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Protective effects of astragaloside in rats with adriamycin nephropathy and underlying mechanism

Chinese Journal of Natural Medicines 2016年第4期14卷 270-277页

作者： WANG Na WEI Ri-Bao LI Qing-Ping YANG Xi CHEN Xiang-Mei Department of nephrology Chinese PLA General Hospital Chinese PLA Institute of NephrologyState Key Laboratory of Kidney DiseasesNational Clinical Research Center for Kidney DiseasesBeijingChina 100853

The present study was designed to determine the mechanism underlying the treatment of nephrotic syndrome using astragaloside by observing the effects of astragaloside on the expression of nephrin and podocin proteins and genes in kidneys of rats with adriamycin nephropathy. The rats were injected with adriamycin and, after successful model establishment, randomly divided into a model group, a Methylprednisolone(MP) group, and an astragaloside group. The 24-h complete urine samples were collected. Biochemical indicators were monitored, and kidney tissues were collected for pathological analysis using light microscopy and electron microscopy. The m RNA expression of nephrin and podocin was measured in the kidney tissues using the real-time q PCR, and the protein expression levels of nephrin and podocin were detected using Western blot analysis. At the end of 12 weeks of drug intervention, the urinary protein level was lower in the MP and astragaloside groups than that in the model group(P = 0.008 and P = 0.01, respectively). Serum albumin was higher in the MP and astragaloside groups than in the model group(P group were nearly normal, and fusion of podocytes in the astragaloside group was significantly less than that in the control group. The nephrin and podocin m RNA and protein expression levels in the intervention groups were higher(P group. Due to the increased expression of podocyte-related nephrin and podocin proteins, astragaloside maintained slit diaphragm integrity and decreased the level of proteinuria in rats with adriamycin nephropathy.

关键词： Astragaloside Adriamycin nephropathy Podocyte Nephrin Podocin

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Effects of Niaoduqing Particles(尿毒清颗粒)on Delaying Progression of Renal Dysfunction:A Post-trial,Open-Label,Follow-up Study

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Chinese Journal of Integrative Medicine 2019年第3期25卷 168-174页

作者： ZHENG Ying WANG Nian-song LIU Yu-ning HE Li-qun JIAN Gui-hua LIU Xu-sheng NI Zhao-hui CHENG Xiao-hong LIN Hong-li ZHOU Wen-hua WANG Ya-ping FANG Jing-ai HE Ya-ni YANG Hong-tao ZHAO Li-juan DING Han-lu WANG Li-hua YU Ren-huan LI Wen-ge YE Zhi-ming GUO Wang ZHAN Yong-li MAO Hui-juan HU Zhao YAO Chen CAI Guang-yan CHEN Xiang-mei Department of nephrology Chinese People's Liberation Army General Hospital Chinese People's Liberation Army Institute of Nephrology State Key Laboratory of Kidney Diseases (2011DAV00088) National Clinical Research Center for Kidney Diseases Department of nephrology and Rheumatology Affiliated Sixth People's Hospital Shanghai Jiaotong University Department of nephrology Dongzhimen Hospital The First Affiliated Hospital of Beijing University of Chinese Medicine Department of nephrology Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine Department of nephrology Guangdong Provincial Hospital of Chinese Medicine Department of nephrology Renji Hospital Shanghai Jiaotong University Department of nephrology Shaanxi Traditional Chinese Medicine Hospital Department of nephrology First Affiliated Hospital of Dalian Medical University Department of nephrology Second Hospital of Jilin University Department of nephrology Army General Hospital Department of nephrology First Affiliated Hospital of Shanxi Medical University Department of nephrology Daping Hospital Army Medical University Department of nephrology First Teaching Hospital of Tianjin University of Traditional Chinese Medicine Department of nephrology Xijing Hospital Air Force Medical University Department of nephrology University of Electronic Science and Technology Sichuan Academy of Sciences and Sichuan Provincial People's Hospital Department of nephrology Second Affiliated Hospital of Shanxi Medical University Department of nephrology Xiyuan Hospital China Academy of Chinese Medical Sciences Department of nephrology China-Japan Friendship Hospital Department of nephrology Guangdong General Hospital Guangdong Academy of Medical Sciences Department of nephrology Beijing Friendship Hospital Capital Medical University Department of nephrology Guang'anmen Hospital of China Academy of Traditional Chinese Medical Sciences Department of nephrology Jiangsu Province Hospital First Affiliated Hospital of Nan

