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Respiratory training interventions improve health status of heart failure patients: A systematic review and network meta-analysis of randomized controlled trials

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World Journal of Clinical Cases 2019年第18期7卷 2760-2775页

作者： Mei-Hua Wang Mei-Ling Yeh school of nursing National Taipei University of Nursing and Health Sciences

BACKGROUND Prior studies indicate that doing breathing exercises improves physical performance and quality of life (QoL) in heart failure patients. However, these effects remain unclear and contradictory. AIM To determine the effects of machine-assisted and non-machine-assisted respiratory training on physical performance and QoL in heart failure patients. METHODS This was a systematic review and network meta-analysis study. A literature search of electronic databases was conducted for randomized controlled trials (RCTs) on heart failure. Respiratory training interventions were grouped as seven categories: IMT_Pn (inspiratory muscle training without pressure or < 10% maximal inspiratory pressure, MIP), IMT_Pl (inspiratory muscle training with low pressure, 10%-15% MIP), IMT_Pm (inspiratory muscle training with medium pressure, 30%-40% MIP), IMT_Ph (inspiratory muscle training with high pressure, 60% MIP or MIP plus aerobics), Aerobics (aerobic exercise or weight training), Qi_Ex (tai chi, yoga, and breathing exercise), and none. The four outcomes were heart rate, peak oxygen uptake (VO2 peak), 6-min walking distance test (6MWT), and Minnesota Living with Heart Failure QoL. The random-effects model, side-splitting model, and the surface under the cumulative ranking curve (SUCRA) were used to test and analyze the data. RESULTS A total of 1499 subjects from 31 RCT studies were included. IMT_Ph had the highest effect sizes for VO2 peak and 6MWT, IMT_Pm highest for QoL, and Qi_Ex highest for heart rate. Aerobics had the second highest for VO2 peak, Qi_Ex second highest for 6MWT, and IMT_Ph second highest for heart rate and *** This study supports that high- and medium-intensity machine-assisted training improves exercise capacity and QoL in hospital-based heart failure patients. After hospital discharge, non-machine-assisted training continuously improves cardiac function.

关键词： Heart failure Network meta-analysis Respiratory training Cardiac function Exercise capacity Quality of life

Low-level laser acupuncture reduces postoperative pain and morphine consumption in older patients with total knee arthroplasty: A randomized placebo-controlled trial

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Journal of Integrative Medicine 2022年第4期20卷 321-328页

作者： Chiung-Hui Huang Mei-Ling Yeh Fang-Pey Chen Daphne Wu Department of nursing Taipei Veterans General HospitalTaipei City 11217TaiwanChina school of nursing National Taipei University of Nursing and Health SciencesTaipei City 11219TaiwanChina Center for Traditional Medicine Taipei Veterans General HospitalTaipei City 11217TaiwanChina Scool of nursing National Taipei University of Nursing and Health Sciences and School of MedicineTaipei City 11217TaiwanChina

Background: Patients commonly develop postoperative pain after total knee arthroplasty(TKA).Acupuncture-related techniques and low-level laser therapy could be beneficial for pain management for older ***: To examine the effect of low-level laser acupuncture(LA) in reducing postoperative pain, painrelated interference in daily life, morphine consumption, and morphine-related side effects in older patients with knee osteoarthritis who underwent ***, setting, participants and intervention: A single-blind randomized placebo-controlled trial was conducted. Patients(N = 82) were recruited and randomly assigned via a computer-generated list to the LA group or a placebo group. The LA group received low-level laser therapy at Sanyinjiao(SP6), Taixi(KI3),Kunlun(BL60), Fengshi(GB31), Futu(ST32) and Neiguan(PC6) after TKA, while the placebo acupuncture group received the same treatment procedure without laser energy *** outcome measures: The primary outcome was postoperative pain intensity, and it was measured at baseline and hours 2, 6, 10, 24, 48 and 72 after TKA. The secondary outcomes, including relative pain,postoperative pain-related interference in daily life and morphine consumption, were measured at hours24, 48 and 72 after ***: Generalized estimating equations revealed significant between-group differences in pain intensity(P = 0.01), and trend differences in pain intensity for the LA group starting at hours 10 to 72(P < 0.05)and morphine consumption at hours 48 and 72(P < 0.05). The changes in pain-related interference in daily life were significant(P < 0.05) at 72 h, with the exception of the parameters for worst pain, mood,and sleep. Nausea and vomiting side effects from morphine had significant between-group differences at hours 10 and 24(P < 0.05).Conclusion: Low-level LA gradually reduced older patients’ postoperative pain intensity and morphine consumption within the first 72 h after their TKA for osteoarthritis. Low-le

