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High-Value-Added Utilization of Turpentine:Screening of Anti-Influenza Virus Agents fromβ-Pinene Derivatives

Journal of Renewable Materials 2024年第1期12卷 45-56页

作者： Yiwen Li Hongyan Si Peng Wang Hai Luo Minggui Shen Xiaoping Rao Zhanqian Song Shibin Shang Zongde Wang Shengliang Liao East china Woody Fragrance and Flavor Engineering Research center of National Forestry and Grassland administration Camphor Engineering Research Center of National Forestry and Grassland AdministrationCollege of ForestryJiangxi Agricultural UniversityNanchang330045China Institute of Chemical Industry of Forestry Products China Academy of ForestryNational Engineering Laboratory for Biomass Chemical UtilizationKey and Open Laboratory of Forest Chemical EngineeringState Forestry AdministrationKey Laboratory of Biomass Energy and MaterialJiangsu ProvinceNanjing210042China College of Chemical Engineering Huaqiao UniversityXiamen361021China

Turpentine is a renewable and resourceful forest *** deep processing and utilization of turpentine,particularly its primary componentβ-pinene,has garnered widespread *** study aimed to synthesize 40 derivatives ofβ-pinene,including nopinone,3-cyanopyridines of nopinone,myrtanyl acid,myrtanyl acylthioureas,and myrtanyl *** assessed the antiviral activities of theseβ-pinene derivatives against influenza virus A/Puerto Rico/8/34(H1N1)using the 3-(4,5-dimetylthiazol-2-yl)-2,5-diphenyltetrazolium bromide ***β-pinene derivatives were used before and after cellular infection with the influenza virus to evaluate their preventive and therapeutic effects against the H1N1 *** results showed that only compound 10o exhibited a preventive effect against the H1N1 virus with a half-maximal inhibitory concentration(IC50)value of 47.6μmol/*** the compounds,4e,4i,and 4l demonstrated therapeutic effects against cellular infection,with compound 4e displaying the most potent therapeutic effect(IC50=17.5μmol/L),comparable to the positive control *** findings indicated that certainβ-pinene derivatives exhibited in vitro antiviral activity against the H1N1 influenza A virus,warranting further investigation as potential anti-influenza agents.

关键词： Antiviral activity β-pinene derivative 3-cyanopyridine influenza virus

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Effects of desert plant communities on soil enzyme activities and soil organic carbon in the proluvial fan in the eastern foothills of the Helan Mountain in Ningxia,china

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Journal of Arid Land 2024年第5期16卷 725-737页

作者： SHEN Aihong SHI Yun MI Wenbao YUE Shaoli SHE Jie ZHANG Fenghong GUO Rui HE Hongyuan WU Tao LI Hongxia ZHAO Na College of Forestry and Prataculture of Ningxia University Yinchuan 750021China School of Geography and Planning of Ningxia University Yinchuan 750021China Ningxia Hui Autonomous Region Agricultural Comprehensive Development center Yinchuan 750002China Ningxia Helan Mountain National Nature Reserve administration Yinchuan 750021China Yinchuan Yinxi Ecological Protection Forest Management center Yinchuan 750002China

It is of great significance to study the effects of desert plants on soil enzyme activities and soil organic carbon(SOC)for maintaining the stability of the desert *** this study,we studied the responses of soil enzyme activities and SOC fractions(particulate organic carbon(POC)and mineral-associated organic carbon(MAOC))to five typical desert plant communities(Convolvulus tragacanthoides,Ephedra rhytidosperma,Stipa breviflora,Stipa tianschanica ***,and Salsola laricifolia communities)in the proluvial fan in the eastern foothills of the Helan Mountain in Ningxia Hui Autonomous Region,*** recorded the plant community information mainly including the plant coverage and herb and shrub species,and obtained the aboveground biomass and plant species diversity through sample surveys in late July *** samples were also collected at depths of 0–10 cm(topsoil)and 10–20 cm(subsoil)to determine the soil physicochemical properties and enzyme *** results showed that the plant coverage and aboveground biomass of *** community were significantly higher than those of ***,***,and *** *** communities(P<0.05).Soil enzyme activities varied among different plant *** the topsoil,the enzyme activities of alkaline phosphatase(ALP)andβ-1,4-glucosidas(βG)were significantly higher in *** and *** *** communities than in other plant communities(P<0.05).The topsoil had higher POC and MAOC contents than the ***,the content of POC in the topsoil was 18.17%–42.73%higher than that in the *** structural equation model(SEM)indicated that plant species diversity,soil pH,and soil water content(SWC)were the main factors influencing POC and *** soil pH inhibited the formation of POC and promoted the formation of ***,SWC stimulated POC production and hindered MAOC *** study aimed to gain insight into the effects of desert plant c

