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Transfer film effects induced by 3D-printed polyether-ether-ketone with excellent tribological properties for joint prosthesis

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Bio-Design and Manufacturing 2024年第1期7卷 43-56页

作者： Yang Li Jibao Zheng Changning Sun Dichen Li State Key laboratory for Manufacturing System Engineering School of Mechanical EngineeringXi’an Jiaotong UniversityXi’an 710054China National Medical products Administration(NMPA)Key laboratory for Research and Evaluation of Additive Manufacturing Medical Devices Xi’an Jiaotong UniversityXi’an 710054China

Based on the building principle of additive manufacturing,printing orientation mainly determines the tribological properties of joint *** this study,we created a polyether-ether-ketone(PEEK)joint prosthesis using fused filament fabrication and investigated the effects of printing orientation on its tribological properties using a pin-on-plate tribometer in 25% newborn calf *** ultrahigh molecular weight polyethylene transfer film is formed on the surface of PEEK due to the mechanical capture of wear debris by the 3D-printed groove morphology,which is significantly impacted by the printing orientation of *** the printing orientation was parallel to the sliding direction of friction,the number and size of the transfer film increased due to higher steady *** transfer film protected the matrix and reduced the friction coefficient and wear rate of friction pairs by 39.13%and 74.33%,***,our findings provide a novel perspective regarding the role of printing orientation in designing knee prostheses,facilitating its practical applications.

关键词： 3D printing orientation Transfer film Tribological properties Polyether-ether-ketone Knee prosthesis

natural polysaccharide-based smart CXCR4-targeted nano-system for magnified liver fibrosis therapy

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Chinese Chemical Letters 2024年第2期35卷 341-346页

作者： Liqiong Sun Xinping Luo Chenxi Zhou Zhanwei Zhou Minjie Sun College of Horticulture Nanjing Agricultural UniversityNanjing 210095China NMPA Key laboratory for Research and Evaluation of Pharmaceutical Preparations and Excipients State Key Laboratory of Natural MedicinesDepartment of PharmaceuticsChina Pharmaceutical UniversityNanjing 210009China

Activated hepatic stellate cells(aHSCs),the main source of extracellular matrix deposition,are key targets in liver ***,no effective drug specific to aHSCs has been clinically applied due to poor drug delivery ***,we designed a CXC chemokine receptor 4(CXCR4)-targeted reactive oxygen species(ROS)-responsive platform AMD-Dex-ROS-responsive-sorafenib(ARS)based on natural polysaccharide and thioctic acid frame,which can deliver anti-fibrosis drug represented by sorafenib specifically to aHSCs on account of CXCR4 over-expression on aHSCs,and smartly disassemble via ROS-responsive thioketal rupture relying on high intracellular ROS in HSCs,realized on-demand drug release and effective liver fibrosis ***,in this platform,the CXCR4 antagonist AMD3100 not only enhanced aHSCs targeting efficiency of sorafenib but also effectively magnified the aHSCs elimination of sorafenib by blocking stroma cell derived factor-1(SDF-1)/CXCR4-induced aHSCs protection,resulting in synergistic anti-fibrosis *** platform provided a new approach for drug delivery system design and liver fibrosis treatment.

关键词： Nanoparticle CXCR4 antagonism ROS-responsive Hepatic stellate cells Liver fibrosis

Elemental Compositions of Clinopyroxenes from Southern Okinawa Trough Basalt:Implications for Magmatism and Structural Environment in an Initial Back-Arc Basin

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Journal of Ocean University of China 2024年第3期23卷 643-653页

作者： GUO Kun ZHAI Shikui FAN Di ZHANG Xia ZHANG Yu ZHU Zhimin Laoshan laboratory Qingdao 266237China Key laboratory of Submarine Geosciences and Prospecting Techniques Ministry of EducationCollege of Marine GeosciencesOcean University of ChinaQingdao 266100China Key laboratory of Submarine Geosciences&Second Institute of Oceanography Ministry of Natural ResourcesHangzhou 310012China

