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science China(Life sciences) 2024年第6期67卷 1321-1324页

作者： Baoman Li Yanyan Tian Puyue Wang department of Life sciences National Natural Science Foundation of ChinaBeijing 100085China

Immunology,a biomedical discipline with an ancient history of maintaining thriving research vitality to date,refers to the study of the structure and function of the immune system of the body,the pathogenesis of immune-related diseases,immunological diagnoses,and prevention mechanisms(National natural science Foundation of China,2023).Immunological research is the foundation of research in biology,as well as basic and clinical medicine(Kubli et al.,2021).

关键词： prevention Foundation natural

Implementing and evaluating an automatic centroid moment tensor procedure for the Indonesia region and surrounding areas

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Earth and Planetary Physics 2024年第4期8卷 609-620页

作者： Madlazim Muhammad Nurul Fahmi Dyah Permata Sari Ella Meilianda Sorja Koesuma Physics department Faculty of Mathematics and Natural SciencesUniversitas Negeri SurabayaSurabaya 60231Indonesia science Education Study Program Faculty of Mathematics and Natural SciencesUniversitas Negeri Surabaya 60231SurabayaIndonesia Disaster science department Faculty of Mathematics and Natural SciencesUniversitas Syiah KualaAceh 23126Indonesia Physics department Faculty of Mathematics and Natural SciencesUniversitas Sebelas MaretSolo 57126Indonesia

The purpose of this research was to suggest an applicable procedure for computing the centroid moment tensor(CMT)automatically and in real time from earthquakes that occur in Indonesia and the surrounding *** software was used to estimate the CMT solution by selecting the velocity model that best suited the local and regional geological conditions in Indonesia and the surrounding *** data used in this study were earthquakes with magnitudes of 5.4 to ***-quality,real-time broadband seismographic data were provided by the International Federation of Digital Seismograph Networks Web Services(FDSNWS)and the European Integrated Data Archive(EIDA)Federation in Indonesia and the surrounding ***,the inversion process and filter adjustment were carried out on the seismographic data to obtain good CMT *** CMT solutions from Gisola provided good-quality solutions,in which all earthquake data had A-level quality(high quality,with good variant reduction).The Gisola CMT solution was justified with the Global CMT(GCMT)solution by using the Kagan angle value,with an average of approximately 11.2°.This result suggested that the CMT solution generated from Gisola was trustworthy and *** Gisola CMT solution was typically available within approximately 15 minutes after an earthquake *** it met the quality requirement,it was automatically published on the *** catalog of local and regional earthquake records obtained through this technology holds great promise for improving the current understanding of regional seismic activity and ongoing tectonic *** accurate and real-time CMT solution generated by implementing the Gisola algorithm consisted of moment tensors and moment magnitudes,which provided invaluable insights into earthquakes occurring in Indonesia and the surrounding areas.

关键词： centroid moment tensor Gisola International Federation of Digital Seismograph Networks Web Services(FDSNWS) real time Indonesia

EvolveKG:a general framework to learn evolving knowledge graphs

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Frontiers of Computer science 2024年第3期18卷 43-59页

作者： Jiaqi LIU Zhiwen YU Bin GUO Cheng DENG Luoyi FU Xinbing WANG Chenghu ZHOU School of Computer science Northwestern Polytechnical UniversityXi’an 710129China department of Computer science Shanghai Jiao Tong UniversityShanghai 200240China Institute of Geographical science and natural Resources Research Chinese Academy of SciencesBejjing 100864China

A great many practical applications have observed knowledge evolution,i.e.,continuous born of new knowledge,with its formation influenced by the structure of historical *** observation gives rise to evolving knowledge graphs whose structure temporally grows over ***,both the modal characterization and the algorithmic implementation of evolving knowledge graphs remain *** this end,we propose EvolveKG–a general framework that enables algorithms in the static knowledge graphs to learn the evolving *** quantifies the influence of a historical fact on a current one,called the effectiveness of the fact,and makes knowledge prediction by leveraging all the cross-time knowledge *** novelty of EvolveKG lies in Derivative Graph–a weighted snapshot of evolution at a certain ***,each weight quantifies knowledge effectiveness through a temporarily decaying function of consistency and attenuation,two proposed factors depicting whether or not the effectiveness of a fact fades away with ***,considering both knowledge creation and loss,we obtain higher prediction accuracy when the effectiveness of all the facts increases with time or remains *** four real datasets,the superiority of EvolveKG is confirmed in prediction accuracy.

