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Determination of Neurotoxin β-ODAP and Non-protein Amino Acids in Lathyrus Sativus by High-Performance Liquid Chromatography with Precolumn Derivatization with 6-Amino quinolyl-N-hydroxysuccinimidyl Carbamate (AQC)

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Chinese chem.cal Letters 2000年第7期11卷 605-608页

作者： Fei WANG Xiong CHEN Qian CHEN Xing Chen QIN Zhi Xiao LI(National lab.ratory of appl.ed organ.c chem.stry, Lanzhou University, Lanzhou 730000State Key lab.ratory of Arid Agroecology, Lanzhou University, Lanzhou 730000) natl. lab. of appl. organ. chem.stry Lanzhou University Lanzhou 730000 China State Key lab. of Arid Agroecology Lanzhou University Lanzhou 730000 China

A new method was developed for the quantitative determination of the neurotoxic nonprotein amino acid, 3-N-oxalyl-L-2,3-diaminopropioni acid (β-ODAP), its nontoxic α-isomer and other non-protein amino acids in the plant samples of Lathyrus sativus after derivatization with 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate (AQC) by reversed-phase high-performance liquid chromatography (HPLC). 2-Amino butyric acid (ABA) was used as an internal *** RP HPLC detection limit for both isomers is 1.8 ng with good response linearity. The results are compared with a colorimetric method.

关键词： RP HPLC Lathyrus sativus 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate

A Facile Synthesis of 3-Oxo-7αH-eudesma-4-ene-9β, 12-diol

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Chinese chem.cal Letters 1998年第7期9卷 625-627页

作者： Li Jun LIU Yong Gang CHEN Zhao Ming XIONG Jiang LI Gang ZHOUand Yu Lin Li(National lab.ratory of appl.ed organ.c chem.stry and Institute of organ.c chem.stry, Lanzhou University, Lanzhou 730000)(Ningxia Medical College, Yinchuan 750001) natl. lab. of appl. organ. chem.stry Institute of Organic Chemistry Lanzhou University Lanzhou 730000 China Ningxia Medical College Yinchuan 750001 China

A facile ndxture of the C-11 isomeric 3 - oxo-7αH-eudes ma-4-en- 9β, 1 2-diol has been achieved ffom oxycarvone. The C-11 configuration of natural product is established through comparison of IHNMR spectra between ... 详细信息

关键词： Synthesis Sesquiterpenoid 3-oxo-7αH-eudesma-4-en-9β 12-diol oxycarvone

Bioisostere of Sulfonyl Moiety-The Synthesis of New ALS Inhibitors N-(Asymmetry Disubstituted Phosphoryl)-N'-(4,6-dimethoxypyrimidin-2-yl) Ureas

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Chinese chem.cal Letters 1998年第5期9卷 455-458页

作者： Guo Feng ZHAO Hua Zheng YANG Yong Hong LI(Institute of Elemento-organ.c chem.stry, National Key lab.ratory of Elemento-organ.cchem.stry, Nankai University, Tianjin 300071) Inst. of Elemento-organ.c chem.stry Natl. Key Lab. Elemento-Organ. Chem. Nankai University Tianjin 300071 China

In view of the isosterism of the sulfonyl (-SO2-) and phosphoryl groups [-P(O)(OR)-,R=H, CH3, C2H5, etc], two new types of ureas, N-(N-aryl-O-alkyl phosphoryl)-N'-(4, 6-dimethoxypyrinddin-2-yl) ureas 2 and N-(N-aryl-N-alkyl phosphoryl)-N'-(4, 6-dimethoxy pyrimidin-2-yl)ureas 3, were synthesized by treating N- (arylandnochlorophosphoryl ) - N'- (4, 6-dimethoxypyriAndinyl-2-) ureas 4 with alcohols or amines. Compounds 4 were obtained by reactingdichlorophosphoryl isocyanate with 4,6 - di meth oxy- 2-aminopyrimidine, and then with aromaticamines. The enzyme tests (in vitro) indicated that compounds 2 and 3 were two novel classes ofacetolactate synthase (ALS) inhibitors, which showed that the phosphoryl group, [-P(O)(OR)-], or[-P(O)(NHR)-], was a good bioisostere of the sulfonyl group (-SO2-) in sulfonylurea.

关键词： isosterism bioisostere sulfonyl phosphoryl,sulfonylurea ALS inhibitor

Cyclization Reaction of α-Triazolyl-α, β-unsaturated Ketones with Phenyl hydrazine

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Chinese chem.cal Letters 1998年第11期9卷 979-982页

作者： Guo Feng ZHAO Jun REN Yu Chang LI Gui Yu JIN (Institute of Elemento-organ.c chem.stry, National Key lab.ratory of Elemento-organ.c chem.stry, Nankai University, Tianjin 300071) Inst. of Elemento-organ.c chem.stry Natl. Key Lab. Elemento-Organ. Chem. Nankai University Tianjin 300071 China

The reaction of α-triazolyl-α, β-unsaturated ketones with phenyl hydrazine was studied. The result indicated that cyclization took place and new heterocyclic compounds of substituted 4,5-2H-pyrazoles were obtained,... 详细信息

