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自然视觉状态下的调节迟滞:近视眼和正视眼儿童的对照研究

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世界核心医学期刊文摘（眼科学分册） 2005年第10期1卷 50-50页

作者： Nakatsuka C. Hasebe S. Nonaka F. Ohtsuki H. 潘佳鸿 Department of Ophthalm ology Okayama University Medical School 2-5-1 Shikata-cho Okayama 700-855 8 Japan

Purpose: To determine whether or not myopic children have a larger lag of acco mmodation than emmetropic children under natural seeing conditions. Methods: In 61 myopic children (age, 9.5±1.3 years; spherical equivalent refractive error, -6.50 to-1.00D), accommodative response was objectively measured while they we re binocularly viewing a target at 50.5, 32.5, 20.9, or 16.0 cm (1.98-6.25 D) t hrough fully correcting glasses. In the 33 children who habitually wore spectacl es, the accommodative responses were also measured while they wore their own spe ctacles. As controls, 18 emmetropic children were recruited. Accommodative respo nse gradients and lags were compared between the groups after calibration for re sidual refractive errors and the vertex distance of the glasses. Results: With f ully correcting glasses, the myopic children showed a larger mean lag of accommo dation than the emmetropic children, as well as wide intersubject variation. How ever, when the children wore their habitual, usually undercorrecting, spectacles , accommodative lags markedly decreased, and a significant correlation was found between residual refractive errors after correcting for the spectacles and acco mmodative lags. Myopic children with near-point exophoria tended to show smalle r lags of accommodation. Conclusion: Under binocular viewing conditions, myopic children when viewing the target through fully correcting glasses tend to show l arger lags of accommodation than emmetropic children, but the lags of accommodat ion are usually reduced by their spectacle undercorrection.

关键词：正视眼调节反应屈光不正观察目标外隐斜顶距

原发性皮肤印戒细胞癌表达细胞角蛋白20的免疫反应性

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世界核心医学期刊文摘（皮肤病学分册） 2006年第5期2卷 7-7页

作者： Kiyohara T. Kumakiri M. Kouraba S. 党倩丽 Department of Dermatology University of Fukui 23-3 ShimoaizukiMatsuoka-choYoshida-gun Fukui 910-1193 Japan Dr.

Primary cutaneous signet ring cell carcinoma (PCSRCC) is a very unusual but distinctive clinicopathologic entity that can simulate metastatic adenocarcinomas. It is defined as a diffuse malignant epithelial neoplasia localized in the dermis and subcutis without epidermal involvement, showing variable amounts of signet ring cells, without evidence of visceral adenocarcinoma. We present 2 cases of PCSRCC, which involved eyelids and axilla respectively. Despite thorough systemic workup, primary sources could not be demonstrated in either case. The tumor cells are positive for gross cystic disease fluid protein 15 in addition to a variety of glandular markers. Furthermore, both cases were immunostained with cytokeratin 20 (CK20). In conclusion, we report 2 cases of PCSRCC expressing CK20 immunoreactivity. CK20-positive primary cutaneous tumors should include PCSRCC in addition to Merkel cell carcinoma.

关键词：印戒细胞癌免疫反应性细胞角蛋白转移性腺癌恶性上皮瘤不等量临床病理学免疫组化染色阳性反

副肿瘤性天疱疮合并小结树突细胞肉瘤的桥粒核心糖蛋白1和3抗体效价

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世界核心医学期刊文摘（皮肤病学分册） 2005年第4期1卷 61-61页

作者： SeishimaM. OdaM. Oyama Z. 田中伟 Department of Dermatology Ogaki Municipal Hospital Minaminokawa-cho4-86Ogaki503-8502Japan Dr.

Background: Most paraneoplastic pemphigus (PNP) cases reported to date have been associated with lymphoproliferative neoplasms. Patients with PNP have autoantibodies against the plakin family (eg, envoplakin and periplakin). Antibodies against desmoglein 3 (Dsg3) and Dsg1, antigens for classic types of pemphigus, have also been reported to play an important role in the initial stage of PNP. Observations: We describe a patient with PNP associated with follicular dendritic cell sarcoma. Antibodies to envoplakin and periplakin were detected. When only mucosal lesions were observed at the early stage, the antibody to Dsg3 but not to Dsg1 was detected by enzyme-linked immunosorbent assay. After skin lesions appeared, antibodies to Dsg1 and Dsg3 were dete cted. These titers were elevated, with exacerbation of skin lesions. Although the patient received corticosteroid therapy, double-filtration plasmapheresis, and intravenous human immunoglobulin therapy after surgical resection of follicular dendritic cell sarcoma, she died of fungal infective lung embolisms. A direct immunofluorescence study of autopsy samples showed IgG deposition intheepidermisoftheskinandoralmucosalmembrane,butnot in the lungs and kidneys and follicular dendritic cell sarcoma of the para-aortic area. Conclusion: In this patient with PNP and follicular dendritic cell sarcoma, there was an association between the clinical phenotype and the anti-Dsg antibody profile, as seen in pemphigus vulgaris.

