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Prevalence of Severe Anemia (Hb ≤ 5 g/dl) in Non-Dialyzed Chronic Renal Failure Patients in the nephrology and hemodialysis department of point g university hospital

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Open Journal of nephrology 2021年第2期11卷 252-264页

作者： Seydou Sy Magara Samaké Aboubacar Sidiki Fofana Awa Diallo Moctar Coulibaly Djibril Sy Atabième Kodio Saharé Fongoro Mahamane Kalil Maïga nephrology department of point g university hospital Bamako Mali Faculty of Medicine of Bamako Bamako Mali nephrology Unit of the Fousseyni Daou hospital Kayes Mali nephrology Unit of Mali gavardo hospital Bamako Mali department of Internal Medicine Point G University Hospital Bamako Mali

Introduction: Chronic renal failure (CRF) is defined as glomerular filtration rate (gFR) less than 60 ml/min/1.73m2 for at least three (3) months. Anemia is one of its most common complications. Anemia increases the r... 详细信息

g>Introduction:g> Chronic renal failure (CRF) is defined as glomerular filtration rate (gFR) less than 60 ml/min/1.73m2 for at least three (3) months. Anemia is one of its most common complications. Anemia increases the risk factor for cardiovascular mortality by 18% per gram of hemoglobin loss. g>Objectives:g> To determine the prevalence and characteristics of this severe anemia, to determine the indications for transfusion, the complications related to this anemia, the evolution and the prognosis of these patients. g>Materials and Methods:g> This was a descriptive study with retrospective data collection over 18 months (January 1, 2017 to June 30, 2018) that included hospitalized CRF patients. Were included, non-dialyzed chronic renal failure patients with Hb ≤ 5 g/dl hospitalized during the said period. Not included were chronic renal failure patients with an Hb level ≥ 5 g/dl, those followed up and/or hospitalized outside the study period. g>Results:g> Among 1176 patients, 26 had severe anemia (Hb level ≤ 5 g/dl) on CRF, a prevalence of 2.21%. The mean age was 40 years ± 32.62 with extremes of 15 and 67 years. Seventeen women and 9 men. The etiology of chronic renal failure (CRF) was hypertensive vascular nephropathy in 50% of cases. CRF was end-stage in 18 patients (69.2%). The mean hemoglobin level was 4.10 g/dl ± 0.64 with extremes of 2 and 5 g/dl. The anemia was microcytic hypochromic in 50% and aregenerative (96.2%). The main symptoms were asthenia in 20 cases (76.9%), dizziness in 20 cases (76.9%), exertional dyspnea in 19 cases (73.1%). Signs of cardiac decompensation (n = 12) were jugular turgor 10 cases (38.5%), hepato-jugular reflux 06 cases (23.1%), mitral insufficiency murmur 06 cases (23.1%). The main complication was left ventricular hypertrophy 17 cases (77.3%). There was no correlation between anemia and sex (p = 0.291), age (p = 0.778), malaria (p = 0.158), etiology of CRF (p = 0.26)

关键词： Severe Anemia Chronic Renal Failure Blood Transfusion Mali

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Predictive value of tacrolimus concentration/dose ratio in first posttransplant week for CYP3A5-polymorphism in kidney-transplant recipients

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World Journal of Transplantation 2025年第2期15卷 197-204页

作者： Pham-Thai Dung Hoang-Xuan Su Nguyen-Chi Tue Nguyen-Huu Ben Nguyen-Minh Phuong Tuan-Ngoc Tran Phan-Ba Nghia Diem-Thi Van Nguyen Thi-Thuy Dung Hoang-Trung Vinh Lionel Rostaing Pham-Quoc Toan Center of Critical Care Medicine Emergency and Clinical ToxicologyMilitary HospitalHanoï100000Viet Nam Institute of Biomedicine and Pharmacy Vietnam Military Medical UniversityHanoï100000Viet Nam department of Post-Transplant Intensive Care and Treatment Center of Organ Transplantation-Military HospitalHanoï100000Viet Nam department of Occupational Medicine Vietnam Military Medical UniversityHanoï100000Viet Nam department of Military Medical Command and Organization Vietnam Military Medical UniversityHanoï100000Viet Nam department of nephrology and Dialysis Military HospitalHanoï100000Viet Nam department of nephrology HemodialysisApheresisand Kidney TransplantationGrenoble University HospitalGrenoble 38043Auvergne-Rhone-AlpesFrance