关键词： Acupuncture Morphine Low-level laser Older patients Osteoarthritis Pain Total knee arthroplasty Randomized controlled trial

Congenital ovarian anomaly manifesting as extra tissue connection between the two ovaries:A case report

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World Journal of Clinical Cases 2022年第26期10卷 9318-9322页

作者： Myeong Gyun Choi Jong Woon Kim Yoon Ha Kim A Mi Kim Tae Young Kim Hyun Kyung Ryu Department of obstetrics and Gynecology Chonnam National University Medical SchoolGwangju 61469South Korea

BACKGROUND Ovarian anomalies except for uni-or bilateral streak gonads are *** present a rare case of an ovarian anomaly in which both ovaries were connected by extra *** SUMMARY A 32-year-old,primipara with a twin pregnancy at 36 weeks of gestation was admitted to the hospital with severe *** underwent emergency cesarean section owing to persistent headache,blurred vision,and general *** a peritoneal incision,a thin rectangular-shaped tissue was seen in front of the *** delivery,the extra tissue was removed;no other anomalies were reported in either the ovaries or *** results of the removed tissue disclosed a well-vascularized loose stromal tissue with few follicles and scattered luteinized *** this case,to prevent pelvic adhesion or intestinal obstruction resulting from volvulus,strangulation,and torsion,the extra tissue was *** We report a case of a rare ovarian anomaly where both ovaries were connected by extra *** the extra tissue extends to the abdominal cavity,it should be removed to prevent pelvic adhesion or abdominal complications including intestinal volvulus,strangulation,and torsion.

关键词： Connected ovaries Extra tissue Ovarian anomaly Case report

Epidemiological status of malaria in Iran,2011-2014

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Asian Pacific Journal of Tropical Medicine 2016年第11期9卷 1033-1039页

作者： Faezeh Norouzinejad Ahmad Raeisi Abbas norouzinejad Fatemeh Ghaffari school of nursing and Midwifery Babol University of Medical SciencesSchool of Nursing and Midwifery Ramsar nursing Care Research Center Babol University of Medical Sciences national Program Manager for Malaria Control Ministry of Health and Medical Education

Objective:To determine the status and epidemiological aspects of malaria in Iran in favor of gaining a better understanding of the national control of ***:This epidemiological study examined the status of malaria from 2011 to 2014 in *** were collected from the Ministry of Health's protocol for controlling and eliminating malaria,which is currently in *** malaria information reporting system is automated in all Iranian provinces and cities,and all information is submitted online to the center for communicable disease control in the Ministry of *** about malaria is available for researchers to ***:The incidence rates decreased from 2011 to *** were 4.76,2.12,1.80,and 1.59 per 100 000 people,respectively from 2011 to *** the four-year period(2011-2014),the highest numbers of cases occurred in those aged 16-25 years,by age,and in men,by *** of the cases were workers and located in rural *** average 52.58%of cases were *** highest incidence rates from 2011 to 2014 were located in Sistan and Baluchestan *** were 89.94,43.9,38.3,and 30.66 per 100 000 *** highest numbers of malaria cases were recorded in the cities Sarbaz,Nickshahr,and Chabahar in Sistan and Baluchestan province and Bandar Abbas,Bandar Jask,and Bandar Lengeh in Hormozgan *** the four-year period,57.05%of cases were caused by imported *** majority of cases were related to the trophozoite lifecycle of *** surveillance,there was inactive care in the majority of *** malaria was the most ***:Despite the recendy declining trend in reported cases,the expansion of local transmission,especially in areas with cross-border travel,is very *** malaria control interventions can be effective for elimination of malaria in Iran;these can include programs to control border travel and focused interventions for high incidence areas and high-risk group

关键词： Malaria Epidemiology Iran

Adjuvant chemotherapy for early-stage cervical cancer

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Chinese Journal of Cancer Research 2016年第2期28卷 228-234页

作者： Hiroshi Asano Yukiharu Todo Hidemichi Watari Department of obstetrics and Gynecology Hokkaido University School of Medicine Division of Gynecologic Oncology National Hospital OrganizationHokkaido Cancer Center

