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China CDC weekly 2024年第33期6卷 834-840页

作者： Minrui Ren Keli Li Yan Li Chunxiang Fan Yuyang Xu Lina Zhang Yuan Li Lei Cao Wenzhou Yu Zundong Yin national Key Laboratory of Intelligent Tracking and Forecasting for Infectious diseases(NITFID) National Immunization ProgrammeChinese Center for Disease Control and PreventionBeijingChina Department of Expanded programme on Immunization Hangzhou Center for Disease Control and PreventionHangzhou CityZhejiang ProvinceChina

Introduction The Haemophilus influenzae type b(Hib)conjugate vaccine is widely administered in *** We extracted data on Hib vaccine doses administered and adverse events following immunization(AEFI)reported between 2010 and 2021 from the Chinese national Immunization Information System(CNIIS).A descriptive analysis was conducted to examine the characteristics and incidence rates of AEFI with the Hib *** In China,between 2010 and 2021,a total of 52,910 AEFIs with the Hib vaccine were reported,resulting in an overall AEFI reporting rate of 38.10 per 100,000 ***(typically minor)and rare(potentially serious)vaccine reactions occurred at rates of 34.71 and 2.78 per 100,000 doses,*** the common vaccine reactions,the incidences of fever(axillary temperature≥38.6℃),injection site redness and swelling(>2.5 cm in diameter),and injection site induration(>2.5 cm in diameter)were 11.93,9.69,and 3.38 per 100,000 doses,*** vaccine reactions included anaphylactic rash,angioedema,and febrile convulsion with reported incidences of 2.42,0.10,and 0.05 per 100,000 doses,*** incidence of serious rare vaccine reactions was 0.16 per 100,000 *** The reported incidence of AEFI with the Hib vaccine was low,with the occurrence of serious rare adverse reactions also being markedly low throughout the period 2010–2021 in China.

关键词： doses markedly injection

Associations Between Changes in Physical Activity and Risk of All-Cause Mortality in Adults With/Without Hypertension—China,2010-2022

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China CDC weekly 2024年第40期6卷 1038-1043页

作者： Xiaoyong He Tingfang Ai Fan Mao Run Zhang Xiaoqing You Jianhong Li national Center for Chronic and noncommunicable Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina

What is already known about this topic?Previous studies indicate that an increase in physical activity can diminish the risk of ***,the relationship between longitudinal changes in physical activity and health improvement among Chinese adults with or without hypertension has not been *** is added by this report?This study found that increasing or maintaining moderate to high physical activity levels reduced the risk of all-cause mortality,irrespective of the baseline physical activity *** addition,the beneficial effects were particularly pronounced in people with *** are the implications for public health practice?It may be beneficial to encourage adults in China,especially those with hypertension,to actively increase physical activity and deter the issue of physical inactivity that accompanies aging.

关键词： mortality hypertension companies

Detection of SARS-CoV-2 based on artificial intelligence-assisted smartphone:A review

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Chinese Chemical Letters 2024年第7期35卷 25-34页

作者： Yunxin Li Jinghui Zhang Jisen Chen Feng Zhu Zhiqiang Liu Peng Bao Wei Shen Sheng Tang School of Environmental and Chemical Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China programme in Emerging Infectious diseases Duke-NUS Medical SchoolSingapore 169857Singapore

In recent years,the application of smartphone in various fields has received great attention,and it has become a promising tool in virus detection,data processing and data *** the rapid spread of COVID-19 around the world,many traditional detection methods have been combined with smartphone to assist in the analysis and detection of the novel coronavirus(SARS-CoV-2),including electrochemistry,fluorescence and *** the gradual development of artificial intelligence(AI),the combination of AI and smartphone to analyze SARS-CoV-2 was also the focus of *** on the summary of the traditional methods combined with smartphone to detect SARS-CoV-2 virus,in addition to AI-based data processing,AI algorithms are also employed for SARS-CoV-2 detection *** review discussed both strategies and focused on the application of the *** combination of AI algorithm and smartphone to detect SARS-CoV-2 has high accuracy,which is more conducive to meeting the needs of portable *** addition,the classification of SARS-CoV-2 virus samples in biological fluids such as blood and saliva was also ***,this paper briefly discussed the limitations of using smartphone analysis to detect SARS-CoV-2,as well as the prospect and future development of virus *** conclusion,the detection methods based on smartphone and AI algorithms show great potential in the detection of SARS-CoV-2 and can be a valuable complement to traditional analysis methods.

