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Unveiling phosphofructokinase as the key target: an innovative strategy combining pull-down assays with optical imaging for snail-killing mechanism exploration

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Science China Chemistry 2025年

作者： Yuxun Lu Weisi Wang Le Yu Yuqiang Zhao Ying Chen Yunhai Guo Bingrong Luo Yuhua Liu Shizhu Li Liping Duan Ying Zhou Yunnan Characteristic Plant Extraction Laboratory College of Chemical Science and Technology Yunnan University College of Biological and Chemical Engineering Guangxi University of Science and Technology National Institute of Parasitic diseases Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research)NHC Key Laboratory of Parasite and Vector Biology WHO Collaborating Centre for Tropical Diseases National Center for International Research on Tropical Diseases School of Chemistry and Environment Yunnan Minzu University Dali Institute of Schistosomiasis control

The Pomacea canaliculata, also known as apple snail, is an invasive species in China, posing a serious threat to agricultural production and public health. To prevent its rampant infestation, we developed a highly efficient snail-killing lead compound, 1-(4-chlorophenyl)-3-(pyridin-3-yl)urea (PBQ). However, the killing mechanism of PBQ remains unclear. To elucidate this, two novel compounds, B-PBQ and J-PBQ, were developed through structural modification of PBQ and were used, through both protein pull-down assay and confocal laser scanning microscopy imaging, to identify and confirm that phosphofructokinase(PFK) in the apple snail is the primary target protein of PBQ. Further studies revealed that PBQ successfully inhibits the activity,content, and expression of PFK in apple snail, disrupting the glycolysis pathway and leading to abnormal energy *** disruptions impair the snail’s tolerance to low oxygen, resulting in its efficient eradication. These findings offer a promising direction for developing next-generation PFK-targeted snail-killing pesticides. Furthermore, the strategy of combining pull-down assays with optical imaging used in this work provides a novel approach for the exploration of mechanisms of other pesticide candidates.

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Epidemiological characteristics of seven notifable respiratory infectious diseases in the mainland of China:an analysis of national surveillance data from 2017 to 2021

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Infectious diseases of Poverty 2023年第6期12卷 96-97页

作者： Le‑le Deng Ya‑jun Han Zhuo‑wei Li Da‑yan Wang Tao Chen Xiang Ren Guang‑xue He National Institute for Viral disease control and Prevention Chinese Center for Disease Control and Prevention Beijing China division of Infectious disease Key Laboratory of Surveillance and Early-Warning On Infectious Disease Chinese Center for Disease Control and Prevention Beijing China

Background Respiratory infectious diseases(RIDs)remain a pressing public health concern,posing a signifcant threat to the well-being and lives of *** study delves into the incidence of seven primary RIDs dur‑ing the period 2017-2021,aiming to gain deeper insights into their epidemiological characteristics for the purpose of enhancing control and prevention *** Data pertaining to seven notifable RIDs,namely,seasonal infuenza,pulmonary tuberculosis(PTB),mumps,scarlet fever,pertussis,rubella and measles,in the mainland of China between 2017 and 2021 were obtained from the National Notifable disease Reporting System(NNDRS).Joinpoint regression software was utilized to analyze temporal trends,while SaTScan software with a Poisson probability model was used to assess seasonal and spatial *** A total of 11,963,886 cases of the seven RIDs were reported during 2017-2021,and yielding a fve-year aver‑age incidence rate of 170.73 per 100,000 *** these RIDs,seasonal infuenza exhibited the highest aver‑age incidence rate(94.14 per 100,000),followed by PTB(55.52 per 100,000),mumps(15.16 per 100,000),scarlet fever(4.02 per 100,000),pertussis(1.10 per 100,000),rubella(0.59 per 100,000),and measles(0.21 per 100,000).Males experi‑enced higher incidence rates across all seven *** incidence was notably elevated among farmers and individu‑als aged over 65,whereas the other RIDs primarily afected children and students under 15 years of *** inci‑dences of PTB and measles exhibited a declining trend from 2017 to 2021(APC=−7.53%,P=0.009;APC=−40.87%,P=0.02),while the other fve RIDs peaked in *** seasonal and spatial distribution,the seven RIDs displayed distinct characteristics,with variations observed for the same RIDs across diferent *** proportion of laboratory-confrmed cases fuctuated among the seven RIDs from 2017 to 2021,with measles and rubella exhibit‑ing higher proportions and mumps and scarlet fever

