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Mobile agent-enabled framework for structuring and building distributed systems on the internet

Science in China(Series F) 2006年第6期49卷 885-905页

作者： CAO Jiannong ZHOU Jingyang ZHU Weiweit LI Xuhui Internet and Mobile Computing lab Department of Computing Hong Kong Polytechnic University Hung Hom KLW Hong Kong China State Key lab of Novel Software Technologies Nanjing University Nanjing 210093 China State Key lab of Software Engineering Wuhan University Wuhan 430072 China

Mobile agent has shown its promise as a powerful means to complement and enhance existing technology in various application areas. In particular, existing work has demonstrated that MA can simplify the development and improve the performance of certain classes of distributed applications, especially for those running on a wide-area, heterogeneous, and dynamic networking environment like the Internet. In our previous work, we extended the application of MA to the design of distributed control functions, which require the maintenance of logical relationship among and/or coordination of processing entities in a distributed system. A novel framework is presented for structuring and building distributed systems, which use cooperating mobile agents as an aid to carry out coordination and cooperation tasks in distributed systems. The framework has been used for designing various distributed control functions such as load balancing and mutual ex- clusion in our previous work. In this paper, we use the framework to propose a novel approach to detecting deadlocks in distributed system by using mobile agents, which demonstrates the advantage of being adaptive and flexible of mobile agents. We first describe the MAEDD （Mobile Agent Enabled Deadlock Detection） scheme, in which mobile agents are dispatched to collect and analyze deadlock information distributed across the network sites and, based on the analysis, to detect and resolve deadlocks. Then the design of an adaptive hybrid algorithm derived from the framework is presented. The algorithm can dynamically adapt itself to the changes in system state by using different deadlock detection strategies. The performance of the proposed algorithm has been evaluated using simulations. The results show that the algorithm can outperform existing algorithms that use a fixed deadlock detection strategy.

关键词： mobile agent internet computing distributed systems deadlock detection.

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Application of Case-Based Flipped Classroom Teaching Mode in Experimental Teaching of pathology

Application of Case-Based Flipped Classroom Teaching Mode in...

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作者： Jie Zheng Fenghua Zhou Yuqing Liu Hongxia Zhang Department of Clinical pathology Weifang Medical University

To determine the effectiveness of case-based flipped classroom teaching model in the experimental teaching of *** medicine students from Weifang medical University were selected and randomly divided into control group and experimental ***-based flipped classroom teaching mode was performed in experimental group students,whereas teaching was conducted using traditional method in the control *** final examination score and comprehensive score of the experimental class were higher than that of the control ***-based flipped classroom can cultivate students’ autonomous learning,clinical thinking,analyzing and solving problems ability,the spirit of cooperation and stimulate enthusiasm for ***-based flipped classroom teaching model can improve the teaching effectiveness and enhance the autonomy and learning flexibility of pathology experimental course greatly.

关键词： Case-Based Flipped Classroom Experimental Teaching pathology

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Roles of galectins in inflammatory bowel disease

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World Journal of Gastroenterology 2008年第33期14卷 5133-5137页

作者： Akira Hokama Emiko Mizoguchi Atsushi Mizoguchi Department of Medicine and Therapeutics (First Department of Internal Medicine) Control and Prevention of Infectious Disease Faculty of Medicine University of the RyukyusOkinawa 903-0215 Japan Gastrointestinal Unit Department of Medicine Massachusetts General Hospital Harvard Medical SchoolBoston MA 02114 United States Center for the Study of Inflammatory Bowel Disease Massachusetts General Hospital Harvard Medical School Boston MA 02114 United States Experimental pathology Unit Department of Pathology Massachusetts General Hospital Harvard Medical SchoolBoston MA 02114 United States

Protein/carbohydrate interactions through specific protein families termed lectin control essential biological processes. Galectins, a family of animal lectins defined by shared amino acid sequence with affinity for β-galactosides, appear to be functionally polyvalent in a wide range of biological activity. Recent studies have identified immunoregulatory roles of galectins in intestinal inflammatory disorders. Galectin-1 and galectin -2 contribute to the suppression of intestinal inflammation by the induction of apoptosis of activated T cells, whereas galectin-4 is involved in the exacerbation of this inflammation by specifically stimulating intestinal CD4+ T cells to produce IL-6. We review how different members of the galectins provide inhibitory or stimulatory signals to control intestinal immune response under intestinal inflammation.

