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A systematic review of progenitor survival and maturation in Parkinsonian models

Neural Regeneration Research 2025年第11期20卷 3172-3178页

作者： Giulia Comini Eilís Dowd Pharmacology&Therapeutics and galway Neuroscience Center University of GalwayGalwayIreland

Stem cell-based brain repair is a promising emergent therapy for Parkinson's disease based on years of foundational research using human fetal donors as a cell *** current therapeutic options for patients,this approach has the potential to provide longterm stem cell–derived reconstruction and restoration of the dopaminergic input to denervated regions of the brain allowing for restoration of certain functions to *** ultimate clinical success of stem cell–derived brain repair will depend on both the safety and efficacy of the approach and the latter is dependent on the ability of the transplanted cells to survive and differentiate into functional dopaminergic neurons in the Parkinsonian *** the pre-clinical literature suggests that there is considerable variability in survival and differentiation between studies,the aim of this systematic review was to assess these parameters in human stem cell-derived dopaminergic progenitor transplant studies in animal models of Parkinson's disease.A defined systematic search of the PubMed database was completed to identify relevant studies published up to March *** screening,76 articles were included in the analysis from which 178 separate transplant studies were *** these,graft survival could be assessed in 52 studies and differentiation in 129 ***,we found that graft survival ranged from<1% to 500% of cells transplanted,with a median of 51%of transplanted cells surviving in the brain;while dopaminergic differentiation of the cells ranged from 0% to 46% of cells transplanted with a median of 3%.This systematic review suggests that there is considerable scope for improvement in the differentiation of stem cell-derived dopaminergic progenitors to maximize the therapeutic potential of this approach for patients.

关键词： cell replacement therapy differentiation embryonic stem cells graft induced pluripotent stem cells Parkinson's disease survival transplant

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The loaded matrix:neurotrophin-enriched hydrogels for stem cell brain repair in Parkinson's disease

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Neural Regeneration Research 2025年第8期20卷 2315-2316页

作者： Giulia Comini Eilis Dowd Pharmacology&Therapeutics University of GalwayGalwayIreland

More than 200 years after Parkinson's disease was first described by the English surgeon whose name would eventually be given to the condition,available treatments remain purely symptomatic,leaving a critical unmet cl... 详细信息

关键词： clinical loaded eventually

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Neuroinflammation as a therapeutic target in Huntington's disease

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Neural Regeneration Research 2025年第3期20卷 817-818页

作者： Andrea Kwakowsky Thulani H.Palpagama Center for Brain Research and Department of Anatomy and Medical Imaging Faculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand Pharmacology and Therapeutics School of MedicineGalway Neuroscience CentreUniversity of GalwayGalwayIreland

In 1872, George Huntington presented his essay “On Chorea” to the Meigs and Mason Academy of Medicine and, in doing so, detailed a disease that would later bear his name. Huntington's disease(HD) is a genetic, neurodegenerative disease that manifests as the loss of motor control,cognitive impairment,and mood and psychiatric changes in paents.

关键词： Huntington inflammation Medicine

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Glial response in the midcingulate cortex in Huntington’s disease

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Neural Regeneration Research 2025年第1期20卷 207-208页

作者： Thulani H.Palpagama Andrea Kwakowsky Center for Brain Research and Department of Anatomy and Medical Imaging Faculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand Pharmacology and Therapeutics School of MedicineGalway Neuroscience CenterUniversity of GalwayGalwayIreland

Huntington’s disease(HD)is a genetic disease characterized by the progressive degeneration of the striatum and *** can present with a variety of symptoms that can broadly be classified into motor symptoms,inclusive of choreatic movements and rigidity,mood and psychiatric symptoms,such as depression and apathy,and cognitive symptoms,such as cognitive *** causal mutation underlying HD results from an expansion of a CAG repeat sequence on the IT15 gene,resulting in the formation and accumulation of a mutant huntingtin protein.

关键词： Huntington degeneration cortex

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Anammox-based technologies:A review of recent advances,mechanism,and bottlenecks

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Journal of Environmental Sciences 2025年第2期148卷 151-173页

作者： Mabruk Adams Eliasu Issaka Chongjun Chen School of Environmental Science and Engineering Suzhou University of Science and TechnologySuzhou 2155009China Civil Engineering School of EngineeringCollege of Science and EngineeringUniversity of GalwayGalway H91 TK33Ireland School of Environmental and Safety Engineering Institute of Environmental Health and Ecological SecurityJiangsu UniversityZhenjiang 212013China

The removal of nitrogen via the ANAMMOX process is a promising green wastewater treatment technology,with numerous *** incessant studies on the ANAMMOX process over the years due to its long start-up and high operational cost has positively influenced its technological advancement,even though at a rather slow *** the moment,relatively newANAMMOX technologies are being developedwith the goal of treating lowcarbon wastewater at low temperatures,tackling nitrite and nitrate accumulation and methane utilization from digestates while also recovering resources(phosphorus)in a sustainable *** review compares and contrasts the handful of ANAMMOX-based processes developed thus far with plausible solutions for addressing their respective bottlenecks hindering full-scale ***,future prospects for advancing understanding of mechanisms and engineering application of ANAMMOX process are *** a whole,technological advances in process design and patents have greatly contributed to better understanding of the ANAMMOX process,which has greatly aided in the optimization and industrialization of the ANAMMOX *** review is intended to provide researchers with an overview of the present state of research and technological development of the ANAMMOX process,thus serving as a guide for realizing energy autarkic future practical applications.