关键词： α β-unsaturated ketones phenyl hydrazine triazole cyclization pyrazoles

Bioisosterism between Sulfonyl Group and Phosphoryl Group-The Synthesis of New ALS Inhibitors N-(Arylamino Hydroxyl Phosphoryl)-N'-(4,6-Dimethoxypyrimidine-2-yl)ureas

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Chinese chem.cal Letters 1998年第8期9卷 723-724,275页

作者： Guo Feng ZHAO Hua Zheng YANG Lin Xiu WANG Yong Hong LI(Institute of Elemento-organ.c chem.stry, National Key lab.ratory of Elemento-organ.c chem.stry, Nankai University, Tianin 300071) Inst. of Elemento-organ.c chem.stry Natl. Key Lab. Elemento-Organ. Chem. Nankai University Tianjin 300071 China

In view of the isosterism of sulfonyl group (-SO2-) and phosphoryl group [-P(O)(OR)-,R=H, CH3, C2H5, etc], a new type of ureas, that is, N-phosphoryl-N'-(4,6-dimethoxypyrimidin-2yl) ureas 2 were synthesized and shown ... 详细信息

关键词： isosterism bioisosterism sulfonylurea phosphorylurea ALS inhibitors

Studies on the Reaction of Vinyl Triazole Derivatives with Hydroxylamine

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Chinese chem.cal Letters 1997年第6期8卷 467-470页

作者： Gui Yu JIN Guo Feng ZHAO Zhong Fa LIU Jin REN Yu Chang LI (Institute of Elemento-organ.c chem.stry, National Key lab.ratory of Elemento-organ.c chem.stry.Nankai University, Tianjin 30007) Inst. of Elemento-organ.c chem.stry Natl. Key Lab. Elemento-Organ. Chem. Nankai University Tianjin 300071 China

In this paper the reaction of vinyl triazole derivatives with hydroxylamine hydrochloride under the action of sodium carbonate was studied. The result indicated that cyclization took place and new heterocyclic compoun... 详细信息

关键词： ppm OH NH Studies on the Reaction of Vinyl Triazole Derivatives with Hydroxylamine Ph IR

A Rapid and Convenient Procedure for the Permethylation of Polysaccharides

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Chinese chem.cal Letters 1998年第4期9卷 339-340页

作者： Cheng Gang HUANG Chen LI Zhi Xiao LI Yao Zu CHEN(Department of chem.stry, Zhejiang University, Hangzhou 310027 State Key lab.ratory of appl.ed organ.c chem.stry, Lanzhou University, Lanzhou 730000) Department of chem.stry Zhejiang University Hangzhou 310027 China State Key lab. of appl. organ. chem. Lanzhou University Lanzhou 730000 China

Butyllithium was directly added to the solution of polysaccharides in dimethyl sulfoxide. The methylsulfinyl carbanion, as a sugar alkoxide forming reagent, was generated from the solution. All the operations were performed as one-pot reactions. Five polysaccharides from different traditional Chinese medicines and three dextrans were methylated and satisfactory results have been achieved.

关键词： methylation polysaccharides butyllithium

A　Study　on　the　Regioselectivity　of　the　Cyclization　Reaction　of　5－Amino－1，　2，　4－triazole　with　Asym－l，　3－dicarbonyl　Compound

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Chinese chem.cal Letters 1996年第12期7卷 1067-1068页

作者： Rong Jian LU Gao Feng ZHAO Hua Zheng YANG(Institute of Elemento-organ.c chem.sed, Nahonal lab.ratory ofElemento-organ.c chem.stry, Nankai University, 94 Weijin Road, Tianjin 300071) Inst. of Elemento-organ.c chem.stry Natl. Lab. of Elemento-Organ. Chem. Nankai University 94 Weijin Road Tianjin 300071

This paper reports the primary results of the study. on the regioselectivity of the cyclization reaction of 5-amino-1, 2, 4-triazole and its analogues until asym-1, 3-dicarbonyl compounds. The mechanistic explanation ... 详细信息

关键词： Regioselectivity Asym triazole Reaction

The Synthesis of Podophyllotoxin Derivatives with Macrocyclic Dilactone

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Chinese chem.cal Letters 1999年第4期10卷 275-276页

作者： Min YANG Ning CHEN Xin Fu PAN Bing Chang QIN(Department of chem.stry. National lab.ratory of appl.ed organ.c chem.stry,Lanzhou University, Lanzhou, 730000)(Department of chem.stry, Anyang Teachers College. Anyang 455002) Department of chem.stry Natl. Lab. of Appl. Organ. Chemistry Lanzhou University Lanzhou 730000 China Department of chem.stry Anyang Teachers College Anyang 455002 China

Starting from podophyllotoxin, five new derivatives with macrocyclic dilactone 5 similar to 9 have been synthesized,and their structures were confirmed by IR, MS,H-1 NMR as well as HRMS. The key step is cyclization by... 详细信息

关键词： podophyllotoxin derivatives macrocyclic dilactone synthesis