检索结果-南通市图书馆

Engineered protein and Jakinib nanoplatform with extraordinary rheumatoid arthritis treatment

Nano Research 2023年第8期16卷 11197-11205页

作者： Yuanxin Li Bo Li Gang Wang Juanjuan Su Yilin Qiao Chao Ma Fan Wang Jian Zhu Jingjing Li Hongjie Zhang Kai Liu Huji Xu State Key Laboratory of rare earth Resource Utilization Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China University of Science and Technology of China Hefei 230026China Engineering Research Center of Advanced rare earth Materials (Ministry of Education)Department of ChemistryTsinghua UniversityBeijing 100084China School of Clinical Medicine Tsinghua UniversityBeijing 100084China College of Materials Science and Opto-Electronic Technology University of Chinese Academy of SciencesBeijing 100049China First Medical centre Chinese PLA General HospitalBeijing 100853China

Rheumatoid arthritis(RA)is a relatively common inflammatory disease that affects the synovial tissue,eventually results in joints destruction and even long-term *** Janus kinase inhibitors(Jakinibs)show a rapid efficacy and are becoming the most successful agents in RA therapy,high dosing at frequent interval and severe toxicities cannot be ***,we developed a new type of fully compatible nanocarriers based on recombinant chimeric proteins with outstanding controlled release of *** addition,the fluorescent protein component of the nanocarriers enabled noninvasive fluorescence imaging of RA lesions,thus allowing real-time detection of RA *** rat models,the nanotherapeutic is shown to be superior to free upadacitinib,as indicated by extended circulation time and sustained ***,this nanosystem possesses an ultralong half-life of 45 h and a bioavailability of 4-times higher than pristine upadacitinib,thus extending the dosing interval from one day to 2 *** effects such as over-immunosuppression and leukocyte levels reduction were significantly *** smart strategy boosts efficacy,safety and visuality of Jakinibs in RA therapy,and potently enables customized designs of nanoplatforms for other therapeutics.

关键词： engineered protein nanocarrier controlled release bioefficacy rheumatoid arthritis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Microstructure and mechanical properties of die-cast AZ91D magnesium alloy by Pr additions

引用

Transactions of Nonferrous Metals Society of China 2010年第B7期20卷 435-438页

作者：崔晓鹏刘海峰孟健张德平 Department of Materials Science and Engineering Key Laboratory of Advanced Structrural Materialsof Ministry of EducationChangchun University of Technology State Key Laboratory of rare earth Resources Utilization Changchun Institute of Applied ChemistryChinese Academy of Sciences R&D centre of Foundry Corporation FAW Group Corporation

Mg-9Al-xPr(x=0.4,0.8 and 1.2,mass fraction,%)magnesium alloys were prepared by high-pressure die-casting *** effects of Pr on the microstructures of die-cast Mg-9Al based alloy were investigated by XRD and ***-like Al11Pr3 phase and polygon Al6Mn6Pr phase are found in the *** 0.4%Pr addition,fine needle-like Al11Pr3 phase and a small amount of polygon Al6Mn6Pr phase near the grain boundary are found in the *** Pr addition to 0.8%, lots of coarse needle-like Al11Pr3 phase within grain and polygon Al6Mn6Pr phase on grain boundary are *** increasing Pr addition,the size of needle-like Al11Pr3 phase decreases,while the size of polygon Al6Mn6Pr relatively *** mass fraction of Pr at around 0.8%is considered to be suitable to obtain the optimal mechanical *** optimal mechanical properties are mainly resulted from grain boundary strengthening obtained by precipitates and solid solution.

关键词： praseodymium magnesium alloy microstructure mechanical properties

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Carbon Turnover in a Crop Rotation Under Free Air CO_2 Enrichment (FACE)

引用

Pedosphere 2005年第6期15卷 728-738页

作者： H. J. WEIGEL A. PACHOLSKI S. BURKART M. HELAL O. HEINEMEYER B. KLEIKAMP R. MANDERSCHEID C. FRüHAUF G. F. HENDREY K. LEWIN J. NAGY Institute of Agroecology Federal Agricultural Research Centre (FAL) Bundesallee 50 38116 Braunschweig (Germany). German Weather Service Agriculture Department Kreuzweg 25 65366 Geisenheim (Germany) earth Systems Sciences Division Brookhaven National Laboratory Building 490D P.O. Box 5000 Upton NY 11973 (USA)