BACKgROUND Tacrolimus(TAC)is metabolized primarily by the CYP3A-encoded enzyme family(CYP3A4,CYP3A5,and CYP3A7).Individuals expressing the CYP3A51 allele are considered fast metabolizers and generally require higher TAC doses to reach therapeutic *** To evaluate the predictive value of the TAC concentration-to-dose(C0/D)ratio for identifying CYP3A5 poly-morphisms in renal transplant *** Eighty-six de novo kidney transplant recipients with TAC-based immunosuppression from the department of nephrology and Dialysis at Military hospital 103(Hanoi,Vietnam)were included in this retrospective *** samples were collected within the first week post-transplantation to monitor TAC levels and to perform genotyping for CYP3A5 genetic *** The CYP3A53/3 genotype was identified in 37 patients(43%),CYP3A51/3 in 40 patients(46.5%),and CYP3A51/1 in 9 patients(10.5%).Patients carrying the CYP3A51/3 or CYP3A51/1 genotype,classified as fast metabolizers(CYP3A5 expressers),had significantly lower TAC C0 concentrations and C0/D ratios compared to slow meta-bolizers(CYP3A53/3 genotype)at multiple time points during follow-up(all Pg in renal transplant recipients in Vietnam and other low-income countries.

关键词： Tacrolimus CYP3A5 Renal transplant recipient Concentration-to-dose Kidney transplant

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Renal Failure of Lithiasis Origin: Frequency and Management in the nephrology and Haemodialysis department of the point g university hospital in Mali

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Open Journal of nephrology 2022年第3期12卷 276-292页

作者： Seydou Sy Magara Samaké Aboubacar Sidiki Fofana Atabieme Kodio Oligue Prudence Oman Djibril Sy Hamadoun Yattara Djénèba Diallo Sah Dit Baba Coulibaly Nouhoum Coulibaly Modi Sidibé Alkaya Touré Moustapha Tangara Mamadou Lamine Diakité Assétou Soukho Kaya Saharé Fongoro nephrology and hemodialysis department University Teaching Hospital of Point-G Bamako Mali Faculty of Medicine and Odontostomatology University of Sciences Techniques and Technologies of Bamako Bamako Mali nephrology Unit Fousseyni Daou Hospital in Kayes Kayes Mali National Center for Scientific and Technological Research (CNRST) Bamako Mali department of Internal Medicine University Teaching Hospital of Point-G Bamako Mali department of Urology University Teaching Hospital of Point-G Bamako Mali

Background: The term urinary lithiasis (UL) from the greek “lithos” refers to the disease characterised by the result of abnormal precipitation of normal constituents of the urine within the urinary tract. The aim of this work was to determine the frequency of obstructive renal failure (ORF) of lithiasis origin and to describe the therapeutic indications. Methods: This was a retrospective prospective study in patients hospitalised in the nephrology department of point g university hospital for ORF of lithiasis origin over a 26-month period from 1 January 2018 to 1 February 2020 inclusive. Results: Among 1898 hospitalized patients, 32 met the inclusion criteria, i.e. a frequency of 1.7%. The male sex was 68.75% with a sex ratio of 2.2. The mean age was 48.38 ± 13.423 years with extremes of 20 and 65 years. Dysuria and urinary bilharzia were the main uro-nephrological antecedents, accounting for 25% of the cases each. Pain syndrome was the main functional sign, accounting for 100%. Ultrasound of the urinary tract (n = 28) showed stones in 92.85%. These stones were bilateral in 22.22% of cases. The dilatation was pyelocalic in 14 cases (51.8%). The uroscanner showed a pyelic location of the stones in both kidneys;42.1% on the right and 33.3% on the left. Hydronephrosis was the most common dilatation: 37.8% on the right and 29.7% on the left. Renal lithiasis was complicated by acute kidney injury (ARI) in 17 cases (53.1%) versus 15 cases (46.9%) of chronic kidney disease (CKD). Urethral catheter was the means of drainage in 24 (75%) followed by nephrostomy in 8 cases (25%). Nephrolithotomy accounted for 9.4% of cases. The case fatality rate was 28.12% (9 cases). Deaths occurred in the context of uraemic coma 6 cases and cardiorespiratory arrest 3 cases. Conclusions: The management of urinary lithiasis complicated by renal failure calls for the correction of hydrolytic disorders, drainage of the excretory tract and treatment of the stone, of which percutaneous nephrolith