关键词： COVID-19 SARS-CoV-2 virus Detection method Smartphone analysis Artificial intelligence

Dysfunction of synaptic endocytic trafficking in Parkinson's disease

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Neural Regeneration Research 2024年第12期19卷 2649-2660页

作者： Xin Yi Ng Mian Cao programme in Neuroscience and Behavioural Disorders Duke-NUS Medical SchoolSingaporeSingapore Department of Physiology National University of SingaporeSingaporeSingapore

Parkinson's disease is characterized by the selective degeneration of dopamine neurons in the nigrostriatal pathway and dopamine deficiency in the *** precise reasons behind the specific degeneration of these dopamine neurons remain largely *** investigations have identified over 20 causative PARK genes and 90 genomic risk loci associated with both familial and sporadic Parkinson's ***,several of these genes are linked to the synaptic vesicle recycling process,particularly the clathrinmediated endocytosis *** suggests that impaired synaptic vesicle recycling might represent an early feature of Parkinson's disease,followed by axonal degeneration and the eventual loss of dopamine cell bodies in the midbrain via a"dying back"***,several new animal and cellular models with Parkinson's disease-linked mutations affecting the endocytic pathway have been created and extensively *** models faithfully recapitulate certain Parkinson's disease-like features at the animal,circuit,and cellular levels,and exhibit defects in synaptic membrane trafficking,further supporting the findings from human genetics and clinical *** this review,we will first summarize the cellular and molecular findings from the models of two Parkinson's disease-linked clathrin uncoating proteins:auxilin(DNAJC6/PARK19)and synaptojanin 1(SYNJ1/PARK20).The mouse models carrying these two PARK gene mutations phenocopy each other with specific dopamine terminal pathology and display a potent synergistic ***,we will delve into the involvement of several clathrin-mediated endocytosis-related proteins(GAK,endophilin A1,SAC2/INPP5 F,synaptotagmin-11),identified as Parkinson's disease risk factors through genome-wide association studies,in Parkinson's disease *** will also explore the direct or indirect roles of some common Parkinson's disease-linked proteins(alpha-synuclein(PARK1/4),Parkin(PARK2),and LRRK2(PARK

关键词： autophagy auxilin/PARK19 clathrin-mediated endocytosis dopamine neurons neurodegeneration nigrostriatal pathway Parkinson's disease synaptic vesicle recycling synaptojanin1/PARK20

Tropical Cyclone Monitoring and Analysis Techniques: A Review

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Journal of Meteorological Research 2024年第2期38卷 351-367页

作者： Chuanhai QIAN Ying LI Yinglong XU Xin WANG Zenghai ZHANG Gaozhen NIE Da LIU Shiwen ZHANG Institute for Development and programme Design China Meteorological AdministrationBeijing 100081 Chinese Academy of Meteorological Sciences China Meteorological AdministrationBeijing 100081 national Meteorological Centre China Meteorological AdministrationBeijing 100081 national Satellite Meteorological Centre China Meteorological AdministrationBeijing 100081

Tropical cyclones(TCs),including tropical depressions and different categories of typhoons,hurricanes,and cyclonic storms,mostly originate over the oceans in the absence of direct ***,detailed monitoring and analysis of TCs has always been an unsolved *** the recent 20 years,great changes have taken place in domestic and foreign TC monitoring techniques,imposing a significant impact on TC operations and *** new technologies and products gradually emerge to support operations,with improved monitoring *** this paper,the progress on TC monitoring and analysis via meteorological satellites,radars,and airplanes in China and the world is reviewed,compared,and summarized,with special focuses on multisatellite fusion observations,in situ aircraft measurements,and some unconventional observation equipment such as rockets,saildrones,and underwater *** this basis,the paper points out future directions for improving TC monitoring and analysis in aid of better TC forecast and early warning.

关键词： tropical cyclone(TC) monitoring and analysis meteorological satellite aircraft reconnaissance

Protein-nucleic acid hybrid nanostructures for molecular diagnostic applications

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Nano Research 2024年第10期17卷 9003-9014页

作者： Noah R.Sundah Yuxuan Seah Auginia Natalia Xiaoyan Chen Panida Cen Yu Liu Huilin Shao Institute for Health Innovation and Technology National University of SingaporeSingapore 117599Singapore Department of Biomedical Engineering College of Design and EngineeringNational University of SingaporeSingapore 117583Singapore Integrative Sciences and Engineering programme NUS Graduate SchoolNational University of SingaporeSingapore 119077Singapore Institute of Molecular and Cell Biology Agency for ScienceTechnology and ResearchSingapore 138673Singapore Department of Surgery Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117597Singapore

Molecular diagnostic technologies empower new clinical opportunities in precision ***,existing approaches face limitations with respect to performance,operation and *** molecules including proteins and nucleic acids are being increasingly adopted as tools in the development of new molecular diagnostic *** particular,leveraging their complementary properties—the functional diversity of proteins and the precision programmability of nucleic acids—a wide range of protein–nucleic acid hybrid nanostructures have been *** hybrid structures take diverse forms,ranging from one-dimensional to three-dimensional hybrids,as static assemblies to dynamic machines,and possess myriad functions to recognize target biomarkers,encode vast information and execute catalytic *** by recent advances in this area of molecular nanotechnology,we review the state-of-art design and application of various types of protein–nucleic acid hybrid nanostructures for molecular diagnostics,and present an outlook on the challenges and opportunities for emerging pre-clinical and clinical applications,highlighting the promise for earlier detection,more refined diagnosis and highly tailored treatment decision that ultimately lead to improved patient outcomes.