Objective: To follow up the participants of the randomized clinical trial "Efficacy and Safety of Niaoduqing Particles(尿毒清颗粒) for Delaying Moderate-to-Severe Renal Dysfunction", and assess the long-term effects of Niaoduqing Particles on delaying the progression of renal dysfunction. Methods: Participants, who had previously been randomly assigned to receive Niaoduqing Particles or placebo for 24 weeks(146 cases in each group), were invited to follow-up and all were administered Niaoduqing Particles 5 g thrice daily and 10 g before bedtime for 24 weeks. The primary endpoints were changes in baseline serum creatinine(Scr) and estimated glomerular filtration rate(e GFR) after completion of the open-label treatment period. Results: After the double-blind period, the median(interquartile range) changes in Scr were 1.1(–13.0–24.1) and 11.7(–2.6–42.9) μmol/L for the Niaoduqing Particle and placebo groups, respectively(P=0.008), and the median changes in e GFRs were –0.2(–4.3–2.7) and –2.21(–5.7–0.8) mL·min^(-1)·1.73 m^(-2), respectively(P=0.016). There were significant differences in the double-blind period changes in renal function between groups. After the open-label period, the median changes in Scr were 9.0(–10.0–41.9) and 17.5(–6.0–50.0) μmol/L for the Niaoduqing Particle and placebo groups according to baseline grouping, respectively(P=0.214), and the median changes in eGFRs were –2.3(–6.4–1.9) and –3.7(–7.5–1.1) mL·min^(-1)·1.73 m^(-2), respectively(P=0.134). There were no statistical differences in the open-label period changes in renal function between groups. The eGFR reduction of participants who accepted Niaoduqing Particle treatment for 48 weeks was projected to 2.5 m L·min^(-1)·1.73 m(-2) per year. Conclusions: Niaoduqing Particles appear to have long-term efficacy for patients with moderate-to-severe renal dysfunction. Although there was no statistical difference, the early use of Niaoduqing Paticles seems to ameliorate the worsening of renal function.

关键词： chronic kidney disease moderate-to-severe renal dysfunction Niaoduqing Particles post-trial follow-up Chinese medicine

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Regional citrate anticoagulation in critically ill patients during continuous blood purification

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Chinese Medical Journal 2003年第3期116卷 41-44页

作者：龚德华季大玺徐斌谢红浪刘云黎磊石 research Institute of nephrology Jinling Hospital Nanjing University School of Medicine Nanjing 210002 China

Objectives To evaluate the safety and define the contraindication of regional citrate anticoagulation treatment on various critically ill patients being treated by continuous blood purification, who also had bleeding tendencies. Methods Forty critically ill patients being treated by continuous blood purification (CBP) were involved in this study. Due to their bleeding tendencies, regional citrate anticoagulation treatment was given to all of them. Those with hepatic function impairment (n=10) were classified as group A, those with hypoxemia were classified as group B (n=10), and the others as group C (n=20). Blood samples were collected before treatment, and at 4, 12, 24, 36, and 48 hour intervals during CBP. These samples then were used arterial blood gas analysis, whole blood activated clotting time (WBACT) pre- and post-filter, and serum ionized calcium examination. Results WBACT pre-filter showed little fluctuant through the 48hr period of CBP, and WBACT post-filter showed obvious prolongation than that of the pre-filter (Pgroup A patients before CBP, and improved during CBP. Normal acid-base conditions of patients were disturbed and deteriorated in group B during CBP, but not in group C. Serum ionized calcium was maintained at a normal range during CBP in group A and C patients, but declined significantly in group B patients (vs. pre-treatment, P<0.05). Conclusions Regional citrate anticoagulation can be safely used in conjunction with CBP treatment for patients with hepatic function impairment , but may induce acidosis and a decline in serum ionized calcium when used with hypoxemic patients.

