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Demonstration of malaria situation analysis,stratification and planning in Minab District,southern Iran

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Asian Pacific Journal of Tropical Medicine 2011年第1期4卷 67-71页

作者： Vatandoost Hassan Rashidian Arash Jafari Mehdi Raeisi Ahmad Hanafi-Bojd Ahmad Ali Yousofzai Abdul Wali Daryanavard Ali Mojahedi AbdulRasool Pakari Abbas Department of Medical Entomology & Vector Control School of Public HealthTehran University of Medical ScienceTehranI.R.Iran national Institute of Health Research Tehran University of Medical SciencesTehranIran Iran University of Medical Sciences TehranIran national Malaria Manager CDCMinistry of Health & Medical EducationIran Global Fund Project Manager National Malaria & Lieshmaniasis Control ProgramMinistry of Public HealthKabul-Afghanistan Hormozgan Province Health Center Bandar AbbasIran Bandar Abbas Health Research Station National Institute of Health ResearchTehran University of Medical ScienceBandar AbbasIran

Objective:To demonstrate malaria situation analysis,stratification and planning for an endemic area in southern ***:Data on health system,population,meteorological parameters, malaria cases,anopheline vectors,and control activities during 2005-2007 was obtained from Minab Health Center,Minab Meteorological Station and published documents about malaria elements in the study area.A datasheet was created in excel 2003 for ***:There were 644 health staff working in Minab District including 99 health staff in malaria control *** health facilities are distributed as follow:1 hospital with 96 beds,23 health centers including private centers(10 in Minab city and 13 in rural area of Minab District) and 119 health houses in rural areas of Minab *** stephensi was the dominant species in Minab District,however,Anopheles dthali,Anopheles superpictus,Anopheles fluviatilis,Anopheles multicolor,Anopheles pulcherrimus and Anopheles turkhudi can also be found in the area. Anopheles stephensi was reported susceptible to malathion,propoxur,primphos-methyl,lambdacyhalothrin permethrin and deltamethrin,and resistant to DDT and dieldrin in the *** the study period a total of 10 665 positive cases were reported,mainly due to local transmission (99.6%).Plasmodium vivax was the main causative agent followed by Plasmodium falciparum. There were reports about drug resistance of Plasmodium falciparum in the ***: Using different parameters,Minab was classified into 3 strata.A plan was designed based on described goal,objectives and *** approaches of this plan were categorized into:health education,early detection and correct treatment,and vector *** constraints of these approaches are population movement between Iran,Pakistan and Afghanistan;vector control challenges at district,inadequate skilled medical staff in malaria case management and weak inter-sectorial coordination for malaria control,especially in urban

关键词： Malaria Situation analysis Stratification Planning Minab Iran

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日本结核病接触调查中存在的问题

中国防痨杂志 2017年第1期39卷 22-27页

作者： Toru Mori 204 8533 Tokyo Research Institute of TuberculosisJapan Anti-Tuberculosis Association204853

尽管在过去的几十年中结核病发病率显著下降，但结核病在日本仍然是一个重大的公共卫生问题。接触调查作为发现活动性肺结核患者的措施，联合疾病预防和感染控制正在成为国家结核病规划（national tuberculosis program，NTP）的重中之... 详细信息

尽管在过去的几十年中结核病发病率显著下降，但结核病在日本仍然是一个重大的公共卫生问题。接触调查作为发现活动性肺结核患者的措施，联合疾病预防和感染控制正在成为国家结核病规划（national tuberculosis program，NTP）的重中之重。作者综述了日本接触者调查的原则和方法，以及取得的成果，并讨论了这个程序当前面临的挑战，包括几个新技术的广泛应用等。

关键词：结核接触者追踪国家卫生规划实验室技术和方法结果评价(卫生保健)

Factors Associated with Mortality among Multidrug Resistant tuberculosis MDR/RR-TB Patients in Democratic Republic of Congo

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Journal of tuberculosis Research 2017年第4期5卷 276-291页