关键词： Renal Failure Urinary Lithiasis nephrology university Teaching hospital of point-g

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Hemogram-derived ratios as prognostic markers for major adverse cardiovascular events in patients with non-ST-segment elevation myocardial infarction

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World Journal of Methodology 2025年第2期15卷 125-136页

作者： Emir Bećirović Minela Bećirović SabinaŠegalo Amir Bećirović Semir Hadžić Kenana Ljuca Emsel Papić Lamija Ferhatbegović Malik Ejubović Amira JagodićEjubović Amila Kovčić ArminŠljivo Emir Begagić department of Intensive Care University Clinical Center TuzlaTuzla 75000Bosnia and Herzegovina department of nephrology University Clinical Center TuzlaTuzla 75000Bosnia and Herzegovina department of Laboratory Technologies Faculty of Health SciencesUniversity of SarajevoSarajevo 71000Bosnia and Herzegovina department of Endocrinology University Clinical Center TuzlaTuzla 75000Bosnia and Herzegovina School of Medicine University of TuzlaTuzla 75000Bosnia and Herzegovina department for Internal Diseases and hemodialysis Canton Hospital ZenicaZenica 72000Bosnia and Herzegovina department of Internal Medicine Canton Hospital ZenicaZenica 72000Bosnia and Herzegovina department of Radiotherapy University Clinical Center TuzlaTuzla 75000Bosnia and Herzegovina department of Cardiology University Clinical Center SarajevoSarajevo 72000Bosnia and Herzegovina department of general Medicine University of ZenicaSchool of MedicineZenica 72000Bosnia and Herzegovina

BACKgROUND Non-ST segment elevation myocardial infarction(NSTEMI)poses significant challenges in clinical management due to its diverse *** the prognostic role of hematological parameters and derived ratios in NSTEMI patients could aid in risk stratification and improve patient *** To evaluate the predictive value of hemogram-derived ratios for major adverse cardiovascular events(MACE)in NSTEMI patients,potentially improving clinical *** A prospective,observational cohort study was conducted in 2021 at the Internal Medicine Clinic of the university hospital in Tuzla,Bosnia and *** study included 170 patients with NSTEMI,who were divided into a group with MACE and a control group without ***,the MACE group was subdivided into lethal and non-lethal groups for prognostic *** hematological parameters,an additional 13 hematological-derived ratios(HDRs)were monitored,and their prognostic role was *** Hematological parameters did not significantly differ between non-ST segment elevation myocardial infarction(NSTEMI)patients with MACE and a control group at T1 and ***,significant disparities emerged in HDRs among NSTEMI patients with lethal and non-lethal outcomes ***,neutrophil-to-lymphocyte ratio(NLR)and platelet-to-lymphocyte ratio(PLR)were elevated in lethal ***,C-reactive protein-to-lymphocyte ratio(CRP/Ly)at T1(>4.737)demonstrated predictive value[odds ratio(OR):3.690,P=0.024].Both NLR at T1(>4.076)and T2(>4.667)emerged as significant predictors,with NLR at T2 exhibiting the highest diagnostic performance,as indicated by an area under the curve of 0.811(95%CI:0.727-0.859)and OR of 4.915(95%CI:1.917-12.602,P=0.001),emphasizing its important role as a prognostic *** This study highlights the significant prognostic value of hemogram-derived indexes in predicting MACE among NSTEMI *** follow-up,NLR,PLR,and CRP/Ly off

关键词： Hemogram-derived ratios Prognostic markers Neutrophil-to-lymphocyte ratio Myocardial infarction