关键词：肿瘤性小结树突细胞桥粒酶联免疫吸附法免疫荧光检查黏膜损害 IgG 皮质类固醇增殖性血浆分离

日本人群中白细胞介素-1β-511C/T的多态性与反流性食管炎的关系

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世界核心医学期刊文摘（胃肠病学分册） 2006年第3期2卷 53-53页

作者： Muramatsu A. Azuma T. Okuda T. 程妍 Second Department of Internal Medicine Faculty of Medical Sciences University of Fukui Matsuoka-cho Yoshida-gun Fukui 910-1193 Japan

Background: Interleukin-1β(IL-1β) gene polymorphisms are related to hypochlorhydria and increase the risk of gastric cancer in the presence of Helicobacter pylori infection. However, little information is available about the genetic risk factors of reflux esophagitis. In this study we investigated its association with the IL-1β.polymorphisms. Methods: We examined 48 patients with reflux esophagitis and 96 control subjects, 89 with gastric cancer. IL-1β-511C/T genotyping was performed by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Results: The frequency of IL-1β-51 1T alleles was significantly higher in reflux esophagitis patients (57.3%) than in controls (41.1%) (P = 0.0215, χ2 = 5.289). The frequency of IL-1β-511T/T genotypes was also significantly higher in reflux esophagitis patients (31.3%) than in controls (15.6%). The odds ratio and the 95%confidence interval were 4.000 and 1.393-11.486, respectively. The frequency of IL-1β-511T/T genotypes was significantly higher in reflux esophagitis patients (31.3%) than in gastric cancer patients (21.4%). The odds ratio and the 95%confidence interval were 2.961 and 1.054-8.316, respectively. Conclusions: IL-1β-511T was associated with reflux esophagitis having hyperacidity. Differences of genetic background regarding gastric acid secretion may exist between Japanese and Caucasians.

关键词：反流性食管炎日本人群白细胞介素多态性遗传危险因素高加索人遗传背景胃酸过多聚合酶链反应

胰腺癌的对比增强超声检查:与病理检查结果的关系

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世界核心医学期刊文摘（胃肠病学分册） 2005年第11期1卷 57-57页

作者： Numata K. Ozawa Y. Kobayashi N. 李宏宇 Gastroenterological Center Yokohama City University Medical Center 4- 57 Urafune-cho Minami-ku Yokohama 232- 0024 Japan

Background: We examined contrast-enhanced harmonic grayscale sonographic findings of pancreatic carcinoma in relation to the pathological findings in resected specimens to evaluate correlations between observations made by this modality and the pathological findings. Methods: The pathological findings of surgical specimens obtained from 16 patients were examined in relation to the contrast-enhanced harmonic gray-scale sonography findings. Lesion vascularity was examined by contrast- enhanced harmonic gray-scale sonography from 20 to 50s after the injection of Levovist (Schering, Berlin, Germany)- (early phase), and lesion enhancement was also monitored at approximately 90s after injection (delayed phase). Results: Contrast-enhanced harmonic gray-scale sonography showed positive enhancement in 12 of the 16 lesions (peripheral tumor region alone, n = 9; entire tumor, n = 3), while the other 4 lesions showed no contrast enhancement in any region. Twelve enhanced regions (9 peripheral tumor region and 3 entire tumor regions) detected by contrast-enhanced harmonic gray-scale sonography showed: (1) mild fibrosis with inflammation, in 10 regions (83% ); (2) the presence of both carcinoma cells and residual acinar cells in 8 (67% ); and (3) presence of relatively large arteries in 2 (17% ). In contrast, 13 non-enhanced regions (4 entire tumor regions and 9 central regions) showed: (1) severe fibrosis in 10 regions (77% ); (2) necrosis in 7 (54% ); and (3)- mucin in 4 (31% ). Conclusions: Contrast-enhanced harmonic gray-scale sonographic findings of pancreatic carcinoma are influenced by interstitial histological features associated with tumor growth.