Mostly based on assumptions derived from controlled-environment studies, predicted future atmospheric CO2 concentrations [CO2] are expected to have considerable impacts on carbon （C） turnover in agro-ecosystems. In order to allow the in situ examination of C-transformations in the plant-soil system of arable crop rotations under future [002], a free air carbon dioxide enrichment （FACE） experiment （550 μmol mol^-1 CO2） was started at Braunschweig, Germany in 1999. The crop rotation under investigation comprised winter barley, a cover crop （ryegrass）, sugar beets and winter wheat. Assessments of CO2 effects included the determination of above- and belowground biomass production, measurements of canopy CO2- and H2O- fluxes, soil microbial biomass and in situ soil respiration. The results obtained during the 1st crop rotation cycle （3 years） showed that for the selected crops elevated [CO2] entailed significant positive effects （P 〈 0.05） on aboveground （6%-14% stimulation） and belowground biomass production （up to 90% stimulation）, while canopy evapotranspiration was reduced. This resulted in increased soil water content. Also, depending on crop type and season, high CO2 stimulated in situ soil respiration （up to 30%）, while soil microbial biomass did not show significant respouses to elevated [CO2] during the first rotation cycle.

关键词： agroecosystems carbon elevated CO2 FACE soil

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effect of ammonium sulfate on the formation of zinc sulfide species on hemimorphite surface and its role in sulfidation flotation

引用

International Journal of Minerals,Metallurgy and Materials 2023年第11期30卷 2147-2156页

作者： Xi Zhang Yu Wang Jiushuai Deng Zhongyi Bai Hongxiang Xu Qingfeng Meng Da Jin Zhenwu Sun Key Laboratory of Separation and Processing of Symbiotic-Associated Mineral Resources in Non-ferrous Metal Industry School of Chemical and Environmental EngineeringChina University of Mining and Technology(Beijing)Beijing 100083China Inner Mongolia Research Institute China University of Mining and Technology(Beijing)Ordos 017001China State Key Laboratory of Complex Nonferrous Metal Resources Clean Utilization Kunming 650093China Engineering Technology Research centre for Comprehensive Utilization of rare earth Rare Metal and Rare-Scattered in Non-ferrous Metal IndustryChina University of Mining and Technology(Beijing)Beijing 100083China

Effectively strengthening the surface sulfidation is essential for recovering hemimorphite by froth *** this work,inductively coupled plasma optical emission spectrometer(ICP-OES)measurements,Visual MINTEQ calculation,X-ray photoelectron spectroscopy(XPS)analysis,time of flight secondary ion mass spectrometry(ToF-SIMS)analysis,and micro-flotation experiments were explored to systematically investigate the effect of ammonium sulfate((NH_(4))_(2)SO_(4))on the formation of zinc sulfide species on hemimorphite surface and its role in sulfidation *** results showed that(NH_(4))_(2)SO_(4)exhibited a positive influence on hemimorphite sulfidation *** was ascribed to the number of zinc components in the form of Zn^(2+)and[Zn(NH_(3))_(i)]^(2+)(i=1–4)increased in the flotation system after hemimorphite treatment with(NH_(4))_(2)SO_(4),which was beneficial to its interaction with sulfur species in solution,resulting in a dense and stable zinc sulfide layer generated on the hemimorphite surface.[Zn(NH_(3))_(i)]^(2+)participated in the sulfidation reaction of hemimorphite as a transition *** addition the sulfidation reaction of hemimorphite was accelerated by(NH_(4))_(2)SO_(4).Thus,(NH_(4))_(2)SO_(4)presents a vital role in promoting the sulfidation of hemimorphite.

关键词： hemimorphite sulfidation ammonium sulfate zinc sulfide species adsorption flotation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Highly Stretchable Shape Memory Self-Soldering Conductive Tape with Reversible Adhesion Switched by Temperature

引用

Nano-Micro Letters 2021年第8期13卷 152-162页

作者： Mengyan Wang Quan Zhang Yiwen Bo Chunyang Zhang Yiwen Lv Xiang Fu Wen He Xiangqian Fan Jiajie Liang Yi Huang Rujun Ma Yongsheng Chen School of Materials Science and Engineering National Institute for Advanced MaterialsTianjin Key Lab for Rare Earth Materials and ApplicationsNankai UniversityTongyan Road 38Tianjin 300350People’s Republic of China State Key Laboratory and Institute of Elemento-Organic Chemistry Centre of Nanoscale Science and Technology and Key Laboratory of Functional Polymer MaterialsCollege of ChemistryNankai UniversityWeijin Road 94Tianjin 300071People’s Republic of China

