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Human chemerin induces eryptosis at concentrations exceeding circulating levels

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BIOCELL 2024年第8期48卷 1197-1208页

作者： MARYNA TKACHENKO ANATOLII ONISHCHENKO LILIYA TRYFONYUK DMYTRO BUTOV KATERYNA KOT VIKTORIIA NOVIKOVA LIWEI FAN VOLODYMYR PROKOPIUK YURII KOT ANTON TKACHENKO Department of Internal Medicine No.2 Clinical Immunology and AllergologyKharkiv National Medical UniversityKharkiv61022Ukraine Research Institute of Experimental and Clinical Medicine Kharkiv National Medical UniversityKharkiv61022Ukraine Institute of Health National University of Water and Environmental EngineeringRivne61022Ukraine Department of Infectious Diseases and Phthisiology Kharkiv National Medical UniversityKharkiv61022Ukraine Biochemistry Department V.N.Karazin Kharkiv National University Ministry of Education and Science of UkraineKharkiv61022Ukraine Department of Chemistry BiochemistryMicrobiology and Food HygieneState Biotechnological UniversityKharkiv61022Ukraine Clinical Research Innovation Lab Floor 26 Block D Qidi Technology Building 8Tsinghua Technology ParkBeijing100084China Department of Cryobiochemistry Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of UkraineKharkiv61015Ukraine

Introduction:Human chemerin is an adipokine that regulates chemotaxis,inflammation,and glucose *** addition,accumulating evidence suggests that chemerin promotes apoptosis,autophagy,and ***,there are no data on its impact on *** current study aimed to analyze the effects of human active Glu^(21)-Ser^(157) chemerin on eryptosis in *** and Methods:Human chemerin 0-2-10-50μg/mL was incubated for 24 h with human erythrocytes(hematocrit 0.4%)obtained from eight healthy *** cytometry-based determination of phospholipid scrambling,reactive oxygen species(ROS)production,and intracellular Ca^(2+)levels was *** supplement data on ROS and Ca^(2+)signaling in chemerin-mediated eryptosis,incubation in the presence or absence of antioxidants vitamin C and N-acetylcysteine and Ca^(2+)-binding agent EGTA was carried out,*** microscopy-based techniques were used to detect reactive nitrogen species(RNS)generation,involvement of caspase-3 and caspase-8,as well as the state of lipid order in cell membranes of erythrocytes exposed to human Glu^(21)-Ser^(157) ***:Our observations suggest that human Glu^(21)-Ser^(157) chemerin had no impact on eryptosis parameters at 2μg/***,chemerin stimulated phosphatidylserine externalization,ROS production,and Ca^(2+)accumulation at higher concentrations suggesting activation of ***^(2+)uptake turned out to be at least partly required for chemerin-mediated ***-mediated erythrotoxicity was additionally mediated by RNS,caspase-3,and ***,Glu^(21)-Ser^(157) chemerin promoted reduction in the liquid-ordered phase of cell membranes in ***:The present study first discloses that human chemerin can induce eryptosis via Ca^(2+)-dependent mechanisms at concentrations noticeably exceeding circulating ***,chemerin-induced eryptosis can hardly contribute to eryptosis-mediated anemia in disease

关键词： Adipokine Cell death Chemerin Oxidative stress Eryptosis

Variation in the Composition of the Essential Oil of Commercial Salvia officinalis *** Samples from Different Countries

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Phyton-International Journal of Experimental Botany 2024年第8期93卷 2051-2062页

作者： Ain Raal Anne Orav Tetiana Ilina Alla Kovalyova Taras Koliadzhyn Yuliia Avidzba Oleh Koshovyi Institute of Pharmacy Faculty of MedicineUniversity of TartuTartu50411Estonia Institute of Chemistry Tallinn University of TechnologyTallinn12618Estonia The Department of Pharmaceutical Management Drug Technology and PharmacognosyIvano-Frankivsk National Medical UniversityIvano-Frankivsk76018Ukraine The Department of Pharmacognosy National University of PharmacyKharkiv61002Ukraine The Department of Clinical Laboratory Diagnostics Kharkiv National Medical UniversityKharkiv61022Ukraine

Salvia officinalis L.(Lamiaceae)leaves and its essential oil is used for mouth and throat disorders,skin disorders,minor wounds,and gastrointestinal disorders,and is widely used *** research aimed to conduct a comparative study of the composition of *** essential oils from commercial samples,and their main *** volatile constituents from *** leaves were investigated using gas chromatography(GC).The commercial samples of sage leaves were obtained from retail pharmacies in nine mainly European *** yield of essential oil in *** commercial leaves was between 10.0 and 24.8 mL/*** principal components(>5%)among the main identified 25 compounds were 1,8-cineole(8.3%–45.3%),α-thujone(3.0%–34.0%),сamphor(11.3%–29.3%),β-thujone(1.5%–12.9%),viridiflorol(1.1%–10.4%),camphene(2.6%–7.1%),andα-pinene(1.3%–5.8%).In seven(Estonia,England,France,Hungary,Belgium,ukraine,Georgia)samplesα-thujone *** samples(Estonia,Georgia,England,Hungary)belong to the most common chemotypeα-thujone>camphor>1,*** chemotypes of *** essential oils have been *** thujones are widespread compounds among them.