The major and trace elemental compositions of clinopyroxene from basalt were used to characterize the nature of the primitive magma and structural environment beneath the southern Okinawa Trough(SOT),which is an initial back-arc basin at a continental *** clinopyroxenes in the basalt were augite with variable Mg^(#)contents(73.37-78.22).The regular variations in major oxide contents(i.e.,CaO,FeO,TiO_(2),and Cr)with decreasing Mg#implied that the clinopyroxenes evolved from being enriched in Mg,Ca,and Cr to being enriched in Fe and *** clinopyroxenes had relatively low rare earth element concentrations(7.51×10^(-6) to 12.68×10^(-6))and negative Eu anomalies(δEu=0.67-0.95).The Kd_(cpx) values of clinopyroxenes(0.2-0.26),which were used to examine whether the clinopyroxene was equilibrated with its host basalt,demonstrate that these clinopyroxene phenocrysts were not captured crystals but were instead produced by crystallization differentiation of the *** calculated clinopyroxene crystallization temperatures showed a narrow range of 990-1061℃,and their crystallization pressures ranged from 2.0 to 3.2 *** geochemistry features of these clinopyroxenes indicated that the parent magma belonged to the subalkaline tholeiitic magma series and suggested that the magma experienced crystallization differentiation of olivine,plagioclase,and clinopyroxene,where the crystallization of plagioclase occurred earlier than that of *** with geophysical data,this research on primitive magma and its crystallization differentiation from clinopyroxene indicates that the SOT is in the stage of‘seafloor spreading’and that basaltic rocks produced from tholeiitic magma represent the generation of oceanic crust.

关键词： trace elements clinopyroxenes southern Okinawa Trough seafloor spreading back-arc basin

Development and Deformation Characteristics of Large Ancient Landslides in the Intensely Hazardous Xiongba-Sela Section of the Jinsha River, Eastern Tibetan Plateau, China

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Journal of Earth Science 2024年第3期35卷 980-997页

作者： Yiqiu Yan Changbao Guo Yanan Zhang Zhendong Qiu Caihong Li Xue Li Institute of Geomechanics Chinese Academy of Geological SciencesBeijing 100081China Key laboratory of Active Tectonics and Geological Safety Ministry of Natural ResourcesBeijing 100081China

The upstream Jinsha River,located in the eastern Tibetan Plateau,has been experiencing intense geological hazards characterized by a high density of ancient landslides,significant deformation and reactivation *** this study,remote sensing interpretation,field investigations,and Small Baseline Subset Interferometric Synthetic Aperture Radar(SBAS-InSAR)technologies have been *** a 17 km stretch of the Jinsha River,specifically in the Xiongba-Sela segment,16 large-scale ancient landslides were identified,9 of which are currently undergoing creeping ***,the Sela and Xiongba ancient landslides exhibit significant deformation,with a maximum deformation rate of-192 mm/yr,indicating a high level of sliding *** volume of the Sela ancient landslide is estimated to be 1.8×108 to 4.5×108 m3,and characterized by extensive fissures and long-term creeping *** SBAS-InSAR results revealed significant spatial variations in the deformation of the Sela ancient landslide,generally displaying two secondary zones of intense deformation,and landslide deformation exhibits nonlinear behavior with *** January 2016 and February 2022,Zone III1 on the southwest side of the Sela ancient landslide,experienced a maximum cumulative deformation of-857 mm,with a maximum deformation rate of-108 mm/*** III2,on the northeast side of the Sela ancient landslide,the maximum cumulative deformation was-456 mm,with a maximum deformation rate of-74 mm/yr;among these,the H2 and H4 secondary bodies on the south side of III1 are in the accelerative deformation stage and at the Warn warning *** propose that the large-scale flood and debris flow disasters triggered by the Baige landslide-dammed lake-dam broken disaster chain in Tibetan Plateau during October and November 2018 caused severe erosion at the foot of downstream *** far-field triggering effect accelerated the creep of the downstream ancient ***,the defo

关键词： Jinsha River SBAS-InSAR landslides surface deformation disasters.

