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AAV2-PDE6B restores retinal structure and function in the retinal degeneration 10 mouse model of retinitis pigmentosa by promoting phototransduction and inhibiting apoptosis

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Neural Regeneration Research 2025年第8期20卷 2408-2419页

作者： Ruiqi Qiu Mingzhu Yang Xiuxiu Jin Jingyang Liu Weiping Wang Xiaoli Zhang Jinfeng Han Bo Lei Henan Eye Hospital Henan Provincial People’s HospitalPeople’s Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina Eye Institute Henan Academy of Innovations in Medical ScienceZhengzhouHenan ProvinceChina Branch of national Clinical Research Center for Ocular Disease Henan Provincial People’s HospitalZhengzhouHenan ProvinceChina Academy of Medical Science Zhengzhou UniversityZhengzhouHenan ProvinceChina

Retinitis pigmentosa is a group of inherited diseases that lead to retinal degeneration and photoreceptor cell ***,there is no effective treatment for retinitis pigmentosa caused by PDE6B ***-associated virus(AAV)-mediated gene therapy is a promising strategy for treating retinitis *** aim of this study was to explore the molecular mechanisms by which AAV2-PDE6B rescues retinal *** do this,we injected retinal degeneration 10(rd10)mice subretinally with AAV2-PDE6B and assessed the therapeutic effects on retinal function and structure using dark-and light-adapted electroretinogram,optical coherence tomography,and ***-independent acquisition-mass spectrometry-based proteomic analysis was conducted to investigate protein expression levels and pathway enrichment,and the results from this analysis were verified by real-time polymerase chain reaction and western ***2-PDE6B injection significantly upregulated PDE6βexpression,preserved electroretinogram responses,and preserved outer nuclear layer thickness in rd10 *** expressed proteins between wild-type and rd10 mice were closely related to visual perception,and treating rd10 mice with AAV2-PDE6B restored differentially expressed protein expression to levels similar to those seen in wild-type *** Encyclopedia of Genes and Genome analysis showed that the differentially expressed proteins whose expression was most significantly altered by AAV2-PDE6B injection were enriched in phototransduction ***,the phototransductionrelated proteins Pde6α,Rom1,Rho,Aldh1a1,and Rbp1 exhibited opposite expression patterns in rd10 mice with or without AAV2-PDE6B ***,Bax/Bcl-2,p-ERK/ERK,and p-c-Fos/c-Fos expression levels decreased in rd10 mice following AAV2-PDE6B *** data suggest that AAV2-PDE6B-mediated gene therapy promotes phototransduction and inhibits apoptosis by inhibiting the ERK signaling pathway and upr

关键词： apoptosis AAV2-PDE6B ERK1/2 gene therapy phototransduction proteomics rd10 retinitis pigmentosa

Enhancing postoperative pain control by surgically-initiated rectus sheath block in abdominal aortic aneurysm open repair: A case report

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World Journal of Clinical Cases 2025年第6期13卷 41-47页

作者： Kuan-Hua Chen Ming-Yuan Kang Yi-Ting Chang Sheng-Yang Huang Yung-Szu Wu Center for Cardiovascular Disease Taichung Veterans General HospitalTaichung 407219TaiwanChina Department of Anesthesiology Taichung Veterans General HospitalTaichung 407219TaiwanChina Division of Pediatric Surgery Department of SurgeryTaichung Veterans General HospitalTaichung 407219TaiwanChina School of Medicine National Yang Ming Chiao Tung UniversityTaipei 112304TaiwanChina Department of Post-Baccalaureate Medicine National Chung Hsing UniversityTaichung 402202TaiwanChina

BACKGROUND Abdominal aortic aneurysm(AAA)repair often involves significant postoperative pain,traditionally managed with systemic opioids,which can cause undesirable side *** case report explores the novel use of a surgically-initiated rectus sheath block with a catheter-over-needle assembly for pain management in AAA *** SUMMARY A 67-year-old female with hypertension and previous aortic dissection underwent elective open repair of an infrarenal AAA,which had grown from 3.4 cm to 4.3 cm over 14 months.A rectus sheath block was initiated surgically for postoperative pain *** patient reported low pain scores and did not require systemic intravenous opioids,enabling early ambulation and discharge on postoperative day seven without *** preventing complications of systemic opi-oids,the method indicating a promising direction for postoperative pain management in major vascular *** Surgically-initiated rectus sheath block as a valuable tool for managing postoperative pain in AAA repair.