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Digestive Pathologies during Chronic Renal Failure in the nephrology and Haemodialysis department at the university hospital Center of point g in Mali

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Open Journal of Clinical Diagnostics 2020年第1期10卷 41-48页

作者： Magara Samaké Seydou Sy Hamadoun Yattara Moctar Coulibaly Mamadou Badou Sanogo Aboubacar Sidiki Fofana Aboudou Messoum Dolo Djénéba Maiga Djénéba Diallo Atabieme Kodio Bakary Diarra Karamoko Djiguiba Djibril Sy Saharé Fongoro nephrology Unit of the Fousseyni DAOU hospital Kayes Mali nephrology and Haemodialysis department of the CHU of point g Bamako Mali Faculty of Medicine of Bamako University of Bamako Bamako Mali nephrology Unit of Mali gAVARDO hospital Bamako Mali nephrology Unit of the Sikasso Regional hospital Sikasso Mali nephrology Unit of the Mother and Child hospital The Luxembourg Bamako Mali Internal Medicine Service of the university hospital Center of point g Bamako Mali

Introduction: Chronic kidney disease (CKD) is the progressive and irreversible loss of kidney function. It exposes to many complications, among which, digestive complications. In Mali, we do not have data on the prevalence of digestive pathologies in people with chronic renal failure, hence the interest of this study. Objective: To determine the prevalence of digestive pathologies and to describe their manifestations during chronic renal failure. Patients and Methods: This was a prospective cross-sectional study conducted from September 2016 to August 2017, a period of 12 months. Included were patients hospitalized in our department with CKD who received digestive endoscopy and/or liver serology. Results: Seventy-one patients underwent digestive endoscopy with oesogastroduodenal fibroscopy (60 patients), rectoscopy (6 patients) and anoscopy (5 patients), i.e. 15.9% of those hospitalized. The mean age of the patients was 48 ± 14 years with extremes of 15 and 84 years. The sample consisted of 59.2% men versus 40.8% women, for a sex ratio of 1.5. The functional signs are in order of frequency: vomiting (72.4%), anorexia (51.3%) and epigastralgia (48.7%). Terminal CKD by creatinine clearance accounted for 88.2% of cases, of which 47.4% were monitored by hemodialysis. Hepatitis C virus infection was present in 21.3% of cases, hepatitis B (18%) and HIV (7.5%). Endoscopic examinations were represented by fibroscopy (84.5%), rectoscopy (8.5%) and anuscopy (7%). The fibroscopic lesions were respectively gastric (96.8%), duodenal (14.1%) and esophageal (12.5%). They were dominated by gastritis (40.5%), duodeno-gastric reflux (16.4%), pyloric gap (12.6%). Rectoscopy found 4 cases of hemorrhoids, 2 cases of rectitis and no lesions were observed at anuscopy. Conclusion: The prevalence of these digestive manifestations and the endoscopic lesions encountered indicate the importance of digestive endoscopy and the performance of hepatic serologies in chronic renal failure patients w

关键词： Chronic Renal Failure Digestive Signs Mali

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Prevalence and Etiologies of Obstructive Renal Failure in the nephrology department of the university hospital Center of point g, Bamako, Mali

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Open Journal of nephrology 2020年第3期10卷 187-198页

作者： Seydou Sy Magara Samaké Moctar Coulibaly Moussa Salifou Diallo Atabième Kodio Hamadoun Yattara Abdoul Aziz Mahamane Seribah Coulibaly Aboubacar Sidiki Fofana Djénèba Diallo Sah Dit Baba Coulibaly Modi Sidibé Moustapha Tangara Alkaya Touré Saharé Fongoro nephrology and Haemodialysis department of the university hospital Center (UHC) of point g Bamako Mali Faculty of Medicine and Odontostomatology of Bamako Bamako Mali nephrology Unit of the Fousseyni Daou hospital in Kayes Kayes Mali nephrology Unit of the Mali gavardo hospital of Sébénikoro Bamako Mali Urology department of university hospital Center of Kati Kati Mali

