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Molecular dynamics simulation of the flow mechanism of shear-thinning fluids in a microchannel

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Chinese Physics B 2024年第4期33卷 516-525页

作者：杨刚郑庭程启昊张会臣 naval Architecture and Ocean Engineering college Dalian Maritime UniversityDalian 116026China

Shear-thinning fluids have been widely used in microfluidic systems,but their internal flow mechanism is still ***,in this paper,molecular dynamics simulations are used to study the laminar flow of shear-thinning fluid in a *** validated the feasibility of our simulation method by evaluating the mean square displacement and Reynolds number of the solution *** results show that the change rule of the fluid system's velocity profile and interaction energy can reflect the shear-thinning characteristics of the *** velocity profile resembles a top-hat shape,intensifying as the fluid's power law index *** interaction energy between the wall and the fluid decreases gradually with increasing velocity,and a high concentration of non-Newtonian fluid reaches a plateau ***,the velocity profile of the fluid is related to the molecule number density distribution and their values are inversely *** analyzing the radial distribution function,we found that the hydrogen bonds between solute and water molecules weaken with the increase in *** observation offers an explanation for the shear-thinning phenomenon of the non-Newtonian flow from a micro perspective.

关键词： molecular dynamics simulation non-Newtonian fluid microchannel shear-thinning

Online task planning method of anti-ship missile based on rolling optimization

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Journal of Systems Engineering and Electronics 2024年第3期35卷 720-731页

作者： LU Faxing DAI Qiuyang YANG Guang JIA Zhengrong college of Weaponry Engineering Naval University of EngineeringWuhan 430033China

Based on the wave attack task planning method in static complex environment and the rolling optimization framework, an online task planning method in dynamic complex environment based on rolling optimization is proposed. In the process of online task planning in dynamic complex environment,online task planning is based on event triggering including target information update event, new target addition event, target failure event, weapon failure event, etc., and the methods include defense area reanalysis, parameter space update, and mission re-planning. Simulation is conducted for different events and the result shows that the index value of the attack scenario after re-planning is better than that before re-planning and according to the probability distribution of statistical simulation method, the index value distribution after re-planning is obviously in the region of high index value, and the index value gap before and after re-planning is related to the degree of posture change.

关键词： target allocation of anti-ship missile defense area rolling optimization task re-planning

A low-frequency and broadband wave-insulating vibration isolator based on plate-shaped metastructures

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Applied Mathematics and Mechanics(English Edition) 2024年第7期45卷 1171-1188页

作者： Wei WEI Feng GUAN Xin FANG college of Intelligent Science National University of Defense TechnologyChangsha410073China naval Research Academy Beijing100161China

A metamaterial vibration isolator,termed as wave-insulating isolator,is proposed,which preserves enough load-bearing capability and offers ultra-low and broad bandgaps for greatly enhanced wave *** consists of plate-shaped metacells,whose symmetric and antisymmetric local resonant modes offer several low and broad mode bandgaps although the complete bandgap remains high and *** bandgap mechanisms,vibration isolation properties,effects of key parameters,and robustness to complex conditions are *** experimentally demonstrated,the wave-insulating isolator can improve the vibration insulation in the ranges of[50 Hz,180 Hz]and[260 Hz,400 Hz]by 15 dB and 25 dB,respectively,in contrast to the conventional isolator with the same first resonant frequency.

关键词： metamaterial and metastructure vibration isolation bandgap wave insulation plate

MetaPINNs:Predicting soliton and rogue wave of nonlinear PDEs via the improved physics-informed neural networks based on meta-learned optimization

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Chinese Physics B 2024年第2期33卷 96-107页

作者：郭亚楠曹小群宋君强冷洪泽 college of Meteorology and Oceanography National University of Defense TechnologyChangsha 410073China college of Computer National University of Defense TechnologyChangsha 410073China naval Aviation University Huludao 125001China

Efficiently solving partial differential equations(PDEs)is a long-standing challenge in mathematics and physics *** recent years,the rapid development of artificial intelligence technology has brought deep learning-based methods to the forefront of research on numerical methods for partial differential *** them,physics-informed neural networks(PINNs)are a new class of deep learning methods that show great potential in solving PDEs and predicting complex physical *** the field of nonlinear science,solitary waves and rogue waves have been important research *** this paper,we propose an improved PINN that enhances the physical constraints of the neural network model by adding gradient information *** addition,we employ meta-learning optimization to speed up the training *** apply the improved PINNs to the numerical simulation and prediction of solitary and rogue *** evaluate the accuracy of the prediction results by error *** experimental results show that the improved PINNs can make more accurate predictions in less time than that of the original PINNs.