关键词： Galectin Inflammatory bowel disease Crohn's disease Ulcerative colitis Pathogenesis Apoptosis Glycosylation

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The Mechanism of HCOOH on Pt electrodes,an Electrochemical in-situ ATR-FTIRS study

The Mechanism of HCOOH on Pt electrodes,an Electrochemical i...

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第三届亚洲光谱会议

作者： J.Xu S.X.Liu Y.X.Chen Dept.of Chemical Physics University of Science and Technology of ChinaHefei National lab for Physical Science at Microscale

In a series of systematic studies done 5 years ago,we have concluded that formate decomposition to CO does not contribute much(less than 20%)to the total formic acid oxidation at Pt Electrodes.1-3 However,Osawa4-6 and...

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Radiomics-based predictive risk score: A scoring system for preoperatively predicting risk of lymph node metastasis in patients with resectable non-small cell lung cancer

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Chinese Journal of Cancer Research 2019年第4期31卷 641-652页

作者： Lan He Yanqi Huang Lixu Yan Junhui Zheng Changhong Liang Zaiyi Liu Department of Radiology Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China Department of pathology Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China

Objective: To develop and validate a radiomics-based predictive risk score(RPRS) for preoperative prediction of lymph node(LN) metastasis in patients with resectable non-small cell lung cancer(NSCLC).Methods: We retrospectively analyzed 717 who underwent surgical resection for primary NSCLC with systematic mediastinal lymphadenectomy from October 2007 to July 2016. By using the method of radiomics analysis, 591 computed tomography(CT)-based radiomics features were extracted, and the radiomics-based classifier was constructed. Then, using multivariable logistic regression analysis, a weighted score RPRS was derived to identify LN metastasis. Apparent prediction performance of RPRS was assessed with its calibration,discrimination, and clinical ***: The radiomics-based classifier was constructed, which consisted of 13 selected radiomics *** models demonstrated that radiomics-based classifier, age group, tumor diameter, tumor location, and CT-based LN status were independent predictors. When we assigned the corresponding score to each variable,patients with RPRSs of 0-3, 4-5, 6, 7-8, and 9 had distinctly very low(0%-20%), low(21%-40%), intermediate(41%-60%), high(61%-80%), and very high(81%-100%) risks of LN involvement, respectively. The developed RPRS showed good discrimination and satisfactory calibration (C-index: 0.785, 95% confidence interval(95% CI):0.780-0.790)Additionally, RPRS outperformed the clinicopathologic-based characteristics model with net reclassification index(NRI) of 0.711(95% CI: 0.555-0.867).Conclusions: The novel clinical scoring system developed as RPRS can serve as an easy-to-use tool to facilitate the preoperatively individualized prediction of LN metastasis in patients with resectable NSCLC. This stratification of patients according to their LN status may provide a basis for individualized treatment.

关键词： Lymph node radiomics risk score CT non-small cell lung cancer

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Cytoplasmic YAP1-mediated ESCRT-III assembly promotes autophagic cell death and is ubiquitinated by NEDD4L in breast cancer

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Cancer Communications 2023年第5期43卷 582-612页

作者： Yan Guo Yuqing Cui Yangyang Li Xiaoying Jin Dandan Wang Mengxia Lei Fengzhi Chen Yali Liu Jinwen Xu Guanyu Yao Guangchun Zeng Xuesong Chen Department of Breast Medical Oncology Harbin Medical University Cancer HospitalHarbinHeilongjiangP.R.China Department of pathology Harbin Medical University Cancer HospitalHarbinHeilongjiangP.R.China

