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The interaction between KIF21A and KANK1 regulates dendritic morphology and synapse plasticity in neurons

Neural Regeneration Research 2025年第1期20卷 209-223页

作者： Shi-Yan Sun Lingyun Nie Jing Zhang Xue Fang Hongmei Luo Chuanhai Fu Zhiyi Wei Ai-Hui Tang Hefei national Research center for Physical Sciences at the Microscale CAS Key Laboratory of Brain Function and DiseaseMinistry of Education Key Laboratory for Membrane-less Organelles and Cellular DynamicsDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefeiAnhui ProvinceChina CAS center for Excellence in Molecular Cell Sciences Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Neurobiology School of Life SciencesSouthern University of Science and TechnologyShenzhenGuangdong ProvinceChina Brain Research center Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina

Morphological alterations in dendritic spines have been linked to changes in functional communication between neurons that affect learning and ***-4 KIF21A helps organize the microtubule-actin network at the cell cortex by interacting with KANK1;however,whether KIF21A modulates dendritic structure and function in neurons remains *** this study,we found that KIF21A was distributed in a subset of dendritic spines,and that these KIF21A-positive spines were larger and more structurally plastic than KIF21A-negative ***,the interaction between KIF21A and KANK1 was found to be critical for dendritic spine morphogenesis and synaptic *** of either KIF21A or KANK1 inhibited dendritic spine morphogenesis and dendritic branching,and these deficits were fully rescued by coexpressing full-length KIF21A or KANK1,but not by proteins with mutations disrupting direct binding between KIF21A and KANK1 or binding between KANK1 and *** down KIF21A in the hippocampus of rats inhibited the amplitudes of long-term potentiation induced by high-frequency stimulation and negatively impacted the animals’cognitive *** together,our findings demonstrate the function of KIF21A in modulating spine morphology and provide insight into its role in synaptic function.

关键词： actin cytoskeleton dendrite KANK1 KIF21A microtubule spine morphology spine synaptic plasticity talin1

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Bidirectional regulation of the brain-gut-microbiota axis following traumatic brain injury

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Neural Regeneration Research 2025年第8期20卷 2153-2168页

作者： Xinyu You Lin Niu Jiafeng Fu Shining Ge Jiangwei Shi Yanjun Zhang Pengwei Zhuang national Key Laboratory of Chinese Medicine Modernization Tianjin University of Traditional Chinese MedicineTianjinChina Haihe Laboratory of Modern Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjinChina First Teaching Hospital of Tianjin University of Traditional Chinese Medicine TianjinChina national Clinical Research center for Chinese Medicine Acupuncture and Moxibustion TianjinChina

Traumatic brain injury is a prevalent disorder of the central nervous *** addition to primary brain parenchymal damage,the enduring biological consequences of traumatic brain injury pose long-term risks for patients with traumatic brain injury;however,the underlying pathogenesis remains unclear,and effective intervention methods are *** dysfunction is a significant consequence of traumatic brain *** the most densely innervated peripheral tissue in the body,the gut possesses multiple pathways for the establishment of a bidirectional“brain-gut axis”with the central nervous *** gut harbors a vast microbial community,and alterations of the gut niche contribute to the progression of traumatic brain injury and its unfavorable prognosis through neuronal,hormonal,and immune pathways.A comprehensive understanding of microbiota-mediated peripheral neuroimmunomodulation mechanisms is needed to enhance treatment strategies for traumatic brain injury and its associated *** comprehensively reviewed alterations in the gut microecological environment following traumatic brain injury,with a specific focus on the complex biological processes of peripheral nerves,immunity,and microbes triggered by traumatic brain injury,encompassing autonomic dysfunction,neuroendocrine disturbances,peripheral immunosuppression,increased intestinal barrier permeability,compromised responses of sensory nerves to microorganisms,and potential effector nuclei in the central nervous system influenced by gut ***,we reviewed the mechanisms underlying secondary biological injury and the dynamic pathological responses that occur following injury to enhance our current understanding of how peripheral pathways impact the outcome of patients with traumatic brain *** review aimed to propose a conceptual model for future risk assessment of central nervous system-related diseases while elucidating novel insights into the bidirectional effec

关键词： traumatic brain injury brain-gut-microbiome axis gut microbiota neuroimmune immunosuppression host defense vagal afferents bacterial infection dorsal root ganglia nociception neural circuitry

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Forecast daily indices of solar activity, F10.7, using support vector regression method

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Research in Astronomy and Astrophysics 2009年第6期9卷 694-702页