With practical interest in the future applications of next-generation electronic devices,it is imperative to develop new conductive interconnecting materials appropriate for modern electronic devices to replace traditional rigid solder tin and silver paste of high melting temperature or corrosive solvent ***,we design highly stretchable shape memory self-soldering conductive(SMSC)tape with reversible adhesion switched by temperature,which is composed of silver particles encapsulated by shape memory *** tape has perfect shape and conductivity memory property and anti-fatigue ability even under the strain of 90%.It also exhibits an initial conductivity of 2772 S cm^(−1) and a maximum tensile strain of~100%.The maximum conductivity could be increased to 5446 S cm^(−1) by decreasing the strain to 17%.Meanwhile,SMSC tape can easily realize a heating induced reversible strong-to-weak adhe-sion transition for self-soldering *** combination of stable conductivity,excellent shape memory performance,and temperature-switching reversible adhesion enables SMSC tape to serve two functions of electrode and solder *** provides a new way for conductive interconnecting materials to meet requirements of modern electronic devices in the future.

关键词： Shape memory performance Self-soldering conductive tape Reversible adhesion Stretchable electronics

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Zircon U-Pb and Hf isotopes of volcanic rocks from the Batamayineishan Formation in the eastern Junggar Basin

引用

Chinese Science Bulletin 2010年第36期55卷 4150-4161页

作者： SU YuPing ZHENG JianPing GRIFFIN William L TANG HuaYun O'REILLY Suzanne Y LIN XiangYang Faculty of earth Sciences China University of Geosciences Wuhan 430074 China national Key centre for Geochemical Evolution and Metallogeny of Continents ( GEMOC) Macquarie University Sydney NSW 2109 Australia

内部结构的研究被进行从 Batamayineishan 形成调查 U-Pb 年龄，踪迹元素和玄武岩的锆石的 Hf 同位素。暗岩从练习井圣罐头被获得 1 在 Junggar 盆以内在东方 Luliang 上高举。跟踪所有样品是 magmatic 的锆石表演的元素数据，与类似的 ... 详细信息

内部结构的研究被进行从 Batamayineishan 形成调查 U-Pb 年龄，踪迹元素和玄武岩的锆石的 Hf 同位素。暗岩从练习井圣罐头被获得 1 在 Junggar 盆以内在东方 Luliang 上高举。跟踪所有样品是 magmatic 的锆石表演的元素数据，与类似的 REE 模式，包括积极 Ce (Ce=5.06134 ) ，而是否定 Eu (Eu=0.06 ? 0.55 ) 在重稀土元素元素的异例和丰富。在 25 谷物之中，一致年龄被细分进三个组；300.4 整潲祺潧整的年龄？

关键词：准噶尔盆地东部岛弧火山岩形成年龄 Hf同位素锆石 Pb 碰撞后构造环境岩石圈地幔

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Nanocrystalline rare earth fluorides doped with Pr^(3+) ions

引用

Journal of rare earths 2016年第8期34卷 802-807页

作者： Marcin Runowski Stefan Lis Department of rare earths Faculty of Chemistry Adam Mickiewicz University

Praseodymium（III） doped CeF3, CeF3：Gd, LaF3, GdF3 and YF3 inorganic fluorides were precipitated in an aqueous, sur- factant-free solution, using NH4F as a source of fluoride ions. The as-prepared products were subjected to a hydrothermal treatment, which led to the formation of crystalline nanoluminophores, composed of spherical （30 nm） and elongated （40-200 nm） nanos- tructures. Due to the presence of Pr3＋ ions, the synthesized nanomaterials showed yellow luminescence under a blue light irradiation. The nanoluminophore based on the YF3 host revealed the most promising spectroscopic properties, i.e., bright and intensive emission, hence it was investigated in detail. The photophysical properties of the nanomaterials obtained were studied by powder X-ray diffrac- tion （XRD）, transmission electron microscopy （TEM） and spectrofluorometry, i.e., measurements of excitation/emission spectra and luminescence decay curves.

