检索结果-南通市图书馆

Nanomanufacturing and metrology 2022年第2期5卷 83-90页

作者： Ichiko Misumi Ryosuke Kizu Hiroshi Itoh Kazuhiro Kumagai Keita Kobayashi Tomoo Sigehuzi national institute of Advanced Industrial Science and Technology AIST Tsukuba Central 51-1-1 HigashiIbaraki305-8565TsukubaJapan

With the progress in nanotechnology,the importance of nanodimensional standards is *** nanodimensional standards requires multiple types of high-precision microscopy *** national metrology institute of japan(NMIJ),one of the research domains in the national institute of Advanced Industrial Science and Technology(AIST),is developing nanodimensional standards using atomic force,transmission electron,and scanning electron *** current status of nanodimensional standards in NMIJ is introduced herein.

关键词： Nanodimensional standards Calibration Uncertainty AFM TEM SEM

New glucocerebrosidase antibodies can advance research in the field of neurodegenerative disorders

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第4期20卷 1085-1086页

作者： Charis Ma Krystyna Rytel Yu Chen Ellen Sidransky Medical Genetics Branch National Human Genome Research InstituteNational Institutes of HealthBethesdaMDUSA

In medical research,there are times when the introduction of a new tool can launch scientific discovery in new *** antibody development may be considered mundane,in the field of glucocerebrosidase(GCase)research,the dearth of validated antibodies for different applications has impeded progress in studies of disease pathogenesis and therapeutic *** recent introduction of new,rigorously evaluated antibodies can now propel research into the link between glucocerebrosidase and Parkinson’s disease(PD)as well as aspects of the pathobiology of Gaucher disease(Jong et al.,2024).

关键词： antibodies cerebro

Study on an improved five-interferogram phase-shifting algorithm

在线全文

学校读者我要写书评

暂无评论

Chinese Optics Letters 2008年第5期6卷 342-345页

作者：罗志勇代佳林 national institute of metrology

Using traditional five-interferogram algorithm to unwrap phase for length measurement, the phase steps must be equal to π/2 exactly, but it is almost impossible to achieve in nanometer positioning technique. Aiming to overcome this defect of traditional five-interferogram algorithm, an improved five-interferogram algorithm is presented. This improved algorithm not only keeps the high accuracy of traditional fiveinterferogram algorithm, but also does not need absolute equal step to unwrap phase. Instead, this algorithm only needs measuring phase-shifting. With the numerical simulation, the improved five-interferogram algorithm shows high accuracy, high reliability, and feasibility in practice. It is very valuable for accurate length measurement with Fizeau interferometer and Fabry-Perot interferometer.

关键词： Study on an improved five-interferogram phase-shifting algorithm than length Figure

Study of Nb/Nb_xSi_(1-x)/Nb Josephson junction arrays

在线全文

学校读者我要写书评

暂无评论

Chinese Physics B 2015年第12期24卷 526-529页

作者：曹文会李劲劲钟源贺青 national institute of metrology

Owing to the adjustable characteristics and superior etching properties of co-sputtered Nbx Si1-x film, we are trying to fabricate Nb/Nbx Si1-x/Nb Josephson junction arrays for voltage standard. It is important to find the suitable Nbx Si1-x barrier for the junctions. Josephson junctions with different barrier content are fabricated. Current–voltage characteristics are measured and analyzed. It is demonstrated in this paper that critical current can be adjusted by using different barrier content and thickness. Shapiro steps of five hundred junctions in series are observed.

关键词： Josephson junctions critical current voltage standard

Role of resident memory T cells in neuroinflammatory and neurodegenerative diseases in the central nervous system

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第11期20卷 3227-3228页

作者： Kimitoshi Kimura Department of Neurology Kyoto University Graduate School of MedicineTokyoJapan Department of Immunology National Center of Neurology and PsychiatryTokyoJapan

The immune system has been attracting increasing attention in the field of chronic neurological disorders in the central nervous system(CNS).Autoreactive T cells targeting CNS antigens play a crucial role in the development of various autoimmune diseases,such as multiple sclerosis(MS)and neuromyelitis optica spectrum disorder(NMOSD).Moreover,T cells are now recognized as a pivotal contributor to the pathology of neurodegenerative disorders,including Alzheimer's disease(AD),Parkinson's disease(PD),and multiple system atrophy.

关键词： diseases degenerative pathology

The development,performances and applications of the monochromatic X-rays facilities in(0.218–301)keV at NIM,China

在线全文

学校读者我要写书评

暂无评论

Nuclear Science and Techniques 2021年第6期32卷 108-121页

作者： Si-Ming Guo Jin-Jie Wu Dong-Jie Hou national institute of metrology BeijingChina

Space scientific exploration is rapidly becoming the primary battlefield for humankind to explore the *** worldwide have launched numerous space exploration *** calibration of the detectors on the ground is a crucial element for space science satellites to obtain observational *** the purpose of providing calibration for various satellite-borne detectors,multiple monochromatic X-rays facilities have been built at the national institute of metrology,***(NIM).These facilities mainly pertain to grating diffraction and Bragg diffraction,and the energy range of the produced monochromatic X-rays is 0.218–301 ke *** facilities have a high performance in terms of energy stability,monochromaticity,and flux *** monochromaticity was greater than 3.0%.The energy stability of the facility is 0.02%at 25 ke V over 8 h,and the flux stability was within 1.0%at 25 ke V over 8 *** experiments on the properties of satellite-borne detectors,such as energy linearity,energy resolution,detection efficiency,and temperature response,can be conducted at the *** far,the calibration of two satellites has been completed by the authors,and the work on three other satellites is in *** study will contribute to the advancement of X-ray astronomy the development of Chinese space science.