关键词： continuous blood purification regional citrate anticoagulation complication

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Mycophenolate mofetil or tacrolimus compared with azathioprine in long-term maintenance treatment for active lupus nephritis

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Frontiers of Medicine 2022年第5期16卷 799-807页

作者： Qianying Zhang Peng Xing Hong Ren Xiaonong Chen Jingyuan Xie Wen Zhang Pingyan Shen Xiao Li Nan Chen Department of nephrology Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200025China

This study aimed to evaluate the efficacy and safety of mycophenolate mofetil(MMF)or tacrolimus(TAC)compared with azathioprine(AZA)as maintenance therapy for active lupus nephritis(ALN).Patients with ALN who responded to 24 weeks of induction treatment were *** who received MMF or TAC as induction therapy continued MMF or TAC treatment during the maintenance period,whereas those who received intravenous cyclophosphamide were subjected to AZA *** primary endpoint was the incidence of renal *** endpoints included extrarenal flares and composite endpoints(deaths,end-stage renal disease,or doubling of serum creatinine levels).A total of 123 ALN patients(47 in the MMF group,37 in the TAC group,and 39 in the AZA group)were *** median follow-up time was 60 *** MMF-treated patients,ten TAC-treated patients,and eight AZA-treated patients experienced renal relapses(P=0.844).The cumulative renal relapse rates in the MMF group(P=0.934)and TAC group(P=0.673)were similar to the renal relapse rate in the AZA *** significant difference in the incidence of severe adverse event was observed among the ***-term maintenance therapies with MMF or TAC might have similarly low rates of renal relapse and similar safety profiles compared with AZA.

关键词： lupus nephritis mycophenolate mofetil tacrolimus maintenance therapy

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Analysis of Factors Associated with Death in Maintenance Hemodialysis Patients： A Multicenter Study in China

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Chinese Medical Journal 2017年第8期130卷 885-891页

作者： Kang-Kang Song De-Long Zhao Yuan-Da Wang Yong Wang Xue-Feng Sun Li-Ning Miao Zhao-Hui Ni Hong-Li Lin Fu-You Liu Ying Li Ya-Ni He Nian-Song Wang Cai-Li Wang Ai-Hua Zhang Meng-Hua Chen Xiao-Ping Yang Yue-Yi Deng Feng-Min Shao Shu-Xia Fu Jing-Ai Fang Guang-Yan Cai Xiang-Mei Chen Department of nephrology Chinese PLA General Hospital Chinese PLA Institute of Nephrology State Key Laboratory of Kidney Diseases National Clinica Research Center for Kidney Diseases Beijing 100853 China Department of nephrology The Second Hospital of Jilin University Changchun Jilin 130041 China Department of nephrology Renji Hospital Shanghai Jiao Tong University School of Medicine Shanghai Peritoneal Dialysis Research Center Shanghai 200127 China Department of nephrology First Affiliated Hospital of Dalian Medical University Dalian Liaoning 116011 China Department of nephrology The Second Xiangya Hospital of Central South University Changsha Hunan 410011 China Department of nephrology Third Hospital of Hebei Medical University Kidney Disease Research Center of Hebei Province Shijiazhuang Hebei 050081 China Department of nephrology Institute of Surgery Research Daping Hospital Third Military Medical University Chongqing 400042 China Department of nephrology Shanghai Jiao Tong University Affiliated The Sixth People's Hospital Shanghai 200233 China Department of nephrology First Affiliated Hospital of Baotou Medical College Baotou Inner Mongolia 014040 China Department of nephrology Peking University Third Hospital Beijing 100191 China Department of nephrology General Hospital of Ningxia Medical University Yinchuan Ningxia 750004 China Department of nephrology The First Affiliated Hospital of Shihezi University School of Medicine Shihezi Xinjiang 832008 China Department of nephrology Longhua Hospital Shanghai University of Traditional Chinese Medicine Shanghai 200032 China Department of nephrology Henan Provincial People's Hospital Zhengzhou Henan 450003 China Department of nephrology The Second Hospital of Hebei Medical University Shijiazhuang Hebei 050000 China Department of nephrology First Hospital of Shanxi Medical University Taiyuan Shanxi 030001 China