Background:Nuclear Yes1-associated transcriptional regulator(YAP1)promotes tumor ***,the function of cytoplasmic YAP1 in breast cancer cells and its impact on the survival of breast cancer patients remain *** research aimed to explore the biological function of cytoplasmic YAP1 in breast cancer cells and the possibility of cytoplasmic YAP1 as a predictive marker of breast cancer ***:We constructed cell mutant models,including NLS-YAP15SA(nuclear localized),YAP1S94A(incapable of binding to the TEA domain transcription factor family)and YAP1S127D(cytoplasmic localized),and used Cell Counting Kit-8(CCK-8)assays,5-ethynyl-2’-deoxyuridine(EdU)incorporation assays,and Western blotting(WB)analysis to detect cell proliferation and *** specific mechanism of cytoplasmic YAP1-mediated endosomal sorting complexes required for transport III(ESCRT-III)assembly was studied by co-immunoprecipitation,immunofluorescence staining,and WB *** gallate(EGCG)was used to simulate YAP1 retention in the cytoplasm in in vitro and in vivo experiments to study the function of cytoplasmic ***1 binding to NEDD4-like E3 ubiquitin protein ligase(NEDD4L)was identified using mass spectrometry and was verified in *** tissue microarrays were used to analyze the relationship between cytoplasmic YAP1 expression and the survival of breast cancer ***:YAP1 was mainly expressed in the cytoplasm in breast cancer *** YAP1 promoted autophagic death of breast cancer *** YAP1 bound to the ESCRT-III complex subunits charged multivesicular body protein 2B(CHMP2B)and vacuolar protein sorting 4 homolog B(VPS4B),promoting assembly of CHMP2B-VPS4B and activating autophagosome *** retained YAP1 in the cytoplasm,promoting the assembly of CHMP2B-VPS4B to promote autophagic death of breast cancer ***1 bound to NEDD4L,and NEDD4L mediated ubiquitination and degradation of *** tis

关键词： Autophagosome closure Autophagy Breast cancer CHMP2B Cytoplasmic YAP1 EGCG ESCRT-III Hippo pathway NEDD4L Ubiquitin VPS4B

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What we learned from geothermal fields in Guangdong Province: conditions from deep underground to ground surface

What we learned from geothermal fields in Guangdong Province...

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2014年中国地球科学联合学术年会——国际专题（2）Microseismic Monitoring and Inversion

作者： Guoping Lu Division of Earth Sciences Lawrence Berkeley National Lab School of Environmental Studies China University of Geosciences(Wuhan)

This work discusses high temperature and high pressure field conditions associated with geothermal *** a geothermal field,hot water usually is able to flow to the ground surface,due to water of lighter density at hotter *** it gets deeper down inside the underground,both the temperature and pressure get higher(Pruess et al.,1999).When the pressure gets greater than 22.5 MPa,the groundwater can become supercritical with temperature greater than *** water has both gas-like and liquid-like *** use our recently developed capability to simulate the behavior of supercritical water in Xinzhou geothermal field in Yangjiang City,Guangdong Province(Fig.1).

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Zebrafish minichromosome maintenance protein 5 gene regulates the development and migration of facial motor neurons via fibroblast growth factor signaling

Zebrafish minichromosome maintenance protein 5 gene regulate...

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中国解剖学会2019年年会

作者： Yongmei Wu Sizhou Huang Haixia Zhao Kang Cao Jinfan Gan Shurong Li Bingyin Su Development and Regeneration Key lab of Sichuan Province Chengdu Medical College Department of Anatomy and Histology and Embryology Chengdu Medical College Department of pathology Chengdu Medical College

＜正＞Minichromosome maintenance protein 5 （MCM5） is a member of the microchromosomal maintenance protein family, which plays an important role in the initiation and extension of DNA ***,its role in neural development is *** explored the developmental features of facial motor neurons （FMNs） in the zebrafish hindbrain when mcm5 was deleted by using the

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ERI Modulated in vitro Cotton Fiber Development by Regulating Flavonoid Metabolism and Auxin Signaling

ERI Modulated in vitro Cotton Fiber Development by Regulatin...