关键词： Monochromatic X-rays Monochromator Bragg diffraction Energy spectra Calibration

Pharmacological intervention for chronic phase of spinal cord injury

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第5期20卷 1377-1389页

作者： Chihiro Tohda Section of Neuromedical Science Institute of Natural MedicineUniversity of ToyamaToyamaJapan

Spinal cord injury is an intractable traumatic injury. The most common hurdles faced during spinal cord injury are failure of axonal regrowth and reconnection to target sites. These also tend to be the most challenging issues in spinal cord injury. As spinal cord injury progresses to the chronic phase, lost motor and sensory functions are not recovered. Several reasons may be attributed to the failure of recovery from chronic spinal cord injury. These include factors that inhibit axonal growth such as activated astrocytes, chondroitin sulfate proteoglycan, myelin-associated proteins, inflammatory microglia, and fibroblasts that accumulate at lesion sites. Skeletal muscle atrophy due to denervation is another chronic and detrimental spinal cord injury–specific condition. Although several intervention strategies based on multiple outlooks have been attempted for treating spinal cord injury, few approaches have been successful. To treat chronic spinal cord injury, neural cells or tissue substitutes may need to be supplied in the cavity area to enable possible axonal growth. Additionally, stimulating axonal growth activity by extrinsic factors is extremely important and essential for maintaining the remaining host neurons and transplanted neurons. This review focuses on pharmacotherapeutic approaches using small compounds and proteins to enable axonal growth in chronic spinal cord injury. This review presents some of these candidates that have shown promising outcomes in basic research(in vivo animal studies) and clinical trials: AA-NgR(310)ecto-Fc(AXER-204), fasudil, phosphatase and tensin homolog protein antagonist peptide 4, chondroitinase ABC, intracellular sigma peptide,(-)-epigallocatechin gallate, matrine, acteoside, pyrvate kinase M2, diosgenin, granulocyte-colony stimulating factor, and fampridine-sustained release. Although the current situation suggests that drug-based therapies to recover function in chronic spinal cord injury are limited, potential candidat

关键词： axonal growth chronic phase clinical study pharmacotherapy spinal cord injury

Design and preliminary test of a free-air ionization chamber for low-energy X-ray

在线全文

学校读者我要写书评

暂无评论

Chinese Physics C 2011年第6期35卷 576-579页

作者：吴金杰杨元第王培玮陈靖柳加成 national institute of metrology

A free-air ionization chamber in low-energy X-ray has been designed and manufactured at the national institute of metrology （NIM, China） according to the defination of air-kerma. The results of a preliminary test show that the leakage current of ionization chamber is around 2×10^-15A, and the correction factor of ion recombination for the ionization chamber is also obtained. The free-air ionization chamber is suitable for the primary standard in low-energy X-rays.

关键词： free-air chamber air-kerma low-energy X-ray

Precise determination of characteristic laser frequencies by an Er-doped fiber optical frequency comb

在线全文

学校读者我要写书评

暂无评论

Chinese Physics B 2022年第7期31卷 327-335页

作者： Shiying Cao Yi Han Yongjin Ding Baike Lin Zhanjun Fang Division of Time and Frequency metrology National Institute of MetrologyBeijing 100029China

Femtosecond optical frequency combs correlate the microwave and optical frequencies accurately and ***,any optical frequency in visible to near-infrared region can be directly traced to a microwave *** a result,the length unit“meter”is directly related to the time unit“second”.This paper validates the capability of the national wavelength standards based on a home-made Er-doped fiber femtosecond optical frequency comb to measure the laser frequencies ranging from visible to near-infrared *** frequency conversion in the femtosecond optical frequency comb is achieved by combining spectral broadening in a highly nonlinear fiber with a single-point frequencydoubling *** signal-to-noise ratio of the beat notes between the femtosecond optical frequency comb and the lasers at 633,698,729,780,1064,and 1542 nm is better than 30 d *** frequency instability of the above lasers is evaluated by using a hydrogen clock signal with a instability of better than 1×10^(-13)at 1-s averaging *** measurement is further validated by measuring the absolute optical frequency of an iodine-stabilized 532-nm laser and an acetylenestabilized 1542-nm *** results are within the uncertainty range of the international recommended *** results demonstrate the accurate optical frequency measurement of lasers at different frequencies using the femtosecond optical frequency comb,which is not only important for the precise and accurate traceability and calibration of the laser frequencies,but also provides technical support for establishing the national wavelength standards based on the femtosecond optical frequency comb.

关键词： optical frequency measurement phase lock Er-doped fiber laser fiber optical frequency comb

Computed Tidal Relativistic Red-Shifts of Frequency Standards on Earth and in Space Stations

在线全文

学校读者我要写书评

暂无评论

Chinese Physics Letters 2017年第11期34卷 11-14页

作者：庄伟房芳王少凯赵阳李天初 national institute of metrology Beijing 100029

Frequencies of frequency standards are shifted by the local static gravity red shifts and also modulated by the tidal relativistic red shifts. We compute the tidal relativistic red shifts using a time-domain method and present the numerical results for the national institute of metrology （NIM） in Beijing, Laboratoire national de Metrologie et Essais-Systeme de References Temps-Espaee （LNE-SYRTE） in Paris and Physikalisch-Teehnische Bundesanstalt （PTB） in Braunschweig. The differences of the tidal relativistic red shift approach as large as 1.1 × 10^-16 when frequency standards at NIM are compared with those at SYRTE and PTB. Moreover, the tidal relativistic red shifts of frequency standards in space stations are also computed.

关键词： Computed Tidal Relativistic Red-Shifts of Frequency Standards on Earth and in Space Stations