作者： Murhula Innocent Kashongwe Leopoldine Mbulula Pierre Umba Francois Bompeka Lepira Michel Kaswa Zacharie Munogolo Kashongwe Lung disease Unit Department of Internal medicine Faculty of Medicine University of Kinshasa Hospital University of Kinshasa Kinshasa Democratic Republic of Congo Centre d’excellence Damien (CEDA) Action Damien DR Congo Nephrology Unit Department of Internal Medicine Faculty of Medicine University of Kinshasa Hospital University of Kinshasa Kinshasa Democratic Republic of Congo national tuberculosis program of DR Congo (NTP) DR Congo

Background: tuberculosis remains a very common infectious disease in Democratic Republic of Congo (DRC). The resistance to drugs worsens the prognosis and the outcome of patients affected tuberculosis and increase their mortality. Objective: To identify factors associated with death among Multidrugs resistant tuberculosis (MDR/RR TB) patients referred to the referential hospital, Centre d’Excellence Damien (CEDA). Materials and Methods: A retrospective cohort study of patients attending health care to the Center CEDA, a referral center for management of MDR/RR-TB in DR Congo. This study included all MDR/RR-TB patients referred from February 1st, 2015 to February 29th, 2017. A multivariate COX regression was performed to identify factors associated with mortality in the target population. Kaplan Meier method described the survival of patients and the comparison of curves was performed by the test of log Rank. Results: 199 patients were included in our study. Male gender was predominant with a sex ratio of 1.3. The mean age of patients was 35.8 ± 13.9 years. Among them, 18 (15.1%) were died. The major complications were Chronicles pulmonary Heart failure (p = 0.035), Chronic respiratory insufficiency (p = 0.004), depression (p = 0.044), undernutrition (p = 0.033), alcohol addiction (p = 0.006) and high smoking (p = 0.019). In multivariated analysis, factors associated to the death were alcohol addiction (HRa = 12.64, 95% CI 2.36 - 14.55, p = 0.003), asthenia (HRa = 4.75, 95% CI 1.56 - 14.50, p < 0.001), pulmonary consolidation (HRa = 10.01 95% CI 2.34 - 12.86, p = 0.02), some chest X-ray abnormalities such as signs of pulmonary fibrosis (HR = 4.7, 95% CI 2.78 - 28.94, p = 0.002) and the Chronic respiratory insufficiency (HRa = 3.77, 95% CI 1.37 - 10.43, p = 0.010). Conclusion: The present retrospective cohort study revealed that structural and functional pulmonary alteration emerged as the main factors associated with mortality among MDR/RR TB patients in Kinshasa. Na

关键词： MDR/RR-TB Mortality Kinshasa Factors

Clinical and pathological features of miR-10b and RHOC gene expression in hepatocellular carcinoma

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Chinese Science Bulletin 2014年第19期59卷 2249-2253页

作者： Jingli Du Yulan Wang Hanjiang Fu Xiaofei Zheng Minggui Lin Mingzhou Guo Lixin Wei Department of Pathology Chinese PLA General Hospital Department of Pathology Urumqi General Hospital Lanzhou Military District Department of Biochemistry and Molecular Biology Beijing Institute of Radiation Medicine Institute of tuberculosis 309th Hospital PLA Department of Gastroenterology and Hepatology Chinese PLA General Hospital

Aberrant expression of microRNAs(miRNAs)was reported frequently in different human *** major role of miRNA is targeting 30-UTR of coding gene and causing translational repression or mRNA ***-10b overexpression was reported to promote breast cancer metastasis by up-regulating RHOC *** its expression in hepatocellular carcinoma(HCC)remains *** study indicated that the expression of miR-10b was different in HCC and adjacent tissue samples,and reduced expression of miR-10b in HCC was related tovein ***-level expression of RHOC was also related to vein invasion in *** no correlation was found between miR-10b and RHOC *** results suggest that miR-10b and RHOC are independent predictors of HCC invasion and metastasis.