关键词： Abdominal aortic aneurysm Postoperative pain management Rectus sheath block Surgical anesthesia Opioid-sparing techniques Case report

Challenges in the management of visual and tactile hallucinations in elderly people

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World Journal of Psychiatry 2025年第1期15卷 185-188页

作者： Si-Sheng Huang Division of Geriatric Psychiatry Department of PsychiatryChanghua Christian HospitalChanghua 500Taiwan Department of Post-Baccalaureate Medicine College of MedicineNational Chung Hsing UniversityTaichung 402Taiwan

This letter provides a concise review of the pertinent literature on visual and tactile hallucinations in elderly *** discussion addresses differential diagnoses and potential underlying mechanisms,as well as the psychopathology associated with tactile hallucinations,and emphasizes the necessity for invest-igation into the possibility of coexisting delusional infestation(parasitosis).These symptoms frequently manifest in patients with primary psychotic disorders,organic mental disorders,and substance use *** proposed pathophy-siological mechanisms may involve dopaminergic imbalances and dysfunction of the striatal dopamine transporter.

关键词： Delusional infestation Dementia Haptic hallucination Scratching behavior Tactile hallucination Visual hallucination Alzheimer’s disease

Regression analysis of squeezing-induced hybrid nanofluid flow in Darcy-Forchheimer porous medium

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Applied Mathematics and Mechanics(English Edition) 2025年第01期 193-208页

作者： K.MUHAMMAD M.SARFRAZ Department of Humanities and Sciences School of Electrical Engineering and Computer Science National University of Sciences and Technology Department of Mathematics Quaid-i-Azam University

This article presents a mathematical model addressing a scenario involving a hybrid nanofluid flow between two infinite parallel plates. One plate remains stationary, while the other moves downward at a squeezing velocity. The space between these plates contains a Darcy-Forchheimer porous medium. A mixture of water-based fluid with gold(Au) and silicon dioxide(Si O2) nanoparticles is formulated. In contrast to the conventional Fourier's heat flux equation, this study employs the Cattaneo-Christov heat flux equation. A uniform magnetic field is applied perpendicular to the flow direction, invoking magnetohydrodynamic(MHD) effects. Further, the model accounts for Joule heating, which is the heat generated when an electric current passes through the fluid. The problem is solved via NDSolve in MATHEMATICA. Numerical and statistical analyses are conducted to provide insights into the behavior of the nanomaterials between the parallel plates with respect to the flow, energy transport, and skin *** findings of this study have potential applications in enhancing cooling systems and optimizing thermal management strategies. It is observed that the squeezing motion generates additional pressure gradients within the fluid, which enhances the flow rate but reduces the frictional drag. Consequently, the fluid is pushed more vigorously between the plates, increasing the flow velocity. As the fluid experiences higher flow rates due to the increased squeezing effect, it spends less time in the region between the plates. The thermal relaxation, however, abruptly changes the temperature, leading to a decrease in the temperature fluctuations.

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Selective enriching of trionic emission in a WS2-ZnO hybrid through type-Ⅱ band alignment

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Science China(Information Sciences) 2023年第6期66卷 63-70页

作者： Jin Feng LEONG Kim Yong LIM Xiao WU Qinghua XU Chorng Haur SOW Eng Tuan POH Department of Physics National University of Singapore Department of Chemistry National University of Singapore

Strategies to modulate the exciton dynamics in ultrathin two-dimensional(2D)semiconductors have always been an integral component in the bid towards improved optoelectronics and quantum photonic devices. The capability to non-destructively tune the relaxation dynamics, valley polarization, binding energies, and population ratio of various excitonic species has been well-sought for advanced *** the rationale design of a WS2-ZnO hybrid platform, we present a distinct increment in the trion-toexciton ratio for WS2emission across a patterned heterostructure. The shift in dominant excitonic species arose due to the efficient charge segregation at the spatially confined interface of the type-Ⅱ *** to the charge transfer process, the resultant emission profile presents up to four times amplification in the trion-to-exciton ratio, with temperature variable trion binding energies up to 59 meV. Since trions possess non-zero charge and spin degrees of freedom, the provision of a higher density of trions with increased binding stability would encourage new opportunities for reproducible optoelectronics and quantum emitters.

关键词： heterostructure trions type-II band alignment

Active control of friction by transverse oscillations

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Friction 2019年第1期7卷 74-85页

作者： J.BENAD K.NAKANO V.L.POPOV M.POPOV Technische Universit?t Berlin Yokohama national university national Research Tomsk Polytechnic university national Research Tomsk State university

The present paper is devoted to a theoretical analysis of sliding friction under the influence of in-plane oscillations perpendicular to the sliding direction. Contrary to previous studies of this mode of active control of friction, we consider the influence of the stiffness of the tribological contact in detail and show that the contact stiffness plays a central role for small oscillation amplitudes. In the present paper we consider the case of a displacement-controlled system, where the contact stiffness is small compared to the stiffness of the measuring system. It is shown that in this case the macroscopic coefficient of friction is a function of two dimensionless parameters— a dimensionless sliding velocity and dimensionless oscillation amplitude. In the limit of very large oscillation amplitudes, known solutions previously reported in the literature are reproduced. The region of small amplitudes is described for the first time in this paper.