关键词： proluvial fan desert plant community soil enzyme activity particulate organic carbon mineral-associated organic carbon Helan Mountain

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TBK1:a new target for overcoming cancer immunotherapy resistance

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Science china(Life Sciences) 2024年第1期67卷 217-218页

作者： Jizhong Guan Long Zhang Fangfang Zhou Institutes of Biology and Medical Science Soochow UniversitySuzhou 215123China MOE Laboratory of Biosystems Homeostasis and Protection and Innovation center for Cell Signaling network Life Sciences InstituteZhejiang UniversityHangzhou 310058China

In a recent study published in Nature,Sun et al.(2023)discovered that targeting TANK-binding kinase 1(TBK1)can successfully overcome resistance to immune checkpoint blockade(ICB)treatment and the study revealed its potential *** authors provided evidence that the disruption of TBK1 signal enhances the blockade of programmed cell death protein-1(PD-1)and promotes anti-tumor immunity in the tumor microenvironment(TME).Tumor cells rely on Janus kinase(JAK)and signal transducer as well as activator of transcription(STAT)signals to elicit an immune response by perceiving tumor necrosis factorα(TNF-α)and interferon-γ(IFN-γ),resulting in receptor-interacting protein kinase(RIPK)-caspase-mediated cell death in tumor cells(Figure 1).

关键词： TBK1 immunity

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Natural Products Improve Organ Microcirculation Dysfunction Following Ischemia/Reperfusion-and Lipopolysaccharide-Induced Disturbances:Mechanistic and Therapeutic Views

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Engineering 2024年第7期38卷 77-99页

作者： Jingyan Han Quan Li Kai Sun Chunshui Pan Jian Liu Ping Huang Juan Feng Yanchen Liu Gerald A.Meininger Department of Integration of Chinese and Western Medicine School of Basic Medical SciencesPeking UniversityBeijing 100191China Tasly Microcirculation Research center Peking University Health Science CenterBeijing 100191China Key Laboratory of Stasis and Phlegm State Administration of Traditional Chinese Medicine of the People’s Republic of ChinaBeijing 100191China Beijing Laboratory of Integrative Microangiopathy Peking University Health Science CenterBeijing 100191China Dalton Cardiovascular Research center and Department of Medical Pharmacology and Physiology University of MissouriColumbiaMO 65211USA

Microcirculatory disturbances are complex processes caused by many factors,including abnormal vasomotor responses,decreased blood flow velocity,vascular endothelial cell injury,altered leukocyte and endothelial cell interactions,plasma albumin leakage,microvascular hemorrhage,and *** disturbances involve multiple mechanisms and interactions among mechanisms that can include energy metabolism,the mitochondrial respiratory chain,oxidative stress,inflammatory factors,adhesion molecules,the cytoskeleton,vascular endothelial cells,caveolae,cell junctions,the vascular basement membrane,neutrophils,monocytes,and *** clinical practice,aside from drugs that target abnormal vasomotor responses and platelet adhesion,there continues to be a lack of multi-target drugs that can regulate the complex mechanistic links and interactions underlying microcirculatory *** products have demonstrated obvious positive therapeutic effects in treating ischemia/reperfusion(I/R)-and lipopolysaccharide(LPS)-induced microcirculatory *** recent years,numerous research papers on the improvement of microcirculatory function by natural products have been published in international *** 2008 and 2017,the first listed author of this review was invited to publish reviews in the journal of Pharmacology&Therapeutics on the improvement of microcirculatory disturbances and organ injury induced by I/R using Salvia miltiorrhiza ingredients and other natural components of compounded Chinese medicine,*** review systematically summarizes the effects,targets of action,and mechanisms of natural products regarding improving I/R-and LPSinduced microcirculatory disturbances and tissue *** on this summary,scientific proposals are suggested for the discovery of new drugs to improve microcirculatory disturbances in disease.