关键词： yellow luminescence lanthanide fluorides Pr3+ doping nanocrystals hydrothermal post-treatment Ce3+ quenching rare earths

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The Influence of Climate Change on Winter Wheat during 2012-2100 under A2 and A1B Scenarios in China

引用

Advances in Climate Change Research 2012年第3期3卷 138-146页

作者： SONG Yan-Ling CHEN De-Liang LIU Yan-Ju XU Ying national Climate centre China Meteorological AdministrationBeijing 100081China Department of earth Sciences University of GothenburgGothenburg Box 460Sweden

By assuming constant winter wheat varieties and agricultural practices in China, the influence of climate change on winter wheat is simulated using the corrected future climate projections under SRES A2 and A1B scenarios from 2012 to 2100, respectively. The results indicate that the growth of winter wheat would be strongly influenced by climate change in future. The average flowering and maturity dates of winter wheat would advance by 26 and 27 days under scenario A2, and by 23 and 24 days respectively under scenario A1B from 2012 to 2100. The simulated potential productivity of winter wheat shows a decrease of 14.3% and 12.5% for scenarios A2 and A1B respectively without the fertilization effect of CO2, while an increase of 1.3% and 0.6% with the fertilization effect of CO2. Additionally, for northern China, the simulated potential productivity would markedly decrease under both scenarios, independent with the fertilization effect of CO2, which indicates that the current planted winter wheat would be more vulnerable than that in southern China. The most likely reason is the current winter wheat varieties in northern China are winter varieties or strong winter varieties, which need some days of low temperature for dormancy. While in southern China, the winter wheat is spring or half winter varieties and can grow slowly during winter, thus, they would be affected slightly when winter temperature increases. The results of this study may have important implications for adaptation measures.

关键词： climate change A2 and A1B scenarios WOFOST winter wheat China

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Simultaneous Prediction of Wheat Yield and Grain Protein Content Using Multitask Deep Learning from Time-Series Proximal Sensing

引用

Plant Phenomics 2022年第1期4卷 371-383页

作者： Zhuangzhuang Sun Qing Li Shichao Jin Yunlin Song Shan Xu Xiao Wang Jian Cai Qin Zhou Yan Ge Ruinan Zhang Jingrong Zang Dong Jiang Plant Phenomics Research centre Academy for Advanced Interdisciplinary StudiesRegional Technique Innovation Center for Wheat ProductionMinistry of AgricultureKey Laboratory of Crop Physiology and Ecology in Southern ChinaMinistry of AgricultureCollaborative Innovation Centre for Modern Crop Production Co-Sponsored by Province and MinistryNanjing Agricultural UniversityNanjing 210095China Jiangsu Provincial Key Laboratory of Geographic Information Science and Technology International Institute for Earth System SciencesNanjing UniversityNanjingJiangsu 210023China

Wheat yield and grain protein content(GPC)are two main optimization targets for breeding and *** sensing provides nondestructive and early predictions of yield and GPC,***,whether it is possible to simultaneously predict yield and GPC in one model and the accuracy and influencing factors are still *** this study,we made a systematic comparison of different deep learning models in terms of data fusion,time-series feature extraction,and multitask *** results showed that time-series data fusion significantly improved yield and GPC prediction accuracy with R 2 values of 0.817 and 0.809.

关键词： Wheat breeding Yield

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A Sandwich-type Sulfur Cathode Based on Multifunctional Ceria Hollow Spheres for High-Performance Lithium-Sulfur Battery

A Sandwich-type Sulfur Cathode Based on Multifunctional Ceri...

引用

中国化学会第十届全国无机化学学术会议

作者： Wang Jianwei Du Yaping Frontier Institute of Science and Technology Xi'an Jiaotong University School of Materials Science and Engineering & national Institute for Advanced Materials Tianjin Key Lab for Rare Earth Materials and Applications Centre for Rare Earth and Inorganic Functional Materials Nankai University

Despite prominent research efforts in developing cathode materials for lithium-sulfur batteries, relatively little emphasis has been placed on constructing functional cathode architectures. Herein, ceria(CeO) hollow spheres are prepared to fabricate the inside and outside structures of cathodes. A sandwich-type sulfur cathode, namely, h-CeO/Sulfur-x-CNT/h-CeO cathode, is designed and fabricated by a simple layer-by-layer process. Due to the unique structural and compositional features, the h-CeO/Sulfur-0.8-CNT/h-CeO cathode delivers high specific capacity of 876, 761, and 644 mAh g at 1 C, 2 C and 5 C rate, and the capacity retentions are 85.7%, 87.8%, and 92.4%, respectively. During 100 test cycles, the material displays high Coulombic efficiencies(above 99%) after the first cycle. More importantly, the cathode with sulfur loading of 1.8 mg/cm also exhibits stable cycling life up to 500 cycles at 1 C with a capacity decay as low as 0.073% per cycle.

关键词： rare earth materials ceria hollow structure electrochemistry Li-S battery

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：