关键词：肝癌病理特征 OC基因 microRNA 临床 RH mRNA降解 miRNA

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The Prevalence of Drug-Resistant tuberculosis among People Living with HIV (PLHIV) in Abia State

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Advances in Infectious Diseases 2016年第2期6卷 63-69页

作者： Onuka Okorie Ahukanna John M. Gidado Gabriel Akang Ubochioma Emperor Enogu Rupert Ibeziako Vivian Emmanuel Meribole Pius Osakwe TB Control program Ministry of Health Umuahia Nigeria KNCV Abuja Nigeria Institute of Human Virology Abuja Nigeria national TB Control program Abuja Nigeria World Health Organization Enugu Nigeria

tuberculosis (TB) is a chronic disease caused by mycobacterium tuberculosis and transmitted from person to person, through inhalation of droplet nuclei aerosolized by coughing of an infected person. It reached epidemic proportions in Europe and North America during the 18th and 19th centuries. The incubation period is 2 - 6 weeks and the control has been complicated with emergence of HIV and drug-resistant TB. In 1993, World Health Organization (WHO) declared TB a global emergency. However, despite the concerted effort of national TB control programs, adoption and implementation of Stop TB strategy, TB has remained a major public health challenge with high mortality rate, especially in developing countries. Methodology: This is a descriptive study, evaluated using the positivist/quantitative approach. The study was conducted at FederalMedical Centre Umuahia, a tertiary specialist hospital with comprehensive TB/HIV treatment services. All the presumptive drug-resistant TB cases and symptomatic PLHIV were screened for HIV and their sputum specimens were tested for tuberculosis using the Gene xpert and the Ziehl- Neelsen technique for detecting Acid Fast bacilli. A pretested structured questionnaire was used tocollect the demographic data and other essential data from the presumptive TB and laboratory registers such as total number of TB presumptive cases registered HIV status, AFB status and rifampicin status within the study period. Result: A total of 493 presumptive TB cases were screened in the study, 49.9% were HIV positive while 50.05% were HIV negative. More so, 77.85% of thescreened cases were AFB negative and 22.15% were AFB positive. Moreover, 11% of the TB/HIV co-infected patients were rifampicin positive. Interestingly among the 493 cases screened with gene xpert machine, 3.6% were rifampicin positive. Furthermore, 3.6% of the HIV negative cases were rifampicin positive while 1.6% of the HIV positive cases were rifampicin positive. Discussion: The data depi

关键词： Multidrug Resistant TB among People Living with HIV

Determinants of the Sensorineural Hearing Loss in Patients with Multidrug-Resistant tuberculosis in Kinshasa (Democratic Republic of the Congo): A Prospective Cohort Study

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International Journal of Otolaryngology and Head & Neck Surgery 2023年第6期12卷 411-425页

作者： Mireille Avilaw Mpwate Eddy Mampuya Mbambu Gabriel Mabuaka Lema Christian Nzanza Matanda Dominique Mayuku Mupepe Michel Kayomo Kaswa Murielle Luengiladio Aloni Nicole Muzutie Anshambi Fabrice Mankangu Matuta Luc Losenga Lukasu Serge Katya Mpwate Pierre Zalagile Akilimali Innocent Murhula Kashongwe Zacharie Munogolo Kashongwe Jean Marie Ntumba Kayembe Richard Nzanza Matanda Department of Otorhinolaryngology University Hospital of Kinshasa Kinshasa 11 University of Kinshasa Kinshasa Democratic Republic of The Congo Division of Cardiology Department of Internal Medicine University Hospital of Kinshasa Kinshasa 11 University of Kinshasa Kinshasa Democratic Republic of The Congo national tuberculosis Control program in Democratic Republic of The Congo Kinshasa Democratic Republic of The Congo Provincial Coordination for The Fight against tuberculosis Kinshasa Democratic Republic of The Congo Multidrug-Resistant tuberculosis Unit “Centre d’Excellence Damien” Damien Foundation Kinshasa Democratic Republic of The Congo Department of Anatomy-Pathology University Hospital of Kinshasa Kinshasa 11 University of Kinshasa Kinshasa Democratic Republic of The Congo Kinshasa School of Public Health Faculty of Medicine University of Kinshasa Kinshasa Democratic Republic of The Congo Pneumology Unit Department of Internal Medicine University Hospital of Kinshasa Kinshasa 11 University of Kinshasa Kinshasa Democratic Republic of The Congo