关键词： Ischemia/reperfusion Lipopolysaccharide Natural products Leukocyte activation Hyperpermeability

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A Deep Learning Approach for Forecasting Thunderstorm Gusts in the Beijing–Tianjin–Hebei Region

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Advances in Atmospheric Sciences 2024年第7期41卷 1342-1363页

作者： Yunqing LIU Lu YANG Mingxuan CHEN Linye SONG Lei HAN Jingfeng XU Faculty of Information Science and Engineering Ocean University of ChinaQingdao 266100China Institute of Urban Meteorology China Meteorological AdministrationBeijing 100089China Collaborative Innovation center on Forecast and Evaluation of Meteorological Disasters(CIC-FEMD) Nanjing University of Information Science&TechnologyNanjing 210044China

Thunderstorm gusts are a common form of severe convective weather in the warm season in North china,and it is of great importance to correctly forecast *** present,the forecasting of thunderstorm gusts is mainly based on traditional subjective methods,which fails to achieve high-resolution and high-frequency gridded forecasts based on multiple observation *** this paper,we propose a deep learning method called Thunderstorm Gusts TransU-net(TGTransUnet)to forecast thunderstorm gusts in North china based on multi-source gridded product data from the Institute of Urban Meteorology(IUM)with a lead time of 1 to 6 *** determine the specific range of thunderstorm gusts,we combine three meteorological variables:radar reflectivity factor,lightning location,and 1-h maximum instantaneous wind speed from automatic weather stations(AWSs),and obtain a reasonable ground truth of thunderstorm ***,we transform the forecasting problem into an image-to-image problem in deep learning under the TG-TransUnet architecture,which is based on convolutional neural networks and a *** analysis and forecast data of the enriched multi-source gridded comprehensive forecasting system for the period 2021–23 are then used as training,validation,and testing ***,the performance of TG-TransUnet is compared with other *** results show that TG-TransUnet has the best prediction results at 1–6 *** IUM is currently using this model to support the forecasting of thunderstorm gusts in North china.

关键词： thunderstorm gusts deep learning weather forecasting convolutional neural network transformer

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Improvement of cloud microphysical parameterization and its advantages in simulating precipitation along the Sichuan-Xizang Railway

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Science china Earth Sciences 2024年第3期67卷 856-873页

作者： Xiaoqi XU Zhiwei HENG Yueqing LI Shunjiu WANG Jian LI Yuan WANG Jinghua CHEN Peiwen ZHANG Chunsong LU china Meteorological administration Transportation Meteorology Key Laboratory Nanjing Joint Institute for Atmospheric SciencesNanjing 210041China Heavy Rain and Drought-Flood Disasters in Plateau and Basin Key Laboratory of Sichuan Province Institute of Plateau MeteorologyCMAChengdu 610072China State Key Laboratory of Disaster Weather Chinese Academy of Meteorological SciencesBeijing 100081China Collaborative Innovation center for Western Ecological Safety Lanzhou UniversityLanzhou 730000China china Meteorological administration Aerosol-Cloud and Precipitation Key Laboratory and Collaborative Innovation center on Forecast and Evaluation of Meteorological Disasters(CIC-FEMD) Nanjing University of Information Science and TechnologyNanjing 210044China

The Sichuan-Xizang Railway is an important part of the railway network in china, and geological disasters, such as mountain floods and landslides, frequently occur in this region. Precipitation is an important cause of these disasters;therefore,accurate simulation of the precipitation in this region is highly important. In this study, the descriptions for uncertain processes in the cloud microphysics scheme are improved;these processes include cloud droplet activation, cloud-rain autoconversion, rain accretion by cloud droplets, and the entrainment-mixing process. In the default scheme, the cloud water content of different sizes corresponds to the same cloud droplet concentration, which is inconsistent with the actual content;this results in excessive cloud droplet size, unreasonable related conversion rates of microphysical process(such as cloud-rain autoconversion), and an overestimation of precipitation. Our new scheme overcomes the problem of excessive cloud droplet size. The processes of cloudrain autoconversion and rain accretion by cloud droplets are similar to the stochastic collection equation, and the mixing mechanism of cloud droplets is more consistent with that occurred during the actual physical process in the cloud. Based on the new and old schemes, multiple precipitation processes in the flood season of 2021 along the Sichuan-Xizang Railway are simulated, and the results are evaluated using ground observations and satellite data. Compared to the default scheme, the new scheme is more suitable for the simulation of cloud physics, reducing the simulation deviation of the liquid water path and droplet radius from 2 times to less than 1 time and significantly alleviating the overestimation of precipitation intensity and range of precipitation center. The average root-mean-square error is reduced by 22%. Our results can provide a scientific reference for improving precipitation forecasting and disaster prevention in this region.