关键词： Respiratory infectious diseases Surveillance Epidemiological characteristics Incidence China

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A COVID-19 Outbreak Emerging in a Food Processing Company——Harbin City,Heilongjiang Province,China,January-February 2021

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China CDC weekly 2021年第32期3卷 681-687页

作者： Lei Hou Hao Zhou Nanxi Meng Xue Yu Xin Wang Tuo Wang Jianfeng Zhang Yan Wang Shie Li Shuzhen Guo Jianxing Yu Muxin Chen Wenhui Shi Ning Xiao Chao Yang Jianxiang Liu National Center for Chronic and Noncommunicable disease control and Prevention Chinese Center for Disease Control and PreventionBeijingChina Harbin Municipal Center for disease control and Prevention HarbinHelilongjiangChina National Institute for Communicable disease control and Prevention Chinese Center for Disease Control and PreventionBeijingChina National Institute for Radiological Protection Chinese Center for Disease Control and PreventionBeijingChina Heilongjiang Provincial Center for disease control and Prevention HarbinHeilongjiangChina National Institute of Parasitic diseases Chinese Center for Disease Control and Prevention/Chinese Center for Tropical Diseases Research/WHO Collaborating Centre for Tropical Diseases/National Center for International Research on Tropical DiseasesMinistry of Science and Technology/Key Laboratory of Parasitic and Vector BiologyNational Health Commission of China/The School of Global HealthChinese Center for Tropical Diseases ResearchShanghai Jiao Tong University School of MedicineShanghaiChina division of Chronic and Noncommunicable disease and Healthy Ageing Chinese Center for Disease Control and PreventionBeijingChina

Summary What is already known about this topic?The coronavirus disease 2019(COVID-19)epidemic in China had been effectively controlled for several months,but as the ambient temperature dropped,large gathering-initiate... 详细信息

关键词： gathering initiated ambient

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Assessment of Tick-Borne diseases in Hainan Province, China

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China CDC weekly 2023年第37期5卷 822-828,I0009-I0015页

作者： Weiqing Zheng Guangyuan Zhao Qianfeng Xia Key Laboratory of tropical Translational Medicine of Ministry of Education NHC Key Laboratory of Tropical Disease ControlSchool of Tropical MedicineHainan Medical UniversityHaikou CityHainan ProvinceChina

China’s six tropical regions include Guangdong Province,Yunnan Province,Hainan Province,Hong Kong Special Administrative Region(SAR),Macao SAR,and Taiwan,***,seated in the southernmost tropical region of China,is home to ticks that remain active throughout all four *** heightens their potential to transmit tick-borne diseases to both animals and *** study provides a succinct overview of the prevailing tick species’spatial distribution and offers an outline of the range and dispersion of emerging tick-borne infections in tick vectors,animal hosts,and human populations within Hainan,China.

关键词： China Hainan prevailing

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The First Detection of Echinococcus Granulosus DNA in Residents’Hands,Dogs’Hair,and Soil in Highly Endemic Region of Echinococcosis-Naqu City,Xizang Autonomous Region,China,2020

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China CDC weekly 2022年第44期4卷 982-985页

作者： Baixue Liu Chuizhao Xue Xu Wang Wenting Wu Shuai Han Weiping Wu National Institute of Parasitic diseases Chinese Center for Disease Control and Prevention(Chinese Center for Tropical Diseases Research)NHC Key Laboratory of Parasite and Vector BiologyWHO Collaborating Centre for Tropical DiseasesNational Center for International Research on Tropical DiseasesShanghaiChina Institute for Infectious disease and Endemic disease control Beijing Center for Disease Prevention and ControlBeijingChina

Summary What is already known about this topic?Echinococcosis is a serious zoonotic parasitic disease that predominantly infects humans;domestic animals like cattle or sheep;as well as wild animals such as small *** date,there is a lack of comprehensive information about all potential environmental transmission routes for *** is added by this report?This study assesses the importance of under-researched environmental factors for the transmission of *** concludes that hand hygiene is an important factor in the robust environmental transmission of Echinococcus *** are the implications for public health practice?This study suggests that residents are at risk of catching echinococcosis through hand-oral transmission *** education given to local residents is thus a key intervention,as well as avoiding close contact with dogs and ensuring proper hand-washing practices are followed.