关键词： physics-informed neural networks gradient-enhanced loss function meta-learned optimization nonlinear science

The gasdermin family:emerging therapeutic targets in diseases

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Signal Transduction and Targeted Therapy 2024年第5期9卷 1905-1937页

作者： Chenglong Zhu Sheng Xu Ruoyu Jiang Yizhi Yu Jinjun Bian Zui Zou Faculty of Anesthesiology Changhai HospitalNaval Medical UniversityShanghai 200433China School of Anesthesiology Naval Medical UniversityShanghai 200433China National Key Laboratory of Immunity&Inflammation Naval Medical UniversityShanghai 200433China d 4 Department of Biochemistry and Molecular Biology College of Basic Medical SciencesNaval Medical UniversityShanghai 200433China

The gasdermin(GSDM)family has garnered significant attention for its pivotal role in immunity and disease as a key player in *** recently characterized class of pore-forming effector proteins is pivotal in orchestrating processes such as membrane permeabilization,pyroptosis,and the follow-up inflammatory response,which are crucial self-defense mechanisms against irritants and *** have been implicated in a range of diseases including,but not limited to,sepsis,viral infections,and cancer,either through involvement in pyroptosis or independently of this *** regulation of GSDM-mediated pyroptosis is gaining recognition as a promising therapeutic strategy for the treatment of various *** strategies for inhibiting GSDMD primarily involve binding to GSDMD,blocking GSDMD cleavage or inhibiting GSDMD-N-terminal(NT)oligomerization,albeit with some off-target *** this review,we delve into the cutting-edge understanding of the interplay between GSDMs and pyroptosis,elucidate the activation mechanisms of GSDMs,explore their associations with a range of diseases,and discuss recent advancements and potential strategies for developing GSDMD inhibitors.

关键词： diseases therapeutic immunity

Study on the mechanism of near-field underwater explosion on supported thin plates with prefabricated holes

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Acta Mechanica Sinica 2024年第8期40卷 32-44页

作者： Si Chen Jian Qin Xiangyao Meng Zhichao Lai Yanbo Wen Ruiyuan Huang School of Mechatronical Engineering Beijing Institute of TechnologyBeijing100081China naval Academy Beijing100161China college of Civil Engineering Fuzhou UniversityFuzhou350116China

In this study,underwater explosion tests with 2.5 g trinitrotoluene explosive under different fixed plates with prefabricated holes were *** experimental results showed that the air inflow from the prefabricated hole caused the bubble to collapse earlier with an increase in the hole *** addition,the deformation mode of the thin plate transitioned from“convex”to“concave”(up to down).Next,the coupled Eulerian-Lagrangian method was used to perform the corresponding numerical *** accuracy of the numerical simulation method was verified through a comparison with the experimental *** addition,a series of numerical simulations were conducted with different prefabricated-hole diameters,blast distances,and prefabricated-hole *** results showed that the bubble-pulsating water jet substantially influenced the deformation of the thin plate when the diameter of the prefabricated hole was within the theoretical maximum bubble *** the blast distance was within the theoretical maximum bubble radius,the thin plate was subjected to only a single bubble pulsation owing to the air inflow from the prefabricated hole.

关键词： Underwater explosion Hole High-speed camera Bubble pulsation Fixed plate

An Innovative Coupled Common-Node Discrete Element Method-Smoothed Particle Hydrodynamics Model Developed with LS-DYNA and Its Applications

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China Ocean Engineering 2024年第3期38卷 467-482页

作者： SHEN Zhong-xiang WANG Wen-qing XU Cheng-yue LUO Jia-xin LIU Ren-wei School of naval Architecture and Ocean Engineering Jiangsu University of Science and TechnologyZhenjiang 212100China college of Harbor Coastal and Offshore EngineeringHohai UniversityNanjing 210098China

In this study,a common-node DEM-SPH coupling model based on the shared node method is proposed,and a fluid–structure coupling method using the common-node discrete element method-smoothed particle hydrodynamics(DS-SPH)method is developed using LS-DYNA *** DEM and SPH are established on the same node to create common-node DEM-SPH particles,allowing for fluid–structure *** simulations of various scenarios,including water entry of a rigid sphere,dam-break propagation over wet beds,impact on an ice plate floating on water and ice accumulation on offshore structures,are *** interaction between DS particles and SPH fluid and the crack generation mechanism and expansion characteristics of the ice plate under the interaction of structure and fluid are also *** results are compared with available data to verify the proposed coupling ***,the simulation results demonstrated that controlling the cutoff pressure of internal SPH particles could effectively control particle splashing during ice crushing failure.