关键词： knowledge graph evolution modal characterization algorithmic implementation

Tracing suspended and bed sediments during high and low water periods using geochemical characteristics-Case study:Vazrood watershed,northern Iran

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Journal of Mountain science 2024年第2期21卷 470-483页

作者： KARIMI Nabiyeh GHOLAMI Leila KAVIAN Ataollah KHALEDI DARVISHAN Abdulvahed department of Watershed Management Faculty of Natural ResourcesSari Agricultural Sciences and Natural Resources UniversitySari ***Iran department of Watershed Management Engineering Faculty of Natural ResourcesTarbiat Modares UniversityNoor ***Iran

Complete and comprehensive information about sediment dynamic and identification of hotspots of sediment production and transport are necessary for understanding the erosion processes and increasing the efficiency of soil and water conservation *** studies used the sediment fingerprint techniques to investigate the contribution of different sources in suspended and bed sediment yield of the ***,the contribution of various land use/land covers in suspended and bed sediment yield for the great Caspian Sea basin is in an aura of ambiguity and the present study was conducted to gather information about an important part of this area in northern Iran,where rangelands are located upstream of Hyrcanian forests and dense agricultural lands are located *** surface soil of different land use/land covers including forest,rangeland,agriculture and streambank lands were sampled in 30 *** and bed sediments were sampled in the watershed outlet in two high and low water *** characteristics of soil and sediment samples containing 59 elements were measured using ICP-OES GBC *** reliable and suitable tracers from 59 elements were then selected using Range test,Kruskal-Wallis and Discriminant Function Analysis,respectively,in FingerPro package of R *** results showed that for suspended sediment,streambank and rangeland had the highest contributions of 86.2%and 47.5%,respectively,in two high and low water *** bed sediment,in two high and low water periods,rangeland and streambank had the highest contributions of 73.8%and 84.4%,*** use change and especially human activities such as agriculture,road construction and development of residential areas along the main river riparian zone has led to a significant increase in suspended and bed sediments.

关键词： Caspian Sea basin FingerPro Geochemistry Sediment transport Tracer combination

Gut flora in multiple sclerosis:implications for pathogenesis and treatment

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Neural Regeneration Research 2024年第7期19卷 1480-1488页

作者： Weiwei Zhang Ying Wang Mingqin Zhu Kangding Liu Hong-Liang Zhang department of Neurology the First Hospital of Jilin UniversityJilin UniversityChangchunJilin ProvinceChina department of Life sciences National Natural Science Foundation of ChinaBeijingChina

Multiple sclerosis is an inflammatory disorder chara cterized by inflammation,demyelination,and neurodegeneration in the central nervous *** current first-line therapies can help manage symptoms and slow down disease progression,there is no cure for multiple *** gut-brain axis refers to complex communications between the gut flo ra and the immune,nervous,and endocrine systems,which bridges the functions of the gut and the *** in the gut flora,termed dys biosis,can lead to systemic inflammation,leaky gut syndrome,and increased susceptibility to *** pathogenesis of multiple sclerosis involves a combination of genetic and environmental factors,and gut flora may play a pivotal role in regulating immune responses related to multiple scle *** develop more effective therapies for multiple scle rosis,we should further uncover the disease processes involved in multiple sclerosis and gain a better understanding of the gut-brain *** review provides an overview of the role of the gut flora in multiple scle rosis.

关键词： gut flora gut-brain axis multiple sclerosis pathogenesis treatment

Facile in situ synthesis and characterization of Fe@Si/zeolite Na composites with magnetic core–shell structures from natural materials for enhanced curcumin loading capacity

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Nanotechnology and Precision Engineering 2024年第2期7卷 69-86页

作者： Munasir Nasir Nuhaa Faaizatunnisa Muhammad Naufal Ariesta Lydia Rohmawati Rifqi Aulia Nurazizah department of Physics Faculty of Mathematics and Natural ScienceUniversitas Negeri Surabaya(Unesa)Surabaya60231Indonesia department of Chemistry Faculty of Science and Data AnalyticsInstitut Teknologi Sepuluh Nopember(ITS)Surabaya 60111Indonesia department of Chemistry Faculty of Mathematics and Natural SciencesUniversitas Sebelas Maret(UNS)Surakarta57126Indonesia department of Medicine Faculty of Medical and Health ScienceUniversitas Islam Negeri(UIN)Maulana Malik IbrahimMalang65151Indonesia