Background： Patients on hemodialysis have a high-mortality risk. Tiffs study analyzed factors associated with death in patients on maintenance hemodialysis （MHD）. While some studies used baseline data of MHD patients, this study used the most recent data obtained from patients just prior to either a primary endpoint or the end of the study period to iliad the characteristics of patients preceding ***： Participants were selected from 16 blood purification centers in China from January 2012 to December 2014, Patients＇ data were collected retrospectively. Based on survival status, the participants were divided into two groups： survival group and the death group. Logistic regression analysis was performed to determine/＇actors associated with all-cause mortality.

关键词： Hemodialysis Mortality: Risk Factors

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Increased duodenal expression of mi R-146a and-155 in pediatric Crohn's disease

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World Journal of Gastroenterology 2016年第26期22卷 6027-6035页

作者： Dániel Szucs Nóra Judit Béres Réka Rokonay Kriszta Boros Katalin Borka Zoltán Kiss András Arató Attila J Szabó ádám Vannay Erna Sziksz Csaba Bereczki Gábor Veres Department of Pediatrics and Pediatric Health Care Center University of Szeged H-6725 Szeged Hungary 1st Department of Pediatrics Semmelweis University H-1083 Budapest Hungary 2nd Department of Pathology Semmelweis University H-1091 Budapest Hungary 1st Department of Pediatrics Semmelweis University and MTA-SE Pediatrics and Nephrology Research Group H-1083 Budapest Hungary

AIM: To evaluate the role of microRNA (miR)-146a, -155 and -122 in the duodenal mucosa of pediatric patients with Crohn’s disease (CD) and the effect of transforming growth factor-β (TGF-β) on these miRs in duodenal epithelial and fibroblast ***: Formalin-fixed, paraffin-embedded biopsies derived from the macroscopically inflamed (CD inflamed: n = 10) and intact (CD intact: n = 10) duodenal mucosa of pediatric CD patients and control children (C: n = 10) were examined. Expression of miR-146a, -155 and -122 was determined by real-time polymerase-chain reaction (PCR). The expression of the above miRs was investigated in recombinant human TGF-β (1 nmol/L, 24 h) or vehicle treated small intestinal epithelial cells (CCL-241) and primary duodenal fibroblast cells derived from healthy children as ***: Expression of miR-146a was significantly higher in the inflamed duodenal mucosa compared to the intact duodenal mucosa of children with CD (CD inflamed: 3.21 ± 0.50 vs CD intact: 0.62 ± 0.26, P ≤ 0.01) and to the control group (CD inflamed: 3.21 ± 0.50 vs C: 1.00 ± 0.33, P ≤ 0.05). The expression of miR-155 was significantly increased in the inflamed region of the duodenum compared to the control group (CD inflamed: 4.87 ± 1.02 vs Control: 1.00 ± 0.40, P ≤ 0.001). The expression of miR-122 was unchanged in the inflamed or intact mucosa of CD patients compared to controls. TGF-β treatment significantly decreased the expression of miR-155 in small intestinal epithelial cells (TGF-β: 0.7 ± 0.083 vs Control: 1 ± 0.09, P ≤ 0.05) and also the expression of miR-146a (TGF-β: 0.67 ± 0.04 vs Control: 1 ± 0.15, P ≤ 0.01) and miR-155 (TGF-β: 0.72 ± 0.09 vs Control: 1 ± 0.06, P ≤ 0.05) in primary duodenal fibroblasts compared to corresponding vehicle treated control

