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Atypical presentation of a posterior fossa tumour:A case report

World Journal of Clinical Cases 2024年第13期12卷 2281-2285页

作者： Alisha Narotam Mikara Archary Poobalan Naidoo Yeshkhir Naidoo Vanesha Naidu Department of Internal Medicine King Edward VIII Hospital-University of Kwazulu-NatalDurban 4001Kwa-Zulu NatalSouth Africa Department of Internal Medicine Nelson R MandelaSchool of MedicineUniversity of Kwa-Zulu NatalDurban 4001Kwa-Zulu NatalSouth Africa Department of Radiology King Edward VIII Hospital-University of Kwazulu-NatalDurban 4001Kwazulu-NatalSouth Africa

BACKGROUND We described a case of a patient with a meningioma in the posterior fossa presenting atypically with an isolated unilateral vocal cord palsy causing severe respiratory *** is of interest as the patient had no other symptomatology,especially given the size of the mass,which would typically cause a pressure effect leading to neurological and auditory *** SUMMARY This case report described a 48-year-old male who was married with two children and employed as a car *** had a medical history of asthma for the past 10 years controlled with an as-needed beta 2 agonist metered dose *** initially presented to our facility with severe respiratory *** reported a 1-wk history of shortness of breath and wheezing that was not relieved by his *** had no constitutional symptoms or impairment of *** clinical examination,the patient’s chest was“silent.”Our initial assessment was status asthmaticus with type 2 respiratory failure,based on the history of asthma,a“silent chest,”and the arterial blood gas *** A posterior fossa meningioma of such a large size and with extensive infiltration rarely presents with an isolated unilateral vocal cord *** patient’s chief presenting feature was severe respiratory distress,which combined with his background medical history of asthma,was *** should thus consider meningioma as a differential diagnosis for a unilateral vocal cord palsy even without audiology involvement.

关键词： Respiratory distress Meningioma Unilateral vocal cord palsy Posterior fossa tumour Neurosurgery Neurology Radiology Case report

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Genetic Diversity of Jute Mallow (Corchorus spp.) Accessions Based on ISSR Markers

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American Journal of Plant Sciences 2024年第5期15卷 316-328页

作者： Munguatosha Ngomuo Tsvetelina Stoilova Tileye Feyissa Patrick A. Ndakidemi School of Life Sciences Nelson Mandela African Institute of Science and Technology Arusha Tanzania Tanzania Official Seed Certification Institute (TOSCI) Arusha Tanzania AVRDC— World Vegetable Centre Arusha Tanzania Institute of Biotechnology Addis Ababa University Addis Ababa Ethiopia

Jute mallow is a nutritious leafy vegetable. The leaves are rich in proteins, vitamins and essential amino acids. Molecular characterization of Jute mallow with focus on improvement of leaf yield is scarcely reported. In the present study, inter sequence simple repeats (ISSR) molecular markers were employed to assess genetic diversity and relationships of 83 accessions of Jute mallow from different parts of Africa and Asia conserved at the World Vegetable Center East and Southern Africa. A total of 89 bands were amplified by 8 ISSR primers. Number of polymorphic bands per primer ranged from 2 to 6 with an average of 2.75 bands per primer. Polymorphic information content (PIC) values ranged from 0.390 to 0.760 with average of 0.53. Average Nei’s gene diversity (h) and Shannon’s information index (I) were 0.335 and 0.494 respectively. The highest pairwise genetic distance was 0.431 observed in a population from East Africa accessions. PC1 and PC2 axis explained 21.69% and 11.66% of the total variation respectively. UPGMA cluster analysis grouped the accessions into six main clusters at genetic similarity coefficient of 0.53 as standard value for classification. These results have important implications for jute mallow breeding and conservation.

