者：秦曦曹继红陈勇张峰简水生 Key laboratory of All Optical network & Advanced Telecommunication network of EMC Beijing Jiaotong University

An analytical expression was proposed to analyze the influence of group-delay ripple （GDR） on timing jitter induced by self-phase modulation （SPM） and intra-channel cross-phase modulation （IXPM） in pseudolinear transmission systems when dispersion was compensated by chirped fiber Bragg grating （CFBG）. Effects of ripple amplitude, period, and phase on timing jitter were discussed by theoretical and numerical analysis in detail. The results show that the influence of GDR on timing jitter changes linearly with the amplitude of GDR and whether it decreases or increases the timing jitter relies on the ripple period and ripple phase. Timing jitter induced by SPM and IXPM could be suppressed totally by adjusting the relative phase between the center frequency of the pulse and the ripples.

关键词： Dispersion compensation Numerical analysis Self phase modulation Timing jitter

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All-fiber modal interferometer based on an up-taper-core-offset structure for curvature sensing

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Chinese Physics B 2015年第4期24卷 207-210页

作者：马林齐艳辉孙将康泽新简水生 Key laboratory of All Optical network and Advanced Telecommunication network of EMC Beijing Jiaotong University

A high-sensitivity curvature sensor based on an up-taper-core-offset structure is proposed and demonstrated in this paper. Here two specially designed cascaded up-tapers with maximum diameters of 247 μm and 251 μm, respectively, are used as a cladding mode exciting component. The excited cladding modes will propagate in the cladding and re-couplers with the core mode at the core-offset jointing point. When the curvature is changed, the dip wavelength of the sensor will shift to a blue wavelength and an average curvature sensitivity of more than -12.5 nm/m^-1 is achieved within the measured curvature intervals.

关键词： curvature sensor up-taper core-offset modal interferometer

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Development and Challenge of HIV/AIDS Testing laboratory network and Quality Assurance System in China

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Virologica Sinica 2007年第6期22卷 434-442页

作者： Yan JIANG National AIDS Reference laboratory of National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and Prevention Beijing 100050 China

This paper describes the development and challenge of HIV/AIDS testing laboratory network and quality assurance system in China. At present,the HIV/AIDS testing laboratories includes three classes,the National AIDS Reference laboratory,HIV/AIDS confirmatory laboratories and HIV/AIDS screening laboratories. All of them are accredited by the health authorities,and each class of laboratories take charge of their function strictly according to the "National Management of HIV/AIDS Detection (2006)". A complete quality assurance and quality control system for HIV/AIDS testing has been developed,which includes technical training,strict laboratory monitoring and approval,examination or proficiency testing on HIV/AIDS detection,and quality evaluation and supervision of HIV/AIDS diagnostic kits. Besides conduct the routine anti-HIV antibody test,more and more laboratories began to conduct other tests,such as CD4+ T lymphocyte cell counting,HIV viral load,HIV DNA PCR,genotyping,drug resistance,and HIV-1 recent infection test. The primary challenges faced by the HIV/AIDS testing laboratory network are in the areas of laboratory management and quality control. For example,the provincial PT program is inefficient,the internal quality control is conducted perfunctorily,personnel training can not met the needs of the workplace,which need to be improved.

关键词： Human immunodeficiency virus (HIV) laboratory Detection Quality assurance Quality control

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