关键词： Inflammatory bowel disease Crohn’ s disease Pediatric MicroRNAs Transforming growth factor-β

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Effect of pirfenidone on renal tubulointerstitial fibrosis

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Frontiers of Medicine 2009年第3期3卷 316-322页

作者： Dixin LI Hongbing ZENG Chunyang JI Department of nephrology The Fifth People’s Hospital of ChengduChengdu 611130China Department of nephrology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Renal tubulointerstitialﬁbrosis(TIF)is the common end stage of various chronic renal diseases,and pirfenidone(PFD)is a novel,broad-spectrum anti-ﬁbrotic compound but little is known about its effect and mechanism of action on renal *** this work,we employed a unilateral ureteral obstruction(UUO)rat model to investigate the apoptosis of renal tubular epithelial cells(RTC)after PFD ***-ﬁve Sprague Dawley(SD)rats were randomized into three groups:sham-operated group(n=7),UUO group(n=14)and PFD group(n=14).All rats were sacriﬁced at day 7 or 14 after *** histology was studied by using periodic acid schiff reagent(PAS)and Masson trichromic stain(MASSON);apoptosis was detected by in situ terminal deoxynucleotide transferase-mediated dUTP-biotin nick end-labeling(TUNEL)method;tubular caspase-3 expression was assessed by *** content of malondialdehyde(MDA)and total activity of superoxide dismutase(T-SOD)in the renal cortex were determined by chemical colorimetry ***,apopto-sis of RTC,tubular expression of caspase-3 and the content of MDA were increased in the UUO group compared with those in the sham-operated group,and were ameliorated signiﬁcantly by PFD treatment(Pgroup,but was increased by PFD treatment(Pgroup,and the possible mechanism was by reducing the apoptosis of RTC,which involved oxidative stress and caspase-3.

关键词： pirfenidone apoptosis caspase 3 oxidative stress

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The Effect of Connective Tissue Growth Factor on Human Renal Tubular Epithelial Cell Transdifferentiation

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2004年第4期24卷 350-353页

作者：张春朱忠华邓安国 Department of nephrology Union Hospital Tongji Medical College Huazhong University of Science and Technology

To investigate the role of connective tissue growth factor (CTGF) in transdifferentiation of human renal tubular epithelial cell (HKC), in vitro cultured HKC cells were divided into 3 groups: negtive control, low dose CTGF-treated group (rh CTGF, 2.5 ng/ml) and high dose CTGF-treated (rhCTGF, 5.0 ng/ml). Then the expression of α-smooth muscle actin (α-SMA) were assessed by indirect immuno-fluorescence, and the percentage of α-SMA positive cells were assessed by flow cytometry. RT-PCR were also performed to examine the mRNA level of α-SMA. Upon the stimulation of different concentrations of rhCTGF, the expression of α-SMA were markedly stronger than that in negative controls. The percentages of α-SMA positive cells were significantly higher in the stimulated groups than that of negative controls (38.9 %, 65.5 % vs 2.4 %, P<0.01) .α-SMA mRNA levels were also up-regulated by the stimulation of rhCTGF (P<0.01). These results suggest that CTGF can promote the transdifferentiation of human renal tubular epithelial cells towards myofibroblast (Myo-F).