关键词： Sage terpenoids chemotypes thujone toxicity

Target acquisition performance in the presence of JPEG image compression

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Defence Technology（防务技术） 2024年第3期33卷 30-41页

作者： Boban Bondzulic Nenad Stojanovic Vladimir Lukin Sergey A.Stankevich Dimitrije Bujakovic Sergii Kryvenko university of Defence in Belgrade Military AcademyVeljka Lukica Kurjaka 3311000 BelgradeSerbia national Aerospace university Department of Information-Communication TechnologiesChkalova 1761070 KharkivUkraine national Academy of Sciences of ukraine Scientific Centre for Aerospace Research of the EarthOles Honchar 55-b01054 KyivUkraine

This paper presents an investigation on the effect of JPEG compression on the similarity between the target image and the background,where the similarity is further used to determine the degree of clutter in the *** new clutter metrics based on image quality assessment are introduced,among which the Haar wavelet-based perceptual similarity index,known as HaarPSI,provides the best target acquisition prediction *** is shown that the similarity between the target and the background at the boundary between visually lossless and visually lossy compression does not change significantly compared to the case when an uncompressed image is *** future work,through subjective tests,it is necessary to check whether this presence of compression at the threshold of just noticeable differences will affect the human target acquisition *** values are compared with the results of subjective tests of the well-known target Search_2 database,where the degree of agreement between objective and subjective scores,measured through linear correlation,reached a value of 90%.

关键词： JPEG compression Target acquisition performance Image quality assessment Just noticeable difference Probability of target detection Target mean searching time

Comparison of the performance and dynamics of the asymmetric single-sided and symmetric double-sided vibro-impact nonlinear energy sinks with optimized designs

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International Journal of Mechanical System Dynamics 2024年第3期4卷 303-316页

作者： Petro Lizunov Olga Pogorelova Tetyana Postnikova Department of Constructive Mechanics Kyiv National University of Construction and ArchitectureKyivUkraine Research Institute of Structural Mechanics Kyiv National University of Construction and ArchitectureKyivUkraine

The operation of symmetric double-sided and asymmetric single-sided vibro-impact nonlinear energy sinks(DSVI NES and SSVI NES)is considered in this *** methodology of optimization procedures is *** is emphasized that the execution of optimization procedures is ambiguous,allows for a great deal of arbitrariness,and requires experience and intuition on the part of the *** are a lot of damper parameter sets providing similar attenuation of the primary structure(PS)*** is shown that the efficiency of such mitigation for both VI NES types with optimized parameters is ***,their dynamic behavior differs *** system with the attached DSVI NES exhibits calm dynamics with periodic motion and symmetrical bilateral impacts on both *** system with attached SSVI NES exhibits rich complex dynamics when the exciting force frequency is *** modes of different periodicity with different numbers of asymmetric impacts per cycle on the PS directly and on the obstacle alternate with various irregular regimes,namely,chaotic mode,intermittency,and crisis-induced *** regions of bilateral impacts are narrow and located near resonance;they are narrower for a system with an attached DSVI *** a system with an attached SSVI NES,there are wider areas of asymmetric unilateral impacts.

关键词： vibro-impact damper nonlinear energy sink single-sided double-sided vibrations mitigation optimization

Comparative Analysis of the Essential Oil of the Underground Organs of Valeriana spp. from Different Countries

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Phyton-International Journal of Experimental Botany 2024年第7期93卷 1365-1382页

作者： Ain Raal Valeriia Kokitko Vira Odyntsova Anne Orav Oleh Koshovyi Institute of Pharmacy University of TartuTartu50411Estonia Zaporizhzhia State Medical and Pharmaceutical university Zaporizhzhia69035Ukraine Institute of Chemistry Tallinn University of TechnologyTallinn12618Estonia national university of Pharmacy Kharkiv61002Ukraine