关键词： sliding friction in-plane oscillation contact stiffness coefficient of friction active control of friction

Design of bridges against large tectonic deformation

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Earthquake Engineering and Engineering Vibration 2008年第4期7卷 345-368页

作者： I.Anastasopoulos G.Gazetas V.Drosos T.Georgarakos R.Kourkoulis national Technical university

The engineering community has devoted much effort to understanding the response of soil-structure systems to seismic ground motions, but little attention to the effects of an outcropping fault offset. The 1999 earthquakes of Turkey and Taiwan, offering a variety of case histories of structural damage due to faulting, have （re）fueled the interest on the subject. This paper presents a methodology for design of bridges against tectonic deformation. The problem is decoupled in two analysis steps： the first （at the local level） deals with the response of a single pier and its foundation to fault rupture propagating through the soil, and the superstructure is modeled in a simplified manner; and the second （at the global level） investigates detailed models of the superstructure subjected to the support （differential） displacements of Step 1. A parametric study investigates typical models of viaduct and overpass bridges, founded on piles or caissons. Fixed-head piled foundations are shown to be rather vulnerable to faulting-dnduced deformation. End-bearing piles in particular are unable to survive bedrock offsets exceeding 10 cm. Floating piles perform better, and if combined with hinged pile-to-cap connections, they could survive much larger offsets. Soil resilience is beneficial in reducing pile distress. Caisson foundations are almost invariably successful. Statically-indeterminate superstructures are quite vulnerable, while statically-determinate are insensitive （allowing differential displacements and rotations without suffering any distress）. For large-span cantilever-construction bridges, where a statically determinate system is hardly an option, inserting resilient seismic isolation bearings is advantageous as long as ample seating can prevent the deck from falling off the supports. An actual application of the developed method is presented for a major bridge, demonstrating the feasibility of design against tectonic deformation.

关键词： fault rupture earthquake soil-structure interaction bridge viaduct pile group caisson foundation finite elements

Fin width and height dependence of bipolar amplification in bulk FinFETs submitted to heavy ion irradiation

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Chinese Physics B 2015年第11期24卷 650-655页

作者：于俊庭陈书明陈建军黄鹏程 College of Computer National University of Defense Technology national Laboratory for Parallel and Distributed Processing National University of Defense Technology

FinFET technologies are becoming the mainstream process as technology scales down. Based on a 28-nm bulk p- FinFET device, we have investigated the fin width and height dependence of bipolar amplification for heavy-ion-irradiated FinFETs by 3D TCAD numerical simulation. Simulation results show that due to a well bipolar conduction mechanism rather than a channel （fin） conduction path, the transistors with narrower fins exhibit a diminished bipolar amplification effect, while the fin height presents a trivial effect on the bipolar amplification and charge collection. The results also indicate that the single event transient （SET） pulse width can be mitigated about 35% at least by optimizing the ratio of fin width and height, which can provide guidance for radiation-hardened applications in bulk FinFET technology.

关键词： fin width and height bipolar amplification single event transient bulk FinFET

Single event upset induced by single event double transient and its well-structure dependency in 65-nm bulk CMOS technology

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Science China(Information Sciences) 2016年第4期59卷 152-159页

作者： Pengcheng HUANG Shuming CHEN Jianjun CHEN College of Computer National University of Defense Technology national Laboratory for Parallel and Distributed Processing National University of Defense Technology

Single event upset (SEU) is one of the most important origins of soft errors in aerospace *** technology scales down persistently, charge sharing is playing a more and more significant effect on SEU of flip-flop. Charge sharing can often bring about multi-node charge collection in storage nodes and non-storage nodes in a flip-flop. In this paper, multi-node charge collection in flip-flop data input and flip-flop clock signal is investigated by 3D TCAD mixed-mode simulations, and the simulate results indicate that single event double transient (SEDT) in flip-flop data input and flip-flop clock signal can also cause a SEU in flip-flop. This novel mechanism is called the SEDT-induced SEU, and it is also verified by heavy-ion experiment in 65 nm twin-well process. The simulation results also indicate that this mechanism is closely related with the well-structure,and the triple-well structure is more effective to increase the SEU threshold of this mechanism than twin-well structure.

关键词： single event upset (SEU) single event double transient (SEDT) SEDT-induced SEU parasitic bipolar effect (PBE) charge sharing