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中国农学会棉花分会2018年年会

作者： Anam Qadir Khan Li Zhonghua Wang Pengcheng Muhammad Mahmood Ahmed Tu Lili national Key lab of Crop Genetics Improvement Group of Cotton Genetics Improvement (GCGI)Huazhong Agricultural University

Flavonoids biosynthesis,secondary metabolic pathway,is vital in modulating various biological *** in cotton,flavonoids have decisively regulated fiber *** fiber length is determined by multiple in vivo,intrinsic and various genetic factors during fiber elongation stage in *** vivo fiber growth was found suppressed when naringenin(NAR) flavonoid was accumulated in developing cotton *** this study,in vitro fiber development was examined through culturing 0 days post anthesis(DPA) ovules for different days,and with different concentrations of NAR,dihydrokaempferol(DHK),dihydroquerectin(DHQ) and eriodictyol(ERI).In conclusion,presence of ERI significantly improved fiber growth in terms of fiber length and total fiber units(TFU).To get insight into transcriptional regulatory networks in ERI mediated enhanced fiber development,whole transcriptome RNA sequencing was performed for samples collected at fiber initiation(1 DPA),early(5 DPA) and late fiber elongation(10 DPA) *** results showed that the expression of flavonoid pathway genes was differentially regulated in ERI treated ovule and fiber *** development was significantly on rise when ovules were cultured in presence of an auxin transport inhibitor(Triiodobenzoic acid,TIBA) to block auxin *** conclusion,ERI positively modulated fiber development by regulating flavonoid metabolism and auxin signaling.

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Development and external validation of a quantitative diagnostic model for malignant gastric lesions in clinical opportunistic screening: A multicenter real-world study

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中华医学杂志(英文版) 2024年第19期137卷 2024 Feb 26页

作者： Zheng Hongchen Liu Zhen Chen Yun Ji Ping Fang Zhengyu He Yujie Guo Chuanhai Xiao Ping Wang Chengwen Yin Weihua Li Fenglei Chen Xiujian Liu Mengfei Pan Yaqi Liu Fangfang Liu Ying He Zhonghu Ke Yang State Key laboratory of Molecular Oncology Beijing Key Laboratory of Carcinogenesis and Translational Research Department of Genetics Peking University Cancer Hospital &amp Institute Beijing China Department of Ultrasound Peking University Shenzhen Hospital Shenzhen Guangdong China Shenzhen Key laboratory for Drug Addiction and Medication Safety Shenzhen Peking University-Hong Kong University of Science and Technology Medical Center Shenzhen Guangdong China Clinical Research Institute Shenzhen Peking University-Hong Kong University of Science and Technology Medical Center Shenzhen Guangdong China Endoscopy Center Hua County People’s Hospital Anyang Henan China Endoscope Group Department of Gastroenterology Peking University Shenzhen Hospital Shenzhen Guangdong China Department of pathology Peking University Shenzhen Hospital Shenzhen Guangdong China Hua County People’s Hospital Anyang Henan China Department of pathology Hua County People’s Hospital Anyang Henan China

Background: Clinical opportunistic screening is a cost-effective cancer screening modality. This study aimed to establish an easy-to-use diagnostic model serving as a risk stratification tool for identification of individuals with malignant gastric lesions for opportunistic ***: We developed a questionnaire-based diagnostic model using a joint dataset including two clinical cohorts from northern and southern China. The cohorts consisted of 17,360 outpatients who had undergone upper gastrointestinal endoscopic examination in endoscopic clinics. The final model was derived based on unconditional logistic regression, and predictors were selected according to the Akaike information criterion. External validation was carried out with 32,614 participants from a community-based randomized controlled ***: This questionnaire-based diagnostic model for malignant gastric lesions had eight predictors, including advanced age, male gender, family history of gastric cancer, low body mass index, unexplained weight loss, consumption of leftover food, consumption of preserved food, and epigastric pain. This model showed high discriminative power in the development set with an area under the receiver operating characteristic curve (AUC) of 0.791 (95% confidence interval [CI]: 0.750–0.831). External validation of the model in the general population generated an AUC of 0.696 (95% CI: 0.570–0.822). This model showed an ideal ability for enriching prevalent malignant gastric lesions when applied to various ***: This easy-to-use questionnaire-based model for diagnosis of prevalent malignant gastric lesions may serve as an effective prescreening tool in clinical opportunistic screening for gastric cancer.

关键词： Early detection of cancer Cancer early diagnosis Gastric cancer Diagnostic model Opportunistic screening Feeding behavior Weight loss Sex characteristics

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