Valeriana ofﬁcinalis *** a plant from the Caprifoliaceae family,which is widely distributed in various parts of the world,especially in Europe and *** species of Valeriana are distinguished by their ability to synthesize essen-tial oil,which has a powerful effect on the physiological and mental aspects of the human *** aim was to study the qualitative and quantitative composition of essential oil from valerian roots,collected in different coun-tries,using the gas chromatography method,and to establish marker compounds for valerian species.13 samples of commercial roots with rhizomes of ***ﬁcinalis from nine countries of the world and a sample of Valeriana pratensis and Valeriana stolonifera growing in ukraine were selected for the *** essential oil was obtained from dried valerian roots by the distillation method described in the European *** determine the component composition of the essential oils of the selected samples,the methods of gas chromatography with a mass spectrometric detector and capillary gas chromatography were *** commercial samples of ***ﬁci-nalis from different countries yielded 0.21%–1.03%of essential *** six of 13 samples contained essential oil in an amount that satisﬁes the requirement of the European Pharmacopoeia standard(not less than 4 mL/kg).150 compounds were identiﬁed in the essential oils of 13 samples of ***ﬁcinalis essential *** range and average content and coefﬁcients of variation of the identiﬁed compounds were *** principal com-pounds of ***ﬁcinalis essential oils were bornyl acetate(1.6%–27.1%),valeranone(0.5%–17.9%),valerenal(0%–14.7%),camphene(0%–14.6%),α-fenchene(0%–10.6%),and valerenic acid(0%–8.5%).The samples of *** and *** yielded rather high levels of essential oil(1.18%and 0.93%,respectively).Three chemotypes of ***ﬁcinalis samples were determined-bornyl acetate/valerenal,valeranone,and isovaleric *** composition of the three essential

关键词： Valeriana ofﬁcinalis Valeriana pratensis Valeriana stolonifera volatile compounds terpenoids chemotype

Green synthesis of biocompatible Gd^(3+)-doped ultrasmall carbon-based nanohybrids from coffee wastes

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Carbon Resources Conversion 2024年第2期7卷 64-73页

作者： Konstantin Paliienko Anna Topchylo Sergei Alekseev Alain Géloën Yurii Milovanov Tetiana Lysenko Valeriy Skryshevsky Tatiana Borisova Vladimir Lysenko Department of Neurochemistry Palladin Institute of BiochemistryNational Academy of Sciences of Ukraine9 Leontovicha strKyiv 01054Ukraine Corporation Science Park Taras Shevchenko University of Kyiv60 Volodymyrska Str.Kyiv 01033Ukraine Institute of High Technologies Taras Shevchenko National University of Kyiv64 Volodymyrska Str.01601 KyivUkraine Faculty of Chemistry Taras Shevchenko National University of Kyiv64 Volodymyrska Str.01601 KyivUkraine UMR Ecologie Microbienne Lyon(LEM) CNRS 5557INRAE 1418Claude Bernard University of LyonVetAgro SupResearch Team“Bacterial Opportunistic Pathogens and Environment”(BPOE)University of LyonF-69622 VilleurbanneFrance Light Matter Institute UMR-5306Claude Bernard University of Lyon/CNRSUniversitéde Lyon69622 Villeurbanne CedexFrance

A cheap method allowing fabrication of biocompatible,ultra-small(2-10 nm)and fluorescent(λ_(em)=425-500 nm)nanohybrids(NHs)from coffee wastes is *** gadolinium-doped nanohybrids(GDNHs)or gadolinium-free carbon dots(GFCDs)can be synthesized in a domestic microwave oven according to green synthesis *** sizes,chemical composition,impact on proton magnetic resonance relaxation time and optical properties of the GDNHs and GFCDs were studied in details and *** particular,doping of the NHs with Gd^(3+)ions,up to 1.87%w/w of gadolinium per particles’weight,will allow their application for magnetic resonance imaging(MRI).Furthermore,cell culture tests on human adenocarcinomic alveolar basal epithelial cells line(A549)have shown high biocompatibility of the GDNHs and in a wide concentration range 100-1000μg/ml.

关键词： Carbon dots from coffee waste Carbon dots for MRI Gadolinium-doped carbon dots Microwave-assisted synthesis

Representation of three-dimensional mass distribution of the Earth's interior by biorthogonal series and its use for studying internal structure of the planet

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Geodesy and Geodynamics 2024年第3期15卷 264-275页

作者： Mykhailo Fys Mariana Yurkiv Andrii Brydun Andrii Sohor Department of Cartography and Geospatial Modelling Lviv Polytechnic National UniversityLviv 79013Ukraine

This paper utilizes the mathematical concept of approximation within an ellipsoid from a single viewpoint to present the spatial mass distribution function of the Earth's interior and its internal *** primary focus lies in constructing the volume distribution of masses in the planet's interior, with the expansion coefficients being linear combinations of the Stokes constants. Several possible approaches are suggested for determining accurately these coefficients employing three-dimensional(biorthogonal)polynomials. By expressing the mass distribution function of the Earth's interior and its internal potential as a series, an algorithm is introduced for the calculation of gravitational energy. It allows us to estimate fluctuations in gravitational energy. The implementation of this algorithm offers the means of establishing the extent to which the Earth deviates from a state of hydrostatic equilibrium as a celestial *** to the aforementioned method, calculations have been conducted to validate its effectiveness and reliability. This example is given as an illustration of a given method for studying the internal structure of planets.