关键词： Anammox Commamox Denitrification Full-scale Partial nitrification

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Generation,interrogation,and future applications of microglia-containing brain organoids

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Neural Regeneration Research 2025年第12期20卷 3448-3460页

作者： Julia Di Stefano Federica Di Marco Ilaria Cicalini Una FitzGerald Damiana Pieragostino Marleen Verhoye Peter Ponsaerts Elise Van Breedam Laboratory of Experimental Hematology Vaccine and Infectious Disease Institute(Vaxinfectio)University of AntwerpWilrijkBelgium Bio-Imaging Lab University of AntwerpWilrijkBelgium Center for Advanced Studies and Technology(CAST) G.d’Annunzio University of Chieti-PescaraChietiItaly Department of Innovative Technologies in Medicine and Dentistry University“G.d’Annunzio”of Chieti-PescaraChietiItaly CÚRAM Center for Research in Medical DevicesBiomedical EngineeringUniversity of GalwayIreland galway Neuroscience Center University of GalwayIreland μNEURO Research Center of Excellence University of AntwerpWilrijkBelgium

Brain organoids encompass a large collection of in vitro stem cell–derived 3D culture systems that aim to recapitulate multiple aspects of in vivo brain development and ***,this review provides a brief introduction to the current state-of-the-art for neuroectoderm brain organoid development,emphasizing their biggest advantages in comparison with classical two-dimensional cell cultures and animal ***,despite their usefulness for developmental studies,a major limitation for most brain organoid models is the absence of contributing cell types from endodermal and mesodermal *** such,current research is highly investing towards the incorporation of a functional vasculature and the microglial immune *** this review,we will specifically focus on the development of immune-competent brain *** summarizing the different approaches applied to incorporate microglia,it is highlighted that immune-competent brain organoids are not only important for studying neuronal network formation,but also offer a clear future as a new tool to study inflammatory responses in vitro in 3D in a brainlike ***,our main focus here is to provide a comprehensive overview of assays to measure microglial phenotype and function within brain organoids,with an outlook on how these findings could better understand neuronal network development or restoration,as well as the influence of physical stress on microglia-containing brain ***,we would like to stress that even though the development of immune-competent brain organoids has largely evolved over the past decade,their full potential as a pre-clinical tool to study novel therapeutic approaches to halt or reduce inflammation-mediated neurodegeneration still needs to be explored and validated.

关键词： 3D cell culture brain organoids immune response immunocompetent model in vitro model microglia neural organoids neuroimmunology neuroinflammation

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Apolipoprotein E elicits targetdirected miRNA degradation to maintain neuronal integrity

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Neural Regeneration Research 2025年第9期20卷 2577-2578页

作者： Jiazi Tan Chin-Tong Ong Temasek Life Sciences Laboratory National University of SingaporeSingapore Department of Biological Sciences National University of SingaporeSingapore

Apolipoprotein E has diverse functions in neurons:Apolipoprotein E(ApoE)is a glycoprotein that primarily regulates lipid metabolism and transport in the central nervous *** are three predominant human ApoE protein isoforms with cysteine and arginine substitutions at amino acid positions 112 and 158 that impact their lipidation and related functions(Flowers and Rebeck,2020).ApoE2 is characterized by Cys112 and Cys158,ApoE3 by Cys112 and Arg158,whereas ApoE4 contains Arg112 and Arg158.

关键词： metabolism glycoprotein maintain

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Mechanical properties and flow stress constitutive relationship of Ti–6Al–4V alloy with equiaxed microstructure at cryogenic temperatures

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Chinese Journal of Aeronautics 2025年第1期38卷 365-379页

作者： Jingwen HU Xun CHEN Yashun WANG Chen YANG College of Intelligence Science and Technology National University of Defense TechnologyChangsha 410073China Laboratory of Science and Technology on Integrated Logistics Support National University of Defense TechnologyChangsha 410073China

This paper investigates the uniaxial tensile mechanical properties and flow behavior of Ti-6Al-4V alloys with equiaxed microstructure at cryogenic temperatures ranging from 77 K to298 K and strain rates from 10^(-4)/s to 10^(-2)/*** electron microscopy is utilized to analyze the fracture morphology,aiming to reveal the fracture behavior at various *** applicability of the Zener-Hollomon parameter and the Johnson-Cook model in describing the flow stress of Ti-6Al-4V at cryogenic temperatures is ***,a constitutive relationship modeling method based on the variational recurrent networks is *** test results show a significant increase in the strength of equiaxed Ti-6Al-4V alloy under cryogenic conditions while the plastic deformation process is ***,the fracture analysis indicates that even at 77 K,the fracture process is still dominated by ductile fracture,and brittle fracture does not occur within the range of 77 K to 298 *** fitting results validate the performance of the Zener-Hollomon parameter and the Johnson-Cook model in describing the deformation flow stress of Ti-6Al-4V alloy at cryogenic *** results also indicate that the proposed constitutive relationship modeling method based on the variational recurrent network performs better,making it a potential method for widespread applications.