关键词： Corchorus spp. Genetic Diversity ISSRs Jute Mallow Leafy Vegetable

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*** model of riboflavin transporter deficiency(RTD)disorder reveals deficits in synaptic transmission and movement

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Genes & Diseases 2024年第4期11卷 120-123页

作者： Ramesh K.Narayanan Gonzalo Perez-siles Kamila A.Marzec Alexandra Boyling Brent Neumann Manoj P.Menezes Marina L.Kennerson Northcott Neuroscience Laboratory ANZAC Research Institute-Sydney Local Health DistrictSydneyNSW 2139Australia Sydney Medical School University of SydneySydneyNSw 2050Australia ANZAC Research Institute-Sydney Local Health District SydneyNSW 2139Australia Neuroscience Program Monash Biomedicine Discovery Institute and Department of Anatomy and Developmental BiologyMonash UniversityMelbourneVictoria 3800Australia TY nelson Department of Neurology and Neurosurgery and Kids Neuroscience Children's Hospital at WestmeadWestmeadSydneyNSW2145Australia Paediatrics and Child Health The University of SydneySydneySydneyNSW 2145Australia Molecular Medicine Laboratory Concord General Repatriation HospitalSydneyNSW 2139Australia

Riboflavin transporter deficiency(RTD),previously known as Brown-Vialetto-Van Laere syndrome,is a childhoodonset neurodegenerative disorder characterized by sensory and motor neuron degeneration causing ataxia,muscle weakness,optic atrophy,and respiratory *** in SLC52A2 and SLC52A3,solute carrier family members that encode riboflavin(RF)transporters RFVT2 and RFVT3,are known to cause RTD types 2 and 3,respectively.

关键词： RTD degeneration TD

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Catatonia:A deep dive into its unfathomable depths

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World Journal of Psychiatry 2024年第2期14卷 210-214页

作者： Peter Phiri Gayathri Delanerolle Oliver Hope Tharangini Murugaiyan Geoffrey Dimba Shanaya Rathod Zukiswa Zingela Research&Innovation Department Southern Health NHS Foundation TrustSouthampton SO303JBUnited Kingdom School of Psychology Faculty of Environmental and Life SciencesUniversity of SouthamptonSouthampton SO171BJHampshireUnited Kingdom Acute Inpatients Services Southern Health NHS Foundation TrustBasingstoke RG249RHUnited Kingdom Home Treatment Team South WestSurrey and Borders Partnerships NHS Foundation TrustGuildford GU27XLSurreyUnited Kingdom Faculty of Health Sciences Nelson Mandela UniversitySummerstrand 6001GqeberhaSouth Africa

This editorial addresses catatonia,a complex neuropsychiatric syndrome characterised by a spectrum of psychomotor *** editorial seeks to clarify the ambiguous aspects of catatonia,integrating recent research findings,including global studies and diagnostic *** discusses catatonia’s clinical manifestations,prevalence,and associated psychiatric and medical conditions,with particular emphasis on its frequent co-occurrence with schizophrenia and mood *** prevalence of catatonia,which varies across psychiatric populations,is illustrated by a significant study conducted in nelson Mandela Bay,South *** study provides valuable insights into the effectiveness of the Bush-Francis Screening Instrument compared to the Diagnostic and Statistical Manual 5 criteria in diagnosing *** editorial evaluates treatment approaches,primarily focusing on benzodiazepines and electroconvulsive therapy,and discusses emerging therapeutic *** underscores the importance of robust diagnostic frameworks and early intervention in managing catatonia,as recommended by the latest evidence-based consensus ***,it suggests future research directions,particularly in exploring the neurobiological and genetic factors of catatonia,to enhance our understanding and improve treatment *** editorial succinctly aims to demystify catatonia and provide valuable insights for clinicians and researchers in mental health care.

关键词： Catatonia Schizophrenia Neuropsychiatry Benzodiazepines Electroconvulsive therapy Bush-Francis screening instrument Diagnosis

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Time and reference frequency transfer over 850 nm VCSEL for digital telecommunication network synchronization

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Optoelectronics Letters 2019年第3期15卷 209-212页

作者： G.M.Isoe S.Wassin A.W.R.Leitch T.B.Gibbon Centre for Broadband Communication Nelson Mandela University