Curcumin is a natural polyphenol that is used in various traditional ***,its inherent properties,such as its rapid degradation and metabolism,low bioavailability,and short half-life,are serious problems that must be *** this end,a drug carrier incorporating natural magnetic cores in a zeolite framework was developed and applied to the loading of curcumin in ethanol *** this system,curcumin is encapsulated in a zeolite Na(ZNA)magnetic core–shell structure(Fe@Si/ZNA),which can be easily synthesized using an in situ *** of Fe_(3)O_(4) nanoparticles was carried out from natural materials using a co-precipitation *** of the prepared magnetic core–shell structures and composites was carried out using vibrating-sample magnetometery,Fourier transform infrared spectroscopy,transmission electron microscopy,and x-ray *** cumulative loading of curcumin in the ZNA composite with 9%nanoparticles was found to reach 90.70%with a relatively long half-life of 32.49 *** tests of curcumin loading in the composite showed that adding magnetic particles to the zeolite framework also increased the stability of the composite *** kinetics and isotherm studies also found that the system follows the pseudo-second-order and Langmuir isotherm models.

关键词： Zeolite Na Magnetic core–shell nanoparticles(MNPs) ZNA Adsorption Curcumin

From concept to commercialization:A review of tubular solid oxide fuel cell technology

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Journal of Energy Chemistry 2024年第10期97卷 79-109页

作者： Ruyan Chen Yuan Gao Jiutao Gao Huiyu Zhang Martin Motola Muhammad Bilal Hanif Cheng-Xin Li State Key Laboratory for Mechanical Behavior of Materials School of Materials Science and Engineering Xi'an Jiaotong University department of Inorganic Chemistry Faculty of Natural Sciences Comenius University Bratislava

The reduced sealing difficulty of tubular solid oxide fuel cells(SOFCs) makes the stacking of tubular cell groups relatively easy,and the thermal stress constraints during stack operation are smaller,which helps the stack to operate stably for a long *** special design of tubular SOFC structures can completely solve the problem of high-temperature sealing,especially in the design of multiple single-cell series integrated into one tube,where each cell tube is equivalent to a small electric stack,with unique characteristics of high voltage and low current output,which can significantly reduce the ohmic polarization loss of tubular *** paper provides an overview of typical tubular SOFC structural designs both domestically and *** on the geometric structure of tubular SOFCs,they can be divided into bamboo tubes,bamboo flat tubes,single-section tubes,and single-section flat tube ***,this article provides an overview of commonly used materials and preparation methods for tubular SOFCs,including commonly used materials and preparation methods for support and functional layers,as well as a comparison of commonly used preparation methods for microtubule SOFCs,It introduced the three most important parts of building a fuel cell stack:manifold,current collector,and ceramic adhesive,and also provided a detailed introduction to the power generation systems of different tubular SOFCs,Finally,the development prospects of tubular SOFCs were discussed.

关键词： Geometric structure Preparation methods Stack Support material Tubular solid oxide fuel cell

Tocotrienol isoforms:The molecular mechanisms underlying their effects in cancer therapy and their implementation in clinical trials

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Journal of Integrative Medicine 2024年第1期22卷 1-11页

作者： Maria Younes Ghady Loubnane Christopher Sleiman Sandra Rizk department of natural sciences Lebanese American UniversityByblosLebanon

Tocotrienols are found in a variety of natural sources,like rice bran,annatto seeds and palm oil,and have been shown to have several health-promoting properties,particularly against chronic diseases such as *** incidence of cancer is rapidly increasing around the world,not only a result of continued aging and population growth,but also due to the adoption of aspects of the Western lifestyle,such as high-fat diets and low-physical *** literature provides strong evidence that tocotrienols are able to inhibit the growth of various cancers,including breast,lung,ovarian,prostate,liver,brain,colon,myeloma and pancreatic *** findings,along with the reported safety profile of tocotrienols in healthy human volunteers,encourage further research into these compounds’potential use in cancer prevention and *** current review provided detailed information about the molecular mechanisms of action of different tocotrienol isoforms in various cancer models and evaluated the potential therapeutic effects of different vitamin E analogues on important cancer hallmarks,such as cellular proliferation,apoptosis,angiogenesis and ***/PubMed and Scopus databases were used to identify recently published articles that investigated the anticancer effects of vitamin E derivatives in various types of cancer in vitro and in vivo along with clinical evidence of adjuvant chemopreventive *** an overview of pre-clinical studies,we describe several completed and ongoing clinical trials that are paving the way for the successful implementation of tocotrienols in cancer chemotherapy.