The aim of this review is to address the current status of adjuvant chemotherapy alone in early-stage cervical cancer treatments in the literature. At present, the therapeutic effect of adjuvant chemotherapy alone after radical surgery （RS） has not yet been established, and radiation therapy （RT） or concurrent chemoradiotherapy （CCRT） is recommended as the standard adjuvant therapy after RS for early-stage cervical cancer in various guidelines. The main purpose of adjuvant therapy after RS, however, should be to reduce extrapelvic recurrence rather than local recurrence, although adjuvant RT or CCRT has survival benefits for patients with intermediate- or high-risk factors for recurrence. Moreover, several studies reported that adjuvant therapies including RT were associated with a higher incidence of complications, such as lymphedema, bowel obstruction and urinary disturbance, and a lower grade of long-term quality of life （QOL） or sexual functioning than adjuvant chemotherapy alone. The effect of adjuvant chemotherapy alone for early-stage cervical cancer with intermediate- or high-risk factors for recurrence were not fully investigated in prospective studies, but several retrospective studies suggest that the adjuvant effects of chemotherapy alone are at least similar to that of RT or CCRT in terms of recurrence rate, disease-free survival, or overall survival （OS） with lower incidence of complications. Whereas cisplatin based combination regimens were used in these studies, paclitaxel/cisplatin （TP） regimen, which is currently recognized as a standard chemotherapy regimen for patients with metastatic, recurrent or persistent cervical cancer by Gynecologic Oncology Group （GOG）, had also survival benefit as an adjuvant therapy. Therefore, it may be worth considering a prospective randomized controlled trial （RCT） of adjuvant chemotherapy alone using TP regimen versus adjuvant RT as an alternative adjuvant therapy. Because early-stage cervical cancer is a curable c

关键词： Adjuvant chemotherapy cervical cancer quality of life (QOL) survival intermediate-risk disease

Development of immature ovarian teratoma after mature teratoma in a girl with familial ovarian teratoma:A case report

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World Journal of Clinical Cases 2024年第8期12卷 1442-1447页

作者： U Chul Ju Woo Dae Kang Seok Mo Kim Department of obstetrics and Gynecology Chonnam National University Medical SchoolGwangju 61469South Korea

BACKGROUND Immature ovarian teratoma is a rare and aggressive neoplasm that affects young *** report is the first to describe the development of immature teratoma after ovarian cystectomy for mature teratoma of the ovary in an adolescent female with a family history of ovarian *** SUMMARY A 16-year-old girl who had undergone bilateral ovarian cystectomy for mature teratomas 3 years ago showed bilateral adnexal tumors during her regular ultrasonography follow-up every 6 *** received laparoscopic bilateral ovarian cystectomy,and final histopathology showed grade-1 immature teratoma of the left ovary and mature teratoma of the right *** left salpingo-oophorectomy and staging procedures were performed *** mother,maternal aunt,and maternal grandmother had also received surgeries for mature ovarian *** It is important to have guidance on management of patient and family members with familial ovarian teratomas.

关键词： Familial ovarian teratomas Adolescent female Immature ovarian teratoma Management Case report

Circulating immune cell landscape in patients who had mild ischaemic stroke

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Stroke & Vascular Neurology 2022年第4期7卷 319-327,I0020-I0022页

作者： Young-Eun Cho Hyangkyu Lee Heekyong R.Bae Hyungsuk Kim Sijung Yun Rany Vorn Ann Cashion Mary Jo Rucker Mariam Afzal Lawrence Latour Jessica Gill College of nursing The University of IowaIowa CityIowaUSA national Institute of nursing Research National Institutes of HealthBethesdaMarylandUSA Mo-Im Kim nursing Research Institute College of NursingYonsei UniversitySeoulSouth Korea national Eye Institute National Institutes of HealthBethesdaMarylandUSA Predictiv Care IncSunnyvaleCaliforniaUSA school of nursing Johns Hopkins UniversityBaltimoreMarylandUSA College of nursing University of Tennessee Health Science CenterMemphisTennesseeUSA Suburban Hospital BethesdaMarylandUSA national Institute of Neurological Disorders and Stroke National Institutes of HealthBethesdaMarylandUSA

Introduction Patients who had a mild ischaemic stroke who present with subtle or resolving symptoms sometimes go undiagnosed,are excluded from treatment and in some cases clinically *** immune cells are potential biomarkers that can assist with diagnosis in ischaemic *** the transcriptomic changes of each cell population caused by ischaemic stroke is critical because they work closely in a complicated *** this study,we investigated peripheral blood mononuclear cells(PBMCs)transcriptomics of patients who had a stroke using a single-cell RNA sequencing to understand peripheral immune response after mild stroke based on the gene expression in an unbiased *** Transcriptomes of PBMCsfrom 10 patients who had an acute ischaemic stroke within 24 hours after stroke onset were compared with 9 race-matched/age-matched/gender-matched *** PBMCs were prepared with ddSeqTM(Illumina-BioRad)and sequenced on the Illumina NovaSeq 6000 *** Notable population changes were observed in patients who had a stroke,especially in NK cells and CD14+*** number of NK cells was increased,which was further confirmed by flow *** analysis implied that the activity of NK cells also is enhanced in patients who had a ***14+monocytes were clustered into two groups;dendritic cell-related CD14+monocytes and NK cell-related CD14+*** found CD14+monocyte subclusters were dramatically reduced in patients who had a *** This is the first study demonstrating the increased number of NK cells and new monocyte subclusters of mild ischaemic stroke based on the transcriptomic *** findings provide the dynamics of circulating immune response that could assist diagnosis and potential therapeutic development of mild ischaemic stroke.