Accurate time transfer and synchronization between different network nodes is a key functional requirement in digital communication. Developments in optical fiber-based frequency dissemination techniques have improved optical frequency stability over time to much lower levels. In this work, we experimentally present the reference frequency transfer employing 850 nm vertical cavity surface emitting laser(VCSEL) over 100.3 m OM3 multimode fiber for synchronization of clocks on networked devices such as servers and racks/pod at different data center network nodes. A low-cost power-efficient multimode VCSEL with central wavelength at 844.26 nm is directly modulated with a 2 GHz reference frequency(RF) clock signal, and transferred over 100.3 m of OM3 multimode fiber. The single side band(SSB) phase noise of-104.62 dBc/Hz and-100.70 dBc/Hz is experimentally measured at back-to-back(B2 B) and 100.3 m OM3 multimode fiber transmission respectively at a 1 kHz frequency offset. The jitter stability of 0.14 ps and 0.15 ps is experimentally achieved at B2 B and 100.3 m fiber transmission, respectively. This work provides an alternative viable approach for the development of time keeping devices in high-speed short-reach optical communication systems.

关键词： VCSEL

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VCSEL wavelength reuse for intrinsically bidirectional data traffics in next generation GPONs

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Optoelectronics Letters 2019年第5期15卷 360-362页

作者： G.M.Isoe S.Wassin T.B.Gibbon Centre for Broadband Communication Nelson Mandela University

An all-optical wavelength reuse technique employing cost effective power efficient vertical surface emitting laser(VCSEL) is proposed to address uplink data streaming from end-users by exploiting the same wavelength assigned to them. A saturated optical erbium-doped optical fiber amplifier(EDFA) is adopted to erase a directly modulated 10 Gbit/s data from an incoming downstream wavelength. We show that with EDFA saturation, the extinction ration of the incoming wavelength is reduced to less than 1 d Bm, therefore allowing for wavelength re-modulation. A receiver sensitivity of -19.65 d Bm and -17.86 d Bm is attained for downstream and upstream data signals respectively. A total of 24.7 km single mode fibre transmission is attained experimentally. This technique opens new perspectives towards development of efficient spectrum utilization for application in wavelength flexible optical networks with non-static flex-spectrum grids.

关键词： VCSEL erbium-doped optical fiber amplifier(EDFA) intrinsically bidirectional

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Real-time 850 nm multimode VCSEL to 1 550 nm single mode VCSEL data routing for optical interconnects

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Optoelectronics Letters 2019年第4期15卷 297-301页

作者： G.M.Isoe A.W.R.Leitch T.B.Gibbon Centre for Broadband Communication Nelson Mandela University

Short-reach optical interconnects among massive serves in data centers have attracted extensive research recently. Increasing capacity, cost and power efficiency as well as wavelength switching between data center network nodes are still key challenges for current optical interconnects. In this work, we experimentally demonstrate the real-time intermode optical wavelength switching technique, for high-speed wavelength flexible data center interconnects. A10 Gbit/s 1 550 nm single mode vertical cavity surface emitting laser(VCSEL) is optically injected and used to control a 10 Gbit/s multimode VCSEL carrier at 850 nm. Results show that a clearly open eye diagram is achieved at back-to-back analysis, implying a successful wavelength switch and error-free operation at 10 Gbit/s. A fully optical wavelength conversion of a multimode VCSEL operation at 850 nm using a single mode VCSEL subject to external optical injection at 1 550 nm is reported. This work opens new perspectives towards the development of a cost effective high-speed real-time inter-band wavelength switching technique between servers and network devices operating at different transmission windows at network nodes, for current and future optical interconnects.

关键词： VCSEL optical interconnects data centers

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Simultaneous 45.2 Gbit/s 4-PAM data and 8 GHz reference frequency clock signal transmission over DWDM VCSEL channels for optical interconnects

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Optoelectronics Letters 2019年第1期15卷 48-51页

作者： G.M.Isoe A.W.R.Leitch T.B.Gibbon Centre for Broadband Communication Nelson Mandela University