关键词： residents Highly education

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Public Awareness and Mask Usage during the COVID-19 Epidemic:A Survey by China CDC New Media

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Biomedical and Environmental Sciences 2020年第8期33卷 639-645页

作者： SUN Cheng Xi HE Bin MU Di LI Pei Long ZHAO Hong Ting LI Zhi Li ZHANG Mu Li FENG Lu Zhao ZHENG Jian Dong CHENG Ying CUI Ying LI Zhong Jie Shandong Center for disease control and Prevention Jinan 250014ShandongChina Health Communication Center Chinese Centre for Disease Control and PreventionBeijing 102206China division of Infectious disease Key Laboratory of Surveillance and Early-warning on Infectious DiseaseChinese Centre for Disease Control and PreventionBeijing 102206China division of Epidemiology National Center for AIDS/STD Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China

An online survey conducted March 18–19,2020 on the official China CDC WeChat account platform was used to evaluate the effect of public education about masks usage during the new coronavirus disease 2019(COVID-19)*** nationals older than 18 were eligible for the *** survey collected 5,761 questionnaires from the 31 provinces,municipalities,and autonomous regions of China's Mainland.99.7%and 97.2%of the respondents answered correctly that respiratory droplets and direct contact were the main transmission routes.73.3%of the respondents considered COVID-19 to be‘serious’or‘very serious’.

关键词： mainland autonomous education

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Prevalence of antifolate drug resistance markers in Plasmodium vivax in China

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Frontiers of Medicine 2022年第1期16卷 83-92页

作者： Fang Huang Yanwen Cui He Yan Hui Liu Xiangrui Guo Guangze Wang Shuisen Zhou Zhigui Xia National Institute of Parasitic diseases Chinese Center for Disease Control and PreventionChinese Center for Tropical Diseases ResearchWHO Collaborating Center for Tropical DiseasesNational Centre for International Research on Tropical DiseasesNHC Key Laboratory of Parasite and Vector Biology(National Institute of Parasitic DiseasesChinese Center for Disease Control and Prevention)Shanghai 200025China Yunnan Institute of Parasitic diseases Puer 665000China Yingjiang County for disease control and Prevention Yingjiang 679300China Hainan Center for disease control&Prevention Haikou 570203China

The dihydrofolate reductase(dhfr)and dihydropteroate synthetase(dhps)genes of Plasmodium vivax,as antifolate resistance-associated genes were used for drug resistance surveillance.A total of 375 *** isolates collected from different geographical locations in China in 2009–2019 were used to sequence Pvdhfr and *** majority of the isolates harbored a mutant type allele for Pvdhfr(94.5%)and Pvdhps(68.2%).The most predominant point mutations were S117T/N(77.7%)in Pvdhfr and A383G(66.8%)in *** acid changes were identified at nine residues in Pvdhfr.A quadruple-mutant haplotype at 57,58,61,and 117 was the most frequent(57.4%)among 16 distinct Pvdhfr *** in Pvdhps were detected at six codons,and the double-mutant A383G/A553G was the most prevalent(39.3%).Pvdhfr exhibited a higher mutation prevalence and greater diversity than Pvdhps in *** isolates from Yunnan carried multiple mutant haplotypes,while the majority of samples from temperate regions and Hainan Island harbored the wild type or single mutant *** study indicated that the antifolate resistance levels of *** parasites were different across China and molecular markers could be used to rapidly monitor drug *** provided evidence for updating national drug policy and treatment guidelines.