Introduction: Obstructive renal failure (ORF) or obstructive uropathy is defined by the simultaneous presence of impaired renal function and urinary excretory tract dilatation on medical imaging. It accounts for 2% to... 详细信息

g>Introduction:g> Obstructive renal failure (ORF) or obstructive uropathy is defined by the simultaneous presence of impaired renal function and urinary excretory tract dilatation on medical imaging. It accounts for 2% to 10% of the causes of acute renal failure (ARF). g>Objective:g> To determine the prevalence and etiologies of ORF in the nephrology department of the university hospital Center of point g. g>Methodology:g> This was a descriptive study with retrospective data collection conducted from January 1, 2017 to June 30, 2018. All patients hospitalized with renal failure due to urinary tract obstruction were included. The parameters studied were age, gender, etiology, type of renal impairment, procedures performed, surgical outcomes of the procedure, pre-and post-management creatinine levels. Information on these clinical and paraclinical variables was collected from individual hospitalization and patient follow-up records. g>Results:g> Among 1133 patients, 83 had obstructive renal failure, a prevalence of 7.32%. The sex ratio was 1.86. The mean age was 48.99 ± 6.81 years with extremes of 7 and 102 years. Signs suggestive of lower urinary tract obstruction were, in order of frequency: dysuria (50.6%), urinary burns (44.6%), urinary frequency (44.6%), pollakiuria (44.6%), macroscopic hematuria (25.3%), low back pain (21.6%), total anuria (18.1%). The etiologies were dominated by lithiasis 36 cases (43.4%), tumours 32 cases (38.55%) followed by sequelae of bilharziasis 12 cases (14.50%). g>Conclusion:g> Obstructive renal failure is becoming more and more common. The etiology is essentially of lithiasic and tumor origin. It must be treated early to allow total or partial recovery of renal function.

关键词： Prevalence Etiologies Obstructive Renal Failure Mali

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Interest of Beta-2-Microglobilin Plasma Assay in Iterative Haemodialysis in the nephrology and Haemodialysis department of university Teaching hospital of point g, Bamako, Mali

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Open Journal of nephrology 2020年第4期10卷 282-289页

作者： Saharé Fongoro Magara Samaké Seydou Sy Hamadoun Yattara Djénèba Diallo Jacques Coulibaly Moctar Coulibaly Aboubacar Sidiki Fofana Atabième Kodio Djénéba Maiga Aboudou M. Dolo Moustapha Tangara Nouhoum Coulibaly Brahima Dégoga Ibrahima Koné nephrology and Haemodialysis department of the university Teaching hospital of point-g Bamako Mali Faculty of Medicine of Bamako Bamako Mali nephrology Unit of the Fousseyni DAOU hospital in Kayes Kayes Mali nephrology Unit of Ségou hospital Ségou Mali nephrology Unit of the Mali gAVARDO hospital of Sébénicoro Bamako Mali nephrology Unit of Sikasso hospital Sikasso Mali nephrology Unit of Somino DOLO hospital in Mopti Mopti Mali

Beta-2-microglobulin (B2M) is a low molecular weight polypeptide (11,800 Da) that exists in a free form and a form bound to cell membranes (light chains of HLA class I molecules). Their dosage is used in the exploration and monitoring of renal function in haemodialysis patients, hence the interest of this study, the objective of which is to study the different players involved in the increase of beta-2-microglobulin. g>Materials and Methods:g> This was a prospective and descriptive study from January 1st, 2017 to August 31, 2017 (08 months). All patients with chronic hemodialysis for 3 years or more were included. We analyzed sociodemographic, clinical and paraclinical data. g>Results:g> We collected 50 patients. The mean age was 50 ± 4.6 years with extremes of 30 and 82 years. The female sex predominated (52%). Chronic end-stage renal failure was hypertensive (86%), diabetic (4%). All patients benefited from intermittent hemodialysis for 8 hours per week using a low permeability membrane (cuprophane). The average duration of hemodialysis was 68 ± 6.4 months with extremes of 36 and 204 months. Twenty percent (20%) and four percent (4%) of chronic dialysis patients had joint pain and sensory deficit. Phalen’s sign was positive in 2% (1 case), Tinel’s sign in 2% (1 case) and carpal tunnel syndrome in 2% (1 case). The mean serum beta-2-microglobulin level was 58.34 ng/l with extremes of 16.99 and 112.24 ng/l. There was a correlation between hypertensive nephropathies and beta-2-microglobulin levels above 50 ng/l (P g>Conclusion:g> Our study has objectified factors such as inadequate dialysis (8 hours/week), use of low permeability membrane in the increase of beta-2-microglobulin. The increase in serum beta-2-microglobulin levels in our patients is evidence of poor purification of medium molecules. Its reduction can be established by improving the quality of dialysis, in particular by