关键词： The Sichuan-Xizang Railway Cloud microphysics Precipitation Model improvement

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Differential response of radial growth and δ^(13)C in Qinghai spruce(Picea crassifolia) to climate change on the southern and northern slopes of the Qilian Mountains in Northwest china

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Journal of Forestry Research 2024年第3期35卷 205-218页

作者： Li Qin Huaming Shang Weiping Liu Yuting Fan Kexiang Liu Tongwen Zhang Ruibo Zhang Key Laboratory of Tree-Ring Physical and Chemical Research(CMA)/Xinjiang Key Laboratory of Tree-Ring Ecology Institute of Desert MeteorologyChina Meteorological AdministrationUrimqi 830002People's Republicof China Xinjiang Meteorological Information center Urimqi 830002People's Republic of China

Tree radial growth can have significantly differ-ent responses to climate change depending on the *** elucidate the effects of climate on radial growth and stable carbon isotope(δ^(13)C)fractionation of Qing-hai spruce(Picea crassifolia),a widely distributed native conifer in northwestern china in different environments,we developed chronologies for tree-ring widths and δ^(13)C in trees on the southern and northern slopes of the Qilian Mountains,and analysed the relationship between these tree-ring variables and major climatic ***-ring widths were strongly influenced by climatic factors early in the growing season,and the radial growth in trees on the northern slopes was more sensitive to climate than in trees on the ***-ring δ^(13)C was more sensitive to climate than radial growth.δ^(13)C fractionation was mainly influenced by summer temperature and precipitation early in the growing *** conductance more strongly limited stable carbon isotope fractionation in tree rings than photosynthetic rate *** response between tree rings and climate in mountains gradually weakened as climate *** in radial growth and stable carbon isotope fractionation of *** in response to climate in the Qilian Mountains may be further complicated by continued climate change.

关键词： Tree rings Qinghai spruce(Picea crassifolia Kom.) Stable carbon isotope(δ^(13)C) Qilian Mountains:Climate change

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Significant contribution of carbonyls to atmospheric oxidation capacity(AOC)during the winter haze pollution over North china Plain

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Journal of Environmental Sciences 2024年第5期139卷 377-388页

作者： Xue Yang Gen Zhang Guang Pan Guolan Fan Houyong Zhang Xuan Ge Mingyue Du School of Municipal and Environmental Engineering Shandong Jianzhu UniversityJi’nan 250101China State Key Laboratory of Severe Weather&Key Laboratory of Atmospheric Chemistry of china Meteorological administration Chinese Academy of Meteorological SciencesBeijing 100081China Shandong Jinan Ecological Environment Monitoring center Ji’nan 250101China

Atmospheric carbonyl compounds play significant roles in the cycling of radicals and have exhibited surprisingly high levels in winter that were well correlated to particulate matter,for which the reason have not been clearly *** we measured carbonyl compounds and other trace gasses together with PM_(2.5)over urban Jinan in North china Plain during the *** higher carbonyl concentrations(average:14.63±4.21 ppbv)were found during wintertime haze pollution,about one to three-times relative to those on nonhaze days,with slight difference in chemical composition except formaldehyde(HCHO).HCHO(3.68 ppbv),acetone(3.17 ppbv),and acetaldehyde(CH_3CHO)(2.83 ppbv)were the three most abundant species,accounting for~75% of the total carbonylson both haze and non-haze *** from observational-based model(OBM)with atmospheric oxidation capacity(AOC)indicated that AOC significantly increased with the increasing carbonyls during the winter haze *** photolysis have supplied key oxidants such as RO_(2) and HO_(2),and thereby enhancing the formation of fine particles and secondary organic aerosols,elucidating the observed haze-carbonyls *** variation with carbonyls exhibiting peak values at early-noon and night highlighted the combined contribution of both secondary formation and primary diesel-fuel sources.1-butene was further confirmed to be the major precursor for *** study confirms the great contribution of carbonyls to AOC,and also suggests that reducing the emissions of carbonyls would be an effective way to mitigate haze pollution in urban area of the NCP region.