关键词：病理检查超声检查超声图延迟相黏液素间质组织超声监测血管损伤心区

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“负性”运动区广泛分布在皮质外周的证据

世界核心医学期刊文摘(神经病学分册) 2006年第4期 42-42页

作者： Mikuni N. Ohara S. Ikeda A. 高中宝 Department of Neurosurgery Kyoto University Graduate School of Medicine 54 kawahara-cho Shogoin Sakyo-ku Kyoto 606- 8507 Japan

Objective: The perirolandic regions were studied by extensive electrical stimulation to clarify the topography and somatotopic distribution of negative motor areas (NMAs) and examine the clinical significance of these areas. Methods: We evaluated the cortical function elicited by electrical stimulation in 30 patients with tumors or intractable epilepsy. The somatotopic distribution of NMAs was examined by localizing these regions using Talairach’s bicommissural reference system. NMAs within the lesions of two patients were removed under local anesthesia. Results: We obtained negative motor responses following the stimulation of 30 electrodes in 15 patients. On the lateral brain surface, the majority of NMAs for the upper extremities were distributed broadly throughout the premotor cortex, while NMAs for the tongue were only found in the inferior frontal gyrus of the dominant hemisphere. During removal of the NMAs within the lesions of two patients, we documented transient hand clumsiness in one patient. Conclusions: NMAs were widely distributed throughout the perirolandic area, as well as the previously reported regions in the inferior frontal gyrus. These areas likely function in the control of skilled movements; dysfunction of such movements transiently follows resection of these regions, but is subsequently well compensated for after surgery. Significance: The localization and consequences of resection of NMAs suggests their clinical significance in motor control.

关键词：运动区外周皮质负性

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veterana诺卡菌所致足菌病治愈1例

世界核心医学期刊文摘（皮肤病学分册） 2005年第12期1卷 38-38页

作者： Kashima M. Kano R. Mikami Y. 罗素菊 Department of Dermatology Toyoko Hospital St. Marianna University 3- 435 Kosugi- cho Kawasaki Kanagawa 211- 0063 Japan

We report a successfully treated case of mycetoma from which an unusual Nocardia species was isolated. The isolate was identified as N. veterona by biochemical characterization and 16S ribosomal RNA gene sequencing, and it has not been previously reported as a causative agent of human mycetomas. Treatment with various antibiotics over 6 years and surgical resection failed to cure the disease. However, the combination of intravenous imipenem/cilastatin and amikacin along with oral clarithromycin and minocycline proved very effective in this case. This is the first case report of mycetoma due to N. veterana in a clinical setting.

关键词：诺卡菌 veterana 分离菌克拉红霉素米诺环素基因测序丁胺卡那霉素化学特征

评估STIR自旋回波成像、扩散加权成像及氟代脱氧葡萄糖PET/CT胸部成像在诊断非小细胞肺癌N分期中定量及定性的效能

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国际医学放射学杂志 2012年第1期 78-78页

作者： Y.Ohno H.Koyama T.Yoshikawa M.Nishio N.Aoyama Y.Onishi 刘靖 Department of Radiology Kobe University Graduate School of Medicine7-5-2 Kusunoki-choChuo-kuKobe 6500017Japan

目的前瞻性比较短反转时间及反转恢复(inversion-recovery,STIR)自旋回波(spin-echo,SE)成像、扩散加权(diffusion-weighted,DW)成像和氟代脱氧葡萄糖(fluorodeoxyglucose,FDG)PET/CT在评估非小细胞肺癌

关键词：脱氧葡萄糖 FDG STIR PET/CT NSCLC 氟代 CT

应用甲硝唑治疗日本人群中耐克拉霉素幽门螺杆菌感染的效果

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世界核心医学期刊文摘（胃肠病学分册） 2005年第5期1卷 43-43页

作者： Shimoyama T. Fukuda S. Mikami T. 赵天智 First Dept. of Internal Medicine Hirosaki Univ. School of Medicine 5 Zaifu-cho Hirosaki 036-8562 Japan

Background: Eradication of Helicobacter pylori has become a common treatment for several diseases. There is an increase in antibiotic-resistant strains, which causes the failure of eradication. The aim of this study was to investigate the usefulness of metronidazole for the treatment of H. pylori infection in patients who failed eradication therapy. Methods: Seventy H. pylori positive patients who had failed eradication treatment with first-line triple therapy, which consisted of a proton pump inhibitor, amoxicillin, and clarithromycin, were enrolled into the study. Before the second-line therapy, patients underwent endoscopy to obtain H. pylori strains to test susceptibility to antibiotics. Lansoprazole (30mg b.d.), amoxicillin (750mg b.d.), and metronidazole (250mg b.d.) were administered for 1 week, and the result was tested by 13C-UBT. Results: H. pylori was isolated from 62 patients, and 52 of them (83.9%) were clarithromycin resistant. There was no amoxicillin-or metronidazole-resistant strain. No major adverse effects were seen, and all the patients completed the 1-week regimen. The eradication rates of lansoprazole-amoxicillin-metronidazole were 96.2%(51/53; 95%CI, 87.0%-99.5%) using both intention-to-treat analysis and per protocol analysis. Conclusions: Lansoprazole-amoxicillin-metronidazole triple therapy is an effective and promising second-line H. pylori eradication therapy in a north Japanese population, which has a low frequency of metronidazole resistance.

关键词：幽门螺杆菌阳性日本人群兰索拉唑三联用药抗生素耐药菌根除率二线用药呼吸试验试验结果菌根