关键词： connective tissue growth factor human renal tubular epithelial cell transdifferentiation

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Independent risk factors for depression in older adult patients receiving peritoneal dialysis for chronic kidney disease

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World Journal of Psychiatry 2023年第11期13卷 884-892页

作者： Yu-Ping Sheng Xiao-Ying Ma Ye Liu Xing-Meng Yang Fu-Yun Sun Department of nephrology Cangzhou Central Hospital Cangzhou 061000Hebei ProvinceChina

BACKGROUND According to the trend of global population aging,the proportion of elderly patients with chronic kidney disease(CKD)is expected to ***,there are more than 20 million people in China with decompensated kidney function,of which 19.25%are elderly ***,special attention should be paid to the education years,sleep quality,anxiety status,comorbidities with diabetes,cardiovascular disease(CVD),and anemia as independent risk factors for depression in elderly CKD *** study explores the clinical management of elderly CKD patients that should address these risk factors to prevent depression and improve their *** To investigate depression risk factors in older patients receiving peritoneal dialysis,aiding future prevention of depression in these *** This retrospective study included a primary study population of 170 patients with CKD who received peritoneal dialysis from January 2020 to December *** assessed the patients’mental status using the Beck Depression Inventory Score-II(BDI-II),Self-Rating Anxiety Scale(SAS),Anxiety Inventory Score,and the Pittsburgh Sleep Quality Index(PSQI).Logistic regression was employed to identify depression independent risk factors among these *** The non-depressed group had a significantly longer education period than the depressed group(Pgroup exhibited significantly higher mental status scores than the non-depressed group(P<0.001).Patients with diabetes mellitus(DM)or CVD had a higher probability of developing *** with depression had significantly lower hemoglobin and albumin levels than patients without depression(P<0.05).Spearman correlation analysis of BDI-II scale scores,measuring depression,indicated positive correlations with BDI-II and SAS scores as risk factors for depression in patients with *** contrast,years of education,hemoglobin levels,and peritoneal Kt/V were negatively correlated,serving as protective

关键词： Depression Chronic kidney disease Peritoneal dialysis Older adults Risk factors for depression Beck Depression Inventory Score-II

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Effects of paricalcitol combined with hemodiafiltration on bonemetabolism-related indexes in patients with diabetic nephropathy and chronic renal failure

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世界糖尿病杂志:英文版(电子版) 2023年第9期14卷 1385-1392页

作者： Xiao-Ying Ma Yu-Ping Sheng Xing-Meng Yang Hao-Ran Zhang Fu-Yun Sun Department of nephrology Cangzhou Central HospitalCangzhou 061000Hebei ProvinceChina

BACKGROUND Diabetic nephropathy(DN)is frequently seen in the development of diabetes mellitus,and its pathogenic factors are *** current treatment is controversial,and there is a lack of a relevant efficacy prediction *** To determine the effects of paricalcitol combined with hemodiafiltration on bonemetabolism-related indexes in patients with DN and chronic renal failure(CRF),and to construct an efficacy prediction *** We retrospectively analyzed 422 patients with DN and CRF treated in Cangzhou Central Hospital between May 2020 and May *** selected 94 patients who met the inclusion and exclusion *** were assigned to a dialysis group(n=45)and a joint group(n=49)in relation to therapeutic *** clinical efficacy of the two groups was compared after *** changes in laboratory indexes after treatment were evaluated,and the two groups were compared for the incidence of adverse *** predictive value of laboratory indexes on the clinical efficacy on patients was *** The dialysis group showed a notably worse improvement in clinical efficacy than the joint group(P=0.017).After treatment,the joint group showed notably lower serum levels of serum creatinine,uric acid(UA)and blood urea nitrogen(BUN)than the dialysis group(Pgroup had lower serum levels of phosphorus,procollagen type I amino-terminal propeptide(PINP)and intact parathyroid hormone than the dialysis group,but a higher calcium level(Pgroups had a similar incidence of adverse reactions(P>0.05).According to least absolute shrinkage and selection operator regression analysis,UA,BUN,phosphorus and PINP were related to treatment *** to further comparison,the non-improvement group had higher risk scores than the improvement group(P<0.0001),and the area under the curve of the risk score in efficacy prediction was *** For treatment of CRF and DN,combined paricalcitol a

关键词： Paricalcitol Hemodiafiltration Diabetic nephropathy Chronic renal failure Serum calcium Serum phosphorus Intact Paricalcitol hormone

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