关键词： patients diagnosis Circulating

Chitosan hydrogel encapsulated with LL-37 peptide promotes deep tissue injury healing in a mouse model

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Military Medical Research 2020年第4期7卷 409-417页

作者： Xu Yang Jing-Lin Guo Jing Han Rui-Juan Si Pan-Pan Liu Zi-Rui Zhang Ai-Min Wang Ju Zhang school of nursing Qingdao UniversityQingdao 266021China

Background:LL-37 peptide is a member of the human cathelicidin family,and has been shown to promote the healing of pressure ***,the low stability of this peptide within the wound environment limits its clinical ***(CS)hydrogel is commonly used as a base material for wound dressing ***:CS hydrogel(2.5%w/v)was encapsulated with *** of the product was examined in cultured NIH3 T3 *** on immune response was examined by measuring tumor necrosis factor-α(TNF-α)release from RAW 264.7 macrophages upon exposure to *** activity was assessed using Staphylococcus *** effect on pressure ulcers was examined using a mouse ***,adult male C57 BL/6 mice were subjected to skin pressure using magnets under a 12/12 h schedule for 21 *** were randomized to receive naked LL-37(20μg),chitosan gel containing 20μg LL-37(LL-37/CS hydrogel)or hydrogel alone under the ulcer bed(n=6).A group of mice receiving no intervention was also included as a ***:LL-37/CS hydrogel did not affect NIH3 T3 cell *** a concentration of 1–5μg/ml,LL-37/CS inhibited TNF-αrelease from *** 5μg/ml,LL-37/CS inhibited the growth of Staphylococcus *** area of the pressure ulcers was significantly lower in mice receiving LL-37/CS hydrogel in comparison to all other 3 groups on days 11(84.24%±0.25%),13(56.22%±3.91%)and 15(48.12%±0.28%).Histological examination on days 15 and 21 showed increased epithelial thickness and density of newly-formed capillary with naked LL-37 and more so with LL-37/*** expression of key macromolecules in the process of angiogenesis(i.e.,hypoxia inducible factor-1α(HIF-1α)and vascular endothelial growth factor-A(VEGF-A))in wound tissue was increased at both the mRNA and protein ***:Chitosan hydrogel encapsulated with LL-37 is biocompatible and could promote the healing of pressure ulcers.

关键词： LL-37 Chitosan hydrogel Deep tissue injury Pressure ulcer Cathelicidin

Recent advances on the molecular mechanisms of exercise-induced improvements of cognitive dysfunction

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Translational Neurodegeneration 2023年第1期12卷 745-765页

作者： Yi Lu Fa-Qian Bu Fang Wang Li Liu Shuai Zhang Guan Wang Xiu-Ying Hu West China school of nursing Sichuan University/Innovation Center of Nursing ResearchNursing Key Laboratory of Sichuan ProvinceState Key Laboratory of Biotherapy and Cancer CenterNational Clinical Research Center for GeriatricsWest China HospitalSichuan UniversityChengdu 610041China

Physical exercise is of great significance for maintaining human *** can provide varying degrees of benefits to cognitive function at all stages of life ***,with the aging of the world’s population and increase of life expectancy,cognitive dysfunction has gradually become a disease of high incidence,which is accompanied by neurodegenerative diseases in elderly *** often exhibit memory loss,aphasia and weakening of orientation once diagnosed,and are unable to have a normal *** dysfunction largely affects the physical and mental health,reduces the quality of life,and causes a great economic burden to the *** present,most of the interventions are aimed to maintain the current cognitive level and delay deterioration of *** contrast,exercise as a nonpharmacological therapy has great advantages in its nontoxicity,low cost and universal *** molecular mechanisms underlying the effect of exercise on cognition are complex,and studies have been extensively centered on neural plasticity,the direct target of exercise in the *** addition,mitochondrial stability and energy metabolism are essential for brain ***,the organ-brain axis responds to exercise and induces release of cytokines related to *** this review,we summarize the latest evidence on the molecular mechanisms underlying the effects of exercise on cognition,and point out directions for future research.

关键词： Exercise Cognitive function Molecular mechanism Neurodegenerative disease Nonpharmacological therapy