关键词： drug resistance antifolates molecular markers Plasmodium vivax China

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Trends in Fruit and Vegetable Intake Among the Labor Force Population—China,2010-2018

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China CDC weekly 2024年第18期6卷 401-407,I0008页

作者： Lan Wang Mei Zhang Xiao Zhang Zhenping Zhao Chun Li Mengting Yu Taotao Xue Feng Tan Limin Wang division of Chronic disease and Risk Factor Surveillance National Center for Chronic and Non-communicable Disease Control and PreventionChinese Center for Disease Control and PreventionBeijingChina Chinese Center for disease control and Prevention BeijingChina

Introduction:This research investigates trends pertaining to the prevalence of low fruit and vegetable consumption among the labor force population in *** study considered data derived from four nationally representative cross-sectional ***:The data under review for this study was derived from the China Chronic disease and Risk Factor Surveillance(CCDRFS)carried out in 2010,2013,2015,and 2018,*** utilized a food frequency questionnaire to evaluate the quantity and frequency of fruit and vegetable *** estimated prevalence of low fruit and vegetable consumption was calculated for each survey,while considering factors such as sex,age,location,and socioeconomic status(SES).Participants’SES was ascertained via latent class analysis,serving to identify distinct classes based on criteria such as education,occupation,and household income per *** regression was deployed to determine the statistical significance of ***:From 2010 to 2018,there was a notable increase in the average daily consumption of vegetables and fruits among the working population,rising from 418.6 g/day to 491.8 g/day(P0.05 for trend).Conclusion:Over the past nine years,there has been a notable decline in the prevalence of low fruit and vegetable consumption among the labor force population in ***,the comparatively deficient intake of fruits and vegetables evident among individuals of lower SES warrants further attention.

关键词： intake occupation utilized

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One Hundred Years of Influenza Since the 1918 Pandemic—Is China Prepared Today?

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China CDC weekly 2019年第4期1卷 56-61页

作者： Ran Zhang Xiaoping Dong Dayan Wang Luzhao Feng Lei Zhou Ruiqi Ren Carolyn Greene Ying Song Alexander J.Millman Eduardo Azziz-Baumgartner Zijian Feng Influenza division United States Centers for Disease Control and Prevention Chinese Center for disease control and Prevention BeijingChina Chinese National Influenza Center National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijingChina

Almost 100 years after the 1918 influenza pandemic,China experienced its largest,most widespread epidemic of human infections with avian influenza A(H7N9),the influenza virus with the greatest pandemic potential of all influenza viruses assessed to date by the United States Centers for disease control and Prevention’s Influenza Risk Assessment *** historical review describes how China was affected by the 1918,1958,1968,and 2009 influenza pandemics,records milestones in China’s capacity to detect and respond to influenza threats,and identifies remaining challenges for pandemic *** review suggests that past influenza pandemics have improved China’s national capabilities such that China has become a global leader in influenza detection and *** enhancing China’s pandemic preparedness to address remaining challenges requires government commitment and increased investment in China’s public health and healthcare systems.

关键词： H7N9 demic remaining

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Spreading of Human Babesiosis in China:Current Epidemiological Status and Future Challenges

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China CDC weekly 2020年第33期2卷 634-637页

作者： Muxin Chen Qin Liu Jingbo Xue Shaohong Chen Dana Huang Yingfang Yu Yuchun Cai Yan Lu Peng Song Renli Zhang Lin Ai Jiaxu Chen National Institute of Parasitic diseases Chinese Center for Disease Control and Prevention/Chinese Center for Tropical Diseases Research/Key Laboratory of Parasite and Vector BiologyMinistry of Health/National Center for International Research on Tropical DiseasesMinistry of Science and Technology/WHO Collaborating Center for Tropical DiseasesShanghaiChina Shenzhen Center for disease control and Prevention ShenzhenChina National Institute of Parasitic diseases Chinese Center for Disease Control and Prevention-Shenzhen Center for Disease Control and Prevention Joint Laboratory for Imported Tropical Disease ControlShanghaiChina

Human babesiosis is an infection caused by intraerythrocytic protozoa of the genus Babesia and is a worldwide emerging tick-borne disease(1).Babesia is mainly parasitized in erythrocytes of human or other vertebrates and transmitted by the bite of ticks,blood transfusion,or organ transplantation(1).Humans are generally susceptible to Babesia,especially those who are immunocompromised with conditions such as splenectomy or splenic dysfunction,as well as those of old age,with infirmity,or with other severe diseases.

关键词： (1) Human transfusion

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