作者： Cong Huang Dan-Dan Liu Jing-Song Wang national center For Space weather CMA Beijing 100081 China

The 10.7 cm solar radio flux （F10.7）, the value of the solar radio emission flux density at a wavelength of 10.7 cm, is a useful index of solar activity as a proxy for solar extreme ultraviolet radiation. It is meaningful and important to predict F10.7 values accurately for both long-term （months-years） and short-term （days） forecasting, which are often used as inputs in space weather models. This study applies a novel neural network technique, support vector regression （SVR）, to forecasting daily values of F10.7. The aim of this study is to examine the feasibility of SVR in short-term F10.7 forecasting. The approach, based on SVR, reduces the dimension of feature space in the training process by using a kernel-based learning algorithm. Thus, the complexity of the calculation becomes lower and a small amount of training data will be sufficient. The time series of F10.7 from 2002 to 2006 are employed as the data sets. The performance of the approach is estimated by calculating the norm mean square error and mean absolute percentage error. It is shown that our approach can perform well by using fewer training data points than the traditional neural network.

关键词： methods data analysis -- Sun activity -- Sun radio radiation

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Leveraging ROTI map derived from Indonesian GNSS receiver network for advancing study of Equatorial Plasma Bubble in Southeast/East Asia

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Earth and Planetary Physics 2025年第1期9卷 101-116页

作者： Prayitno Abadi Ihsan N.Muafiry Teguh N.Pratama Angga Y.Putra Suraina Gatot H.Pramono Sidik T.Wibowo Febrylian F.Chabibi Umar A.Ahmad Wildan P.Tresna Asnawi Research center for Climate and Atmosphere Indonesian National Research and Innovation Agency(BRIN)BandungIndonesia School of Electrical Engineering Telkom UniversityBandungIndonesia Directorate of Laboratory Management Facilities and Science and Technology Park Indonesian National Research and Innovation Agency(BRIN)PontianakIndonesia Geophysics Laboratory Master Program in PhysicsUniversitas Gadjah Mada(UGM)YogyakartaIndonesia Research center for Space Indonesian National Research and Innovation Agency(BRIN)BandungIndonesia Indonesian Geospatial Information Agency(BIG) JakartaIndonesia Research center for Photonics Indonesian National Research and Innovation Agency(BRIN)Tangerang SelatanIndonesia Department of Earth and Planetary Sciences Hokkaido UniversitySapporoJapan

This paper highlights the crucial role of Indonesia’s GNSS receiver network in advancing Equatorial Plasma Bubble(EPB)studies in Southeast and East Asia,as ionospheric irregularities within EPB can disrupt GNSS signals and degrade positioning *** by the Indonesian Geospatial Information Agency(BIG),the Indonesia Continuously Operating Reference Station(Ina-CORS)network comprises over 300 GNSS receivers spanning equatorial to southern low-latitude ***-CORS is uniquely situated to monitor EPB generation,zonal drift,and dissipation across Southeast *** provide a practical tool for EPB research,by sharing two-dimensional rate of Total Electron Content(TEC)change index(ROTI)derived from this *** generate ROTI maps with a 10-minute resolution,and samples from May 2024 are publicly available for further scientific *** preliminary findings from the ROTI maps of Ina-CORS are ***,the Ina-CORS ROTI maps reveal that the irregularities within a broader EPB structure persist longer,increasing the potential for these irregularities to migrate farther ***,we demonstrate that combined ROTI maps from Ina-CORS and GNSS receivers in East Asia and Australia can be used to monitor the development of ionospheric irregularities in Southeast and East *** have demonstrated the combined ROTI maps to capture the development of ionospheric irregularities in the Southeast/East Asian sector during the G5 Geomagnetic Storm on May 11,*** observed simultaneous ionospheric irregularities in Japan and Australia,respectively propagating northwestward and southwestward,before midnight,whereas Southeast Asia’s equatorial and low-latitude regions exhibited irregularities *** sharing ROTI maps from Indonesia and integrating them with regional GNSS networks,researchers can conduct comprehensive EPB studies,enhancing the understanding of EPB behavior across Southeast and East Asia and contributing significantly to ionosphe

关键词： Equatorial Plasma Bubble(EPB) GNSS receivers’network Indonesia Continuously Operating Reference Station(Ina-CORS) ionospheric map Rate of TEC change index(ROTI)map

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Calculating Auroral Oval Pattern by AE Index

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Acta meteorologica Sinica 2008年第1期22卷 91-96页