Background: The onset of the hearing loss is a major challenge during the treatment of multidrug-resistant tuberculosis (MDR-TB). Aminoglycoside-based regimens, to a lesser extent based on bedaquiline, induce ototoxic sensorineural hearing loss. Research on risk factors is essential to enable high-risk individuals to benefit from preventive measures in settings with limited resources. Objective: This study aimed to assess the determinants of the hearing loss in patients with MDR-TB. Methods: This prospective multicenter cohort study included 337 patients with MDR-TB. It was performed in Kinshasa (Democratic Republic of the Congo) between January 2020 and January 2021. Sociodemographic, clinical, biological, therapeutic, and audiometric data were exported and analyzed using Stata 17 and MedCalc. The fixed-effect linear regression panel model was used to assess the degree of the hearing loss over time according to the following covariates: therapeutic regimen (aminoglycosides, bedaquiline, or alternate), stage of chronic kidney disease (CKD), age at inclusion, body mass index, serum albumin level, HIV status, alcohol intake, hypertension, and hemoglobin level. The Hausman test was used to select between fixed- and random-effect estimators. The threshold for statistical significance was set at p Result: A total of 236 patients (70%) received an aminoglycoside-based regimen, 61 (18%) received a bedaquiline-based regimen, and 40 (12%) received aminoglycosides relayed by bedaquiline. The frequency of the hearing loss increased from 62% to 96.3% within six months for all therapeutic regimens. The Hearing loss worsened, with moderate (72.4%) and profound (16%) deafness being predominant. An Exposure to the treatment for more than one month (β coeff: 27.695, Se: 0.793, p β coeff: 6.102, Se: 1.779, p β coeff: 5.610, Se: 1.682, p = 0.001), and an eGFR β coeff: 6.730, Se: 2.70, p = 0.013) were the independent risk factors associated with the hearing loss in patients with MDR-TB

关键词： Multidrug-Resistant tuberculosis Determinants Hearing Loss DRC

Sensorineural Hearing Loss in Multidrug-Resistant tuberculosis Patients in Kinshasa (Democratic Republic of Congo): Prospective Cohort Study of Therapeutic Regimen with Aminoglycoside versus Bedaquiline

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Journal of tuberculosis Research 2023年第3期11卷 109-119页

作者： Mireille A. Mpwate Eddy M. Mbambu Christian N. Matanda Gabriel M. Lema Michel K. Kaswa Murielle L. Aloni Nicole M. Anshambi Fabrice M. Matuta Luc L. Lukasu Dominique M. Mupepe Serge K. Mpwate Pierre Z. Akilimali Zacharie M. Kashongwe Richard N. Matanda Department of Otorhinolaryngology University Clinics of Kinshasa Kinshasa 11 University of Kinshasa Kinshasa Democratic Republic of Congo national tuberculosis Control program in the Democratic Republic of Congo Kinshasa Democratic Republic of Congo Provincial Coordination for the Fight against tuberculosis Kinshasa Democratic Republic of Congo Multidrug-Resistant tuberculosis Unit “Centre d’Excellence Damien” Damien Foundation Kinshasa Democratic Republic of Congo Division of Cardiology Department of Internal Medicine University Clinics of Kinshasa Kinshasa 11 University of Kinshasa Kinshasa Democratic Republic of Congo Department of Anatomy-Pathology University Clinics of Kinshasa Kinshasa 11 University of Kinshasa Kinshasa Democratic Republic of Congo Kinshasa School of Public Health Faculty of Medicine University of Kinshasa Kinshasa Democratic Republic of Congo Pneumology Unit Department of Internal Medicine University Clinics of Kinshasa Kinshasa 11 University of Kinshasa Kinshasa Democratic Republic of Congo