Observation of Arctic surface currents using data from a surface drifting buoy

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Acta Oceanologica Sinica 2024年第1期43卷 70-79页

作者： Hongxia Chen Lina Lin Long Fan Wangxiao Yang Yinke Dou Bingrui Li Yan He Bin Kong Guangyu Zuo Na Liu First Institute of Oceanography Ministry of Natural ResourcesQingdao 266061China laboratory for Regional Oceanography and Numerical Modeling Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao 266237China Key laboratory of Marine Science and Numerical Modeling Ministry of Natural ResourcesQingdao 266061China Naval Research Academy Tianjin 300061China College of Electrical and Power Engineering Taiyuan University of TechnologyTaiyuan 030024China Polar Research Institute of China Shanghai 443005China

During the 10th Chinese Arctic scientific expedition carried out in the summer of 2019,the surface current in the high-latitude areas of the Arctic Ocean was observed using a self-developed surface drifting buoy,which was initially deployed in the Chukchi *** buoy traversed the Chukchi Sea,Chukchi Abyssal Plain,Mendeleev Ridge,Makarov Basin,and Canada Basin over a period of 632 *** returning to the Mendeleev Ridge,it continued to drift toward the ***,the track of the buoy reflected the characteristics of the transpolar drift and Chukchi Slope Current,as well as the inertial flow,cross-ridge surface flow,and even the surface disorganized flow for some time *** results showed that:(1)the transpolar drift mainly occurs in the Chukchi Abyssal Plain,Mendeleev Ridge,and western Canada Basin to the east of the ridge where sea ice concentration is high,and the average northward flow velocity in the region between 79.41°N and 86.32°N was 5.1 cm/s;(2)the average surface velocity of the Chukchi Slope Current was 13.5 cm/s,and while this current moves westward along the continental slope,it also extends northwestward across the continental slope and flows to the deep sea;and(3)when sea ice concentration was less than 50%,the inertial flow was more significant(the maximum observed inertial flow was 26 cm/s,and the radius of the inertia circle was 3.6 km).

关键词： Chinese National Arctic Research Expedition(CHINARE) surface drifting buoy transpolar drift Chukchi Slope Current inertial flow

Rapid discovery of two unprecedented meroterpenoids from Daphne altaica *** molecular networking integrated with MolNetEnhancer and Network Annotation Propagation

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Chinese Chemical Letters 2024年第8期35卷 294-298页

作者： Wei-Yu Zhou Zi-Han Xi Ning-Ning Du Li Ye Ming-Hao Jiang Jin-Le Hao Bin Lin Guo-Dong Yao Xiao-Xiao Huang Shao-Jiang Song Key laboratory of Computational Chemistry-Based natural Antitumor Drug Research&Development Liaoning ProvinceEngineering Research Center of Natural Medicine Active Molecule Research&DevelopmentLiaoning ProvinceKey Laboratory of Natural Bioactive Compounds Discovery&ModificationShenyangSchool of Traditional Chinese Materia Medic1Shenyang Pharmaceutical UniversityShenyang 110016China Key laboratory of Structure-Based Drug Design and Discovery of Ministry of Education Shenyang Pharmaceutical UniversityShenyang 110016China Wuya College of Innovation Shenyang Pharmaceutical UniversityShenyang 110016China

Under the guidance of the approach which integrates molecular networking,MolNetEnhancer and Net-work Annotation Propagation(NAP),daphnaltaicanoids A and B(1 and 2)with unprecedented 9-oxa-tetracyclo[6.***.1.0^(2,6).0^(8,13)]pentadecane and tetracyclo[5.***.0.1^(2,5).2^(4,11)]tridecane central frameworks were iso-lated from Daphne altaica Pall.,representing two types of unparalleled meroterpenoid *** struc-tures were elucidated by extensive spectroscopic analysis,nuclear magnetic resonance(NMR)calcula-tions,DP4+analysis and electronic circular dichroism(ECD)*** plausible biosynthetic path-ways for 1 and 2 were ***,2 exerted potent neuroprotective activities which were su-perior to trolox at 12.5 and 25μmol/***,1 and 2 exhibited more noticeable acetylcholinesterase inhibitory activities than *** docking simulations were performed to explore the inter-molecular interaction of compounds 1 and 2 with *** bioactivity evaluation results highlight the prospects of 1 and 2 as a novel category of neurological agents.