关键词： Mass distribution function Potential Stokes constants Biorthogonal polynomials

In Situ Mineralization of Biomass-Derived Hydrogels Boosts Capacitive Electrochemical Energy Storage in Free-Standing 3D Carbon Aerogels

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Energy & Environmental Materials 2024年第2期7卷 359-371页

作者： Anjali Achazhiyath Edathil Babak Rezaei Kristoffer Almdal Stephan Sylνest Keller national Centre for Nano Fabrication and Characterization DTU NanolabTechnical University of Denmark2800LyngbyDenmark DTU Chemistry Technical University of Denmark2800LyngbyDenmark

Here,a novel fabrication method for making free-standing 3D hierarchical porous carbon aerogels from molecularly engineered biomass-derived hydrogels is *** situ formed flower-like CaCO_(3)molecularly embedded within the hydrogel network regulated the pore structure during in situ mineralization assisted one-step activation graphitization(iMAG),while the intrinsic structural integrity of the carbon aerogels was *** homogenously distributed minerals simultaneously acted as a hard template,activating agent,and graphitization *** decomposition of the homogenously distributed CaCO_(3)during iMAG followed by the etching of residual CaO through a mild acid washing endowed a robust carbon aerogel with high porosity and excellent electrochemical *** 0.5 mA cm^(-2),the gravimetric capacitance increased from 0.01 F g^(-1)without mineralization to 322 F g^(-1)with iMAG,which exceeds values reported for any other free-standing or powder-based biomass-derived carbon *** outstanding cycling stability of~104%after 1000 cycles in 1 M HClO4 was *** assembled symmetric supercapacitor device delivered a high specific capacitance of 376 F g^(-1)and a high energy density of 26 W h kg^(-1)at a power density of 4000 W kg^(-1),with excellent cycling performance(98.5%retention after 2000 cycles).In combination with the proposed 3D printed mold-assisted solution casting(3DMASC),iMAG allows for the generation of free-standing carbon aerogel architectures with arbitrary ***,the novel method introduces flexibility in constructing free-standing carbon aerogels from any ionically cross-linkable biopolymer while maintaining the ability to tailor the design,dimensions,and pore size distribution for specific energy storage applications.

关键词： biomass carbon aerogel sustainable energy materials free-standing supercapacitors

Assessing the impacts of traffic calming at network level:A multimodal agent-based simulation

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Journal of Traffic and Transportation Engineering(English Edition) 2024年第1期11卷 41-54页

作者： Eftychia Zargiannaki Panagiotis G.Tzouras Eleni Antoniou Christos Karolemeas Konstantinos Kepaptsoglou School of Rural Surveying and Geoinformatics EngineeringNational Technical University of AthensZografou 15780Greece

The reduction of speed limits in urban roads through traffic calming schemes intends to ensure safer traffic conditions among road users by reducing the probability related to the occurrence of severe *** it from a different perspective,traffic calming measures can potentially resolve congestion problems at the same time by lowering the overall accessibility and attractiveness of private cars in urban *** study proposes a new methodological approach to explore and assess the direct impacts of traffic calming in the transport system efficiency of a metropolitan *** multi-agent transport simulation(MATSim)and Open-Berlin scenario are utilized to perform this simulation *** developing a new external tool,the free flow speed and road capacity of each network link is updated based on new speed limits and different compliance rates,which are defined per road hierarchy *** test scenarios that are formulated present radical conditions,where the speed limit in most urban roads of Berlin drops to 30 km/h or even 15 km/*** findings of this study show a considerably high increase in trips,passenger hours,and passenger kilometers using public transport modes,when traffic calming links are introduced,the reserve change is observed in private cars *** the speed limits are decreased in inner urban roads in most of the scenarios,the decrease of average travel speed of private cars is not so high as it was ***,private cars are used for longer distances in all test *** drivers seem to use already existed motorways and private road to *** simulations,driver compliance to the new speed limits seems to be a determinant factor that is strongly influenced by the design interventions applied in a traffic calming area.

关键词： Agent-based simulation Traffic calming Impact assessment Urban road network