Context: Multidrug-resistant tuberculosis (MDR-TB) remains a major public health problem in developing countries such as the Democratic Republic of Congo (DRC), which continues to face the emergence of MDR-TB cases. Because of the ototoxic effects of AGs, the World Health Organization (WHO) has recommended the introduction of the bedaquiline regimen. However, very few data are available regarding the susceptibility of bedaquiline to induce hearing loss, hence the present study set out to compare the AG-based regimen and the bedaquiline-based regimen in the occurrence of hearing loss in MDR-TB patients. Methods: This is a prospective multicenter cohort study that included 335 MDR-TB patients, performed in Kinshasa (DRC) during the period from January 2020 to January 2021. Sociodemographic, clinical, biological and audiometric data were analyzed using Stata 17. Repeated-measures analysis of variance was used to compare changes in the degree of hearing loss over time between the two groups of patients on AG and bedaquiline regimens. The double-difference method was estimated using regression with fixed-effects. A p value < 0.05 was considered the threshold for statistical significance. Results: The degree of hearing loss was similar between the two groups at the first month [AGs (28 dB) vs BDQ (30 dB);p = 0.298]. At six months, the mean degree of hearing loss was significantly greater in the aminoglycoside regimen group [AGs (60.5 dB) vs BDQ (44 dB);p < 0.001]. The double difference was significant, with a greater increase in hearing loss in the AGs group (diff-in-diff 18.3;p < 0.001). After adjustment for age and serum albumin, the group receiving the AG-based regimen had a 2-point greater worsening than those with bedaquiline at the sixth month (diff-in-diff 19.8;p Conclusion: Hearing loss is frequent with both treatment regimens, but more marked with the Aminoglycoside-based regimen. Thus, bedaquiline should also benefit for audiometric monitoring in future MDR-TB p

关键词： Multidrug-Resistant tuberculosis Aminoglycosides Bedaquiline Hearing Loss

A highly efficient in vivo plasmid editing tool based on CRISPR-Cas12a and phage λ Red recombineering

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Journal of Genetics and Genomics 2019年第9期46卷 455-458页

作者： Yiman Geng Haiqin Yan Pei Li Gaixian Ren Xiaopeng Guo Peiqi Yin Leiliang Zhang Zhaohui Qian Zhendong Zhao Yi-Cheng Sun NHC Key Laboratory of Systems Biology of Pathogens Institute of Pathogen BiologyCenter for Tuberculosis ResearchChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing100730China Department of Basic Medical Sciences Anhui Key Laboratory of Infection and ImmunityBengbu Medical CollegeBengbu233030China

Plasmids are useful tools for studying genetic information in living cells,as well as heterologous expression of genes and pathways in cells(Lauritsen et al.,2018).Various methods have been developed for plasmid manipulation both in vivo and in vitro(Aslanidis and de Jong,1990;Li and Elledge,2007;Xia et al.,2018).However,large plasmids,such as P1-based artificial chromosomes(PACs),bacterial artificial chromosomes(BACs),and fosmids,are difficult to manipulate.

关键词： vivo artificial al.

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Protection of Mice with a Divalent tuberculosis DNA Vaccine Encoding Antigens Ag85B and MPT64

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Acta Biochimica et Biophysica Sinica 2004年第4期36卷 269-276页

作者： Xia TIAN, Hong CAI, and Yu-Xian ZHU* The national Laboratory of Protein Engineering and Plant Genetic Engineering, Peking University, Beijing 100871, China The national Laboratory of Protein Engineering and Plant Genetic Engineering Peking UniversityBeijing 100871 China

DNA vaccine may be a promising tool for controlling tuberculosis development. However, vaccines encoding single antigens of mycobacterium did not produce protective effect as BCG did. In the present study, we evaluated the immunogenicity and protective efficacy of a divalent DNA vaccine encoding two immunodominant antigens Ag85B and MPT64 of Mycobacterium tuberculosis. We found that both humoral and Th1-type (high IFN-γ, low IL-4) cellular responses obtained from the divalent DNA vaccine group were significantly higher than that conferred by BCG. RT-PCR results showed that antigens were expressed differentially in various organs in divalent DNA vaccine group. The survival rate for mice treated with the divalent DNA vaccine after challenging with high doses of virulent M. tuberculosis H37Rv was significantly higher than that of the BCG group or any of the single DNA vaccine group. Significant differ- ences were also found between the single and divalent DNA vaccinated mice in terms of body, spleen and lung weight. Bacterial loading decreased about 2000-fold in lungs and about 100-fold in spleens of divalent DNA vaccinated mice when compared with that of the control group. We conclude that our divalent DNA vaccine may be a better choice for controlling tuberculosis disease in animals.

关键词： tuberculosis divalent DNA vaccine immunogenicity protection