关键词： Titanium alloys Mechanical properties Cryogenics Fracture testing Flow behavior

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Identification of patients with advanced pancreatic cancer who might benefit from third-line chemotherapy

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World Journal of Gastrointestinal Oncology 2025年第2期17卷 74-83页

作者： Bomi Kim Jaihwan Kim Soomin Yang Jinwoo Ahn Kwangrok Jung Jong-Chan Lee Jin-Hyeok Hwang Department of Internal Medicine Seoul National University Bundang HospitalSeoul National University College of MedicineSeongnam 13620South Korea

BACKGROUND Survival rates of patients with advanced pancreatic cancer(APC)have been improved with palliative chemotherapy *** current preferred first-line regimen consists of combination therapy of 5-fluorouracil(5-FU)/leucovorin(LV),irinotecan,and oxaliplatin(FOLFIRINOX)or gemcitabine plus albumin-bound paclitaxel(GNP).After failure of first-line chemotherapy,there are a few options for subsequent therapy including switch to the unused first-line regimen or nanoliposomal irinotecan and 5-FU/***,there are limited studies on the efficacy of third-line chemotherapy after failure of second-line *** To identify patients with APC who might benefit from third-line *** Medical records from a single tertiary hospital were retrospectively reviewed between 2012 and *** study included patients with histologically or cytologically confirmed metastatic or locally APC who underwent first-line FOLFIRINOX or GNP and subsequently received third-line *** survival(OS)after diagnosis and OS after third-line chemotherapy(OS3)were defined as the interval from the diagnosis to all-cause death and the time between the initiation of the third-line chemotherapy to all-cause death,*** A total of 141 patients were *** median patient age at diagnosis was 61.8 years(36.0-86.0),and 54.9%were *** first-line regimen was FOLFIRINOX(67.4%)or GNP(32.6%).The second-line regimen was FOLFIRINOX(27.0%),GNP(52.5%),or other(20.6%).The median OS was 19.0 months,and the median OS3 and progression-free survival after third-line treatment were 15.3 and 7.3 weeks,*** regard to the best tumor response during third-line chemotherapy,1.4%had partial response,24.8%had stable disease,and 59.6%had progressive *** following clinical factors before third-line chemotherapy affected OS3:Good performance status(PS),serum carbohydrate antigen 19-9(CA19-9)level<1000 U/mL,duration of second-line chemotherapy≥

关键词： Pancreatic cancer Chemotherapy Survival Performance status Carbohydrate antigen 19-9

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A Multifunctional Hydrogel with Multimodal Self-Powered Sensing Capability and Stable Direct Current Output for Outdoor Plant Monitoring Systems

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Nano-Micro Letters 2025年第4期17卷 1-24页

作者： Xinge Guo Luwei Wang Zhenyang Jin Chengkuo Lee Department of Electrical&Computer Engineering National University of Singapore4 Engineering Drive 3Singapore 117576Singapore Center for Intelligent Sensors and MEMS(CISM) National University of Singapore5 Engineering Drive 1Singapore 117608Singapore NUS Graduate School-Integrative Sciences and Engineering Program(ISEP) National University of SingaporeSingapore 119077Singapore Research Center for Sustainable Urban Farming(SUrF) National University of SingaporeSingapore 117558Singapore

Smart farming with outdoor monitoring systems is critical to address food shortages and sustainability *** systems facilitate informed decisions that enhance efficiency in broader environmental *** outdoor systems equipped with energy harvesters and self-powered sensors often struggle with fluctuating energy sources,low durability under harsh conditions,non-transparent or non-biocompatible materials,and complex ***,a multifunctional hydrogel is developed,which can fulfill all the above requirements and build selfsustainable outdoor monitoring systems solely by *** can serve as a stable energy harvester that continuously generates direct current output with an average power density of 1.9 W m^(-3)for nearly 60 days of operation in normal environments(24℃,60%RH),with an energy density of around 1.36×10^(7)J m^(-3).It also shows good self-recoverability in severe environments(45℃,30%RH)in nearly 40 days of continuous ***,this hydrogel enables noninvasive and self-powered monitoring of leaf relative water content,providing critical data on evaluating plant health,previously obtainable only through invasive or high-power consumption *** potential extends to acting as other self-powered environmental *** multifunctional hydrogel enables self-sustainable outdoor systems with scalable and low-cost production,paving the way for future agriculture.

关键词： Self-powered sensor Hydrogel Energy harvester Outdoor farming Self-sustainable IoT

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