关键词： Daphne altaica Pall. Molecular networking MolNetEnhancer NAP Unprecedented meroterpenoid frameworks Neuroprotective activities Acetylcholinesterase inhibitors

Commentary:brain endothelial GSDMD as a novel target for brain disorders associated with BBB damage

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Chinese Journal of natural Medicines 2024年第7期22卷 580-581页

作者： LIU Kui PANG Tao State Key laboratory of natural Medicines New Drug Screening and Pharmacodynamics Evaluation CenterChina Pharmaceutical UniversityNanjing 210009China

The blood-brain barrier(BBB)is a highly selective and critical interface between the blood and the central nervous system(CNS),essential for maintaining the microenvironment necessary for normal brain function and homeostasis[1].The BBB is primarily formed by brain endothelial cells(bECs),pericytes,and astrocytes,and it operates in concert with microglia/macrophages and neurons[2,3]to constitute the neurovascular unit(Fig.1).Disruption of the BBB or the presence of systemic inflammation can precipitate or exacerbate various CNS pathologies,including Alzheimer’s disease[4],amyotrophic lateral sclerosis[5],Huntington’s disease[6]and multiple sclerosis.

关键词： Brain endothelial cells GSDMD Blood-brain barrier natural products Neuroinflammation Brain disorders

Biodegradation of Crystalline Chitin: A Review of Recent Advancement, Challenges, and Future Study Directions

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Journal of Ocean University of China 2024年第5期23卷 1319-1328页

作者： SONG Jianlin SU Haipeng SUN Jianan MAO Xiangzhao Sanya Institute of Oceanography Ocean University of China State Key laboratory of Marine Food Processing and Safety Control College of Food Science and Engineering Ocean University of China Qingdao Key laboratory of Food Biotechnology Key laboratory of Biological Processing of Aquatic products China National Light Industry laboratory for Marine Drugs and Bioproducts of Laoshan laboratory

Chitin is the second most abundant renewable polysaccharide on Earth. The degradation of chitin into soluble and bioactive N-acetyl chitooligosaccharides(NCOSs) and N-acetyl-D-glucosamine(GlcNAc) has emerged as a pivotal step in the efficient and sustainable utilization of chitin resources. However, because of its dense structure, high crystallinity, and poor solubility, chitin typically needs pretreatment via chemical, physical, and other methods before enzymatic conversion to enhance the accessibility between substrates and enzyme molecules. Consequently, there has been considerable interest in exploring the direct biological degradation of crystalline chitin as a cost-effective and environment-friendly technology. This review endeavors to present several biological methods for the direct degradation of chitin. We primarily focused on the importance of chitinase containing chitin-binding domain(CBD). Additionally, various modification strategies for increasing the degradation efficiency of crystalline chitin were introduced. Subsequently, the review systematically elucidated critical components of multi-enzyme catalytic systems, highlighting their potential for chitin degradation. Furthermore, the application of microorganisms in the degradation of crystalline chitin was also discussed. The insights in this review contribute to the explorations and investigations of enzymatic and microbial approaches for the direct degradation of crystalline chitin, thereby fostering advancements in biomass conversion.

关键词： biological degradation chitinase crystalline chitin engineering microorganisms

Organic Synthesis through Radical Innovation:Frustrated Radical Pairs

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Chinese Journal of Chemistry 2024年第10期42卷 1157-1160页

作者： Zhibin Hu Zengrui Cheng Ning Jiao State Key laboratory of natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijing 100191China Shanghai Key laboratory of Green Chemistry and Chemical Processes East China Normal UniversityShanghai 200062China

Frustrated Lewis Pairs(FLPs)represent a unique class of interactions in Lewis acid-base chemistry,driven by spatial hindrance or incongruent orbital energy levels that hinder the formation of effective coordination *** have received significant attention for their application in activating small molecules and facilitating organic synthesis *** developments have led to the emergence of Frustrated Radical Pairs(FRPs)as an extension of the radical *** are formed from FLPs through Single Electron Transfer(SET)and exhibit the ability to activate a variety of chemical *** research on FLPs is well-established,investigations into FRPs in organic reactions remain *** review highlights the current state of FRPs in organic synthesis,delves into mechanistic insights,explores their potential,and underscores the challenges in this emerging field.

关键词： Radicals Frustrated Lewis Pairs Frustrated Radical Pairs Methodology and reactions Reaction mechanisms