关键词： Chronic hemodialysis Beta-2-Microglobulin Carpal Tunnel Syndrome

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First Consultation in nephrology: Case of the point g university hospital (Bamako-Mali)

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Open Journal of nephrology 2021年第3期11卷 412-421页

作者： Hamadoun Yattara Nouhoum Coulibaly Djeneba Diallo Mamadou Sanogo Seydou Sy Pamela Samiza Moustapha Tanagra Alakay Touré Magara Samaké Sah Dit Baba Coulibaly Aboubacar Sidiki Fofana Atabieme Kodio Saharé Fongoro nephrology and hemodialysis department of the point g university hospital Bamako Mali nephrology department of the Regional hospital of Kayes Kayes Mali

Understanding the first consultation of people with kidney disease seems to us to be essential to understand the attitude of the referring physician and the nephrologist. The aim was to find out to whom a patient with kidney disease should be referred in the first instance and for what reason? Hence the evaluation of the prevalence of the first consultation in the nephrology department of the point g university hospital in Bamako was made. g>Patients and Method:g> This was a prospective descriptive study which took place from July 2017 to June 2018 in the nephrology department of the point g university hospital. The study included all patients who came to the nephrology department for the first time during this period. g>Results:g> Between July 2017 and June 2018 at the nephrology and haemodialysis service of the g point university hospital, we retained 643 out of 1031 patients who came for their first consultation, i.e. 62.36%. There were many patients aged between 41 and 50 years. The average age was 42.6 ± 5.03 years with extremes of 30 and 82 years. The sex ratio (M/F) was in favor of males, 1.14. The majority of patients were referred/evacuated from the referral health centres (57.6%). The majority of patients were referred/evacuated by general practitioners (70.5%). Cardiologists were the main specialists to refer/evacuate patients (21.2%). The main reasons for consultation that led to the first diagnostic hypotheses were: arterial hypertension for vascular nephropathy, glomerular syndrome for glomerular nephropathy, acute uraemia syndrome for acute renal failure, hydronephrosis for obstructive uropathy and finally diabetes for diabetic nephropathy. g>Conclusion:g> The first consultation in nephrology remains an important step in the management of renal disease, especially when the referral is an emergency. The percentage of referrals is dominated by general practitioners.

关键词： Renal Failure First Consultation nephrology CHU du point g

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Parathyroidectomy in Chronic Haemodialysis in the nephrology and Haemodialysis department at the university hospital Center of point g in Bamako, Mali

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Open Journal of nephrology 2020年第2期10卷 135-143页

作者： Saharé Fongoro Hamadoun Yattara Seydou Sy Magara Samaké Djénèba Diallo Moctar Coulibaly Fatoumata Modjéré Doumbia Djibril Samaké Moustapha Tangara Alkaya Touré Atabième Kodio Nouhoum Coulibaly nephrology and Haemodialysis department of the university hospital Centre of point g Bamako Mali Faculty of Medicine University of Bamako Bamako Mali nephrology Unit of the Fousseyni Daou hospital in Kayes Kayes Mali nephrology Unit of the Mali gavardo hospital in Sébénikoro Bamako Mali ORL Unit Reference Health Center of the Municipality V Bamako Bamako Mali