关键词： common-node DEM-SPH fluid-structure interaction discrete element method smoothed particle hydrodynamics

Predicting hepatocellular carcinoma: A new non-invasive model based on shear wave elastography

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World Journal of Gastroenterology 2024年第25期30卷 3166-3178页

作者： Dong Jiang Yi Qian Yi-Jun Gu Ru Wang Hua Yu Hui Dong Dong-Yu Chen Yan Chen Hao-Zheng Jiang Bi-Bo Tan Min Peng Yi-Ran Li Department of Ultrasound Eastern Hepatobiliary Surgery HospitalThe Third Affiliated Hospital of Naval Medical UniversityShanghai 200433China Department of Pathology Shanghai Eastern Hepatobiliary Surgery HospitalThird Affiliated Hospital of Naval Medical UniversityShanghai 200433China Department of college of Art and Science Case Western Reserve UniversityClevelandOH 44106United States Ultrasound Diagnosis PLA Naval Medical CenterShanghai 200437China

BACKGROUND Integrating conventional ultrasound features with 2D shear wave elastography(2D-SWE)can potentially enhance preoperative hepatocellular carcinoma(HCC)*** To develop a 2D-SWE-based predictive model for preoperative identification of *** A retrospective analysis of 884 patients who underwent liver resection and pathology evaluation from February 2021 to August 2023 was conducted at the Oriental Hepatobiliary Surgery *** patients were divided into the modeling group(n=720)and the control group(n=164).The study included conventional ultrasound,2D-SWE,and preoperative laboratory *** logistic regression was used to identify independent predictive factors for RESULTS In the modeling group analysis,maximal elasticity(Emax)of tumors and their peripheries,platelet count,cirrhosis,and blood flow were independent risk indicators for *** factors yielded an area under the curve of 0.77(95%confidence interval:0.73-0.81)with 84%sensitivity and 61%*** model demonstrated good calibration in both the construction and validation cohorts,as shown by the calibration graph and Hosmer-Lemeshow test(P=0.683 and P=0.658,respectively).Additionally,the mean elasticity(Emean)of the tumor periphery was identified as a risk factor for microvascular invasion(MVI)in malignant liver tumors(P=0.003).Patients receiving antiviral treatment differed significantly in platelet count(P=0.002),Emax of tumors(P=0.033),Emean of tumors(P=0.042),Emax at tumor periphery(P<0.001),and Emean at tumor periphery(P=0.003).CONCLUSION 2D-SWE’s hardness value serves as a valuable marker for enhancing the preoperative diagnosis of malignant liver lesions,correlating significantly with MVI and antiviral treatment efficacy.

关键词： Shear wave elastography Predicting model Microvascular invasion Antiviral treatment Hepatocellular carcinoma

A PDGFRβ-targeting nanodrill system for pancreatic fibrosis therapy

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Chinese Chemical Letters 2024年第10期35卷 379-385页

作者： Han Han Bi-Te Chen Jia-Rong Ding Jin-Ming Si Tian-Jiao Zhou Yi Wang Lei Xing Hu-Lin Jiang State Key Laboratory of Natural Medicines Department of Pharmaceutics China Pharmaceutical University Department of Nephrology Changhai Hospital Naval Medical University college of Pharmacy Yanbian University

Activated pancreatic stellate cells(PSCs) are the main source of collagen layer deposition and the key target in pancreatic fibrosis. However, no effective treatment specific to pancreatic fibrosis clinically, owing to the drug accumulation blocked by the collagen barrier and thus it is difficult to inhibit activated PSCs precisely. Herein, a PSCs-targeting nano-system based on “nanodrill” strategy(LA-PC) was designed to enhance the accumulation of all-trans retinoic acid(ATRA) in PSCs, relying on the platelet-derived growth factor receptor beta(PDGFRβ)-targeting peptide(p PB: C*SRNLIDC*) and collagenase(Col). After being injected into fibrotic mice via tail vein, the Col modified on LA-PC can remove the excess collagen layer,and the drug delivery efficiency through pPB targeting peptide was more than 5 times higher than that of free ATRA, as well as the degree of fibrosis significantly reduced. Notably, this nano-system effectively inhibited platelet-derived growth factor subunit B(PDGF-BB)/PDGFRβ axis on PSCs via a down-regulated extracellular signal-regulated protein kinase(ERK) pathway, and accordingly reduced the level of PDGFBB. Thus, the smart platform provided a promising strategy for the treatment of pancreatic fibrosis to achieve the precise regulation of PSCs.

关键词： Liposome Pancreatic fibrosis Pancreatic stellate cells PDGFRβ pPB peptide