作者：陈安芹李嘉巍杨光林王劲松 national center for Space weather China Meteorological Administration

The relationship between the auroral oval pattern, i.e., location, size, shape, and intensity, and the auroral electrojet activity index （AE index） is studied. It is found that the maximal auroral intensity is elliptically distributed, and the lengths of semimajor and semiminor axes are positively correlated to AE. The intensity along the normal of the auroral oval can be satisfyingly described by a Gaussian distribution, and the maximum and the full width at half maximum of the Gaussian distribution ave both positively correlated to AE. Based on these statistical results, a series of experimental formulas as a function of AE are developed to calculate the location, size, shape, and intensity of the auroral oval. These formulas are validated by the auroral images released by SWPC/NOAA.

关键词： auroral oval AE index (auroral electrojet activity index) linear correlation.

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Apolipoprotein A-I binding protein-mediated neuroprotection in glaucomatous neuroinflammation and neurodegeneration

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Neural Regeneration Research 2025年第5期20卷 1414-1415页

作者： Sinwoo Hwang Seunghwan Choi Soo-Ho Choi Keun-Young Kim Yury I.Miller Won-Kyu Ju Hamilton Glaucoma center and Shiley Eye Institute The Viterbi Family Department of OphthalmologyUniversity of California San DiegoLa JollaCAUSA Department of Medicine University of California San DiegoLa JollaCAUSA national center for Microscopy and Imaging Research Department of NeurosciencesUniversity of California San DiegoLa JollaCAUSA

Glaucoma is a multifactorial eye disorder that can cause vision loss and irreversible blindness,affecting individ uals aged 40 to 80 yea rs *** to the aging population,it is expected that the number of people affected by glaucoma will surpass 111 million by 2040 as the disease becomes more *** primarily contributes to optic nerve axon loss and the progressive degeneration of retinal ganglion cells (RGCs),subsequently leading to vision impairment.

关键词： irreversible pass primarily

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Dipole tilt controls bow shock location and flaring angle

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Science China Earth Sciences 2017年第1期60卷 198-206页

作者： LU JianYong YUAN HuanZhi WANG Ming YANG YaFen Institute of Space weather College of Math & StatisticsNanjing University of Information Science & Technology national center for Space weather China Meteorological Administration

The dipole tilt angle has beenfound to affect Earth's bow *** work presents a quantitative relationship between the dipole tilt angle and the bow shock location and flaring *** collected a large data set of bow shock crossings from four different satellites(IMP 8,Geotail,Magion 4,and Cluster),including some recent crossings obtained during *** results from a statistical analysis demonstrate that:(1)the subsolar standoff distance increases but the flaring angle decreases with increasing dipole tilt angle;(2)when the dipole tilt angle changes sign from negative to positive,the dayside bow shock moves toward Earth and the shift can be as much as 2.29 R_E,during which the flaring angle increases;and(3)the shape of bow shock in the northern and southern hemispheres *** the northern hemisphere bow shock,with increasing positive/negative dipole tilt angle,the flaring angle increases/*** for the southern hemisphere,the trend is the opposite;with increasing positive/negative dipole tilt angle,the flaring angle decreases/*** results are helpful for future bow shock modeling that needs to include the effects of dipole tilt angle.

关键词： Bow shock Dipole tilt Solar wind-magnetosphere coupling

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A study on the dynamic spectral indices for SEP events on 2000 July 14 and 2005 January 20

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Research in Astronomy and Astrophysics 2020年第3期20卷 129-135页

作者： Ming-Xian Zhao Gui-Ming Le Key Laboratory of Space weather National Center for Space WeatherChina Meteorological Administration.Beijing 100081China

We have studied the dynamic proton spectra for the two solar energetic particle(SEP)events on2000 July 14(hereafter GLE59)and 2005 January 20(hereafter GLE69).The source locations of GLE59 and GLE69 are N22 W07 and N12 W58 *** fluxes>30 Me V have been used to compute the dynamic spectral indices of the two SEP *** results show that spectral indices of the two SEP events increased more swiftly at early times,suggesting that the proton fluxes>30 Me V might be accelerated particularly by the concurrent flares at early times for the two SEP *** the GLE69 with source location at N12 W58,both flare site and shock nose are well connected with the Earth at the earliest ***,only the particles accelerated by the shock driven by eastern flank of the CME can propagate along the interplanetary magnetic field line to the Earth after the *** the GLE59 with source location at N22 W07,only the particles accelerated by the shock driven by western flank of the associated CME can reach the Earth after the *** results also show that there was slightly more than one hour during which the proton spectra for GLE69 are softer than that for GLE59 after the flares,suggesting that the shock driven by eastern flank of the CME associated with GLE69 is weaker than the shock driven by the western flank of the CME associated with *** results support that quasi-perpendicular shock has stronger potential in accelerating particles than the quasi-parallel *** results also suggest that only a small part of the shock driven by western flank of the CME associated with the GLE59 is quasi-perpendicular.