Introduction: Secondary hyperparathyroidism is a common complication in chronic hemodialysis patients. It is characterized by hypersecretion of parathormone by the parathyroid glands to maintain phosphocalcium homeost... 详细信息

g>Introduction:g> Secondary hyperparathyroidism is a common complication in chronic hemodialysis patients. It is characterized by hypersecretion of parathormone by the parathyroid glands to maintain phosphocalcium homeostasis in response to hypocalcemia, lowering of 1.25 dihydroxy vitamin D3 and hyperphosphatemia. g>Objective:g> To analyze the results of parathyroidectomy (PTX) in cases of secondary hyperparathyroidism (HPTS), report the post-operative course and early and late complications. Patients and Methods: We conducted a retrospective study of ten (10) patients with chronic renal failure operated on at the CHU of point g over a 32-month period, from January 1, 2016 to August 31, 2019. We analyzed the clinical, biological, radiological and histological parameters of the thyroid glands. g>Results:g> We have collected 33 cases of secondary hyperparathyroidism. Ten (10) patients met the inclusion criteria. They were 45 years old on average, seven (7) women and three (3) men, in dialysis for an average of 6.8 years before parathyroidectomy. Half of the initial kidney disease was of vascular origin (HTA). No cases of diabetic nephropathy were identified. Symptoms were in order of frequency: bone pain (60%), paresthesia (50%), functional impotence of the lower limbs (50%). Radiological signs included demineralisation (5 out of 6 cases) and brown tumour associated with a fracture (1 out of 6 cases). The most frequent indication for parathyroidectomy (100%) was persistence despite treatment of a serum PTH concentration above 1000 pg/ml. Subtotal PTX (7/8) was performed after cervical ultrasound in all patients. Histological analysis of the parathyroid glands showed adenoma (60%) and hyperplasia in 40% of cases. The evolution was marked by a progressive reduction of the parathormone level over twelve (12) months, without achieving normalization. This could be related to sub-dialysis (generator failure with reduction of dialysis t

关键词： Chronic Renal Failure Secondary Hyperparathyroidism Dialysis Parathyroidectomy

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Estimation of glomerular Filtration Rate: Which Formula to Apply in g-Spot Subjects Aged 1 - 17 Years?

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Open Journal of nephrology 2021年第3期11卷 397-402页

作者： Hamadoun Yattara Djibril Mamadou Couliblay Nouhoum Coulibaly Pamela Samiza Seydou Sy Arboncana Maiga Djeneba Diallo Moustapha Tanagra Alkaya Touré Magara Samaké Niagalé Diakité Aboubacar Sidiki Fofana Ibrahim Izetiengou Maiga Sahare Fongoro nephrology and hemodialysis department of the point g university hospital Bamako Mali Medical biology Laboratory Service of the point g university hospital Bamako Mali nephrology department of the Regional hospital of Kayes Kayes Mali

Introduction: Morbidity and mortality in paediatric practice is dominated in Africa by malaria, diarrhoeal diseases and acute respiratory infections. Aim: In order to evaluate the glomerular Filtration Rate (gFR) with... 详细信息

g>Introduction:g> Morbidity and mortality in paediatric practice is dominated in Africa by malaria, diarrhoeal diseases and acute respiratory infections. g>Aim:g> In order to evaluate the glomerular Filtration Rate (gFR) with the formulas commonly used by medical laboratories, we proposed to undertake this study. g>Patients and Method:g> This was a descriptive, prospective and cross-sectional study conducted at the PA and KA medical biology laboratory in Bamako Hamdalaye ACI 2000 in collaboration with the medical biology and hospital hygiene laboratory service at the point g university hospital. g>Results:g> During the study period, we recruited 360 subjects, 189 of whom were male (52.5%) and 171 female (47.5%). The mean age was 8.75 ± 4.8 years with extremes of 1 and 17 years. Subjects aged 15 to 17 years were the most numerous. The reference means gFR of the subjects according to age was with the SCHWARTZ formula 179.16 ± 50.47 with extremes of 173.93 and 184.39;with CKD-Epi 37.63 ± 11.25 with extremes of 36.46 and 38.79;with MAYO 107.87 ± 18.11 with extremes of 105.99 and 109.75 and MDRD 350.83 ± 251.15 with extremes of 324.79 and 376.86. g>Conclusion:g> The Mayo formula showed a better distribution around the mean than other formulas for estimating the glomerular filtration rate.

关键词： glomerular Filtration Rate Reference Value Young Subjects

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