关键词： molecular nanotechnology DNA-protein hybrid molecular diagnostics precision medicine

The Association Between Depression and All-Cause,Cause-Specific Mortality in the Chinese Population—China,2010-2022

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China CDC weekly 2024年第40期6卷 1022-1027页

作者： Jifei Wang Zhenping Zhao Jing Yang Limin Wang Mei Zhang Maigeng Zhou Department of Epidemiology School of Public HealthCheeloo College of MedicineShandong UniversityJinan CityShandong ProvinceChina national Center for Chronic and noncommunicable Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina

What is already known about this topic?Depression is linked to higher all-cause and cardiovascular mortality rates,but its effects on specific subgroups and non-cardiovascular mortality in the Chinese population remain *** is added by this report?Both severe and mild to moderate depression were found to elevate mortality rates among the Chinese *** impact was particularly notable among males,urban residents,younger individuals,and those with higher education *** exhibited a stronger connection with fatalities related to suicide and non-suicidal *** are the implications for public health practice?Individuals experiencing mild depression require healthcare attention to avoid negative *** physical and psychological support is particularly crucial for high-risk subgroups.

关键词： mortality injuries cardiovascular

Hearing Loss and Depressive Symptoms Among Community-Dwelling Older Adults-Liaoning,Henan,and Guangdong Provinces,China,2019-2020

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China CDC weekly 2024年第32期6卷 811-815,I0002页

作者： Ran An Lu Cui Liyuan Yang Han Zhang Shige Qi Haoyan Guo national Center for Chronic and noncommunicable Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina School of Public Health Capital Medical UniversityBeijingChina Chengnan Community Health Service Center of Changping District BeijingChina national Institute for Nutrition and Health Chinese Center for Disease Control and PreventionBeijingChina

Summary What is already known about this topic?More than half of Chinese older adults over 60 are suffering from hearing loss(HL),which might increase the risk of depressive *** is added by this report?The results indicated a significant association between severe or profound HL and depressive symptoms,characterized by notable age and gender disparities,particularly among women aged 60–74 years *** are the implications for public health practice?Timely intervention and treatment for elderly individuals with HL,particularly younger female elders suffering from severe or profound HL,are pivotal in reducing depressive symptom rates and are key policy considerations.

关键词： younger policy suffering

Establishment and Application of a Radiation Dose Rate Model for Nuclear Medicine Examinees

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China CDC weekly 2024年第23期6卷 553-557,I0019-I0025页

作者： Yuehua Hu Xinyu He Wenjia Zhao Lixin Ding Meiying You Zihan Li Xinyu Liu Miaomiao Wang Siyi Chen Ziwei Lu Lei Qu Kuke Ding Li Zhang Qiuxian Fu Office of Epidemiology Chinese Center for Disease Control and PreventionBeijingChina Department of Oncology Central Hospital Affiliated to Shandong First Medical UniversityJinan CityShandong ProvinceChina national Institute for Radiological Protection Chinese Center for Disease Control and PreventionBeijingChina national Center for Chronic and noncommunicable Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina Laboratory Animal Center Chinese Center for Disease Control and PreventionBeijingChina national Institute of Parasitic diseases Chinese Center for Disease Control and PreventionShanghaiChina Office of Public Health Management Chinese Center for Disease Control and PreventionBeijingChina Hainan Medical University Haikou CityHainan ProvinceChina

Introduction:Traditional methods for determining radiation dose in nuclear medicine include the Monte Carlo method,the discrete ordinate method,and the point kernel integration *** study presents a new mathematical model for predicting the radiation dose rate in the vicinity of nuclear medicine ***:A new algorithm was created by combining the physical model of“cylinder superposition”of the human body with integral analysis to assess the radiation dose rate in the vicinity of nuclear medicine ***:The model accurately predicted radiation dose rates within distances of 0.1–3.0 m,with a deviation of less than 11%compared to observed *** model demonstrated greater accuracy at shorter distances from the radiation source,with a deviation of only 1.55%from observed values at 0.1 ***:The model proposed in this study effectively represents the spatial and temporal distribution of the radiation field around nuclear medicine patients and demonstrates good agreement with actual *** model has the potential to serve as a radiation dose rate alert system in hospital environments.

关键词： method. deviation cylinder

Interpretation of the Standards of Basic Dataset of Chronic diseases Behavior Risk Factor Surveillance in Adults

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Biomedical and Environmental Sciences 2024年第5期37卷 551-556页

作者： ZHAO Yan Fang ZHANG Mei WEI Wen Qiang SUN Ke Xin LI Xin Hua WANG Li Min national Center for Chronic and noncommunicable Disease Control and Prevention(NCNCD) Chinese Center for Disease Control and PreventionBeijing 100050China Cancer Hospital Chinese Academy of Medical SciencesBeijing 100021China Chinese Center for Disease Control and Prevention Beijing 102206China People's Medical Publishing House Beijing 100021China

BACKGROUND China’s Behavioral Risk Factor Surveillance System(BRFSS)originated from the World Bankfunded HealthⅦLoan Project in the 1990s,which conducted behavioral risk factor surveillance in seven cities and one province^([1]).Drawing on the World Health Organization’s(WHO)STEPwise approach to surveillance(STEPs)and the *** Risk Factor Surveillance System(BRFSS)^([2,3]).

关键词： funded Basic originated