关键词： Sun:flares-Sun coronal mass ejections(CMEs)-Sun particle emission-Sun solarterrestrial relations

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Latitudinal and Solar Cycle Distribution of Extreme(≥X5) Flares During1976–2018

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Research in Astronomy and Astrophysics 2024年第12期24卷 63-70页

作者： Qi Li Xi-Wen Zhang Gui-Ming Le Institute of Geophysics China Earthquake Administration Key Laboratory of Space weather National Satellite Meteorological Center (National Center for Space Weather)China Meteorological Administration Innovation center for FengYun Meteorological Satellite (FYSIC)

We studied the latitudinal and solar cycle distribution of extreme(≥X5) solar flares spanning 1976–2018. We found that all such flares were confined within the latitudinal range of [S30, N35]. Nonetheless, the majority of these flares during different solar cycles were confined in different latitudinal scopes. Statistical results showed that the southeast quadrant experienced the highest activity of extreme flares. 47.5% of the extreme flares occurred within the latitudes ≤15° of the two hemispheres, with 26.2%, 31.1%, and 42.6% in the latitudinal bands [5°, 10°],>20° and [11°, 20°] of both hemispheres, respectively. Significant N–S asymmetries were observed in the ascending phase of SC 21, the descending phase of SC 23, and both phases of SC 24. Other phases showed asymmetries primarily in latitudinal distribution. The proportion of extreme flares in the ascending phases of SCs21–24 was 22.2%, 33.3%, 38.9%, and 50%, respectively. Stronger flares(≥X10) were more likely to occur in the descending phase, with 39% of X5–X9 flares and 20% of(≥X10) flares occurring in the ascending phase. On average, 83.6% of extreme flares occurred within a period extending from two years prior to three years following the solar peak, according to our statistical analysis, with specific percentages for each cycle being 88.9%, 100%,61.1%, and 75%.

关键词： (Sun:) sunspots Gamma-rays Sun: flares Sun: X-rays

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Small extracellular vesicles derived from human induced pluripotent stem cell-differentiated neural progenitor cells mitigate retinal ganglion cell degeneration in a mouse model of optic nerve injury

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Neural Regeneration Research 2025年第2期20卷 587-597页

作者： Tong Li Hui-Min Xing Hai-Dong Qian Qiao Gao Sheng-Lan Xu Hua Ma Zai-Long Chi State Key Laboratory of Ophthalmology Optometry and Visual ScienceEye HospitalWenzhou Medical UniversityWenzhouZhejiang ProvinceChina national Clinical Research center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhouZhejiang ProvinceChina

Several studies have found that transplantation of neural progenitor cells(NPCs)promotes the survival of injured ***,a poor integration rate and high risk of tumorigenicity after cell transplantation limits their clinical *** extracellular vesicles(sEVs)contain bioactive molecules for neuronal protection and *** studies have shown that stem/progenitor cell-derived sEVs can promote neuronal survival and recovery of neurological function in neurodegenerative eye diseases and other eye *** this study,we intravitreally transplanted sEVs derived from human induced pluripotent stem cells(hiPSCs)and hiPSCs-differentiated NPCs(hiPSC-NPC)in a mouse model of optic nerve *** results show that these intravitreally injected sEVs were ingested by retinal cells,especially those localized in the ganglion cell *** with hiPSC-NPC-derived sEVs mitigated optic nerve crush-induced retinal ganglion cell degeneration,and regulated the retinal microenvironment by inhibiting excessive activation of *** analysis further revealed that hiPSC-NPC derived sEVs transported neuroprotective and anti-inflammatory miRNA cargos to target cells,which had protective effects on RGCs after optic nerve *** findings suggest that sEVs derived from hiPSC-NPC are a promising cell-free therapeutic strategy for optic neuropathy.

关键词： exosome miRNA neural progenitor cell neurodegeneration neuroinflammation neuroprotection optic nerve crush optic neuropathy retinal ganglion cell small extracellular vesicles

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