关键词： Vitamin E Tocotrienols Cancer Molecular mechanism Clinical trials

Enhancement of porcine in vitro embryonic development through luteolin‑mediated activation of the Nrf2/Keap1 signaling pathway

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Journal of Animal science and Biotechnology 2024年第2期15卷 600-613页

作者： Se-Been Jeon Pil-Soo Jeong Min Ju Kim Hyo-Gu Kang Bong-Seok Song Sun-Uk Kim Seong-Keun Cho Bo-Woong Sim Futuristic Animal Resource&Research Center(FARRC) Korea Research Institute of Bioscience and Biotechnology(KRIBB)Cheongju 28116Republic of Korea department of Animal science College of Natural Resources&Life SciencePusan National UniversityMiryang 50463Republic of Korea department of Animal science and Biotechnology College of Agriculture and Life ScienceChungnam National UniversityDaejeon 34134Republic of Korea department of Functional Genomics University of Science and TechnologyDaejeon 34113Republic of Korea department of Animal science Life and Industry Convergence Research Institute(RICRI)College of Natural Resources&Life SciencePusan National UniversityMiryang 50463Republic of Korea

Background Oxidative stress,caused by an imbalance in the production and elimination of intracellular reactive oxygen species(ROS),has been recognized for its detrimental effects on mammalian embryonic ***(Lut)has been documented for its protective effects against oxidative stress in various ***,its specific role in embryonic development remains *** study aims to investigate the influence of Lut on porcine embryonic development and to elucidate the underlying *** After undergoing parthenogenetic activation(PA)or in vitro fertilization,embryos supplemented with 0.5μmol/L Lut displayed a significant enhancement in cleavage and blastocyst formation rates,with an increase in total cell numbers and a decrease in the apoptosis rate compared to the *** on D2 and D6 revealed that embryos with Lut supplementation had lower ROS levels and higher glutathione levels compared to the ***,Lut supplementation significantly augmented mitochondrial content and membrane ***,activation of the Nrf2/Keap1 signaling pathway was observed in embryos supplemented with Lut,leading to the upregulation of antioxidant-related gene transcription *** further validate the relationship between the Nrf2/Keap1 signaling pathway and effects of Lut in porcine embryonic development,we cultured PA embryos in a medium supplemented with brusatol,with or without the inclusion of *** positive effects of Lut on developmental competence were negated by brusatol *** Our findings indicate that Lut-mediated activation of the Nrf2/Keap1 signaling pathway contributes to the enhanced production of porcine embryos with high developmental competence,and offers insight into the mechanisms regulating early embryonic development.

关键词： Luteolin Mitochondrial function Nrf2/Keap1 signaling pathway Oxidative stress Porcine embryo development

In vitro engineered models of neurodegenerative diseases

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BIOCELL 2024年第1期48卷 79-96页

作者： ZEHRA GÜL MORÇIMEN ŞEYMA TAŞDEMIR AYLIN ŞENDEMIR Bioengineering department Graduate School of Natural and Applied SciencesEge UniversityIzmir35040Türkiye Bioengineering department Faculty of Engineering and Natural ScienceCelal Bayar UniversityManisa45110Türkiye Bioengineering department Ege UniversityIzmir35040Türkiye department of Biomedical Technologies Graduate School of Natural and Applied SciencesEge UniversityIzmir35040Türkiye

Neurodegeneration is a catastrophic process that develops progressive damage leading to functional andstructural loss of the cells of the nervous system and is among the biggest unavoidable problems of our *** do not reflect the pathophysiology observed in humans due to distinct differences between the neuralpathways,gene expression patterns,neuronal plasticity,and other disease-related mechanisms in animals *** in vitro cell culture models are also not sufficient for pre-clinical drug testing in reflecting thecomplex pathophysiology of neurodegenerative ***,modern,engineered techniques are applied to developmulticellular,intricate in vitro models and to create the closest microenvironment simulating biological,biochemical,and mechanical characteristics of the in vivo degenerating *** THIS review,the capabilities and shortcomings ofscaffold-based and scaffold-free techniques,organoids,and microfluidic models that best reflect neurodegeneration invitro in the biomimetic framework are discussed.

关键词： Neurodegenerative diseases In vitro models Scaffolds Organoids Microfluidic devices