关键词： Carbonyls Haze Observation-based model Source apportionment Atmospheric oxidation capacity

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Spatial-temporal shifting patterns and in situ conservation of spotted seal(Phoca largha)populations in the Yellow Sea ecoregion

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Integrative Zoology 2024年第2期19卷 307-318页

作者： Hongfei ZHUANG Fei SHAO Chao ZHANG Wancai XIA Shouqiang WANG Fangyuan QU Zongling WANG Zhichuang LU Linlin ZHAO Zhaohui ZHANG First Institute of Oceanography Ministry of Natural ResourcesQingdaoChina Department of Natural Resources of Shandong Province Shandong Forestry Protection and Development Service CenterJinanChina National Park(Protected Areas)Development center National Forestry and Grassland AdministrationBeijingChina College of Life Science China West Normal UniversityNanchongChina Liaoning Ocean and Fisheries Science Research Institute DalianChina

Understanding the habitat shifting pattern is a prerequisite for implementing in situ conservation of migratory *** seals(Phoca largha)inhabiting the Yellow Sea ecoregion(YSE)comprise a small population with independent genes and represent a charismatic flagship species in this ***,this population has declined by 80%since the 1940s,and increased support from the countries around the YSE is urgently needed to address the potential local extinction risk.A time-series niche model and life-history weighted systematic conservation planning were designed on the basis of a satellite beacon tracking survey(2010–2020)of the YSE *** results showed clustering and spreading shifting patterns during the breeding and migratory seasons,*** closed-loop migration route formed in the YSE indicated that this population might be geographically isolated from populations in other breeding areas around the *** conservation priority area(CPA),with an area of 19632 km^(2)(3.58%of the total YSE area),was the most effective response to the potential in situ ***,nearly 80%of the CPA was exposed outside the existing marine protected areas(MPAs).Future establishment of MPAs in china should strategically consider the conservation gap identified herein,and it is recommended for Korea’s closed fishing season to be spatially set in the western Korean Peninsula from May to *** study also exemplified that the lack of temporal information would lead to the dislocation of niche modeling for migratory species represented by spotted *** should be paid to protecting small and migratory populations in marine biodiversity conservation planning.

关键词： conservation priority area marine protected area migration seasonal management spotted seal

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Changes in microstructure and properties of weld heat-affected zone of high-strength low-alloy steel

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Journal of Iron and Steel Research International 2024年第8期31卷 2041-2052页

作者： Shu-jun Jia Qi-lin Ma Yu Hou Ba Li He-song Zhang Qing-you Liu Central Iron and Steel Research Institute Co. Ltd.Beijing 100081China Collaborative Innovation center for Steel Commonality University of Science and Technology BeijingBeijing 100083China Construction Project Management Branch of china National Petroleum Pipeline network Group Co. Ltd.Langfang 065000HebeiChina

The evolution of the microstructure and toughness of APL5L X80 pipeline steel after thermal welding simulation was investigated by X-ray diffraction,electron backscatter diffraction,and transmission electron *** results indicated that primary heat-affected zones can be divided into weld,coarse-grained,fine-grained,intercritical,and sub-critical *** microstructure of the weld zone is mainly composed of bainitic ferrite and a small amount of granular bainite;however,the original austenite grains are distributed in the columnar *** structure of the coarse-grained zone is similar to that of the weld zone,but the original austenite grains are *** contrast,the microstructure in the fine-grained zone is dominated by fine granular bainite,and the effective grain size is only 8.15μm,thus providing the highest toughness in the entire heat-affected *** intercritical and subcritical zones were brittle valley regions,and the microstructure was dominated by granular ***,the martensite-austenite(M/A)constituents are present in island chains along the grain boundaries,and the coarse size of the M/A constituents seriously reduces the *** results of the crack propagation analyzes revealed that high-angle grain boundaries can significantly slow down crack growth and change the crack direction,thereby increasing the material *** impact toughness of the low-temperature tempering zone was equivalent to that of the columnar grain zone,and the impact toughness was between those of the critical and fine-grained zones.

关键词： Welding thermal simulation Impact toughness Crack propagation Martensite-austenite constituent High-strength low-alloy steel weld Heat-affected zone

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