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Uremic clearance granule combined with Alprostadil in the treatment of chronic renal failure: A systematic review and meta-analysis

引用

TMR Theory and Hypothesis 2019年第3期2卷 195-203页

作者： Jing Gan Ya-Fang Guo Dong-Dong Li Zi-Zheng Zhou Jia-Bao Zhou Jian-Dong Gao Department of nephrology Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineTCM institute of kidney disease Shanghai University of Traditional Chinese MedicineKey Laboratory of Liver and Kidney Diseases (Shanghai University of Traditional Chinese Medicine) Ministry of EducationShanghai Key Laboratory of Traditional Chinese Clinical Medicine (14DZ2273200) Shanghai China Department of TCM Shanghai Pudong Hospital Fudan University Pudong Medical Center Shanghai China

Objective: To evaluate whether the combination of Uremic clearance granule with Alprostadil is superior to Alprostadil alone for CRF. Methods: Relevant RCTs were searched through March 2019. Data were analyzed by Stata 15.0. Results: Nine articles involving 726 patients were enrolled in this study. Meta-analysis showed that the total effective rate [OR = 3.68 (2.44, 5.55), P group. But there were no significant difference in UA, CysC, 24h-Upro and incidence of adverse reactions (all P > 0.05) between two groups. No serious adverse reactions were found. Conclusions: The effect of the integrated medicine on CRF was better than Alprostadil alone. Uremic clearance granule is safe and has no obvious adverse reactions.

关键词： Uremic clearance granule Chronic Renal Failure Alprostadil Meta-Analysis

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