In this paper, we propose and experimentally demonstrate a vertical cavity surface emitting laser(VCSEL)-based simultaneous 45.2 Gbit/s(2×22.6 Gbit/s) 4-PAM data and 8 GHz(2×4 GHz) phase modulated reference frequency(RF) clock signal transmission dense wavelength division multiplexing(DWDM) system for optical interconnects. Two low-cost power-efficient 10 G VCSEL channels with central wavelengths at 1 550.71 nm and 1 551.11 nm are separately modulated with 22.6 Gbit/s 4-PAM data, therefore doubling the channel bit rate. Carrier spectral efficiency per channel is further maximized by exploiting the phase attribute in transmission of a 4 Hz RF clock signal. To further maximize the network capacity, the two VCSEL channels are densely multiplexed at 0.4 nm spacing. We therefore experimentally achieve the network data rate of 45.2 Gbit/s with 8 GHz phase modulated RF clock signal. The results show that receiver sensitivities of-11.02 dBm and-9.98 dBm are experimentally achieved for VCSEL channels of 1 550.71 nm and 1 551.11 nm respectively without the phase modulated RF clock signal. However, the introduction of a phase modulated clock signal contributes to a maximum interference penalty of 0.57 dBm and 0.41 dBm for the considered channels respectively. Simultaneous distribution of transmission data and reference clock signal over shared network structure maximizes the carrier spectral efficiency and network capacity with low cost.

关键词： VCSEL Simultaneous reference

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Multicast-enabled high-speed VCSEL technology for flexible data center networks

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Optoelectronics Letters 2018年第6期14卷 438-441页

作者： G.M.Isoe S.Wassin T.B.Gibbon Center for Broadband Communication Nelson Mandela University

We experimentally demonstrate the multiple signal modulation on a single class 10 G vertical cavity surface emitting laser(VCSEL) carrier at 1 310 nm for next generation multicast-enabled data center networks. A 10 Gbit/s data signal is directly modulated onto a single mode VCSEL carrier. To maximize carrier spectral efficiency, a 2 GHz reference frequency(RF) clock tone is simultaneously modulated on the VCSEL phase attribute. The inherent VCSEL orthogonal polarization bistability with changing bias current is further exploited in transmission of a polarization based pulse per second(PPS) timing clock signal. Therefore, we simultaneously transmit a 10 Gbit/s directly modulated data, 2 GHz phase modulated RF and a polarization-based PPS clock signals using a single mode 10 GHz bandwidth VCSEL carrier. It is the first time that a single class 10 G VCSEL carrier is reported to transmit a directly modulated data, phase modulated RF clock and polarization based PPS timing signal simultaneously in a single wavelength. A of G.652 single mode fibre(SMF) transmission over 3.21 km is experimentally attained. A receiver sensitivity of-15.60 dBm is experimentally obtained for the directly modulated 10 Gbit/s data signal. A 3.21-km-long SMF transmission introduces a penalty of 0.23 dB to the data signal. The contribution of a 2 GHz phase modulated RF and a polarization-based PPS clock signal to this penalty is found to be 0.03 dB. An RF single-side band(SSB) phase noise values of -82.36 dBc/Hz and -77.97 dBc/Hz are attained without and with simultaneous directly modulated data and polarization-based PPS clock signals respectively for a 3.21-km-long SMF transmission. This work provides an alternative efficient and cost effective technique for simultaneous high-speed multiple information transmission to different network nodes within a data center network through shared network infrastructure.

关键词： VCSEL Multicast-enabled data center networks

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VCSEL-based Raman technology for extended reach time and reference frequency transfer systems

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Optoelectronics Letters 2019年第2期15卷 139-143页

作者： G.M.Isoe E.K.Rotich T.B.Gibbon Centre for Broadband Communication Nelson Mandela University

This paper experimentally demonstrates a low-cost energy efficient alternative technique for long reach transfer of accurate reference frequency(RF) clock signals for extended reach RF distribution *** is achieved by adopting distributed forward Raman amplification and vertical cavity surface emitting laser(VCSEL) technology.A class 10 G VCSEL is directly modulated with a 2 GHz RF clock *** exploiting a forward Raman pump with the flat gain of 8.6 dB, a 100.8-km-long standard single mode fiber(SMF) RF clock distribution is experimentally achieved.A maximum phase noise of-117.66 dBc/Hz at offset frequency of 100 kHz and an RF clock jitter(RMS) of 5.36 ps is experimentally measured for 100.8-km-long fiber transmission without forward Raman ***, with the adoption of forward Raman amplification, the measured phase noise and RMS improves to-86.59 dBc/Hz and 1.7 ps, *** Raman pumping offers distributed high flat gain over a wide spectra range(over 35.5 nm), while VCSELs offer cost effective broadband signal distribution, therefore keeping the network optics investment low.

关键词： technology reference amplification

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